mGluR5-Ca2+ -apoptotic pathway

Mutation-inactivated SIGMAR1 to Ca2+ -apoptotic pathway

26S proteasome-mediated protein degradation

Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation

Mutation-inactivated VCP to 26S proteasome-mediated protein degradation

Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation

PERK-ATF4 signaling pathway

Mutation-caused aberrant SOD1 to PERK-ATF4 signaling pathway

IRE1a-XBP1 signaling pathway

Mutation-caused aberrant SOD1 to IRE1a-XBP1 signaling pathway

ATF6-mediated transcription

Mutation-inactivated VAPB to ATF6-mediated transcription

Mutation-caused aberrant SOD1 to ATF6-mediated transcription

C9orf72-mediated autophagy initiation

Mutation-inactivated C9orf72 to C9orf72-mediated autophagy initiation

PINK-Parkin-mediated autophagosome formation

Mutation-inactivated OPTN to PINK-Parkin-mediated autophagosome formation

Mutation-inactivated p62 to PINK-Parkin-mediated autophagosome formation

TBK1-mediated autophagosome formation

Mutation-inactivated TBK1 to TBK1-mediated autophagosome formation

Intrinsic apoptotic pathway

Mutation-caused aberrant SOD1 to intrinsic apoptotic pathway

NRG-ERBB4-PI3K signaling pathway

Mutation-inactivated ERBB4 to NRG-ERBB4-PI3K signaling pathway

Electron transfer in Complex I

Mutation-caused aberrant TDP43 to electron transfer in Complex I

Retrograde axonal transport

Mutation-caused aberrant SOD1 to retrograde axonal transport

Mutation-caused aberrant DCTN1 to retrograde axonal transport

Mutation-caused aberrant TUBA4A to retrograde axonal transport

Actin polymerization

Mutation-caused aberrant PFN1 to actin polymerization

TDP-43-regulated splicing

Mutation-caused aberrant TDP43 to TDP-43-regulated splicing

FUS-regulated splicing

Mutation-caused aberrant FUS to FUS-regulated splicing

Nuclear export of mRNA

Mutation-caused aberrant GLE1 to nuclear export of mRNA