KEGG   NETWORK: N01152
Entry
N01152                      Network                                

Name
Nuclear export of mRNA
Definition
(mRNA(nuclear)+CBP+ALY+SR+TAP+p15) -- (NPC+GLE1+DDX19B) -> (mRNA(cytoplasmic),CBP,ALY,SR,TAP,p15)
  Expanded
(C00046+4686+10189+(6428,6432)+10482+(29107,55916)) -- ((81929+55746+57122+79023+23279+79902+348995+23636+9818+53371+9688+23165+23511+9631+129401+23225+55706+9883+8021+4927+5903)+2733+11269) -> (C00046,4686,10189,(6428,6432),10482,(29107,55916))
Class
nt06424 RNA processing
nt06464 Amyotrophic lateral sclerosis
Type
Reference
Pathway
hsa03013  Nucleocytoplasmic transport
Gene
4686  NCBP1; nuclear cap binding protein subunit 1
10189  ALYREF; Aly/REF export factor
6428  SRSF3; serine and arginine rich splicing factor 3
6432  SRSF7; serine and arginine rich splicing factor 7
10482  NXF1; nuclear RNA export factor 1
29107  NXT1; nuclear transport factor 2 like export factor 1
55916  NXT2; nuclear transport factor 2 like export factor 2
81929  SEH1L; SEH1 like nucleoporin
55746  NUP133; nucleoporin 133
57122  NUP107; nucleoporin 107
79023  NUP37; nucleoporin 37
23279  NUP160; nucleoporin 160
79902  NUP85; nucleoporin 85
348995  NUP43; nucleoporin 43
23636  NUP62; nucleoporin 62
9818  NUP58; nucleoporin 58
53371  NUP54; nucleoporin 54
9688  NUP93; nucleoporin 93
23165  NUP205; nucleoporin 205
23511  NUP188; nucleoporin 188
9631  NUP155; nucleoporin 155
129401  NUP35; nucleoporin 35
23225  NUP210; nucleoporin 210
55706  NDC1; NDC1 transmembrane nucleoporin
9883  POM121; POM121 transmembrane nucleoporin
8021  NUP214; nucleoporin 214
4927  NUP88; nucleoporin 88
5903  RANBP2; RAN binding protein 2
2733  GLE1; GLE1 RNA export mediator
11269  DDX19B; DEAD-box helicase 19B
Metabolite
C00046  RNA
C00046  RNA
Reference
  Authors
Kohler A, Hurt E
  Title
Exporting RNA from the nucleus to the cytoplasm.
  Journal
Nat Rev Mol Cell Biol 8:761-73 (2007)
DOI:10.1038/nrm2255
Reference
  Authors
Erkmann JA, Kutay U
  Title
Nuclear export of mRNA: from the site of transcription to the cytoplasm.
  Journal
Exp Cell Res 296:12-20 (2004)
DOI:10.1016/j.yexcr.2004.03.015
Reference
  Authors
Schwartz TU
  Title
The Structure Inventory of the Nuclear Pore Complex.
  Journal
J Mol Biol 428:1986-2000 (2016)
DOI:10.1016/j.jmb.2016.03.015
Reference
  Authors
Stewart M
  Title
Nuclear export of mRNA.
  Journal
Trends Biochem Sci 35:609-17 (2010)
DOI:10.1016/j.tibs.2010.07.001
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