KEGG   PATHWAY: oaa00330
Entry
oaa00330                    Pathway                                
Name
Arginine and proline metabolism - Ornithorhynchus anatinus (platypus)
Class
Metabolism; Amino acid metabolism
Pathway map
oaa00330  Arginine and proline metabolism
oaa00330

Module
oaa_M00015  Proline biosynthesis, glutamate => proline [PATH:oaa00330]
oaa_M00047  Creatine pathway [PATH:oaa00330]
oaa_M00134  Polyamine biosynthesis, arginine => ornithine => putrescine [PATH:oaa00330]
oaa_M00135  GABA biosynthesis, eukaryotes, putrescine => GABA [PATH:oaa00330]
oaa_M00970  Proline degradation, proline => glutamate [PATH:oaa00330]
oaa_M00972  Proline metabolism [PATH:oaa00330]
Other DBs
GO: 0006525 0006560
Organism
Ornithorhynchus anatinus (platypus) [GN:oaa]
Gene
100073477  GATM; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
103164686  GAMT; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
100085972  creatine kinase U-type, mitochondrial [KO:K00933] [EC:2.7.3.2]
100081308  CKMT2; creatine kinase S-type, mitochondrial [KO:K00933] [EC:2.7.3.2]
100076820  CKB; creatine kinase B-type isoform X1 [KO:K00933] [EC:2.7.3.2]
100082097  CKM; creatine kinase M-type isoform X1 [KO:K27382] [EC:2.7.3.2]
103167103  AZIN2; antizyme inhibitor 2 isoform X1 [KO:K01583] [EC:4.1.1.19]
100093130  ODC1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
100077385  antizyme inhibitor 2-like [KO:K01581] [EC:4.1.1.17]
100077254  antizyme inhibitor 2-like isoform X1 [KO:K01581] [EC:4.1.1.17]
114811997  SRM; spermidine synthase [KO:K00797] [EC:2.5.1.16]
100083114  SMS; spermine synthase isoform X2 [KO:K00802] [EC:2.5.1.22]
100083534  AMD1; S-adenosylmethionine decarboxylase proenzyme isoform X1 [KO:K01611] [EC:4.1.1.50]
100075142  amiloride-sensitive amine oxidase [copper-containing]-like [KO:K11182] [EC:1.4.3.22]
100092837  amiloride-sensitive amine oxidase [copper-containing] isoform X2 [KO:K11182] [EC:1.4.3.22]
100085736  SMOX; spermine oxidase [KO:K12259] [EC:1.5.3.16 1.5.3.-]
100074904  ALDH2; aldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
100090227  ALDH1B1; aldehyde dehydrogenase X, mitochondrial isoform X2 [KO:K00128] [EC:1.2.1.3]
100076898  ALDH3A2; aldehyde dehydrogenase family 3 member A2 isoform X1 [KO:K00128] [EC:1.2.1.3]
100090493  ALDH16A1; aldehyde dehydrogenase family 16 member A1 isoform X1 [KO:K00128] [EC:1.2.1.3]
100074256  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase isoform X1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
100076925  ALDH9A1; 4-trimethylaminobutyraldehyde dehydrogenase [KO:K00149] [EC:1.2.1.47 1.2.1.3]
100076860  CNDP1; beta-Ala-His dipeptidase isoform X1 [KO:K05604] [EC:3.4.13.20]
100076934  cytosolic non-specific dipeptidase [KO:K08660] [EC:3.4.13.18]
100076899  cytosolic non-specific dipeptidase [KO:K08660] [EC:3.4.13.18]
100681134  CARNS1; carnosine synthase 1 isoform X1 [KO:K14755] [EC:6.3.2.11]
100082554  SAT1; diamine acetyltransferase 1 [KO:K00657] [EC:2.3.1.57]
114808151  SAT2; thialysine N-epsilon-acetyltransferase isoform X1 [KO:K00657] [EC:2.3.1.57]
100081953  amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
100082010  MAOA; amine oxidase [flavin-containing] A isoform X1 [KO:K00274] [EC:1.4.3.4]
100093512  AGMAT; agmatinase, mitochondrial [KO:K27001] [EC:3.5.3.- 3.5.3.7 3.5.3.17]
100093259  NOS1; LOW QUALITY PROTEIN: nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
100075386  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
100091599  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
100073732  ARG1; arginase-1 [KO:K01476] [EC:3.5.3.1]
100087902  ARG2; arginase-2, mitochondrial [KO:K01476] [EC:3.5.3.1]
100085429  OAT; ornithine aminotransferase, mitochondrial [KO:K00819] [EC:2.6.1.13]
100089440  PYCR3; pyrroline-5-carboxylate reductase 3 [KO:K00286] [EC:1.5.1.2]
100079115  PYCR1; pyrroline-5-carboxylate reductase 1, mitochondrial isoform X1 [KO:K00286] [EC:1.5.1.2]
100090277  PRODH; proline dehydrogenase 1, mitochondrial isoform X1 [KO:K00318] [EC:1.5.5.2]
100092834  ALDH4A1; delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial isoform X2 [KO:K00294] [EC:1.2.1.88]
100077152  ALDH18A1; delta-1-pyrroline-5-carboxylate synthase isoform X1 [KO:K12657] [EC:2.7.2.11 1.2.1.41]
100082274  LAP3; cytosol aminopeptidase [KO:K11142] [EC:3.4.11.1 3.4.11.5]
100079170  P4HA2; prolyl 4-hydroxylase subunit alpha-2 isoform X1 [KO:K00472] [EC:1.14.11.2]
100077226  P4HA1; prolyl 4-hydroxylase subunit alpha-1 isoform X1 [KO:K00472] [EC:1.14.11.2]
114812117  PRODH2; hydroxyproline dehydrogenase isoform X1 [KO:K11394] [EC:1.5.5.3]
100076641  GOT1; aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
100090021  GOT1L1; putative aspartate aminotransferase, cytoplasmic 2 isoform X2 [KO:K14454] [EC:2.6.1.1]
100075744  GOT2; aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
100088274  HOGA1; 4-hydroxy-2-oxoglutarate aldolase, mitochondrial isoform X1 [KO:K18123] [EC:4.1.3.16]
100082667  DAO; D-amino-acid oxidase isoform X1 [KO:K00273] [EC:1.4.3.3]
100086994  L3HYPDH; trans-3-hydroxy-L-proline dehydratase isoform X1 [KO:K18384] [EC:4.2.1.77]
Compound
C00012  Peptide
C00019  S-Adenosyl-L-methionine
C00022  Pyruvate
C00025  L-Glutamate
C00048  Glyoxylate
C00062  L-Arginine
C00077  L-Ornithine
C00086  Urea
C00134  Putrescine
C00148  L-Proline
C00179  Agmatine
C00213  Sarcosine
C00223  p-Coumaroyl-CoA
C00300  Creatine
C00315  Spermidine
C00334  4-Aminobutanoate
C00406  Feruloyl-CoA
C00431  5-Aminopentanoate
C00436  N-Carbamoylputrescine
C00441  L-Aspartate 4-semialdehyde
C00533  Nitric oxide
C00555  4-Aminobutyraldehyde
C00581  Guanidinoacetate
C00750  Spermine
C00763  D-Proline
C00791  Creatinine
C00884  Homocarnosine
C00986  1,3-Diaminopropane
C01035  4-Guanidinobutanoate
C01043  N-Carbamoylsarcosine
C01110  5-Amino-2-oxopentanoic acid
C01137  S-Adenosylmethioninamine
C01157  Hydroxyproline
C01165  L-Glutamate 5-semialdehyde
C01250  N-Acetyl-L-glutamate 5-semialdehyde
C01682  Nopaline
C02305  Phosphocreatine
C02565  N-Methylhydantoin
C02647  4-Guanidinobutanal
C02714  N-Acetylputrescine
C02946  4-Acetamidobutanoate
C03078  4-Guanidinobutanamide
C03166  Phosphoguanidinoacetate
C03287  L-Glutamyl 5-phosphate
C03296  N2-Succinyl-L-arginine
C03375  Norspermidine
C03415  N2-Succinyl-L-ornithine
C03564  1-Pyrroline-2-carboxylate
C03771  5-Guanidino-2-oxopentanoate
C03912  (S)-1-Pyrroline-5-carboxylate
C04137  Octopine
C04281  L-1-Pyrroline-3-hydroxy-5-carboxylate
C05147  trans-3-Hydroxy-L-proline
C05931  N-Succinyl-L-glutamate
C05932  N-Succinyl-L-glutamate 5-semialdehyde
C05933  N(omega)-Hydroxyarginine
C05936  N4-Acetylaminobutanal
C05938  L-4-Hydroxyglutamate semialdehyde
C05945  L-Arginine phosphate
C05946  (4R)-4-Hydroxy-2-oxoglutarate
C05947  L-erythro-4-Hydroxyglutamate
C10497  Feruloylputrescine
C15699  gamma-L-Glutamylputrescine
C15700  gamma-Glutamyl-gamma-aminobutyraldehyde
C15767  4-(L-gamma-Glutamylamino)butanoate
C18172  Carboxyspermidine
C18174  Carboxynorspermidine
C18326  p-Coumaroylputrescine
C19706  cis-3-Hydroxy-L-proline
Reference
PMID:5288244
  Authors
Haake P, Allen GW.
  Title
Studies on phosphorylation by phosphoroguanidinates. The mechanism of action of creatine: ATP transphosphorylase (creatine kinase).
  Journal
Proc Natl Acad Sci U S A 68:2691-3 (1971)
DOI:10.1073/pnas.68.11.2691
Reference
PMID:16499623
  Authors
Kurihara S, Oda S, Kumagai H, Suzuki H.
  Title
Gamma-glutamyl-gamma-aminobutyrate hydrolase in the putrescine utilization pathway of Escherichia coli K-12.
  Journal
FEMS Microbiol Lett 256:318-23 (2006)
DOI:10.1111/j.1574-6968.2006.00137.x
Reference
PMID:15590624
  Authors
Kurihara S, Oda S, Kato K, Kim HG, Koyanagi T, Kumagai H, Suzuki H.
  Title
A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12.
  Journal
J Biol Chem 280:4602-8 (2005)
DOI:10.1074/jbc.M411114200
Related
pathway
oaa00020  Citrate cycle (TCA cycle)
oaa00220  Arginine biosynthesis
oaa00250  Alanine, aspartate and glutamate metabolism
oaa00260  Glycine, serine and threonine metabolism
oaa00270  Cysteine and methionine metabolism
oaa00310  Lysine degradation
oaa00410  beta-Alanine metabolism
oaa00470  D-Amino acid metabolism
oaa00480  Glutathione metabolism
oaa00630  Glyoxylate and dicarboxylate metabolism
oaa00650  Butanoate metabolism
oaa00770  Pantothenate and CoA biosynthesis
KO pathway
ko00330   
LinkDB

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