KEGG   PATHWAY: pads04514
Entry
pads04514                   Pathway                                
Name
Cell adhesion molecules - Pyxicephalus adspersus (African bullfrog)
Description
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
pads04514  Cell adhesion molecules
pads04514

Other DBs
GO: 0050839
Organism
Pyxicephalus adspersus (African bullfrog) [GN:pads]
Gene
140321331  [KO:K06087]
140321619  [KO:K06081]
140321643  IGSF11; immunoglobulin superfamily member 11 [KO:K06791]
140321716  ICOSLG; ICOS ligand isoform X1 [KO:K06710]
140322606  [KO:K06087]
140322613  CLDN34; claudin-34 [KO:K06087]
140322618  CLDN7; claudin-7 [KO:K06087]
140322674  NLGN2; neuroligin-2 isoform X1 [KO:K07378]
140322716  CLDN15; LOW QUALITY PROTEIN: claudin-15 [KO:K06087]
140322885  CLDN14; claudin-14 [KO:K06087]
140323042  [KO:K06747]
140323986  CNTN1; contactin-1 [KO:K06759]
140323987  NRCAM; neuronal cell adhesion molecule isoform X1 [KO:K06756]
140324235  LRRC4; leucine-rich repeat-containing protein 4 [KO:K16351]
140324323  NEO1; neogenin isoform X1 [KO:K06766]
140324327  CD276; CD276 antigen isoform X1 [KO:K06746]
140325663  [KO:K06087]
140325786  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
140325879  CNTNAP1; contactin-associated protein 1 [KO:K07379]
140326042  PTPRD; receptor-type tyrosine-protein phosphatase delta isoform X1 [KO:K06777] [EC:3.1.3.48]
140326257  [KO:K06088]
140326470  PTPRS; receptor-type tyrosine-protein phosphatase S isoform X1 [KO:K06778] [EC:3.1.3.48]
140326548  CLDN23; claudin-23 [KO:K06087]
140326833  ITGB7; integrin beta-7 [KO:K06590]
140327269  CD8A; T-cell surface glycoprotein CD8 alpha chain [KO:K06458]
140327270  CD8B; T-cell surface glycoprotein CD8 beta chain [KO:K06459]
140327327  SIGLEC1; sialoadhesin isoform X1 [KO:K06548]
140327462  [KO:K06087]
140327795  [KO:K06087]
140328210  CLDN18; claudin-18 isoform X1 [KO:K06087]
140328278  [KO:K06087]
140328452  SLITRK3; SLIT and NTRK-like protein 3 [KO:K25834]
140328473  CLDN11; claudin-11 [KO:K06087]
140328484  NLGN1; neuroligin-1 isoform X1 [KO:K07378]
140328547  CLDN16; claudin-16 [KO:K06087]
140328548  CLDN1; claudin-1 [KO:K06087]
140329232  CLDN20; claudin-20 [KO:K06087]
140329436  NRXN1; neurexin-1 isoform X1 [KO:K07377]
140329774  PDCD1; programmed cell death protein 1 [KO:K06744]
140330607  SDC2; syndecan-2 isoform X1 [KO:K16336]
140330677  SLITRK1; SLIT and NTRK-like protein 1 [KO:K25832]
140330685  SLITRK6; SLIT and NTRK-like protein 6 [KO:K25837]
140330693  SLITRK5; SLIT and NTRK-like protein 5 [KO:K25836]
140330756  CLDN10; claudin-10 [KO:K06087]
140330822  CDH2; cadherin-2 [KO:K06736]
140330876  PTPRM; receptor-type tyrosine-protein phosphatase mu isoform X1 [KO:K05693] [EC:3.1.3.48]
140330915  CD226; CD226 antigen [KO:K06567]
140331264  ITGA9; integrin alpha-9 [KO:K06585]
140331323  CNTNAP2; contactin-associated protein-like 2 [KO:K07380]
140331490  ITGB8; integrin beta-8 [KO:K06591]
140331555  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
140332127  ITGA8; integrin alpha-8 [KO:K06584]
140332393  CDH4; cadherin-4 [KO:K06797]
140332876  PECAM1; platelet endothelial cell adhesion molecule [KO:K06471]
140333338  [KO:K16338]
140333447  ALCAM; CD166 antigen [KO:K06547]
140333771  CLDN5; claudin-5 [KO:K06087]
140334105  OCLN; occludin [KO:K06088]
140334462  [KO:K06087]
140334584  [KO:K06713]
140334778  ITGAL; integrin alpha-L [KO:K05718]
140335598  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
140335718  ITGB2; integrin beta-2 [KO:K06464]
140335818  CD28; T-cell-specific surface glycoprotein CD28 [KO:K06470]
140335819  CTLA4; cytotoxic T-lymphocyte protein 4 [KO:K06538]
140336050  ITGA4; integrin alpha-4 [KO:K06483]
140336319  PTPRF; receptor-type tyrosine-protein phosphatase F isoform X1 [KO:K05695] [EC:3.1.3.48]
140336409  NEGR1; neuronal growth regulator 1 isoform X1 [KO:K06775]
140336709  VCAM1; vascular cell adhesion protein 1 [KO:K06527]
140336723  NTNG1; netrin-G1 isoform X1 [KO:K07522]
140336737  PTPRC; receptor-type tyrosine-protein phosphatase C isoform X1 [KO:K06478] [EC:3.1.3.48]
140336794  [KO:K06496]
140336795  [KO:K06496]
140336796  SELL; L-selectin [KO:K06495]
140336841  SDC3; syndecan-3 isoform X1 [KO:K16337]
140337571  GLG1; Golgi apparatus protein 1 [KO:K06816]
140338041  NECTIN3; nectin-3 isoform X1 [KO:K06592]
140338103  LRRC4C; leucine-rich repeat-containing protein 4C [KO:K07523]
140338376  [KO:K05689]
140338377  [KO:K05689]
140338415  CDH15; cadherin-15 isoform X1 [KO:K06809]
140338444  CDH5; cadherin-5 [KO:K06533]
140338515  [KO:K07377]
140339335  VSIR; V-type immunoglobulin domain-containing suppressor of T-cell activation [KO:K23268]
140339597  [KO:K06454]
140339833  NFASC; neurofascin isoform X1 [KO:K06757]
140339835  [KO:K06785]
140339904  [KO:K06454]
140339968  CNTN2; contactin-2 [KO:K06760]
140340154  [KO:K06087]
140340212  NECTIN2; nectin-2 isoform X1 [KO:K06531]
140340365  LRRC4B; leucine-rich repeat-containing protein 4B [KO:K16360]
140340381  NCAM1; neural cell adhesion molecule 1 isoform X1 [KO:K06491]
140340400  CLDN19; claudin-19 isoform X1 [KO:K06087]
140340422  ESAM; endothelial cell-selective adhesion molecule [KO:K06787]
140340667  [KO:K06771]
140341091  JAM3; junctional adhesion molecule C [KO:K06785]
140341242  CADM1; cell adhesion molecule 1 isoform X1 [KO:K06781]
140341303  NECTIN1; nectin-1 isoform X1 [KO:K06081]
140341329  [KO:K06467]
140341331  [KO:K06467]
140341332  [KO:K06467]
140341629  NLGN4X; neuroligin-4, X-linked isoform X1 [KO:K07378]
140341681  [KO:K06520]
140341900  VSIG8; V-set and immunoglobulin domain-containing protein 8 [KO:K06788]
140341952  NRXN3; neurexin 3 [KO:K07377]
140342027  F11R; junctional adhesion molecule A [KO:K06089]
140342158  MPZ; myelin protein P0 isoform X1 [KO:K06770]
140342416  CADM3; cell adhesion molecule 3 isoform X1 [KO:K06780]
140342445  [KO:K06791]
140342450  CLDN3; claudin-3 [KO:K06087]
140342459  CLDN4; claudin-4 [KO:K06087]
140342917  [KO:K07378]
140343009  [KO:K06751]
140343022  [KO:K06751]
140343122  SLITRK2; SLIT and NTRK-like protein 2 [KO:K25833]
140343172  [KO:K06752]
140343230  [KO:K06752]
140343342  [KO:K06751]
140343647  SLITRK4; SLIT and NTRK-like protein 4 [KO:K25835]
140343666  CD40LG; CD40 ligand [KO:K03161]
140343708  [KO:K06751]
140343856  NTNG2; netrin-G2 isoform X1 [KO:K16359]
140343903  [KO:K06751]
140343904  [KO:K06752]
140343915  CLDN2; claudin-2 [KO:K06087]
140343971  [KO:K06751]
140344222  [KO:K06751]
140344244  NLGN3; neuroligin-3 isoform X1 [KO:K07378]
140344338  [KO:K06752]
140344339  [KO:K06752]
140344340  [KO:K06752]
140344342  [KO:K06751]
140344547  L1CAM; neural cell adhesion molecule L1 isoform X1 [KO:K06550]
140344556  ITGAV; integrin alpha-V [KO:K06487]
140344561  CD99L2; CD99 antigen-like protein 2 isoform X1 [KO:K06520]
140344908  CXADR; coxsackievirus and adenovirus receptor isoform X1 [KO:K06788]
140344993  NCAM2; neural cell adhesion molecule 2 isoform X1 [KO:K06491]
140345073  JAM2; junctional adhesion molecule B isoform X2 [KO:K06735]
Reference
PMID:14690046
  Authors
Barclay AN.
  Title
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
  Journal
Semin Immunol 15:215-23 (2003)
DOI:10.1016/S1044-5323(03)00047-2
Reference
PMID:11910893
  Authors
Sharpe AH, Freeman GJ.
  Title
The B7-CD28 superfamily.
  Journal
Nat Rev Immunol 2:116-26 (2002)
DOI:10.1038/nri727
Reference
PMID:9597126
  Authors
Grewal IS, Flavell RA.
  Title
CD40 and CD154 in cell-mediated immunity.
  Journal
Annu Rev Immunol 16:111-35 (1998)
DOI:10.1146/annurev.immunol.16.1.111
Reference
PMID:16034094
  Authors
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
  Title
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
  Journal
J Immunol 175:1558-65 (2005)
DOI:10.4049/jimmunol.175.3.1558
Reference
PMID:12234363
  Authors
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
  Title
Cell adhesion and polarity during immune interactions.
  Journal
Immunol Rev 186:68-82 (2002)
DOI:10.1034/j.1600-065X.2002.18607.x
Reference
PMID:15071551
  Authors
Dejana E.
  Title
Endothelial cell-cell junctions: happy together.
  Journal
Nat Rev Mol Cell Biol 5:261-70 (2004)
DOI:10.1038/nrm1357
Reference
PMID:14519386
  Authors
Bazzoni G.
  Title
The JAM family of junctional adhesion molecules.
  Journal
Curr Opin Cell Biol 15:525-30 (2003)
DOI:10.1016/S0955-0674(03)00104-2
Reference
PMID:10798271
  Authors
Becker BF, Heindl B, Kupatt C, Zahler S.
  Title
Endothelial function and hemostasis.
  Journal
Z Kardiol 89:160-7 (2000)
DOI:10.1007/PL00007320
Reference
PMID:9150551
  Authors
Elangbam CS, Qualls CW Jr, Dahlgren RR.
  Title
Cell adhesion molecules--update.
  Journal
Vet Pathol 34:61-73 (1997)
DOI:10.1177/030098589703400113
Reference
PMID:12810109
  Authors
Muller WA.
  Title
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
  Journal
Trends Immunol 24:327-34 (2003)
DOI:10.1016/S1471-4906(03)00117-0
Reference
PMID:14519398
  Authors
Yamagata M, Sanes JR, Weiner JA.
  Title
Synaptic adhesion molecules.
  Journal
Curr Opin Cell Biol 15:621-32 (2003)
DOI:10.1016/S0955-0674(03)00107-8
Reference
PMID:15882774
  Authors
Ethell IM, Pasquale EB.
  Title
Molecular mechanisms of dendritic spine development and remodeling.
  Journal
Prog Neurobiol 75:161-205 (2005)
DOI:10.1016/j.pneurobio.2005.02.003
Reference
PMID:11050419
  Authors
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
  Title
Making memories stick: cell-adhesion molecules in synaptic plasticity.
  Journal
Trends Cell Biol 10:473-82 (2000)
DOI:10.1016/S0962-8924(00)01838-9
Reference
PMID:11860281
  Authors
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
  Title
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
  Journal
Mol Cell Neurosci 19:292-306 (2002)
DOI:10.1006/mcne.2001.1071
Reference
PMID:10964748
  Authors
Dunican DJ, Doherty P.
  Title
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
  Journal
Mol Cell Biol Res Commun 3:255-63 (2000)
DOI:10.1006/mcbr.2000.0225
Reference
PMID:12367625
  Authors
Girault JA, Peles E.
  Title
Development of nodes of Ranvier.
  Journal
Curr Opin Neurobiol 12:476-85 (2002)
DOI:10.1016/S0959-4388(02)00370-7
Reference
PMID:10664064
  Authors
Arroyo EJ, Scherer SS.
  Title
On the molecular architecture of myelinated fibers.
  Journal
Histochem Cell Biol 113:1-18 (2000)
DOI:10.1007/s004180050001
Reference
PMID:14556710
  Authors
Salzer JL.
  Title
Polarized domains of myelinated axons.
  Journal
Neuron 40:297-318 (2003)
DOI:10.1016/S0896-6273(03)00628-7
Reference
PMID:15561584
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Reference
PMID:15551862
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
PMID:15115723
  Authors
Siu MK, Cheng CY.
  Title
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
  Journal
Biol Reprod 71:375-91 (2004)
DOI:10.1095/biolreprod.104.028225
Reference
PMID:15056568
  Authors
Lee NP, Cheng CY.
  Title
Adaptors, junction dynamics, and spermatogenesis.
  Journal
Biol Reprod 71:392-404 (2004)
DOI:10.1095/biolreprod.104.027268
Reference
PMID:15728677
  Authors
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
  Title
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
  Journal
Development 132:1525-37 (2005)
DOI:10.1242/dev.01697
Reference
PMID:12500939
  Authors
Marthiens V, Gavard J, Lambert M, Mege RM.
  Title
Cadherin-based cell adhesion in neuromuscular development.
  Journal
Biol Cell 94:315-26 (2002)
DOI:10.1016/S0248-4900(02)00005-9
Reference
PMID:15923648
  Authors
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
  Title
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
  Journal
J Cell Sci 118:2355-62 (2005)
DOI:10.1242/jcs.02397
Related
pathway
pads04520  Adherens junction
pads04530  Tight junction
KO pathway
ko04514   

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