Entry Name Cell adhesion molecules
Description Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class Environmental Information Processing; Signaling molecules and interactionBRITE hierarchy
Pathway map Ortholog table Other DBs Orthology K06449 T-cell surface glycoprotein CD2
K23268 V-type immunoglobulin domain-containing suppressor of T-cell activation
K06791 immunoglobulin superfamily, member 11
K06745 programmed cell death 1 ligand 1
K06538 cytotoxic T-lymphocyte-associated protein 4
K06710 inducible T-cell co-stimulator ligand
K06713 inducible T-cell co-stimulator
K10784 T cell receptor alpha chain V region
K10785 T-cell receptor beta chain V region
K06454 T-cell surface glycoprotein CD4
K06458 T-cell surface glycoprotein CD8 alpha chain
K06459 T-cell surface glycoprotein CD8 beta chain
K06708 programmed cell death 1 ligand 2
K06746 immune costimulatory protein B7-H3
K06747 immune costimulatory protein B7-H4
K06744 programmed cell death protein 1
K03160 tumor necrosis factor receptor superfamily member 5
K03161 tumor necrosis factor ligand superfamily member 5
K06547 activated leukocyte cell adhesion molecule
K06456 T-cell surface glycoprotein CD6
K06531 poliovirus receptor-related protein 2
K16350 T-cell immunoreceptor with Ig and ITIM domains
K06490 intercellular adhesion molecule 1
K06523 intercellular adhesion molecule 2
K06486 intercellular adhesion molecule 3
K06592 poliovirus receptor-related protein 3
K06089 junctional adhesion molecule 1
K06735 junctional adhesion molecule 2
K06785 junctional adhesion molecule 3
K06787 endothelial cell adhesion molecule
K06533 cadherin 5, type 2, VE-cadherin
K06471 platelet/endothelial cell adhesion molecule
K06527 vascular cell adhesion molecule 1
K06779 mucosal vascular addressin cell adhesion molecule 1
K06815 glycosylation dependent cell adhesion molecule 1
K06816 golgi apparatus protein 1
K06494 selectin, endothelial cell
K06081 poliovirus receptor-related protein 1
K06736 cadherin 2, type 1, N-cadherin
K06491 neural cell adhesion molecule
K06550 L1 cell adhesion molecule
K06781 cell adhesion molecule 1
K06775 neuronal growth regulator 1
K25832 SLIT and NTRK-like protein 1
K25833 SLIT and NTRK-like protein 2
K25835 SLIT and NTRK-like protein 4
K25836 SLIT and NTRK-like protein 5
K25837 SLIT and NTRK-like protein 6
K25834 SLIT and NTRK-like protein 3
K06780 cell adhesion molecule 3
K06756 neuronal cell adhesion molecule
K07379 contactin associated protein 1
K07380 contactin associated protein-like 2
K06771 myelin associated glycoprotein
K05689 cadherin 1, type 1, E-cadherin
K06796 cadherin 3, type 1, P-cadherin
K06797 cadherin 4, type 1, R-cadherin
K06809 cadherin 15, M-cadherin
Reference Authors Barclay AN.
Title Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
Journal Reference Authors Sharpe AH, Freeman GJ.
Title The B7-CD28 superfamily.
Journal Reference Authors Grewal IS, Flavell RA.
Title CD40 and CD154 in cell-mediated immunity.
Journal Reference Authors Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
Title CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
Journal Reference Authors Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
Title Cell adhesion and polarity during immune interactions.
Journal Reference Authors Dejana E.
Title Endothelial cell-cell junctions: happy together.
Journal Reference Authors Bazzoni G.
Title The JAM family of junctional adhesion molecules.
Journal Reference Authors Becker BF, Heindl B, Kupatt C, Zahler S.
Title Endothelial function and hemostasis.
Journal Reference Authors Elangbam CS, Qualls CW Jr, Dahlgren RR.
Title Cell adhesion molecules--update.
Journal Reference Authors Muller WA.
Title Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
Journal Reference Authors Yamagata M, Sanes JR, Weiner JA.
Title Synaptic adhesion molecules.
Journal Reference Authors Ethell IM, Pasquale EB.
Title Molecular mechanisms of dendritic spine development and remodeling.
Journal Reference Authors Benson DL, Schnapp LM, Shapiro L, Huntley GW.
Title Making memories stick: cell-adhesion molecules in synaptic plasticity.
Journal Reference Authors Rosdahl JA, Mourton TL, Brady-Kalnay SM.
Title Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
Journal Reference Authors Dunican DJ, Doherty P.
Title The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
Journal Reference Authors Girault JA, Peles E.
Title Development of nodes of Ranvier.
Journal Reference Authors Arroyo EJ, Scherer SS.
Title On the molecular architecture of myelinated fibers.
Journal Reference Authors Salzer JL.
Title Polarized domains of myelinated axons.
Journal Reference Authors Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
Title Roles and modes of action of nectins in cell-cell adhesion.
Journal Reference Authors Nakanishi H, Takai Y.
Title Roles of nectins in cell adhesion, migration and polarization.
Journal Reference Authors Siu MK, Cheng CY.
Title Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
Journal Reference Authors Lee NP, Cheng CY.
Title Adaptors, junction dynamics, and spermatogenesis.
Journal Reference Authors Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
Title Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
Journal Reference Authors Marthiens V, Gavard J, Lambert M, Mege RM.
Title Cadherin-based cell adhesion in neuromuscular development.
Journal Reference Authors Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
Title Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
Journal Related ko04610 Complement and coagulation cascades
ko04660 T cell receptor signaling pathway
ko04670 Leukocyte transendothelial migration
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