KEGG ORTHOLOGY: K06531

ORTHOLOGY: K06531

Entry

K06531                      KO

Symbol

NECTIN2, PVRL2, CD112

Name

poliovirus receptor-related protein 2

Pathway

map03266

Virion - Herpesvirus

map04514

Cell adhesion molecules

map04520

Adherens junction

map05168

Herpes simplex virus 1 infection

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09125 Information processing in viruses
   03266 Virion - Herpesvirus
    K06531  NECTIN2, PVRL2, CD112; poliovirus receptor-related protein 2
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules
    K06531  NECTIN2, PVRL2, CD112; poliovirus receptor-related protein 2
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K06531  NECTIN2, PVRL2, CD112; poliovirus receptor-related protein 2
09160 Human Diseases
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    K06531  NECTIN2, PVRL2, CD112; poliovirus receptor-related protein 2
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04515 Cell adhesion molecules
    K06531  NECTIN2, PVRL2, CD112; poliovirus receptor-related protein 2
   04090 CD molecules
    K06531  NECTIN2, PVRL2, CD112; poliovirus receptor-related protein 2
Cell adhesion molecules [BR:ko04515]
Immunoglobulin superfamily
  Nectin family
   K06531  NECTIN2, PVRL2, CD112; poliovirus receptor-related protein 2
CD molecules [BR:ko04090]
Proteins
  K06531  CD112, PVRL2; poliovirus receptor-related 2 (herpesvirus entry mediator B)

Genes

HSA:	5819(NECTIN2)

PTR:	456118(NECTIN2)

PPS:	100995294(NECTIN2)

GGO:	101149746(NECTIN2)

PON:	100447663(NECTIN2)

PPYG:

129019960(NECTIN2)

NLE:	100592381(NECTIN2)

HMH:	116482915(NECTIN2)

SSYN:

129466244(NECTIN2)

MCC:	713229(NECTIN2)

MCF:	102137456(NECTIN2)

MTHB:

126943452

MNI:	105478519(NECTIN2)

CSAB:

103234839(NECTIN2)

CATY:

105595123(PVRL2)

PANU:

101018321(NECTIN2)

TGE:	112612476(NECTIN2)

MLEU:

105535883(PVRL2)

RRO:	104673464(NECTIN2)

RBB:	108531048(NECTIN2)

TFN:	117091370(NECTIN2)

PTEH:

111527896(NECTIN2)

CANG:

105526985

CJC:	100396645(NECTIN2)

SBQ:	101042126(PVRL2)

CIMI:

108285321(NECTIN2)

ANAN:

105713055(NECTIN2)

CSYR:

103250682(NECTIN2)

MMUR:

105869507(NECTIN2)

LCAT:

123623981(NECTIN2)

PCOQ:

105817700(PVRL2)

OGA:	100961786(NECTIN2)

MMU:	19294(Nectin2)

MCAL:

110297511(Nectin2)

MPAH:

110336368(Nectin2)

RNO:	308417(Nectin2)

MCOC:

116101769(Nectin2)

ANU:	117718608(Nectin2)

ASYL:

127675265(Nectin2)

MUN:	110551530(Nectin2)

CGE:	100751945(Nectin2)

MAUA:

101839886(Nectin2)

PROB:

127238845(Nectin2)

PLEU:

114709861(Nectin2)

MORG:

121449706(Nectin2)

MFOT:

126490977

AAMP:

119820953(Nectin2)

NGI:	103749168(Nectin2)

HGL:	101715823(Nectin2)

CPOC:

100730603(Nectin2)

CCAN:

109692402(Nectin2)

DORD:

105997970(Pvrl2)

DSP:	122125802(Nectin2)

DMER:

138812929 138813838

PLOP:

125368074(Nectin2)

NCAR:

124966877

MMMA:

107151365(Nectin2)

ITI:	101966076(Nectin2)

OCU:

100357545

OPI:	101522841(NECTIN2)

OCZ:	121153766(NECTIN2)

TUP:	102488465(NECTIN2)

GVR:	103601573(PVRL2)

CFA:	611060(NECTIN2)

CLUD:

112645323(NECTIN2)

VVP:	112931233(NECTIN2)

VLG:	121484590(NECTIN2)

NPO:	129500206(NECTIN2)

AML:	100473649(NECTIN2)

UMR:	103657174(NECTIN2)

UAH:	113243454(NECTIN2)

UAR:	123802304(NECTIN2)

ELK:

111160672

LLV:

125088673

MPUF:

101680327(PVRL2)

MNP:	132005262(NECTIN2)

MLK:	131818104(NECTIN2)

NVS:	122911961(NECTIN2)

ORO:	101362224(PVRL2)

EJU:	114197181(NECTIN2)

ZCA:	113936423(NECTIN2)

MLX:	117998116(NECTIN2)

NSU:	110572903(NECTIN2)

LWW:	102738537(NECTIN2)

FCA:	101087027(NECTIN2)

PYU:	121018581(NECTIN2)

PCOO:

112850713(NECTIN2)

PBG:	122493907(NECTIN2)

PVIV:

125153421(NECTIN2)

LRUF:

124511038

LGF:	123578791(NECTIN2)

AJU:

106973662

PTG:	102969236(NECTIN2) 107180059

PPAD:

109252897(NECTIN2)

PUC:

125915170

PLEZ:

122208356(NECTIN2)

HHV:	120240839(NECTIN2)

BTA:	505580(NECTIN2)

BOM:	102275439(NECTIN2)

BIU:	109572641(NECTIN2)

BBUB:

102401663(NECTIN2)

BBIS:

104997681(PVRL2)

CHX:	102172535(NECTIN2)

OAS:	101111996(NECTIN2)

BTAX:

128063214(NECTIN2)

CSUM:

138095835(NECTIN2)

ODA:	120872296(NECTIN2)

CCAD:

122421686(NECTIN2)

MREE:

136161433(NECTIN2)

OVR:	110137007(NECTIN2)

MBEZ:

129546684(NECTIN2)

SSC:	100038012(NECTIN2)

CFR:	102507819(NECTIN2)

CBAI:

105062714(PVRL2) 105078133

CDK:	105095468(NECTIN2)

VPC:	102544516(NECTIN2)

BACU:

103003524(NECTIN2)

BMUS:

118885677(NECTIN2)

LVE:	103082415(PVRL2)

OOR:	101271022(NECTIN2)

LALB:

132509696(NECTIN2)

GMF:	115862322(NECTIN2)

DDP:	132415851(NECTIN2)

DLE:	111180760(NECTIN2)

PCAD:

102977293

PSIU:

116744059(NECTIN2)

PPHC:

136140467(NECTIN2)

NASI:

112415650(NECTIN2)

ECB:	100065463(NECTIN2)

EPZ:	103540189(NECTIN2)

EAI:	106838862(NECTIN2)

MYB:	102260086(NECTIN2)

MYD:	102754978(NECTIN2)

MMYO:

118674230(NECTIN2)

MLF:

102422476

MDT:	132216751(NECTIN2)

MYUM:

139000352(NECTIN2)

PKL:	118713907(NECTIN2)

EFUS:

103301406(NECTIN2)

MNA:	107536798(NECTIN2)

DRO:	112312912(NECTIN2)

SHON:

118995232(NECTIN2)

AJM:	119034836(NECTIN2)

PDIC:

114511315(NECTIN2)

PHAS:

123822956(NECTIN2)

MMF:	118638715(NECTIN2)

PPAM:

129082845(NECTIN2)

HAI:	109372813(NECTIN2)

RFQ:	117034791(NECTIN2)

PALE:

102885429(NECTIN2)

PGIG:

120605272(NECTIN2)

PVP:	105297357(NECTIN2)

RAY:	107513467(NECTIN2)

MJV:	108403922(NECTIN2)

TOD:	119248658(NECTIN2)

SARA:

101542041(PVRL2)

SFUM:

130043259(NECTIN2)

SETR:

126028225(NECTIN2)

LAV:	100669354(NECTIN2)

TMU:

101349417

ETF:	101659021(NECTIN2)

DNM:	101422649(NECTIN2)

MDO:

103098385

GAS:	123239953(NECTIN2) 123255107

SHR:	100917500 100918796(NECTIN2)

AFZ:	127556341 127556363

PCW:	110219715 110219892(NECTIN2)

TVP:	118836038 118837759(NECTIN2)

PBRV:

138161908(NECTIN2) 138161924

MLAO:

141509631

OAA:	100089672 103165967(NECTIN2)

TACU:

119946001(NECTIN2) 119946111

AROW:

112971693

DNE:

112987703

ASN:	112548658(NECTIN2)

AMJ:	102571136(NECTIN2)

CIZ:	142003564(NECTIN2)

CMY:	102934072(NECTIN2)

CCAY:

125625569(NECTIN2)

DCC:	119847619(NECTIN2)

CPIC:

101937341(NECTIN2)

CABI:

116819083(NECTIN2)

MRV:	120390304(NECTIN2)

ACS:	100563439(pvrl2) 107982278

PVT:	110089453(NECTIN2)

SUND:

121915947(NECTIN2)

PBI:	103049946(NECTIN2)

PGUT:

117677680(NECTIN2)

PCAE:

139321061(NECTIN2)

APRI:

131204421(NECTIN2)

NSS:	113427748 113427757

VKO:	123025784(NECTIN2)

PMUA:

114603334(NECTIN2)

PRAF:

128418306(NECTIN2)

ZVI:	118086181(NECTIN2)

HCG:	128332584(NECTIN2)

GJA:

107115266

STOW:

125435518

EMC:	129343342(NECTIN2)

XLA:

100505446

BBUF:

121002734(NECTIN2)

PWL:

138246689

MUO:	115476452(NECTIN2)

GSH:

117369007

DRE:	560816(si:ch73-22o12.1) 560933(pvrl2l)

SRX:	107717440 107723468 107752518 107753776

SANH:

107665153 107666334 107671184 107700179

SGH:	107549846 107551686 107554349 107582119

CCAR:

109054052 109063162 109070789 109095072

CAUA:

113059993 113062588 113078193 113099081 113099573 113116417 113119856 113119898

CGIB:

127935725 127942810 127974389 127978918 128030738

PTET:

122343299(pvrl2l) 122360945(si:ch73-22o12.1)

LROH:

127178972(si:ch73-22o12.1) 127182218(pvrl2l)

GRF:	141289402(pvrl2l) 141342768

OMC:	131521916(si:ch73-22o12.1) 131525263

PPRM:

120483500(pvrl2l) 120484351(si:ch73-22o12.1)

RKG:	130076689(si:ch73-22o12.1) 130102383(pvrl2l)

MAMB:

125242898(si:ch73-22o12.1) 125275673(pvrl2l)

CIDE:

127496977(si:ch73-22o12.1) 127501172

CERY:

137032289(si:ch73-22o12.1) 137037352(pvrl2l)

MASI:

127421095 127425046 127452606 127454223(si:ch73-22o12.1)

TROS:

130558463(si:ch73-22o12.1) 130566514(pvrl2l)

TDW:	130415338(pvrl2l) 130432650(si:ch73-22o12.1)

MANU:

129447900 129447935 129455975(pvrl2l)

PDAB:

135727798 135743386 135776009(pvrl2l)

IPU:	108261109 108262464 108266341(si:ch73-22o12.1) 128635221

IFU:	128607730(si:ch73-22o12.1)

PHYP:

113542494(nectin2)

SMEO:

124383969(si:ch73-22o12.1)

TFD:	113643429(si:ch73-22o12.1)

TVC:	132846131(si:ch73-22o12.1)

CGAR:

128519958(si:ch73-22o12.1)

NGRA:

132886635(si:ch73-22o12.1)

TRN:

134310315

AMEX:

103033523(si:ch73-22o12.1) 107197718(pvrl2l)

CMAO:

118805928(pvrl2l) 118811062 118811076 118824566(si:ch73-22o12.1)

EEE:

113581256

CHAR:

105891982(pvrl2l) 105893531(si:ch73-22o12.1)

SPIL:

134072463(pvrl2l) 134082242 134082243 134092101

ASAD:

121695166(pvrl2l) 121721264(si:ch73-22o12.1)

TRU:	101074231 101078311

TFS:	130532962(si:ch73-22o12.1)

TNG:	GSTEN00015290G001

LCO:	104922249 104929036

NCC:	104962292(pvrl2)

TBEN:

117477305

CGOB:

115021339(nectin2)

PGEO:

117461567

GACU:

117549611

EMAC:

134861260(si:ch73-22o12.1)

ELY:	117263765(pvrl2l) 117265655(si:ch73-22o12.1)

EFO:

125893127

PLEP:

121945257(si:ch73-22o12.1) 121957648(pvrl2l)

SLUC:

116047077(pvrl2l) 116049756(si:ch73-22o12.1)

ECRA:

117946230

ESP:	116691244(nectin2)

PFLV:

114557488(nectin2)

GAT:	120810835(si:ch73-22o12.1) 120826869(pvrl2l)

PPUG:

119197238(si:ch73-22o12.1)

AFB:

129109531

CLUM:

117745454(si:ch73-22o12.1)

PSWI:

130213439(si:ch73-22o12.1)

CANA:

137781227(si:ch73-22o12.1)

CVE:	137891725(si:ch73-22o12.1)

MSAM:

119897390 119906980(pvrl2l)

SCHU:

122882039

CUD:	121513669(si:ch73-22o12.1) 121524540(pvrl2l)

SPUL:

LMIX:

HTC:

ALAT:

ASTR:

MZE:	101472823 101487351

ONL:	100707658 100711853

OAU:	116323773 116331938(pvrl2l)

OLA:	101173334(nectin2)

OML:	112142143 112143668(si:ch73-22o12.1)

CSAI:

133435574(si:ch73-22o12.1)

XMA:	102222444 102231310

XCO:	114138921(nectin2) 114155734

XHE:	116714276(nectin2) 116731758

PRET:

103472957 103477952(nectin2)

PFOR:

103136796 103136823

PLAI:

106949641 106955637

PMEI:

106917864

GAF:	122831081 122843580(pvrl2l)

PPRL:

129371063

CVG:	107082216(pvrl2) 107086737

CTUL:

119782961(si:ch73-22o12.1) 119795034(pvrl2l)

GMU:

124865500

NFU:	107379501 107394869

KMR:	108235411(si:ch73-22o12.1) 108242658(pvrl2l)

ALIM:

106519562 106521035 106529162

NWH:	119409335(si:ch73-22o12.1) 119425530(pvrl2l)

AOCE:

111569485(si:ch73-22o12.1) 111580359(pvrl2l)

EJA:

138194032

BFRE:

138619275 138633214

MCEP:

125016836(si:ch73-22o12.1)

CSEM:

103387988 103393864

POV:	109633274(nectin2)

SSEN:

122774382(si:ch73-22o12.1)

SSOE:

131471003(si:ch73-22o12.1)

HHIP:

117776798

HSP:

118113194

PPLT:

128448977

SMAU:

118315053(si:ch73-22o12.1)

LCF:	108880686 108880692 108881916

SDU:	111220842 111230059 111230064

SLAL:

111645600 111672477(nectin2)

XGL:	120784088 120786167(pvrl2l)

HCQ:	109516373 109531669

SSCV:

125975689(si:ch73-22o12.1)

SBIA:

133500709(si:ch73-22o12.1)

PEE:	133402065(si:ch73-22o12.1)

PTAO:

133479322(si:ch73-22o12.1)

BPEC:

110162461 110172189

ENY:

140373940

MALB:

109966235 109970720

BSPL:

114842929(si:ch73-22o12.1)

SJO:	128365836(si:ch73-22o12.1)

SSCO:

133982925(si:ch73-22o12.1)

TTY:	137191192(si:ch73-22o12.1)

GMH:	115553438(nectin2)

SASA:

106569973 106579633 106588412 106605406

STRU:

115173533 115175936 115176381 115180632

OTW:	112228268 112229823 112244584(si:ch73-22o12.1) 112264802

OMY:	110485821(si:ch73-22o12.1) 110488365 110496212(pvrl2l) 110512638

OGO:	123997875 123997927 124005724 124013351 124043550

ONE:	115102731 115128370 115131626 115140949

OKI:	109901894 109903468 109903621 109907539

OKE:	118364554(si:ch73-22o12.1) 118398201 118399291(pvrl2l) 127915181

OMM:	135520362 135522126 135549984 135552237(pvrl2l)

OCLA:

139373439 139391597 139392233 139424350

SALP:

111954919 111956214 111958638 111964965

SNH:	120022450 120026916 120030757 120048493(si:ch73-22o12.1)

SFON:

129819728 129831252 129837678 129857576

CCLU:

121570062 121571563 121585391 121586447

ELS:	105006124(nectin2) 105028598

OEP:	134023532 134040609(pvrl2l)

SFM:	108922111 108923690 108937929

PKI:	111839734 111842903(nectin2)

AANG:

118206701 118222894 118233692(pvrl2l)

AROT:

135240427(si:ch73-22o12.1) 135261549

CCOG:

133125077(si:ch73-22o12.1) 133136813

LOC:

102691978

PSPA:

121298584 121304221

ARUT:

117433224 117434013 117964905

PSEX:

120541481(si:ch73-22o12.1)

CPLA:

122544222

HOC:	132833883 132833934 132834014

SCAU:

LERI:

HAKA:

HRJ:

CRG:

LAK:

Reference

PMID:7622062

Authors

Eberle F, Dubreuil P, Mattei MG, Devilard E, Lopez M

Title

The human PRR2 gene, related to the human poliovirus receptor gene (PVR), is the true homolog of the murine MPH gene.

Journal

Gene 159:267-72 (1995)
DOI:10.1016/0378-1119(95)00180-E

Sequence

[hsa:5819]

Reference

PMID:15561584

Authors

Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.

Title

Roles and modes of action of nectins in cell-cell adhesion.

Journal

Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002

Reference

PMID:12901789

Authors

Takai Y, Irie K, Shimizu K, Sakisaka T, Ikeda W.

Title

Nectins and nectin-like molecules: roles in cell adhesion, migration, and polarization.

Journal

Cancer Sci 94:655-67 (2003)
DOI:10.1111/j.1349-7006.2003.tb01499.x

LinkDB

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