KEGG   PATHWAY: aamp00983
Entry
aamp00983                   Pathway                                
Name
Drug metabolism - other enzymes - Arvicola amphibius (Eurasian water vole)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
aamp00983  Drug metabolism - other enzymes
aamp00983

Organism
Arvicola amphibius (Eurasian water vole) [GN:aamp]
Gene
119804789  Hprt1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
119809514  Impdh2; inosine-5'-monophosphate dehydrogenase 2 [KO:K00088] [EC:1.1.1.205]
119806859  Impdh1; inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
119826402  Gmps; GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
119816405  Tpmt; thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
119806353  Xdh; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
119815516  Itpa; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
119801643  carboxylesterase 1D [KO:K01044] [EC:3.1.1.1]
119801644  carboxylesterase 1C-like isoform X1 [KO:K01044] [EC:3.1.1.1]
119801645  carboxylesterase 1F-like [KO:K01044] [EC:3.1.1.1]
119802062  carboxylesterase 1D-like [KO:K01044] [EC:3.1.1.1]
119801649  liver carboxylesterase 1-like [KO:K01044] [EC:3.1.1.1]
119801648  liver carboxylesterase 1 [KO:K01044] [EC:3.1.1.1]
119802211  liver carboxylesterase 1-like [KO:K01044] [EC:3.1.1.1]
119801812  pyrethroid hydrolase Ces2e-like isoform X1 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
119801816  acylcarnitine hydrolase-like isoform X1 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
119801817  acylcarnitine hydrolase-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
119801819  acylcarnitine hydrolase-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
119801821  pyrethroid hydrolase Ces2e-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
119801822  acylcarnitine hydrolase-like isoform X2 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
119802117  acylcarnitine hydrolase-like isoform X1 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
119801725  acylcarnitine hydrolase-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
119801814  acylcarnitine hydrolase-like isoform X1 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
119801724  acylcarnitine hydrolase-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
119801820  pyrethroid hydrolase Ces2e-like isoform X1 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
119801825  acylcarnitine hydrolase-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
119807749  UDP-glucuronosyltransferase 2B17-like isoform X1 [KO:K00699] [EC:2.4.1.17]
119821012  UDP-glucuronosyltransferase 1A8-like [KO:K00699] [EC:2.4.1.17]
119821939  UDP-glucuronosyltransferase 1A9-like [KO:K00699] [EC:2.4.1.17]
119821940  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 1A8-like [KO:K00699] [EC:2.4.1.17]
119822847  UDP-glucuronosyltransferase 2B7-like isoform X1 [KO:K00699] [EC:2.4.1.17]
119822864  UDP-glucuronosyltransferase 2B7-like isoform X1 [KO:K00699] [EC:2.4.1.17]
119822892  UDP-glucuronosyltransferase 2B7-like isoform X1 [KO:K00699] [EC:2.4.1.17]
119817029  UDP-glucuronosyltransferase 2A2 isoform X2 [KO:K00699] [EC:2.4.1.17]
119812268  UDP-glucuronosyltransferase 2A3-like isoform X1 [KO:K00699] [EC:2.4.1.17]
119806347  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
119826010  UDP-glucuronosyltransferase 2B31-like isoform X1 [KO:K00699] [EC:2.4.1.17]
119826027  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
119826038  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
119826049  UDP-glucuronosyltransferase 2B31-like isoform X1 [KO:K00699] [EC:2.4.1.17]
119820370  UDP-glucuronosyltransferase 2B1 [KO:K00699] [EC:2.4.1.17]
119807687  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
119807696  UDP-glucuronosyltransferase 2B17-like isoform X1 [KO:K00699] [EC:2.4.1.17]
119807714  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
119807722  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
119807732  UDP-glucuronosyltransferase 2B17-like isoform X1 [KO:K00699] [EC:2.4.1.17]
119820660  UDP-glucuronosyltransferase 1-2-like [KO:K00699] [EC:2.4.1.17]
119820716  UDP-glucuronosyltransferase 1-2 isoform X1 [KO:K00699] [EC:2.4.1.17]
119820717  UDP-glucuronosyltransferase 1A7-like [KO:K00699] [EC:2.4.1.17]
119820718  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 1A7-like [KO:K00699] [EC:2.4.1.17]
119820719  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 1A8-like [KO:K00699] [EC:2.4.1.17]
119820720  UDP-glucuronosyltransferase 1A8-like [KO:K00699] [EC:2.4.1.17]
119820721  UDP-glucuronosyltransferase 1A7-like [KO:K00699] [EC:2.4.1.17]
119820722  UDP-glucuronosyltransferase 1A7-like [KO:K00699] [EC:2.4.1.17]
119820723  UDP-glucuronosyltransferase 1A9-like [KO:K00699] [EC:2.4.1.17]
119820726  UDP-glucuronosyltransferase 1A8-like [KO:K00699] [EC:2.4.1.17]
119820794  UDP-glucuronosyltransferase 1A8-like [KO:K00699] [EC:2.4.1.17]
119824748  Gusb; beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
119816222  Cda; cytidine deaminase [KO:K01489] [EC:3.5.4.5]
119822264  thymidine phosphorylase [KO:K00758] [EC:2.4.2.4]
119801309  Dpyd; dihydropyrimidine dehydrogenase [NADP(+)] [KO:K00207] [EC:1.3.1.2]
119823919  Dpys; dihydropyrimidinase [KO:K01464] [EC:3.5.2.2]
119822187  Upb1; beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
119823384  Upp1; uridine phosphorylase 1 isoform X1 [KO:K00757] [EC:2.4.2.3]
119819520  Upp2; uridine phosphorylase 2 [KO:K00757] [EC:2.4.2.3]
119827114  Uck2; uridine-cytidine kinase 2 [KO:K00876] [EC:2.7.1.48]
119815862  Uckl1; uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
119818626  Uck1; uridine-cytidine kinase 1 [KO:K00876] [EC:2.7.1.48]
119802112  Tk2; thymidine kinase 2, mitochondrial [KO:K00857] [EC:2.7.1.21]
119811432  Tk1; thymidine kinase, cytosolic [KO:K00857] [EC:2.7.1.21]
119825363  Umps; uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
119817651  Cmpk1; UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
119824709  Rrm1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
119807655  Rrm2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
119822934  Rrm2b; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
119809633  Nme6; LOW QUALITY PROTEIN: nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
119811790  nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
119811791  Nme1; nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
119811919  Nme3; nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
119812650  Nme4; nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
119827291  Nme7; nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
119814607  Dut; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial [KO:K01520] [EC:3.6.1.23]
119813072  Mpo; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
119812563  arylamine N-acetyltransferase 1 [KO:K00622] [EC:2.3.1.5]
119813085  arylamine N-acetyltransferase 3-like [KO:K00622] [EC:2.3.1.5]
119813102  arylamine N-acetyltransferase 2 [KO:K00622] [EC:2.3.1.5]
119809971  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
119800665  LOW QUALITY PROTEIN: glutathione S-transferase Mu 3-like [KO:K00799] [EC:2.5.1.18]
119800819  Gstm3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
119800820  glutathione S-transferase Mu 2-like [KO:K00799] [EC:2.5.1.18]
119800821  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
119800822  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
119800823  glutathione S-transferase Mu 4 isoform X1 [KO:K00799] [EC:2.5.1.18]
119800824  glutathione S-transferase Mu 4-like [KO:K00799] [EC:2.5.1.18]
119800825  glutathione S-transferase Mu 2 [KO:K00799] [EC:2.5.1.18]
119800828  glutathione S-transferase Mu 7 [KO:K00799] [EC:2.5.1.18]
119828086  Mgst3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
119809017  glutathione S-transferase A2-like isoform X1 [KO:K00799] [EC:2.5.1.18]
119809018  glutathione S-transferase A2-like isoform X1 [KO:K00799] [EC:2.5.1.18]
119809423  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
119822331  LOW QUALITY PROTEIN: glutathione S-transferase alpha-3-like [KO:K00799] [EC:2.5.1.18]
119822623  glutathione S-transferase A6 [KO:K00799] [EC:2.5.1.18]
119822639  glutathione S-transferase theta-3 [KO:K00799] [EC:2.5.1.18]
119809666  glutathione S-transferase A4 isoform X1 [KO:K00799] [EC:2.5.1.18]
119822842  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
119823006  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
119823076  glutathione S-transferase theta-2-like isoform X1 [KO:K00799] [EC:2.5.1.18]
119810380  Gsto2; glutathione S-transferase omega-2 isoform X1 [KO:K00799] [EC:2.5.1.18]
119810407  Gsto1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
119817036  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
119805014  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
119805073  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
119826537  glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
119826538  Mgst2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
119806887  Mgst1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
119821268  LOW QUALITY PROTEIN: glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
119817596  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
119823311  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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