KEGG   PATHWAY: acep04141
Entry
acep04141                   Pathway                                
Name
Protein processing in endoplasmic reticulum - Atta cephalotes (leaf cutting ant)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
acep04141  Protein processing in endoplasmic reticulum
acep04141

Other DBs
GO: 0030433 0034976
Organism
Atta cephalotes (leaf cutting ant) [GN:acep]
Gene
105621039  protein transport protein Sec61 subunit alpha isoform 2 [KO:K10956]
105618439  protein transport protein Sec61 subunit beta [KO:K09481]
105626390  protein transport protein Sec61 subunit gamma [KO:K07342]
105619587  translocation protein SEC62 [KO:K12275]
105623151  translocation protein SEC63 homolog [KO:K09540]
105622398  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 [KO:K12666]
105617733  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [KO:K12667]
105617621  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
105625379  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
105618230  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
105618742  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
105627263  tumor suppressor candidate 3 [KO:K19478]
105627489  oligosaccharyltransferase complex subunit OSTC [KO:K26501]
105621167  mannosyl-oligosaccharide glucosidase GCS1 [KO:K01228] [EC:3.2.1.106]
105626678  nucleotide exchange factor SIL1 [KO:K14001]
105625314  hypoxia up-regulated protein 1-like [KO:K09486]
105625230  hypoxia up-regulated protein 1-like [KO:K09486]
105627133  heat shock 70 kDa protein cognate 3 isoform X1 [KO:K09490] [EC:3.6.4.10]
105627685  dnaJ homolog subfamily B member 11 [KO:K09517]
105618809  LOW QUALITY PROTEIN: dnaJ homolog subfamily C member 1-like [KO:K09521]
105624836  dnaJ homolog subfamily C member 3 [KO:K09523]
105620385  dnaJ homolog subfamily C member 10-like [KO:K09530] [EC:1.8.4.-]
105621208  endoplasmin [KO:K09487]
105618699  neutral alpha-glucosidase AB [KO:K05546] [EC:3.2.1.207]
105626248  glucosidase 2 subunit beta [KO:K08288]
105617256  calnexin [KO:K08054]
105625275  protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
105621220  calreticulin [KO:K08057]
105620656  mannosyl-oligosaccharide alpha-1,2-mannosidase isoform B [KO:K01230] [EC:3.2.1.113]
105622350  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase [KO:K23741] [EC:3.2.1.209]
105625575  vesicular integral-membrane protein VIP36 [KO:K10082]
105626088  protein ERGIC-53 [KO:K10080]
105622213  prolactin regulatory element-binding protein [KO:K14003]
105620521  GTP-binding protein SAR1b [KO:K07953] [EC:3.6.5.-]
105621977  protein SEC13 homolog [KO:K14004]
105627077  LOW QUALITY PROTEIN: protein transport protein Sec31A [KO:K14005]
105617635  protein transport protein Sec23A [KO:K14006]
105618952  protein transport protein Sec24A [KO:K14007]
105617408  protein transport protein Sec24C [KO:K14007]
105624702  UDP-glucose:glycoprotein glucosyltransferase [KO:K11718] [EC:2.4.1.-]
105625291  ER degradation-enhancing alpha-mannosidase-like protein 2 [KO:K10085]
105624777  ER degradation-enhancing alpha-mannosidase-like protein 3 [KO:K10086]
105627167  protein disulfide-isomerase [KO:K09580] [EC:5.3.4.1]
105618218  protein disulfide-isomerase A6 [KO:K09584] [EC:5.3.4.1]
105625007  endoplasmic reticulum resident protein 29 [KO:K09586]
105618058  clavesin-2-like [KO:K09586]
105625688  thioredoxin domain-containing protein 5 [KO:K13984] [EC:5.3.4.1]
105617064  ero1-like protein [KO:K10950] [EC:1.8.4.-]
105623259  endoplasmic reticulum lectin 1 [KO:K14008]
105625691  translocon-associated protein subunit alpha [KO:K13249]
105625103  translocon-associated protein subunit beta [KO:K13250]
105618720  translocon-associated protein subunit gamma [KO:K13251]
105620027  translocon-associated protein subunit delta [KO:K04571]
105625626  B-cell receptor-associated protein 31 [KO:K14009]
105622382  translocating chain-associated membrane protein 1 [KO:K14010]
105625692  derlin-1 [KO:K11519]
105620935  derlin-2 [KO:K13989]
105618464  UBX domain-containing protein 4 [KO:K24348]
105626178  UBX domain-containing protein 1 [KO:K24348]
105620664  UBX domain-containing protein 6 [KO:K14011]
105627693  NSFL1 cofactor p47 [KO:K14012]
105625401  small VCP/p97-interacting protein [KO:K14014]
105627561  transitional endoplasmic reticulum ATPase TER94 [KO:K13525]
105623479  nuclear protein localization protein 4 homolog [KO:K14015]
105624603  ubiquitin fusion degradation protein 1 homolog [KO:K14016]
105627126  heat shock 70 kDa protein cognate 4 isoform X1 [KO:K03283]
105626745  heat shock 70 kDa protein cognate 4 isoform X1 [KO:K03283]
105625882  dnaJ homolog subfamily A member 1 [KO:K09502]
105624532  dnaJ protein homolog 1-like [KO:K09507]
105619893  LOW QUALITY PROTEIN: dnaJ homolog subfamily B member 12-like [KO:K09518]
105625136  cysteine string protein [KO:K09525]
105622363  heat shock protein 83 [KO:K04079]
105622593  97 kDa heat shock protein [KO:K09485]
105620180  BAG family molecular chaperone regulator 2 [KO:K09556]
105627899  hsp70-binding protein 1 [KO:K09562]
105626309  protein lethal(2)essential for life-like [KO:K09542]
105626624  protein lethal(2)essential for life-like [KO:K09542]
105621877  ubiquitin thioesterase OTU1 [KO:K13719] [EC:3.1.2.-]
105624450  phospholipase A-2-activating protein [KO:K14018]
105624193  UV excision repair protein RAD23 homolog B [KO:K10839]
105624632  ubiquilin-1 [KO:K04523]
105617818  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase [KO:K01456] [EC:3.5.1.52]
105619350  ataxin-3-like [KO:K11863] [EC:3.4.22.-]
105624965  ubiquitin conjugation factor E4 B [KO:K10597] [EC:2.3.2.27]
105622963  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
105624047  activating transcription factor of chaperone [KO:K04374]
105620651  cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
105625597  wolframin [KO:K14020]
105624409  membrane-bound transcription factor site-1 protease [KO:K08653] [EC:3.4.21.112]
105620494  membrane-bound transcription factor site-2 protease [KO:K07765] [EC:3.4.24.85]
105620358  uncharacterized protein LOC105620358 [KO:K09027]
105621969  serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
105626733  mitogen-activated protein kinase kinase kinase 15 [KO:K04426] [EC:2.7.11.25]
105619941  dual specificity mitogen-activated protein kinase kinase 7-like [KO:K04431] [EC:2.7.12.2]
105619924  stress-activated protein kinase JNK [KO:K04440] [EC:2.7.11.24]
105621068  E3 ubiquitin-protein ligase MARCH6 [KO:K10661] [EC:2.3.2.27]
105625922  ubiquitin-conjugating enzyme E2 J1-like [KO:K10578] [EC:2.3.2.23]
105617531  ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
105620947  ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
105623899  ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
105620817  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase synoviolin A-like [KO:K10601] [EC:2.3.2.27]
105624894  E3 ubiquitin-protein ligase RNF185-like [KO:K10666] [EC:2.3.2.27]
105622175  uncharacterized protein LOC105622175 [KO:K14025]
105627046  protein sel-1 homolog 1 [KO:K14026]
105617620  E3 ubiquitin-protein ligase AMFR-like [KO:K10636] [EC:2.3.2.36]
105619288  E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
105621530  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
105622910  E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
105626311  RING-box protein 1A [KO:K03868] [EC:2.3.2.32]
105627427  cullin-1 [KO:K03347]
105626331  S-phase kinase-associated protein 1 [KO:K03094]
105625287  F-box only protein 44-like [KO:K10100]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
acep00510  N-Glycan biosynthesis
acep03050  Proteasome
acep03060  Protein export
KO pathway
ko04141   
LinkDB

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