KEGG   PATHWAY: adf04141
Entry
adf04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Acropora digitifera (stony coral)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
adf04141  Protein processing in endoplasmic reticulum
adf04141

Other DBs
GO: 0030433 0034976
Organism
Acropora digitifera (stony coral) [GN:adf]
Gene
107337419  protein transport protein Sec61 subunit alpha isoform 2-like [KO:K10956]
107331102  protein transport protein Sec61 subunit beta-like [KO:K09481]
107346470  translocation protein SEC62-like [KO:K12275]
107338395  translocation protein SEC63 homolog [KO:K09540]
107358317  translocation protein SEC63 homolog [KO:K09540]
107332734  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1-like [KO:K12666]
107336777  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2-like [KO:K12667]
107357506  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit-like [KO:K12670]
107351495  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B-like [KO:K07151] [EC:2.4.99.18]
107336892  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
107358565  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A-like [KO:K07151] [EC:2.4.99.18]
107348062  tumor suppressor candidate 3-like [KO:K19478]
107348061  tumor suppressor candidate 3-like [KO:K19478]
107340177  tumor suppressor candidate 3-like [KO:K19478]
107353174  transmembrane protein 258 [KO:K26502]
107327751  mannosyl-oligosaccharide glucosidase-like [KO:K01228] [EC:3.2.1.106]
107353008  ribosome-binding protein 1-like [KO:K14000]
107343535  hypoxia up-regulated protein 1-like [KO:K09486]
107342073  78 kDa glucose-regulated protein-like [KO:K09490] [EC:3.6.4.10]
107347913  dnaJ homolog subfamily B member 11-like [KO:K09517]
107357227  dnaJ homolog subfamily C member 1-like [KO:K09521]
107327939  dnaJ homolog subfamily C member 3-like [KO:K09523]
107331046  dnaJ homolog subfamily C member 10-like [KO:K09530] [EC:1.8.4.-]
107340942  endoplasmin-like [KO:K09487]
107329091  neutral alpha-glucosidase AB-like [KO:K05546] [EC:3.2.1.207]
107351988  neutral alpha-glucosidase AB-like [KO:K05546] [EC:3.2.1.207]
107351954  calnexin-like [KO:K08054]
107334277  protein disulfide-isomerase A3-like [KO:K08056] [EC:5.3.4.1]
107335183  calreticulin-like [KO:K08057]
107355569  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA-like [KO:K01230] [EC:3.2.1.113]
107335017  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase-like [KO:K23741] [EC:3.2.1.209]
107353455  vesicular integral-membrane protein VIP36-like [KO:K10082]
107347288  protein ERGIC-53-like [KO:K10080]
107334202  prolactin regulatory element-binding protein-like [KO:K14003]
107335096  GTP-binding protein SAR1-like [KO:K07953] [EC:3.6.5.-]
107330060  GTP-binding protein SAR1-like [KO:K07953] [EC:3.6.5.-]
107333450  protein SEC13 homolog [KO:K14004]
107358708  protein transport protein Sec31A-like [KO:K14005]
107356876  protein transport protein Sec23A-like [KO:K14006]
107337397  protein transport protein Sec24C-like [KO:K14007]
107337399  protein transport protein Sec24A-like [KO:K14007]
107329082  UDP-glucose:glycoprotein glucosyltransferase 1-like [KO:K11718] [EC:2.4.1.-]
107346500  UDP-glucose:glycoprotein glucosyltransferase 1-like [KO:K11718] [EC:2.4.1.-]
107346501  UDP-glucose:glycoprotein glucosyltransferase 1-like [KO:K11718] [EC:2.4.1.-]
107331067  ER degradation-enhancing alpha-mannosidase-like protein 1 [KO:K10084]
107354359  ER degradation-enhancing alpha-mannosidase-like protein 1 [KO:K10084]
107355070  ER degradation-enhancing alpha-mannosidase-like protein 3 [KO:K10086]
107330730  protein disulfide-isomerase 2-like [KO:K09580] [EC:5.3.4.1]
107329840  protein disulfide-isomerase like 2-1-like [KO:K09584] [EC:5.3.4.1]
107336852  protein disulfide-isomerase A6-like [KO:K09584] [EC:5.3.4.1]
107331559  protein disulfide isomerase-like 2-2 [KO:K09584] [EC:5.3.4.1]
107331912  probable protein disulfide-isomerase A6 [KO:K09584] [EC:5.3.4.1]
107342814  endoplasmic reticulum resident protein 29-like [KO:K09586]
107350145  thioredoxin domain-containing protein 5-like [KO:K13984] [EC:5.3.4.1]
107347884  ERO1-like protein beta [KO:K10976] [EC:1.8.4.-]
107350186  protein OS-9-like [KO:K10088]
107343018  translocon-associated protein subunit alpha-like [KO:K13249]
107334188  translocon-associated protein subunit beta-like [KO:K13250]
107335725  translocon-associated protein subunit gamma-like [KO:K13251]
107339659  translocon-associated protein subunit delta-like [KO:K04571]
107350237  B-cell receptor-associated protein 31-like [KO:K14009]
107354286  translocating chain-associated membrane protein 1-like [KO:K14010]
107334444  derlin-1-like [KO:K11519]
107341536  derlin-2-like [KO:K13989]
107335464  UBX domain-containing protein 4-like [KO:K24348]
107345256  UBX domain-containing protein 1-like [KO:K24348]
107358758  UBX domain-containing protein 6-like [KO:K14011]
107340313  NSFL1 cofactor p47-like [KO:K14012]
107353095  transitional endoplasmic reticulum ATPase-like [KO:K13525]
107350247  ubiquitin fusion degradation protein 1 homolog [KO:K14016]
107333345  heat shock cognate 71 kDa protein-like [KO:K03283]
107328733  heat shock 70 kDa protein 1-like [KO:K03283]
107327405  heat shock 70 kDa protein-like [KO:K03283]
107333658  heat shock cognate 71 kDa protein-like [KO:K03283]
107333660  heat shock cognate 71 kDa protein-like [KO:K03283]
107333661  heat shock cognate 71 kDa protein-like [KO:K03283]
107333665  heat shock cognate 71 kDa protein-like [KO:K03283]
107327872  heat shock 70 kDa protein-like [KO:K03283]
107346114  dnaJ homolog subfamily A member 1-like [KO:K09502]
107348989  dnaJ homolog subfamily A member 2-like [KO:K09503]
107335618  dnaJ homolog subfamily B member 1-like [KO:K09507]
107333798  dnaJ homolog subfamily C member 5-like [KO:K09525]
107342603  heat shock protein HSP 90-alpha-like [KO:K04079]
107337403  97 kDa heat shock protein-like [KO:K09485]
107337405  97 kDa heat shock protein-like [KO:K09485]
107354567  BAG family molecular chaperone regulator 1-like [KO:K09555]
107345137  hsp70-binding protein 1-like [KO:K09562]
107348279  uncharacterized LOC107348279 [KO:K09541]
107346285  heat shock protein beta-2-like [KO:K09542]
107355602  ubiquitin thioesterase OTU1-like [KO:K13719] [EC:3.1.2.-]
107327614  ubiquitin thioesterase OTU1-like [KO:K13719] [EC:3.1.2.-]
107344035  phospholipase A-2-activating protein-like [KO:K14018]
107335160  UV excision repair protein RAD23 homolog A-like [KO:K10839]
107351505  ubiquilin-1-like [KO:K04523]
107350428  peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase-like [KO:K01456] [EC:3.5.1.52]
107350447  peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase-like [KO:K01456] [EC:3.5.1.52]
107355011  ataxin-3-like [KO:K11863] [EC:3.4.22.-]
107356180  ubiquitin conjugation factor E4 B-like [KO:K10597] [EC:2.3.2.27]
107335867  eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237]
107334727  apoptosis regulator Bcl-2-like [KO:K02161]
107331321  uncharacterized LOC107331321 [KO:K09054]
107334656  membrane-bound transcription factor site-1 protease-like [KO:K08653] [EC:3.4.21.112]
107356457  membrane-bound transcription factor site-1 protease-like [KO:K08653] [EC:3.4.21.112]
107339251  membrane-bound transcription factor site-2 protease-like [KO:K07765] [EC:3.4.24.85]
107342737  X-box-binding protein 1-like [KO:K09027]
107329655  serine/threonine-protein kinase/endoribonuclease IRE1-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
107358059  uncharacterized LOC107358059 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
107329899  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
107350626  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
107346324  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
107346321  TNF receptor-associated factor 3-like [KO:K03173] [EC:2.3.2.27]
107332902  dual specificity mitogen-activated protein kinase kinase 7-like [KO:K04431] [EC:2.7.12.2]
107341807  stress-activated protein kinase JNK-like [KO:K04440] [EC:2.7.11.24]
107346175  apoptosis regulator BAX-like [KO:K02159]
107336689  bcl-2 homologous antagonist/killer-like [KO:K14021]
107355003  E3 ubiquitin-protein ligase MARCH6-like [KO:K10661] [EC:2.3.2.27]
107338424  ubiquitin-conjugating enzyme E2 J1-like [KO:K10578] [EC:2.3.2.23]
107343621  ubiquitin-conjugating enzyme E2 J2-like [KO:K04554] [EC:2.3.2.23]
107339694  ubiquitin-conjugating enzyme E2 G1-like [KO:K10575] [EC:2.3.2.23]
107349416  ubiquitin-conjugating enzyme E2 G2-like [KO:K04555] [EC:2.3.2.23]
107354898  E3 ubiquitin-protein ligase synoviolin-like [KO:K10601] [EC:2.3.2.27]
107351104  selenoprotein S-like [KO:K14025]
107352469  protein sel-1 homolog 1-like [KO:K14026]
107345732  E3 ubiquitin-protein ligase AMFR-like [KO:K10636] [EC:2.3.2.36]
107354974  STIP1 homology and U box-containing protein 1-like [KO:K09561] [EC:2.3.2.27]
107357338  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
107339248  E3 ubiquitin-protein ligase parkin-like [KO:K04556] [EC:2.3.2.31]
107349974  RING-box protein 1 [KO:K03868] [EC:2.3.2.32]
107336444  cullin-1-like [KO:K03347]
107329145  S-phase kinase-associated protein 1-like [KO:K03094]
107328649  S-phase kinase-associated protein 1 [KO:K03094]
107340886  S-phase kinase-associated protein 1-like [KO:K03094]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
adf00510  N-Glycan biosynthesis
adf03050  Proteasome
adf03060  Protein export
KO pathway
ko04141   
LinkDB

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