K03173                      KO                                     
TNF receptor-associated factor 2 [EC:]
map04010  MAPK signaling pathway
map04064  NF-kappa B signaling pathway
map04071  Sphingolipid signaling pathway
map04137  Mitophagy - animal
map04141  Protein processing in endoplasmic reticulum
map04210  Apoptosis
map04217  Necroptosis
map04380  Osteoclast differentiation
map04621  NOD-like receptor signaling pathway
map04622  RIG-I-like receptor signaling pathway
map04657  IL-17 signaling pathway
map04668  TNF signaling pathway
map04920  Adipocytokine signaling pathway
map04932  Non-alcoholic fatty liver disease
map05010  Alzheimer disease
map05014  Amyotrophic lateral sclerosis
map05016  Huntington disease
map05017  Spinocerebellar ataxia
map05022  Pathways of neurodegeneration - multiple diseases
map05130  Pathogenic Escherichia coli infection
map05131  Shigellosis
map05132  Salmonella infection
map05135  Yersinia infection
map05160  Hepatitis C
map05163  Human cytomegalovirus infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05168  Herpes simplex virus 1 infection
map05169  Epstein-Barr virus infection
map05170  Human immunodeficiency virus 1 infection
map05200  Pathways in cancer
map05203  Viral carcinogenesis
map05222  Small cell lung cancer
map05417  Lipid and atherosclerosis
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K03173  TRAF2; TNF receptor-associated factor 2
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
   04064 NF-kappa B signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
   04668 TNF signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
   04071 Sphingolipid signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
 09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    K03173  TRAF2; TNF receptor-associated factor 2
  09143 Cell growth and death
   04210 Apoptosis
    K03173  TRAF2; TNF receptor-associated factor 2
   04217 Necroptosis
    K03173  TRAF2; TNF receptor-associated factor 2
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
   04622 RIG-I-like receptor signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
   04657 IL-17 signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K03173  TRAF2; TNF receptor-associated factor 2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K03173  TRAF2; TNF receptor-associated factor 2
   05203 Viral carcinogenesis
    K03173  TRAF2; TNF receptor-associated factor 2
  09162 Cancer: specific types
   05222 Small cell lung cancer
    K03173  TRAF2; TNF receptor-associated factor 2
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K03173  TRAF2; TNF receptor-associated factor 2
   05160 Hepatitis C
    K03173  TRAF2; TNF receptor-associated factor 2
   05168 Herpes simplex virus 1 infection
    K03173  TRAF2; TNF receptor-associated factor 2
   05163 Human cytomegalovirus infection
    K03173  TRAF2; TNF receptor-associated factor 2
   05167 Kaposi sarcoma-associated herpesvirus infection
    K03173  TRAF2; TNF receptor-associated factor 2
   05169 Epstein-Barr virus infection
    K03173  TRAF2; TNF receptor-associated factor 2
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K03173  TRAF2; TNF receptor-associated factor 2
   05132 Salmonella infection
    K03173  TRAF2; TNF receptor-associated factor 2
   05131 Shigellosis
    K03173  TRAF2; TNF receptor-associated factor 2
   05135 Yersinia infection
    K03173  TRAF2; TNF receptor-associated factor 2
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K03173  TRAF2; TNF receptor-associated factor 2
   05014 Amyotrophic lateral sclerosis
    K03173  TRAF2; TNF receptor-associated factor 2
   05016 Huntington disease
    K03173  TRAF2; TNF receptor-associated factor 2
   05017 Spinocerebellar ataxia
    K03173  TRAF2; TNF receptor-associated factor 2
   05022 Pathways of neurodegeneration - multiple diseases
    K03173  TRAF2; TNF receptor-associated factor 2
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K03173  TRAF2; TNF receptor-associated factor 2
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K03173  TRAF2; TNF receptor-associated factor 2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis
    K03173  TRAF2; TNF receptor-associated factor 2
   04121 Ubiquitin system
    K03173  TRAF2; TNF receptor-associated factor 2
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases  RING-type E3 ubiquitin transferase
     K03173  TRAF2; TNF receptor-associated factor 2
Messenger RNA biogenesis [BR:ko03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   mRNA cycle factors
    Stress granule specific factors
     K03173  TRAF2; TNF receptor-associated factor 2
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   TRAF proteins
    K03173  TRAF2; TNF receptor-associated factor 2
HSA: 7186(TRAF2)
PTR: 464876(TRAF2)
PPS: 100982095(TRAF2)
GGO: 101144745(TRAF2)
PON: 100458089(TRAF2)
NLE: 100590721(TRAF2)
HMH: 116475877(TRAF2)
MCC: 708391(TRAF2)
MCF: 101925175(TRAF2)
MTHB: 126936973
MNI: 105471953(TRAF2)
CSAB: 103239600(TRAF2)
CATY: 105580591(TRAF2)
PANU: 101017914(TRAF2)
TGE: 112608018(TRAF2)
MLEU: 105543266(TRAF2)
RRO: 104669650(TRAF2)
RBB: 108542901(TRAF2)
TFN: 117099135(TRAF2)
PTEH: 111553030(TRAF2)
CANG: 105522700(TRAF2)
CJC: 100404226(TRAF2)
SBQ: 101035434(TRAF2)
CIMI: 108287258(TRAF2)
CSYR: 103252426(TRAF2)
MMUR: 105882282(TRAF2)
LCAT: 123645603(TRAF2)
PCOQ: 105818690(TRAF2)
OGA: 100966378(TRAF2)
MMU: 22030(Traf2)
MCAL: 110289986(Traf2)
MPAH: 110318405(Traf2)
RNO: 311786(Traf2)
MCOC: 116089826(Traf2)
ANU: 117710914(Traf2)
MUN: 110557003(Traf2)
CGE: 100762099(Traf2)
MAUA: 101823322(Traf2)
PROB: 127222603(Traf2)
PLEU: 114692795(Traf2)
MORG: 121463096(Traf2)
MFOT: 126509272
AAMP: 119818726(Traf2)
NGI: 103741188(Traf2)
HGL: 101705156(Traf2)
CPOC: 100733145(Traf2)
CCAN: 109699331(Traf2)
DORD: 105995582(Traf2)
DSP: 122099715(Traf2)
PLOP: 125351527(Traf2)
NCAR: 124964641
MMMA: 107159171(Traf2)
OPI: 101527835(TRAF2)
TUP: 102473925(C8G)
GVR: 103610047 103610988(TRAF2)
CFA: 480673(TRAF2)
CLUD: 112677465(TRAF2)
VVP: 112906881(TRAF2)
VLG: 121473786(TRAF2)
NPO: 129515072(TRAF2)
AML: 100474087(TRAF2)
UMR: 103675245(TRAF2)
UAR: 123796334(TRAF2)
LLV: 125083298
MPUF: 101691230(TRAF2)
MNP: 132024227(TRAF2)
MLK: 131812685(TRAF2)
NVS: 122917083(TRAF2)
ORO: 101371938(TRAF2)
EJU: 114201735(TRAF2)
ZCA: 113934602(TRAF2)
MLX: 118017503(TRAF2)
NSU: 110581233(TRAF2)
FCA: 101096363(TRAF2)
PYU: 121020261(TRAF2)
PCOO: 112860577(TRAF2)
PBG: 122474992(TRAF2)
LRUF: 124522349
PTG: 102966802(TRAF2)
PPAD: 109258781(TRAF2)
PUC: 125923516
AJU: 106989490
HHV: 120226445(TRAF2)
BTA: 512355(TRAF2)
BOM: 102275265(TRAF2)
BIU: 109566626(TRAF2)
BBUB: 102395129(TRAF2)
BBIS: 104982944(TRAF2)
CHX: 102184255(TRAF2)
OAS: 101105235(TRAF2)
BTAX: 128055475(TRAF2)
ODA: 120852193(TRAF2)
CCAD: 122442423(TRAF2)
MBEZ: 129539173(TRAF2)
SSC: 100513840(TRAF2)
CFR: 102511649(TRAF2)
CBAI: 105068625(TRAF2)
CDK: 105106196(TRAF2)
VPC: 102537793(TRAF2)
BACU: 103013880(TRAF2)
LVE: 103088738(TRAF2)
OOR: 101281303(TRAF2)
DLE: 111177009(TRAF2)
PCAD: 102996185(TRAF2)
PSIU: 116755387(TRAF2)
NASI: 112411269(TRAF2)
ECB: 100068006(TRAF2)
EPZ: 103567822(TRAF2)
EAI: 106845532(TRAF2)
MYB: 102263277(TRAF2)
MYD: 102772361(TRAF2)
MMYO: 118655263(TRAF2)
MNA: 107536208(TRAF2)
PKL: 118707045(TRAF2)
EFUS: 103295968(TRAF2)
HAI: 109381672(TRAF2)
DRO: 112306448(TRAF2)
SHON: 118980132(TRAF2)
AJM: 119036073(TRAF2)
PDIC: 114504307(TRAF2)
PHAS: 123823598(TRAF2)
MMF: 118629846(TRAF2)
RFQ: 117031652(TRAF2)
PPAM: 129079528(TRAF2)
PALE: 102889343(TRAF2)
PGIG: 120599784(TRAF2)
PVP: 105298613(TRAF2)
RAY: 107503081(TRAF2)
MJV: 108406827(TRAF2)
TOD: 119230651(TRAF2)
SARA: 101550002(TRAF2)
LAV: 100670400(TRAF2)
TMU: 101354911
ETF: 101643556(TRAF2)
DNM: 101412100(TRAF2)
MDO: 100017243(TRAF2)
GAS: 123237194(TRAF2)
SHR: 100934749(TRAF2)
AFZ: 127549124
PCW: 110205309(TRAF2)
OAA: 100681066 100681935(TRAF2)
GGA: 417287(TRAF2)
PCOC: 116234112(TRAF2)
MGP: 100545697(TRAF2)
CJO: 107321623(TRAF2)
TPAI: 128079775(TRAF2)
LMUT: 125702608(TRAF2)
NMEL: 110406784(TRAF2)
APLA: 101798982(TRAF2)
ACYG: 106037085(TRAF2)
CATA: 118260735(TRAF2)
AFUL: 116496858(TRAF2)
TGU: 100223400(TRAF2)
LSR: 110472193(TRAF2)
SCAN: 103819084(TRAF2)
PMOA: 120507355(TRAF2)
OTC: 121336904(TRAF2)
PRUF: 121357539(TRAF2)
GFR: 102033115(TRAF2)
FAB: 101807272(TRAF2)
OMA: 130260219(TRAF2)
PHI: 102106384(TRAF2)
PMAJ: 107212160(TRAF2)
CCAE: 111936895(TRAF2)
CCW: 104688205(TRAF2)
CBRC: 103614998(TRAF2)
ETL: 114064144(TRAF2)
ZAB: 102065720(TRAF2)
ACHL: 103808775
SVG: 106855986(TRAF2)
MMEA: 130584583(TRAF2)
HRT: 120761764(TRAF2)
FPG: 101911961(TRAF2)
FCH: 102059920(TRAF2)
CLV: 102095289(TRAF2)
EGZ: 104124021(TRAF2)
NNI: 104018369(TRAF2)
PCRI: 104031731
PLET: 104628503(TRAF2)
EHS: 104513443(TRAF2)
PCAO: 104048946(TRAF2)
ACUN: 113486502(TRAF2)
TALA: 104362632(TRAF2)
PADL: 103921138(TRAF2)
AFOR: 103908292(TRAF2)
ACHC: 115335375(TRAF2)
HALD: 104317841(TRAF2)
HLE: 104829986(TRAF2)
AGEN: 126052119
GCL: 127023695
CCRI: 104160587(TRAF2)
CSTI: 104553367(TRAF2)
CMAC: 104475837(TRAF2)
MUI: 104546430(TRAF2)
BREG: 104643597(TRAF2)
FGA: 104083588(TRAF2)
GSTE: 104261965
MNB: 103772482(TRAF2)
OHA: 104338189(TRAF2)
NNT: 104402074(TRAF2)
SHAB: 115616900(TRAF2)
DPUB: 104300175(TRAF2)
PGUU: 104465418
ACAR: 104525088(TRAF2)
CPEA: 104397857(TRAF2)
AVIT: 104271225(TRAF2)
CVF: 104291072(TRAF2)
RTD: 128917342(TRAF2)
CUCA: 104059100(TRAF2)
TEO: 104383777(TRAF2)
AAM: 106494252(TRAF2)
AROW: 112969740(TRAF2)
NPD: 112956027(TRAF2)
TGT: 104573520(TRAF2)
DNE: 112986768(TRAF2)
SCAM: 104139746(TRAF2)
ASN: 102384689(TRAF2)
AMJ: 102564363(TRAF2)
CPOO: 109313783(TRAF2)
GGN: 109292831(TRAF2)
PSS: 102449635(TRAF2)
CMY: 102941067(TRAF2)
CCAY: 125623442(TRAF2)
DCC: 119842911 119844349(TRAF2)
CPIC: 101933518(TRAF2) 101946577
TST: 117867260(TRAF2)
CABI: 116832957(TRAF2)
ACS: 100561141(traf2) 100566904
ASAO: 132763641(TRAF2)
PVT: 110087462(TRAF2)
SUND: 121936587(TRAF2)
PBI: 103050015 103066991(TRAF2)
PMUR: 107296550 107302543(TRAF2)
CTIG: 120308629(TRAF2)
TSR: 106541963(TRAF2)
PGUT: 117667903 117676633(TRAF2)
PTEX: 113443864(TRAF2)
NSS: 113424253(TRAF2)
VKO: 123018020 123028318(TRAF2)
PRAF: 128406935
HCG: 128338845(TRAF2) 128341897
GJA: 107115164(TRAF2) 107118266
STOW: 125427740 125441693(TRAF2)
EMC: 129341859(TRAF2)
XLA: 108698135(traf2.L) 431974(traf2.S)
XTR: 100494415(traf2)
NPR: 108787259(TRAF2)
RTEM: 120914048(TRAF2)
BBUF: 120977315(TRAF2)
BGAR: 122946429(TRAF2)
MUO: 115472619(TRAF2)
GSH: 117367797(TRAF2)
DRE: 100005446 557526(traf2b) 564295(traf2a)
PTET: 122345294(traf2b) 122345455 122345572(traf2a)
LROH: 127165041(traf2b) 127165370(traf2a) 127166047
OMC: 131540102(traf2b) 131540439(traf2a) 131540710
PPRM: 120469445(traf2a) 120471951(traf2b) 120490283
RKG: 130088204 130089827(traf2a)
MAMB: 125266535(traf2a) 125266915 125267992(traf2b)
TROS: 130546805(traf2a) 130550412(traf2b) 130564431
TDW: 130419012 130419428(traf2a) 130419591(traf2b)
MANU: 129439479 129440131(traf2a) 129441176(traf2b)
IPU: 108255825(traf2a) 108259928(traf2b)
IFU: 128598910(traf2a) 128603337(traf2b)
PHYP: 113531130(traf2) 113537061
SMEO: 124378726(traf2b) 124380617(traf2a)
TFD: 113641050(traf2b) 113653235(traf2a)
TVC: 132841351(traf2b) 132855231(traf2a)
AMEX: 103028261(traf2) 103036375
CMAO: 118814555(traf2b) 118827146(traf2a)
EFO: 125890245(traf2a) 125905897 125906290(traf2b)
GAT: 120830981(traf2a) 120831561 120831631(traf2b)
PPUG: 119225392(traf2a) 119226924 119226959(traf2b)
AFB: 129101424 129102855(traf2b)
CLUM: 117735999(traf2a) 117740351(traf2b) 117740886
SCHU: 122865199(traf2b) 122865536 122876306(traf2a)
CUD: 121509988(traf2a) 121525571 121525626(traf2b)
ALAT: 119019943(traf2a) 119029609(traf2b) 119030239
KMR: 108230862(traf2b) 108244062 108249884(traf2a)
HHIP: 117767837(traf2a) 117771243(traf2b) 117771259
HSP: 118098034 118115649(traf2a) 118125819(traf2b)
LCF: 108874450(traf2b) 108878507(traf2a) 108895456
XGL: 120805168(traf2a) 120806199(traf2b) 120806563
OMY: 100136087(traf2) 110509690 110523473 110523569(traf2b) 110525908(traf2a)
PSEX: 120541999(traf2b) 120543219(traf2a)
APLC: 110981046
SLIU: 111354513
PPOI: 119109797
RSAN: 119372506
RMP: 119163172
VDE: 111252987
VJA: 111271634
SDM: 118188644
PVUL: 126808639
BGT: 106056737
GAE: 121384699
HRF: 124143458
HRJ: 124270272
CANU: 128155390
MYI: 110464971
PMAX: 117315227
RPHI: 132725349
OBI: 106879639
OSN: 115209082
HMG: 100213781
 » show all
He L, Grammer AC, Wu X, Lipsky PE
TRAF3 forms heterotrimers with TRAF2 and modulates its ability to mediate NF-{kappa}B activation.
J Biol Chem 279:55855-65 (2004)
Mauro C, Crescenzi E, De Mattia R, Pacifico F, Mellone S, Salzano S, de Luca C, D'Adamio L, Palumbo G, Formisano S, Vito P, Leonardi A
Central role of the scaffold protein tumor necrosis factor receptor-associated factor 2 in regulating endoplasmic reticulum stress-induced apoptosis.
J Biol Chem 281:2631-8 (2006)
Zhou AY, Shen RR, Kim E, Lock YJ, Xu M, Chen ZJ, Hahn WC
IKKepsilon-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex.
Cell Rep 3:724-33 (2013)
Song HY, Donner DB
Association of a RING finger protein with the cytoplasmic domain of the human type-2 tumour necrosis factor receptor.
Biochem J 309 ( Pt 3):825-9 (1995)

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