KEGG   PATHWAY: afor04914
Entry
afor04914                   Pathway                                
Name
Progesterone-mediated oocyte maturation - Aptenodytes forsteri (emperor penguin)
Description
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Class
Organismal Systems; Endocrine system
Pathway map
afor04914  Progesterone-mediated oocyte maturation
afor04914

Other DBs
GO: 0001556
Organism
Aptenodytes forsteri (emperor penguin) [GN:afor]
Gene
103900650  PGR; progesterone receptor [KO:K08556]
103899302  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
103905595  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X3 [KO:K02649]
103893369  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
103906182  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103894035  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
103907467  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
103897639  MAPK8; mitogen-activated protein kinase 8 isoform X2 [KO:K04440] [EC:2.7.11.24]
103904405  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
103899746  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
103905253  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
103905254  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
103893653  MAPK13; mitogen-activated protein kinase 13 isoform X2 [KO:K04441] [EC:2.7.11.24]
103893654  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
103904152  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
103908267  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
103895232  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
103904001  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
103898441  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
103902407  ADCY3; LOW QUALITY PROTEIN: adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
103895406  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
103903427  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
103896863  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
103894564  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
103897456  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
103894879  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
103894635  AURKA; aurora kinase A [KO:K11481] [EC:2.7.11.1]
103896466  CPEB1; cytoplasmic polyadenylation element-binding protein 1 isoform X1 [KO:K02602]
103898778  CPEB2; cytoplasmic polyadenylation element-binding protein 2 [KO:K02602]
103897669  CPEB3; cytoplasmic polyadenylation element-binding protein 3 isoform X1 [KO:K02602]
103904318  CPEB4; cytoplasmic polyadenylation element-binding protein 4 [KO:K02602]
103904186  SPDYA; speedy protein A [KO:K08694]
103908178  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
103907360  CCNA2; cyclin-A2 [KO:K06627]
103907991  CCNA1; cyclin-A1 [KO:K06627]
103907201  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
103902670  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
103900214  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
103899919  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103900168  MAPK1; LOW QUALITY PROTEIN: mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103896414  RPS6KA1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
103896960  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
103898235  ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
103906170  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
103894799  ribosomal protein S6 kinase alpha-2-like [KO:K04373] [EC:2.7.11.1]
103893417  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
103899878  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
103904500  STK10; serine/threonine-protein kinase 10 [KO:K08837] [EC:2.7.11.1]
103905060  PLK1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
103903477  CDC25A; M-phase inducer phosphatase 1 [KO:K06645] [EC:3.1.3.48]
103906715  INS; insulin [KO:K04526]
103906465  IGF1; insulin-like growth factor I [KO:K05459]
103900344  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
103896250  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103900090  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103900238  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103906839  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
103898696  KRAS; GTPase KRas isoform X1 [KO:K07827]
103906442  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
103905412  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
103906545  BUB1; mitotic checkpoint serine/threonine-protein kinase BUB1 [KO:K02178] [EC:2.7.11.1]
103904865  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
103907239  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
103907445  MAD2L2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
103897088  FZR1; fizzy-related protein homolog [KO:K03364]
103906517  ANAPC1; anaphase-promoting complex subunit 1 [KO:K03348]
103902559  ANAPC2; anaphase-promoting complex subunit 2 [KO:K03349]
103906107  CDC27; LOW QUALITY PROTEIN: cell division cycle protein 27 homolog [KO:K03350]
103893248  ANAPC4; anaphase-promoting complex subunit 4 [KO:K03351]
103902794  ANAPC5; anaphase-promoting complex subunit 5 [KO:K03352]
103896314  CDC16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
103902868  ANAPC7; anaphase-promoting complex subunit 7 [KO:K03354]
103904602  CDC23; cell division cycle protein 23 homolog [KO:K03355]
103899744  ANAPC10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
103903704  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
103908223  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
Compound
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:12045215
  Authors
Schmitt A, Nebreda AR.
  Title
Signalling pathways in oocyte meiotic maturation.
  Journal
J Cell Sci 115:2457-9 (2002)
Reference
PMID:12084906
  Authors
Cato AC, Nestl A, Mink S.
  Title
Rapid actions of steroid receptors in cellular signaling pathways.
  Journal
Sci STKE 2002:RE9 (2002)
DOI:10.1126/stke.2002.138.re9
Reference
PMID:11730319
  Authors
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
  Title
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
  Journal
Biol Cell 93:27-33 (2001)
DOI:10.1016/S0248-4900(01)01127-3
Reference
PMID:11063930
  Authors
Nebreda AR, Ferby I.
  Title
Regulation of the meiotic cell cycle in oocytes.
  Journal
Curr Opin Cell Biol 12:666-75 (2000)
DOI:10.1016/S0955-0674(00)00150-2
Reference
PMID:10497333
  Authors
Ferrell JE Jr.
  Title
Xenopus oocyte maturation: new lessons from a good egg.
  Journal
Bioessays 21:833-42 (1999)
DOI:10.1002/(SICI)1521-1878(199910)21:10<833::AID-BIES5>3.0.CO;2-P
Reference
PMID:12374568
  Authors
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
  Title
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
  Journal
Biochem J 369:227-38 (2003)
DOI:10.1042/BJ20021243
Reference
PMID:12477927
  Authors
Duckworth BC, Weaver JS, Ruderman JV.
  Title
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
  Journal
Proc Natl Acad Sci U S A 99:16794-9 (2002)
DOI:10.1073/pnas.222661299
Reference
PMID:11148128
  Authors
Abrieu A, Doree M, Fisher D.
  Title
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
  Journal
J Cell Sci 114:257-67 (2001)
Related
pathway
afor04010  MAPK signaling pathway
afor04110  Cell cycle
KO pathway
ko04914   
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