KEGG   PATHWAY: afz00983
Entry
afz00983                    Pathway                                
Name
Drug metabolism - other enzymes - Antechinus flavipes (yellow-footed antechinus)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
afz00983  Drug metabolism - other enzymes
afz00983

Organism
Antechinus flavipes (yellow-footed antechinus) [GN:afz]
Gene
127543659  hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
127557400  hypoxanthine-guanine phosphoribosyltransferase-like [KO:K00760] [EC:2.4.2.8]
127538171  hypoxanthine-guanine phosphoribosyltransferase-like [KO:K00760] [EC:2.4.2.8]
127545326  hypoxanthine-guanine phosphoribosyltransferase-like [KO:K00760] [EC:2.4.2.8]
127537882  inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
127552811  LOW QUALITY PROTEIN: GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
127544135  thiopurine S-methyltransferase isoform X1 [KO:K00569] [EC:2.1.1.67]
127548630  xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
127539627  inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
127550724  liver carboxylesterase 1-like [KO:K01044] [EC:3.1.1.1]
127550725  liver carboxylesterase 1-like [KO:K01044] [EC:3.1.1.1]
127550726  liver carboxylesterase 1-like [KO:K01044] [EC:3.1.1.1]
127546835  liver carboxylesterase 1-like [KO:K01044] [EC:3.1.1.1]
127546836  LOW QUALITY PROTEIN: carboxylesterase 1D-like [KO:K01044] [EC:3.1.1.1]
127547933  pyrethroid hydrolase Ces2e-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
127547934  cocaine esterase-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
127541237  UDP-glucuronosyltransferase 2B31-like isoform X1 [KO:K00699] [EC:2.4.1.17]
127541389  uncharacterized protein LOC127541389 [KO:K00699] [EC:2.4.1.17]
127562560  UDP-glucuronosyltransferase 1A5-like isoform X1 [KO:K00699] [EC:2.4.1.17]
127558754  beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
127555764  cytidine deaminase [KO:K01489] [EC:3.5.4.5]
127538818  thymidine phosphorylase [KO:K00758] [EC:2.4.2.4]
127559473  dihydropyrimidine dehydrogenase [NADP(+)] isoform X1 [KO:K00207] [EC:1.3.1.2]
127544358  dihydropyrimidinase [KO:K01464] [EC:3.5.2.2]
127545897  beta-ureidopropionase isoform X1 [KO:K01431] [EC:3.5.1.6]
127553592  uridine phosphorylase 1 isoform X1 [KO:K00757] [EC:2.4.2.3]
127554636  uridine phosphorylase 2 isoform X1 [KO:K00757] [EC:2.4.2.3]
127562962  uridine-cytidine kinase 2 [KO:K00876] [EC:2.7.1.48]
127550919  uridine-cytidine kinase 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
127560695  thymidine kinase, cytosolic isoform X1 [KO:K00857] [EC:2.7.1.21]
127547949  thymidine kinase 2, mitochondrial [KO:K00857] [EC:2.7.1.21]
127554159  uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
127563358  UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
127555272  ribonucleoside-diphosphate reductase large subunit isoform X1 [KO:K10807] [EC:1.17.4.1]
127544345  ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
127548691  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
127564258  nucleoside diphosphate kinase A 1-like [KO:K00940] [EC:2.7.4.6]
127562931  nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
127542955  nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
127543396  nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
127539008  nucleoside diphosphate kinase 6 isoform X1 [KO:K00940] [EC:2.7.4.6]
127560046  nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
127560047  nucleoside diphosphate kinase A 1 isoform X1 [KO:K00940] [EC:2.7.4.6]
127551128  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 [KO:K01520] [EC:3.6.1.23]
127559988  myeloperoxidase-like [KO:K10789] [EC:1.11.2.2]
127548676  LOW QUALITY PROTEIN: arylamine N-acetyltransferase 1-like [KO:K00622] [EC:2.3.1.5]
127546978  cytochrome P450 2E1-like [KO:K07415] [EC:1.14.14.-]
127546992  cytochrome P450 2C42-like [KO:K07415] [EC:1.14.14.-]
127562969  microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
127543324  glutathione S-transferase theta-2-like [KO:K00799] [EC:2.5.1.18]
127551551  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
127551555  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
127538443  microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
127559374  glutathione S-transferase Mu 3-like [KO:K00799] [EC:2.5.1.18]
127559375  glutathione S-transferase Mu 4-like [KO:K00799] [EC:2.5.1.18]
127559376  glutathione S-transferase Mu 4-like isoform X1 [KO:K00799] [EC:2.5.1.18]
127539983  glutathione S-transferase theta-2B [KO:K00799] [EC:2.5.1.18]
127540523  microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
127561852  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
127561853  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
127561854  glutathione S-transferase A4-like isoform X1 [KO:K00799] [EC:2.5.1.18]
127561855  glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
127539723  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
127539724  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
127539725  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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