KEGG   PATHWAY: ajm00983
Entry
ajm00983                    Pathway                                
Name
Drug metabolism - other enzymes - Artibeus jamaicensis (Jamaican fruit-eating bat)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
ajm00983  Drug metabolism - other enzymes
ajm00983

Organism
Artibeus jamaicensis (Jamaican fruit-eating bat) [GN:ajm]
Gene
119064324  LOW QUALITY PROTEIN: hypoxanthine-guanine phosphoribosyltransferase-like [KO:K00760] [EC:2.4.2.8]
119050188  HPRT1; hypoxanthine-guanine phosphoribosyltransferase isoform X1 [KO:K00760] [EC:2.4.2.8]
119036708  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
119065636  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
119041217  GMPS; GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
119058700  TPMT; thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
119050452  XDH; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
119051185  ITPA; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
119046439  CES1; liver carboxylesterase 1 [KO:K01044] [EC:3.1.1.1]
119043920  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2B4-like [KO:K00699] [EC:2.4.1.17]
119043922  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
119043925  UDP-glucuronosyltransferase 2A3-like [KO:K00699] [EC:2.4.1.17]
119043927  UDP-glucuronosyltransferase 2A2 isoform X1 [KO:K00699] [EC:2.4.1.17]
119061001  UGT1A1; UDP-glucuronosyltransferase 1A1 [KO:K00699] [EC:2.4.1.17]
119048258  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 1A10-like [KO:K00699] [EC:2.4.1.17]
119048433  UDP-glucuronosyltransferase 1A10-like [KO:K00699] [EC:2.4.1.17]
119042036  GUSB; beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
119045400  CDA; cytidine deaminase isoform X1 [KO:K01489] [EC:3.5.4.5]
119060213  LOW QUALITY PROTEIN: thymidine phosphorylase [KO:K00758] [EC:2.4.2.4]
119054992  DPYD; dihydropyrimidine dehydrogenase [NADP(+)] [KO:K00207] [EC:1.3.1.2]
119040386  DPYS; dihydropyrimidinase isoform X1 [KO:K01464] [EC:3.5.2.2]
119059164  UPB1; beta-ureidopropionase isoform X1 [KO:K01431] [EC:3.5.1.6]
119044107  UPP2; LOW QUALITY PROTEIN: uridine phosphorylase 2 [KO:K00757] [EC:2.4.2.3]
119057323  UPP1; uridine phosphorylase 1 [KO:K00757] [EC:2.4.2.3]
119059012  UCK1; uridine-cytidine kinase 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
119061131  UCKL1; uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
119065370  UCK2; uridine-cytidine kinase 2 [KO:K00876] [EC:2.7.1.48]
119061908  TK2; thymidine kinase 2, mitochondrial isoform X1 [KO:K00857] [EC:2.7.1.21]
119058499  TK1; thymidine kinase, cytosolic [KO:K00857] [EC:2.7.1.21]
119039410  UMPS; uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
119039829  CMPK1; UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
119042096  RRM1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
119040393  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
119054007  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
119036676  NME6; nucleoside diphosphate kinase 6 isoform X1 [KO:K00940] [EC:2.7.4.6]
119037436  nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
119037437  nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
119034522  nucleoside diphosphate kinase 1-like [KO:K00940] [EC:2.7.4.6]
119034523  nucleoside diphosphate kinase 1 [KO:K00940] [EC:2.7.4.6]
119063952  nucleoside diphosphate kinase-like [KO:K00940] [EC:2.7.4.6]
119065452  NME7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
119058172  NME3; nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
119058190  NME4; nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
119057615  DUT; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 [KO:K01520] [EC:3.6.1.23]
119062632  MPO; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
119038484  arylamine N-acetyltransferase 1-like [KO:K00622] [EC:2.3.1.5]
119046537  arylamine N-acetyltransferase 1-like [KO:K00622] [EC:2.3.1.5]
119047229  arylamine N-acetyltransferase 1-like [KO:K00622] [EC:2.3.1.5]
119059516  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
119043286  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
119044181  glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
119038198  protein IN2-1 homolog B [KO:K00799] [EC:2.5.1.18]
119038509  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
119039311  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
119041343  probable glutathione S-transferase GSTF1 [KO:K00799] [EC:2.5.1.18]
119041344  probable glutathione S-transferase GSTF1 [KO:K00799] [EC:2.5.1.18]
119034965  MGST2; microsomal glutathione S-transferase 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
119042793  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
119042872  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
119059001  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
119059190  LOW QUALITY PROTEIN: glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
119059191  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
119059193  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
119059228  glutathione S-transferase theta-2B-like [KO:K00799] [EC:2.5.1.18]
119059627  glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
119059706  GSTO1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
119059742  glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
119059743  glutathione S-transferase alpha-4 [KO:K00799] [EC:2.5.1.18]
119059745  glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
119059996  probable glutathione S-transferase GSTU1 [KO:K00799] [EC:2.5.1.18]
119054553  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
119054555  GSTM4; glutathione S-transferase Mu 4 [KO:K00799] [EC:2.5.1.18]
119054565  glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
119062912  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
119055852  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
119065408  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
119041910  glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
119041911  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
LinkDB

DBGET integrated database retrieval system