KEGG   PATHWAY: ajm04814
Entry
ajm04814                    Pathway                                
Name
Motor proteins - Artibeus jamaicensis (Jamaican fruit-eating bat)
Class
Cellular Processes; Cell motility
Pathway map
ajm04814  Motor proteins
ajm04814

Organism
Artibeus jamaicensis (Jamaican fruit-eating bat) [GN:ajm]
Gene
119037954  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
119061505  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 [KO:K10414]
119044928  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
119042900  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
119051513  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
119061893  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
119061527  DYNC2LI1; cytoplasmic dynein 2 light intermediate chain 1 [KO:K10417]
119046624  dynein light chain 1, cytoplasmic [KO:K10418]
119062636  DYNLL2; dynein light chain 2, cytoplasmic [KO:K10418]
119057382  dynein light chain 1, cytoplasmic-like [KO:K10418]
119057433  DYNLL1; dynein light chain 1, cytoplasmic [KO:K10418]
119063271  DYNLRB1; dynein light chain roadblock-type 1 [KO:K10419]
119049239  DYNLRB2; dynein light chain roadblock-type 2 [KO:K10419]
119034983  DYNLT1; dynein light chain Tctex-type 1 [KO:K10420]
119063660  DYNLT3; dynein light chain Tctex-type 3 [KO:K10420]
119034969  DYNLT2; tctex1 domain-containing protein 3 isoform X1 [KO:K25419]
119052334  DYNLT4; tctex1 domain-containing protein 4 isoform X1 [KO:K25420]
119063520  tctex1 domain-containing protein 1-like [KO:K25421]
119044466  DNAH14; dynein heavy chain 14, axonemal [KO:K10408]
119038701  dynein heavy chain 7, axonemal-like [KO:K10408]
119041458  DNAH1; dynein heavy chain 1, axonemal [KO:K10408]
119059900  DNAH6; LOW QUALITY PROTEIN: dynein heavy chain 6, axonemal [KO:K10408]
119053533  DNAH2; dynein heavy chain 2, axonemal [KO:K10408]
119060710  DNAH10; dynein heavy chain 10, axonemal [KO:K10408]
119046042  dynein heavy chain 12, axonemal-like [KO:K10408]
119046631  DNAH7; dynein heavy chain 7, axonemal [KO:K10408]
119054150  DNAH3; dynein heavy chain 3, axonemal [KO:K10408]
119061678  DNAH11; dynein heavy chain 11, axonemal [KO:K10408]
119047853  dynein heavy chain 9, axonemal-like [KO:K10408]
119056194  DNAH5; dynein heavy chain 5, axonemal [KO:K10408]
119057091  dynein heavy chain 9, axonemal-like [KO:K10408]
119050021  DNAH8; LOW QUALITY PROTEIN: dynein heavy chain 8, axonemal [KO:K10408]
119058580  DNAH17; dynein heavy chain 17, axonemal [KO:K10408]
119053855  DNAI1; dynein intermediate chain 1, axonemal [KO:K10409]
119065317  DNAI2; dynein intermediate chain 2, axonemal [KO:K11143]
119062894  DNAI3; dynein intermediate chain 3, axonemal [KO:K24722]
119063515  DNAI4; dynein intermediate chain 4, axonemal [KO:K24723]
119052440  DNALI1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
119036151  DNAL1; dynein light chain 1, axonemal [KO:K10411]
119060580  DNAL4; dynein light chain 4, axonemal isoform X1 [KO:K10412]
119038365  DCTN1; dynactin subunit 1 isoform X1 [KO:K04648]
119035662  DCTN2; dynactin subunit 2 isoform X1 [KO:K10424]
119053851  DCTN3; dynactin subunit 3 [KO:K10425]
119061351  DCTN4; dynactin subunit 4 [KO:K10426]
119059245  DCTN5; dynactin subunit 5 [KO:K10427]
119036880  DCTN6; dynactin subunit 6 [KO:K10428]
119059665  ACTR1A; alpha-centractin [KO:K16575]
119055994  ACTR1B; beta-centractin [KO:K16575]
119045110  ACTR10; actin-related protein 10 [KO:K16576]
119038257  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
119042784  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
119054573  CAPZA1; LOW QUALITY PROTEIN: F-actin-capping protein subunit alpha-1 [KO:K10364]
119051996  F-actin-capping protein subunit beta-like [KO:K10365]
119045408  CAPZB; F-actin-capping protein subunit beta [KO:K10365]
119056247  BICDL2; BICD family-like cargo adapter 2 isoform X1 [KO:K16756]
119057392  BICDL1; BICD family-like cargo adapter 1 isoform X1 [KO:K16756]
119063066  HOOK3; protein Hook homolog 3 isoform X1 [KO:K16536]
119044362  TUBA8; tubulin alpha-8 chain [KO:K07374]
119038898  LOW QUALITY PROTEIN: tubulin alpha-3 chain-like [KO:K07374]
119038913  tubulin alpha-3 chain-like [KO:K07374]
119042369  tubulin alpha-1A chain-like [KO:K07374]
119042383  TUBA1A; tubulin alpha-1A chain [KO:K07374]
119042392  tubulin alpha-1C chain [KO:K07374]
119056884  tubulin alpha-4A chain [KO:K07374]
119056902  tubulin alpha-1D chain [KO:K07374]
119057309  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
119057933  tubulin alpha-2 chain [KO:K07374]
119035893  tubulin beta chain-like [KO:K07375]
119036117  TUBB4B; tubulin beta-4B chain [KO:K07375]
119043932  tubulin beta chain-like [KO:K07375]
119041269  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
119051789  tubulin beta-2B chain [KO:K07375]
119051790  TUBB2A; tubulin beta-2A chain isoform X1 [KO:K07375]
119046346  TUBB; tubulin beta chain [KO:K07375]
119047208  TUBB3; tubulin beta-3 chain isoform X1 [KO:K07375]
119055365  TUBB1; tubulin beta-1 chain [KO:K07375]
119063792  TUBB4A; tubulin beta-4A chain [KO:K07375]
119050603  tubulin beta-1 chain [KO:K07375]
119052025  tubulin gamma-1 chain [KO:K10389]
119052032  tubulin gamma-2 chain-like [KO:K10389]
119062642  TUBD1; tubulin delta chain isoform X1 [KO:K10390]
119043292  TUBE1; tubulin epsilon chain isoform X1 [KO:K10391]
119035670  KIF5A; kinesin heavy chain isoform X1 [KO:K10396]
119064196  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396]
119065583  KIF5C; kinesin heavy chain [KO:K10396]
119041903  KLC2; kinesin light chain 2 isoform X1 [KO:K10407]
119051343  KLC3; kinesin light chain 3 [KO:K10407]
119063096  KLC1; kinesin light chain 1 [KO:K10407]
119056066  KLC4; kinesin light chain 4 [KO:K10407]
119037641  KIF3A; kinesin-like protein KIF3A isoform X1 [KO:K10394]
119047738  KIF3B; kinesin-like protein KIF3B [KO:K20196]
119065400  KIFAP3; kinesin-associated protein 3 isoform X1 [KO:K25388]
119064008  kinesin-like protein KIF3C [KO:K20197]
119050406  KIF3C; kinesin-like protein KIF3C [KO:K20197]
119045377  KIF17; kinesin-like protein KIF17 [KO:K20198]
119061022  KIF1A; kinesin-like protein KIF1A [KO:K10392]
119048598  KIF1C; kinesin-like protein KIF1C [KO:K10392]
119064081  KIF1B; kinesin-like protein KIF1B isoform X1 [KO:K10392]
119042047  kinesin-like protein KIF13B [KO:K17914]
119051287  KIF13A; kinesin-like protein KIF13A isoform X1 [KO:K17914]
119053027  KIF13B; kinesin-like protein KIF13B [KO:K17914]
119060753  KIF14; kinesin-like protein KIF14 [KO:K17915]
119054625  KIF16B; kinesin-like protein KIF16B [KO:K17916]
119054626  kinesin-like protein KIF16B isoform X1 [KO:K17916]
119061218  STARD9; stAR-related lipid transfer protein 9 [KO:K16491]
119040214  KIF4A; chromosome-associated kinesin KIF4A isoform X1 [KO:K10395]
119049100  KIF7; kinesin-like protein KIF7 isoform X1 [KO:K18806]
119045121  KIF21A; kinesin-like protein KIF21A [KO:K24185]
119060703  KIF21B; kinesin-like protein KIF21B isoform X1 [KO:K24185]
119050119  kinesin-like protein KIF27 [KO:K24186]
119057772  KIF11; kinesin-like protein KIF11 [KO:K10398]
119062488  LOW QUALITY PROTEIN: kinesin-like protein KIF20A [KO:K10402]
119057765  KIF20B; kinesin-like protein KIF20B isoform X1 [KO:K10402]
119051066  KIF20A; kinesin-like protein KIF20A [KO:K10402]
119057070  KIF23; kinesin-like protein KIF23 isoform X1 [KO:K17387]
119065771  CENPE; centromere-associated protein E isoform X1 [KO:K11498]
119049908  KIF18A; kinesin-like protein KIF18A [KO:K10401]
119061597  KIF18B; kinesin-like protein KIF18B [KO:K26156]
119065269  KIF19; kinesin-like protein KIF19 [KO:K26157]
119043810  kinesin-like protein KIF19 [KO:K26157]
119037889  KIF9; kinesin-like protein KIF9 isoform X1 [KO:K10397]
119050013  KIF6; kinesin-like protein KIF6 [KO:K10397]
119058821  KIF22; kinesin-like protein KIF22 [KO:K10403]
119053385  KIF26B; kinesin-like protein KIF26B isoform X1 [KO:K10404]
119063110  KIF26A; kinesin-like protein KIF26A [KO:K10404]
119044912  KIF12; kinesin-like protein KIF12 isoform X1 [KO:K10399]
119051474  KIF15; kinesin-like protein KIF15 isoform X1 [KO:K10400]
119037456  KIF2B; kinesin-like protein KIF2B [KO:K10393]
119052351  KIF2C; kinesin-like protein KIF2C isoform X1 [KO:K10393]
119053821  KIF24; kinesin-like protein KIF24 [KO:K10393]
119057177  KIF2A; kinesin-like protein KIF2A isoform X1 [KO:K10393]
119041233  KIFC1; kinesin-like protein KIFC1 isoform X1 [KO:K10405]
119046411  KIFC3; kinesin-like protein KIFC3 isoform X1 [KO:K10406]
119064689  KIFC2; kinesin-like protein KIFC2 isoform X1 [KO:K10406]
119036308  unconventional myosin-Id [KO:K10356]
119040668  MYO1C; unconventional myosin-Ic isoform X1 [KO:K10356]
119059318  MYO1F; unconventional myosin-If isoform X1 [KO:K10356]
119052882  MYO1G; unconventional myosin-Ig isoform X1 [KO:K10356]
119053460  MYO1E; unconventional myosin-Ie [KO:K10356]
119062098  MYO1B; unconventional myosin-Ib isoform X1 [KO:K10356]
119062538  MYO1A; unconventional myosin-Ia [KO:K10356]
119057428  MYO1H; unconventional myosin-Ih [KO:K10356]
119045818  MYO3B; myosin-IIIb isoform X1 [KO:K08834] [EC:2.7.11.1]
119050167  MYO3A; myosin-IIIa [KO:K08834] [EC:2.7.11.1]
119047601  MYO5C; unconventional myosin-Vc [KO:K10357]
119047603  MYO5A; unconventional myosin-Va [KO:K10357]
119063646  MYO5B; unconventional myosin-Vb [KO:K10357]
119040142  MYO6; unconventional myosin-VI isoform X1 [KO:K10358]
119043910  MYO7A; unconventional myosin-VIIa [KO:K10359]
119034554  MYO7B; unconventional myosin-VIIb isoform X1 [KO:K21868]
119043297  MYO9A; unconventional myosin-IXa [KO:K10360]
119046787  MYO9B; unconventional myosin-IXb isoform X1 [KO:K10360]
119056207  MYO10; unconventional myosin-X isoform X1 [KO:K12559]
119062247  MYO15A; unconventional myosin-XV [KO:K10361]
119058569  MYO15B; myosin XVB [KO:K10361]
119037085  MYO16; unconventional myosin-XVI [KO:K17481]
119062057  MYO18A; unconventional myosin-XVIIIa isoform X1 [KO:K10362]
119057440  MYO18B; unconventional myosin-XVIIIb [KO:K10362]
119062596  MYO19; unconventional myosin-XIX [KO:K25838]
119051902  MYH15; myosin-15 [KO:K24220]
119063333  MYH7B; myosin-7B [KO:K24220]
119056592  myosin-2 [KO:K24220]
119056593  myosin-1 [KO:K24220]
119056594  LOW QUALITY PROTEIN: myosin-8-like [KO:K24220]
119056595  myosin-1-like [KO:K24220]
119056596  LOW QUALITY PROTEIN: myosin-13-like [KO:K24220]
119056600  myosin-3 [KO:K24220]
119037272  myosin-6 [KO:K17751]
119037273  myosin-7 [KO:K17751]
119049833  LOW QUALITY PROTEIN: myosin heavy chain, muscle-like [KO:K17751]
119037064  MYH11; myosin-11 isoform X1 [KO:K10352]
119052006  myosin-14-like [KO:K10352]
119060356  MYH9; myosin-9 [KO:K10352]
119063564  MYH10; myosin-10 isoform X1 [KO:K10352]
119050616  myosin-14 [KO:K10352]
119064361  MYL1; myosin light chain 1/3, skeletal muscle isoform isoform X1 [KO:K05738]
119037779  MYL3; myosin light chain 3 [KO:K12749]
119062691  MYL4; myosin light chain 4 isoform X1 [KO:K12750]
119040323  MYL6B; myosin light chain 6B [KO:K12751]
119040324  MYL6; myosin light polypeptide 6 isoform X1 [KO:K12751]
119040469  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
119035521  MYL5; myosin light chain 5 isoform X1 [KO:K12753]
119052883  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
119063288  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
119044655  MYL10; myosin regulatory light chain 10 [KO:K12756]
119042370  myosin regulatory light chain 12B [KO:K12757]
119042371  myosin regulatory light polypeptide 9 [KO:K12757]
119058905  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform isoform X1 [KO:K12758]
119048515  ACTA1; actin, alpha skeletal muscle [KO:K10354]
119057748  ACTA2; actin, aortic smooth muscle [KO:K12313]
119040247  ACTC1; actin, alpha cardiac muscle 1 [KO:K12314]
119038380  ACTG2; actin, gamma-enteric smooth muscle [KO:K12315]
119041512  ACTB; actin, cytoplasmic 1 [KO:K05692]
119046540  actin-5C-like [KO:K05692]
119058560  ACTG1; actin, cytoplasmic 2 [KO:K05692]
119050854  actin-3 [KO:K10355]
119041449  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
119060778  TNNI1; troponin I, slow skeletal muscle [KO:K10371]
119046576  troponin I, slow skeletal muscle-like [KO:K10371]
119057278  troponin I, slow skeletal muscle-like [KO:K10371]
119059947  TNNT1; troponin T, slow skeletal muscle isoform X1 [KO:K10372]
119063251  TNNC2; troponin C, skeletal muscle [KO:K12042]
119057542  TNNI2; troponin I, fast skeletal muscle [KO:K12043]
119057549  TNNT3; troponin T, fast skeletal muscle isoform X1 [KO:K12046]
119059954  TNNI3; troponin I, cardiac muscle isoform X1 [KO:K12044]
119060719  TNNT2; troponin T, cardiac muscle isoform X1 [KO:K12045]
119053433  TPM1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
119054670  tropomyosin-1-like [KO:K10373]
119048738  TPM2; tropomyosin beta chain isoform X1 [KO:K10374]
119061771  TPM3; tropomyosin alpha-3 chain isoform X1 [KO:K09290]
119046770  TPM4; tropomyosin alpha-4 chain isoform X1 [KO:K10375]
Reference
PMID:21092854
  Authors
Hirokawa N, Niwa S, Tanaka Y
  Title
Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease.
  Journal
Neuron 68:610-38 (2010)
DOI:10.1016/j.neuron.2010.09.039
Reference
PMID:25470043 (PDB:4RH7)
  Authors
Schmidt H, Zalyte R, Urnavicius L, Carter AP
  Title
Structure of human cytoplasmic dynein-2 primed for its power stroke.
  Journal
Nature 518:435-438 (2015)
DOI:10.1038/nature14023
Reference
PMID:22398446 (PDB:3VKG 3VKH)
  Authors
Kon T, Oyama T, Shimo-Kon R, Imamula K, Shima T, Sutoh K, Kurisu G
  Title
The 2.8 A crystal structure of the dynein motor domain.
  Journal
Nature 484:345-50 (2012)
DOI:10.1038/nature10955
Reference
PMID:22997337 (PDB:3J1T 3J1U)
  Authors
Redwine WB, Hernandez-Lopez R, Zou S, Huang J, Reck-Peterson SL, Leschziner AE
  Title
Structural basis for microtubule binding and release by dynein.
  Journal
Science 337:1532-1536 (2012)
DOI:10.1126/science.1224151
Reference
PMID:26410600
  Authors
Gibbs KL, Greensmith L, Schiavo G
  Title
Regulation of Axonal Transport by Protein Kinases.
  Journal
Trends Biochem Sci 40:597-610 (2015)
DOI:10.1016/j.tibs.2015.08.003
Reference
PMID:28602352 (PDB:5NUG 5NVS 5NVU 5NW4)
  Authors
Zhang K, Foster HE, Rondelet A, Lacey SE, Bahi-Buisson N, Bird AW, Carter AP
  Title
Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated.
  Journal
Cell 169:1303-1314.e18 (2017)
DOI:10.1016/j.cell.2017.05.025
Reference
PMID:25814576 (PDB:5ADX 5AFR 5AFU)
  Authors
Urnavicius L, Zhang K, Diamant AG, Motz C, Schlager MA, Yu M, Patel NA, Robinson CV, Carter AP
  Title
The structure of the dynactin complex and its interaction with dynein.
  Journal
Science 347:1441-1446 (2015)
DOI:10.1126/science.aaa4080
Reference
PMID:29420470 (PDB:5OWO 6F1T 6F1U 6F1V 6F1Y 6F1Z 6F38 6F3A)
  Authors
Urnavicius L, Lau CK, Elshenawy MM, Morales-Rios E, Motz C, Yildiz A, Carter AP
  Title
Cryo-EM shows how dynactin recruits two dyneins for faster movement.
  Journal
Nature 554:202-206 (2018)
DOI:10.1038/nature25462
Reference
PMID:29662141
  Authors
Reck-Peterson SL, Redwine WB, Vale RD, Carter AP
  Title
The cytoplasmic dynein transport machinery and its many cargoes.
  Journal
Nat Rev Mol Cell Biol 19:382-398 (2018)
DOI:10.1038/s41580-018-0004-3
Reference
PMID:23434508 (PDB:3J2U)
  Authors
Asenjo AB, Chatterjee C, Tan D, DePaoli V, Rice WJ, Diaz-Avalos R, Silvestry M, Sosa H
  Title
Structural model for tubulin recognition and deformation by kinesin-13 microtubule depolymerases.
  Journal
Cell Rep 3:759-68 (2013)
DOI:10.1016/j.celrep.2013.01.030
Reference
PMID:10338210 (PDB:1B7T)
  Authors
Houdusse A, Kalabokis VN, Himmel D, Szent-Gyorgyi AG, Cohen C
  Title
Atomic structure of scallop myosin subfragment S1 complexed with MgADP: a novel conformation of the myosin head.
  Journal
Cell 97:459-70 (1999)
DOI:10.1016/s0092-8674(00)80756-4
Reference
PMID:9428521 (PDB:3KIN)
  Authors
Kozielski F, Sack S, Marx A, Thormahlen M, Schonbrunn E, Biou V, Thompson A, Mandelkow EM, Mandelkow E
  Title
The crystal structure of dimeric kinesin and implications for microtubule-dependent motility.
  Journal
Cell 91:985-94 (1997)
DOI:10.1016/s0092-8674(00)80489-4
Reference
PMID:8316857 (PDB:2MYS)
  Authors
Rayment I, Rypniewski WR, Schmidt-Base K, Smith R, Tomchick DR, Benning MM, Winkelmann DA, Wesenberg G, Holden HM
  Title
Three-dimensional structure of myosin subfragment-1: a molecular motor.
  Journal
Science 261:50-8 (1993)
DOI:10.1126/science.8316857
Reference
PMID:20428469
  Authors
Parker D, Bryant Z, Delp SL
  Title
Coarse-Grained Structural Modeling of Molecular Motors Using Multibody Dynamics.
  Journal
Cell Mol Bioeng 2:366-374 (2009)
DOI:10.1007/s12195-009-0084-4
Reference
PMID:21314430
  Authors
Dominguez R, Holmes KC
  Title
Actin structure and function.
  Journal
Annu Rev Biophys 40:169-86 (2011)
DOI:10.1146/annurev-biophys-042910-155359
Reference
PMID:31919429 (PDB:6KN7 6KN8)
  Authors
Yamada Y, Namba K, Fujii T
  Title
Cardiac muscle thin filament structures reveal calcium regulatory mechanism.
  Journal
Nat Commun 11:153 (2020)
DOI:10.1038/s41467-019-14008-1
Reference
PMID:33912943
  Authors
Kruppa AJ, Buss F
  Title
Motor proteins at the mitochondria-cytoskeleton interface.
  Journal
J Cell Sci 134:239092 (2021)
DOI:10.1242/jcs.226084
KO pathway
ko04814   
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