KEGG   PATHWAY: aly00053
Entry
aly00053                    Pathway                                
Name
Ascorbate and aldarate metabolism - Arabidopsis lyrata (lyrate rockcress)
Class
Metabolism; Carbohydrate metabolism
Pathway map
aly00053  Ascorbate and aldarate metabolism
aly00053

Module
aly_M00114  Ascorbate biosynthesis, plants, fructose-6P => ascorbate [PATH:aly00053]
Other DBs
GO: 0019852 0019577 0019572
Organism
Arabidopsis lyrata (lyrate rockcress) [GN:aly]
Gene
9313244  UDP-glucose 6-dehydrogenase 2 [KO:K00012] [EC:1.1.1.22]
9309796  UDP-glucose 6-dehydrogenase 3 [KO:K00012] [EC:1.1.1.22]
9306865  UDP-glucose 6-dehydrogenase 4 [KO:K00012] [EC:1.1.1.22]
9329457  UDP-glucose 6-dehydrogenase 1 [KO:K00012] [EC:1.1.1.22]
9320366  UDP-glucose 6-dehydrogenase 3 [KO:K00012] [EC:1.1.1.22]
9301995  UDP-sugar pyrophosphorylase [KO:K12447] [EC:2.7.7.64]
9320336  glucuronokinase 1 [KO:K16190] [EC:2.7.1.43]
9309737  probable glucuronokinase 2 [KO:K16190] [EC:2.7.1.43]
9300549  inositol oxygenase 5 [KO:K00469] [EC:1.13.99.1]
9305689  inositol oxygenase 4 isoform X1 [KO:K00469] [EC:1.13.99.1]
9326124  inositol oxygenase 1 isoform X1 [KO:K00469] [EC:1.13.99.1]
9303646  inositol oxygenase 4 [KO:K00469] [EC:1.13.99.1]
9320036  inositol oxygenase 2 isoform X1 [KO:K00469] [EC:1.13.99.1]
9299043  aldo-keto reductase family 4 member C10 [KO:K00002] [EC:1.1.1.2]
9306975  aldose reductase isoform X1 [KO:K00002] [EC:1.1.1.2]
110228858  aldo-keto reductase family 4 member C10 [KO:K00002] [EC:1.1.1.2]
9318153  LOW QUALITY PROTEIN: L-gulonolactone oxidase 2 [KO:K00103] [EC:1.1.3.8]
9321645  LOW QUALITY PROTEIN: probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
9327042  probable L-gulonolactone oxidase 1 [KO:K00103] [EC:1.1.3.8]
9307550  L-gulonolactone oxidase 3 [KO:K00103] [EC:1.1.3.8]
9316330  L-gulonolactone oxidase 5 [KO:K00103] [EC:1.1.3.8]
9318154  probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
9300533  probable L-gulonolactone oxidase 1 [KO:K00103] [EC:1.1.3.8]
9308399  GDP-mannose 3,5-epimerase [KO:K10046] [EC:5.1.3.18 5.1.3.-]
9303610  GDP-L-galactose phosphorylase 1 [KO:K14190] [EC:2.7.7.69]
9300451  GDP-L-galactose phosphorylase 2 [KO:K14190] [EC:2.7.7.69]
9320409  inositol-phosphate phosphatase [KO:K10047] [EC:3.1.3.25 3.1.3.93]
9304959  bifunctional phosphatase IMPL2, chloroplastic [KO:K18649] [EC:3.1.3.25 3.1.3.93 3.1.3.15]
9303236  L-galactose dehydrogenase [KO:K17744] [EC:1.1.1.316]
9313653  L-galactono-1,4-lactone dehydrogenase, mitochondrial [KO:K00225] [EC:1.3.2.3]
9303420  UDP-glucuronate 4-epimerase 1 [KO:K08679] [EC:5.1.3.6]
9321667  UDP-glucuronate 4-epimerase 6 [KO:K08679] [EC:5.1.3.6]
9309040  UDP-glucuronate 4-epimerase 3 [KO:K08679] [EC:5.1.3.6]
9316238  UDP-glucuronate 4-epimerase 4 [KO:K08679] [EC:5.1.3.6]
9328095  UDP-glucuronate 4-epimerase 2 [KO:K08679] [EC:5.1.3.6]
9308717  UDP-glucuronate 4-epimerase 5 [KO:K08679] [EC:5.1.3.6]
9307119  monodehydroascorbate reductase 2 [KO:K08232] [EC:1.6.5.4]
9313959  monodehydroascorbate reductase 1, peroxisomal [KO:K08232] [EC:1.6.5.4]
9311471  monodehydroascorbate reductase 4, peroxisomal [KO:K08232] [EC:1.6.5.4]
9323993  monodehydroascorbate reductase 5, mitochondrial [KO:K08232] [EC:1.6.5.4]
9318712  monodehydroascorbate reductase 3 [KO:K08232] [EC:1.6.5.4]
9318697  L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
9303168  L-ascorbate peroxidase 3, peroxisomal [KO:K00434] [EC:1.11.1.11]
9305354  putative L-ascorbate peroxidase 6 isoform X2 [KO:K00434] [EC:1.11.1.11]
9303117  L-ascorbate peroxidase 5, peroxisomal isoform X2 [KO:K00434] [EC:1.11.1.11]
9325208  L-ascorbate peroxidase T, chloroplastic [KO:K00434] [EC:1.11.1.11]
9310603  L-ascorbate peroxidase S, chloroplastic/mitochondrial [KO:K00434] [EC:1.11.1.11]
9322135  L-ascorbate peroxidase 3, peroxisomal [KO:K00434] [EC:1.11.1.11]
9322136  L-ascorbate peroxidase 3, peroxisomal [KO:K00434] [EC:1.11.1.11]
9328486  L-ascorbate peroxidase 1, cytosolic [KO:K00434] [EC:1.11.1.11]
9323647  glutathione S-transferase DHAR2 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
110227884  glutathione S-transferase DHAR3, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
9326409  glutathione S-transferase DHAR1, mitochondrial [KO:K21888] [EC:1.8.5.1 2.5.1.18]
9304537  putative glutathione S-transferase DHAR4 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
9318886  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
9327906  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
9330573  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
9310099  L-ascorbate oxidase [KO:K00423] [EC:1.10.3.3]
110227744  L-ascorbate oxidase-like [KO:K00423] [EC:1.10.3.3]
9321031  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
9313658  aldehyde dehydrogenase family 2 member B4, mitochondrial [KO:K00128] [EC:1.2.1.3]
9323192  aldehyde dehydrogenase family 3 member H1 [KO:K00128] [EC:1.2.1.3]
9303098  aldehyde dehydrogenase family 3 member F1 [KO:K00128] [EC:1.2.1.3]
9305234  aldehyde dehydrogenase family 3 member I1, chloroplastic [KO:K00128] [EC:1.2.1.3]
9326659  aldehyde dehydrogenase family 2 member B7, mitochondrial [KO:K00128] [EC:1.2.1.3]
9327349  LOW QUALITY PROTEIN: aldehyde dehydrogenase family 3 member H1 [KO:K00128] [EC:1.2.1.3]
9327851  aldehyde dehydrogenase family 7 member B4 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
Compound
C00022  Pyruvate
C00026  2-Oxoglutarate
C00029  UDP-glucose
C00072  Ascorbate
C00096  GDP-mannose
C00137  myo-Inositol
C00167  UDP-glucuronate
C00191  D-Glucuronate
C00216  D-Arabinose
C00231  D-Xylulose 5-phosphate
C00259  L-Arabinose
C00333  D-Galacturonate
C00433  2,5-Dioxopentanoate
C00545  L-Arabinonate
C00558  D-Tagaturonate
C00617  UDP-D-galacturonate
C00618  3-Dehydro-L-gulonate
C00652  D-Arabinono-1,4-lactone
C00679  5-Dehydro-4-deoxy-D-glucarate
C00684  2-Dehydro-3-deoxy-L-arabinonate
C00800  L-Gulonate
C00818  D-Glucarate
C00878  D-Arabinonate
C00879  D-Galactarate
C01040  L-Gulono-1,4-lactone
C01041  Monodehydroascorbate
C01101  L-Ribulose 5-phosphate
C01114  L-Arabinono-1,4-lactone
C01115  L-Galactono-1,4-lactone
C01146  2-Hydroxy-3-oxopropanoate
C01620  Threonate
C01825  L-Galactose
C02280  GDP-L-galactose
C02670  D-Glucuronolactone
C03033  beta-D-Glucuronoside
C03064  3-Dehydro-L-threonate
C03289  L-xylo-Hexulonolactone
C03291  L-Xylulose 5-phosphate
C03826  2-Dehydro-3-deoxy-D-xylonate
C03921  2-Dehydro-3-deoxy-D-glucarate
C04037  1-Phospho-alpha-D-galacturonate
C04575  (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
C05385  D-Glucuronate 1-phosphate
C05411  L-Xylonate
C05412  L-Lyxonate
C05422  Dehydroascorbate
C06316  Dehydro-D-arabinono-1,4-lactone
C14899  3-Dehydro-L-gulonate 6-phosphate
C15923  L-Gulose
C15924  L-Gulose 1-phosphate
C15925  GDP-L-gulose
C15926  beta-L-Galactose 1-phosphate
C15930  L-Galactonate
C16186  L-Ascorbate 6-phosphate
C20889  D-Galactaro-1,5-lactone
C20896  D-Galactaro-1,4-lactone
C21955  L-Galactono-1,5-lactone
Reference
PMID:17222174
  Authors
Linster CL, Van Schaftingen E
  Title
Vitamin C. Biosynthesis, recycling and degradation in mammals.
  Journal
FEBS J 274:1-22 (2007)
DOI:10.1111/j.1742-4658.2006.05607.x
Reference
PMID:15564123
  Authors
Valpuesta V, Botella MA.
  Title
Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.
  Journal
Trends Plant Sci 9:573-7 (2004)
DOI:10.1016/j.tplants.2004.10.002
Reference
PMID:10517845
  Authors
Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.
  Title
Ascorbate biosynthesis in Arabidopsis cell suspension culture.
  Journal
Plant Physiol 121:535-43 (1999)
DOI:10.1104/pp.121.2.535
Reference
PMID:16595667
  Authors
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  Title
Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  Journal
J Biol Chem 281:15662-70 (2006)
DOI:10.1074/jbc.M601409200
Reference
PMID:17462988
  Authors
Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  Title
Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  Journal
J Biol Chem 282:18879-85 (2007)
DOI:10.1074/jbc.M702094200
Reference
PMID:14996803
  Authors
Campos E, Baldoma L, Aguilar J, Badia J.
  Title
Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.
  Journal
J Bacteriol 186:1720-8 (2004)
DOI:10.1128/JB.186.6.1720-1728.2004
Reference
PMID:12644495
  Authors
Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.
  Title
The ascorbate transporter of Escherichia coli.
  Journal
J Bacteriol 185:2243-50 (2003)
DOI:10.1128/JB.185.7.2243-2250.2003
Related
pathway
aly00020  Citrate cycle (TCA cycle)
aly00040  Pentose and glucuronate interconversions
aly00051  Fructose and mannose metabolism
aly00520  Amino sugar and nucleotide sugar metabolism
aly00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00053   
LinkDB

DBGET integrated database retrieval system