KEGG   PATHWAY: amil04141
Entry
amil04141                   Pathway                                
Name
Protein processing in endoplasmic reticulum - Acropora millepora
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
amil04141  Protein processing in endoplasmic reticulum
amil04141

Other DBs
GO: 0030433 0034976
Organism
Acropora millepora [GN:amil]
Gene
114963929  protein transport protein Sec61 subunit alpha [KO:K10956]
114977875  protein transport protein Sec61 subunit beta-like [KO:K09481]
114975847  translocation protein SEC62-like [KO:K12275]
114954660  translocation protein SEC63 homolog [KO:K09540]
114959830  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1-like [KO:K12666]
114961235  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2-like isoform X1 [KO:K12667]
114965088  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1-like [KO:K12668]
114951178  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit-like [KO:K12670]
114964901  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B-like [KO:K07151] [EC:2.4.99.18]
114963893  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
114971852  LOW QUALITY PROTEIN: tumor suppressor candidate 3-like [KO:K19478]
114976587  oligosaccharyltransferase complex subunit OSTC-like [KO:K26501]
114971302  transmembrane protein 258 [KO:K26502]
114960255  mannosyl-oligosaccharide glucosidase-like [KO:K01228] [EC:3.2.1.106]
114953582  ribosome-binding protein 1-like isoform X1 [KO:K14000]
114962497  nucleotide exchange factor SIL1-like [KO:K14001]
114951919  hypoxia up-regulated protein 1-like [KO:K09486]
114955027  endoplasmic reticulum chaperone BiP-like [KO:K09490] [EC:3.6.4.10]
114951069  dnaJ homolog subfamily B member 11-like [KO:K09517]
114959782  dnaJ homolog subfamily C member 1-like [KO:K09521]
114977109  dnaJ homolog subfamily C member 3-like [KO:K09523]
114977877  dnaJ homolog subfamily C member 10-like [KO:K09530] [EC:1.8.4.-]
114969049  endoplasmin-like [KO:K09487]
114967227  neutral alpha-glucosidase AB-like isoform X1 [KO:K05546] [EC:3.2.1.207]
114976694  glucosidase 2 subunit beta-like [KO:K08288]
114970390  calnexin-like [KO:K08054]
114958676  protein disulfide-isomerase A3-like isoform X1 [KO:K08056] [EC:5.3.4.1]
114952877  calreticulin-like [KO:K08057]
114954647  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA-like [KO:K01230] [EC:3.2.1.113]
114954655  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA-like [KO:K01230] [EC:3.2.1.113]
114946959  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase-like [KO:K23741] [EC:3.2.1.209]
114972920  vesicular integral-membrane protein VIP36-like [KO:K10082]
114975965  protein ERGIC-53-like [KO:K10080]
114958829  prolactin regulatory element-binding protein-like [KO:K14003]
114948180  GTP-binding protein SAR1b-like isoform X1 [KO:K07953] [EC:3.6.5.-]
114966058  protein SEC13 homolog isoform X1 [KO:K14004]
114957441  protein transport protein Sec31A-like isoform X1 [KO:K14005]
114956594  protein transport protein Sec23A-like [KO:K14006]
114963945  protein transport protein Sec24A-like [KO:K14007]
114963946  protein transport protein Sec24C-like isoform X1 [KO:K14007]
114973224  UDP-glucose:glycoprotein glucosyltransferase 1-like isoform X1 [KO:K11718] [EC:2.4.1.-]
114953430  ER degradation-enhancing alpha-mannosidase-like protein 1 [KO:K10084]
114968674  ER degradation-enhancing alpha-mannosidase-like protein 2 [KO:K10085]
114975765  ER degradation-enhancing alpha-mannosidase-like protein 3 [KO:K10086]
114956711  protein disulfide-isomerase 2-like isoform X1 [KO:K09580] [EC:5.3.4.1]
114971442  protein disulfide-isomerase A4-like [KO:K09582] [EC:5.3.4.1]
114961478  protein disulfide isomerase-like 2-2 [KO:K09584] [EC:5.3.4.1]
114961257  protein disulfide-isomerase A6-like [KO:K09584] [EC:5.3.4.1]
114954735  probable protein disulfide-isomerase A6 [KO:K09584] [EC:5.3.4.1]
114959987  endoplasmic reticulum resident protein 29-like [KO:K09586]
114949997  thioredoxin domain-containing protein 5-like [KO:K13984] [EC:5.3.4.1]
114962617  ERO1-like protein beta isoform X1 [KO:K10976] [EC:1.8.4.-]
114971640  protein OS-9-like [KO:K10088]
114955181  endoplasmic reticulum lectin 1-like [KO:K14008]
114976166  translocon-associated protein subunit alpha-like [KO:K13249]
114964808  translocon-associated protein subunit beta-like [KO:K13250]
114954726  translocon-associated protein subunit gamma-like [KO:K13251]
114972545  uncharacterized protein LOC114972545 [KO:K04571]
114972555  translocon-associated protein subunit delta-like [KO:K04571]
114953452  translocon-associated protein subunit delta-like [KO:K04571]
114953755  B-cell receptor-associated protein 31-like [KO:K14009]
114963855  translocating chain-associated membrane protein 1-like [KO:K14010]
114954194  derlin-1-like [KO:K11519]
114958329  derlin-2-like [KO:K13989]
114964906  UBX domain-containing protein 4-like isoform X1 [KO:K24348]
114967252  UBX domain-containing protein 1-like [KO:K24348]
114967877  UBX domain-containing protein 6-like [KO:K14011]
114948754  UBX domain-containing protein 8-like [KO:K24351]
114955072  NSFL1 cofactor p47-like [KO:K14012]
114960271  small VCP/p97-interacting protein-like [KO:K14014]
114973736  transitional endoplasmic reticulum ATPase isoform X1 [KO:K13525]
114975137  nuclear protein localization protein 4 homolog [KO:K14015]
114957844  ubiquitin recognition factor in ER-associated degradation protein 1-like isoform X1 [KO:K14016]
114970286  heat shock cognate 71 kDa protein-like [KO:K03283]
114974793  heat shock protein 68-like [KO:K03283]
114960586  heat shock cognate 71 kDa protein-like [KO:K03283]
114960603  heat shock cognate 71 kDa protein-like [KO:K03283]
114960605  heat shock cognate 71 kDa protein-like [KO:K03283]
114963375  dnaJ homolog subfamily A member 1-like [KO:K09502]
114970822  dnaJ homolog subfamily A member 2-like [KO:K09503]
114966294  dnaJ homolog subfamily B member 1-like [KO:K09507]
114966148  dnaJ homolog subfamily B member 12-like [KO:K09518]
114977325  dnaJ homolog subfamily C member 5-like isoform X1 [KO:K09525]
114975712  heat shock protein HSP 90-alpha-like [KO:K04079]
114973055  97 kDa heat shock protein-like isoform X1 [KO:K09485]
114967214  BAG family molecular chaperone regulator 1-like isoform X1 [KO:K09555]
114964663  hsp70-binding protein 1-like [KO:K09562]
114957795  heat shock protein beta-2-like [KO:K09542]
114966755  ubiquitin thioesterase OTU1-like isoform X1 [KO:K13719] [EC:3.1.2.-]
114958908  phospholipase A-2-activating protein-like [KO:K14018]
114952846  UV excision repair protein RAD23 homolog A-like [KO:K10839]
114975509  ubiquilin-1-like [KO:K04523]
114967644  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase-like isoform X1 [KO:K01456] [EC:3.5.1.52]
114967774  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase-like isoform X1 [KO:K01456] [EC:3.5.1.52]
114961451  LOW QUALITY PROTEIN: ataxin-3-like [KO:K11863] [EC:3.4.22.-]
114968877  uncharacterized protein LOC114968877 [KO:K10597] [EC:2.3.2.27]
114976333  ubiquitin conjugation factor E4 B-like [KO:K10597] [EC:2.3.2.27]
114960373  eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237]
114950848  uncharacterized protein LOC114950848 [KO:K05638]
114953195  cyclic AMP-dependent transcription factor ATF-5-like [KO:K04374]
114959371  apoptosis regulator Bcl-2-like [KO:K02161]
114954997  cyclic AMP-dependent transcription factor ATF-6 beta-like isoform X1 [KO:K09049]
114962121  membrane-bound transcription factor site-1 protease-like [KO:K08653] [EC:3.4.21.112]
114977501  membrane-bound transcription factor site-2 protease-like isoform X1 [KO:K07765] [EC:3.4.24.85]
114968976  X-box-binding protein 1-like isoform X1 [KO:K09027]
114956719  serine/threonine-protein kinase/endoribonuclease IRE1-like isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
114962688  uncharacterized protein LOC114962688 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
114974969  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
114976313  TNF receptor-associated factor 5-like [KO:K03173] [EC:2.3.2.27]
114947543  dual specificity mitogen-activated protein kinase kinase 7-like [KO:K04431] [EC:2.7.12.2]
114970322  stress-activated protein kinase JNK-like isoform X1 [KO:K04440] [EC:2.7.11.24]
114958535  apoptosis regulator BAX-like [KO:K02159]
114957375  bcl-2 homologous antagonist/killer-like [KO:K14021]
114961450  E3 ubiquitin-protein ligase MARCH6-like [KO:K10661] [EC:2.3.2.27]
114959820  ubiquitin-conjugating enzyme E2 J1-like isoform X1 [KO:K10578] [EC:2.3.2.23]
114969115  ubiquitin-conjugating enzyme E2 J2-like [KO:K04554] [EC:2.3.2.23]
114959698  ubiquitin-conjugating enzyme E2 G1-like isoform X1 [KO:K10575] [EC:2.3.2.23]
114947561  ubiquitin-conjugating enzyme E2 G2-like isoform X1 [KO:K04555] [EC:2.3.2.23]
114962605  E3 ubiquitin-protein ligase synoviolin-like isoform X1 [KO:K10601] [EC:2.3.2.27]
114960217  E3 ubiquitin-protein ligase RNF185-like [KO:K10666] [EC:2.3.2.27]
114977566  selenoprotein S-like [KO:K14025]
114953584  protein sel-1 homolog 1-like [KO:K14026]
114965122  E3 ubiquitin-protein ligase AMFR-like [KO:K10636] [EC:2.3.2.36]
114958625  E3 ubiquitin-protein ligase CHIP-like [KO:K09561] [EC:2.3.2.27]
114976588  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
114977498  E3 ubiquitin-protein ligase parkin-like [KO:K04556] [EC:2.3.2.31]
114969829  RING-box protein 1 [KO:K03868] [EC:2.3.2.32]
114977368  cullin-1-like isoform X1 [KO:K03347]
114964935  S-phase kinase-associated protein 1-like [KO:K03094]
114964949  S-phase kinase-associated protein 1-like isoform X1 [KO:K03094]
114964951  S-phase kinase-associated protein 1 isoform X1 [KO:K03094]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
amil00510  N-Glycan biosynthesis
amil03050  Proteasome
amil03060  Protein export
KO pathway
ko04141   
LinkDB

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