KEGG   PATHWAY: anu03420
Entry
anu03420                    Pathway                                
Name
Nucleotide excision repair - Arvicanthis niloticus (African grass rat)
Description
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Class
Genetic Information Processing; Replication and repair
Pathway map
anu03420  Nucleotide excision repair
anu03420

Other DBs
GO: 0006289
Organism
Arvicanthis niloticus (African grass rat) [GN:anu]
Gene
117719097  Rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
117695280  Cul4b; cullin-4B isoform X1 [KO:K10609]
117721685  Cul4a; cullin-4A [KO:K10609]
117704863  Ddb1; DNA damage-binding protein 1 isoform X1 [KO:K10610]
117703801  Ddb2; DNA damage-binding protein 2 [KO:K10140]
117714862  Xpc; DNA repair protein complementing XP-C cells [KO:K10838]
117723051  Rad23a; UV excision repair protein RAD23 homolog A isoform X1 [KO:K10839]
117708576  Rad23b; UV excision repair protein RAD23 homolog B [KO:K10839]
117694450  Cetn2; centrin-2 [KO:K10840]
117724015  Ercc8; DNA excision repair protein ERCC-8 isoform X1 [KO:K10570]
117705806  Ercc6; DNA excision repair protein ERCC-6 [KO:K10841]
117713182  Uvssa; UV-stimulated scaffold protein A isoform X1 [KO:K23720]
117710205  Polr2a; DNA-directed RNA polymerase II subunit RPB1 [KO:K03006] [EC:2.7.7.6]
117713110  Polr2b; DNA-directed RNA polymerase II subunit RPB2 [KO:K03010] [EC:2.7.7.6]
117723139  Polr2c; DNA-directed RNA polymerase II subunit RPB3 isoform X1 [KO:K03011]
117720207  Polr2d; DNA-directed RNA polymerase II subunit RPB4 [KO:K03012]
117696840  Polr2e; DNA-directed RNA polymerases I, II, and III subunit RPABC1 [KO:K03013]
117718945  Polr2f; DNA-directed RNA polymerases I, II, and III subunit RPABC2 [KO:K03014]
117713465  Polr2g; DNA-directed RNA polymerase II subunit RPB7 [KO:K03015]
117717821  Polr2h; DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X1 [KO:K03016]
117696323  Polr2i; DNA-directed RNA polymerase II subunit RPB9 [KO:K03017]
117709139  Polr2l; DNA-directed RNA polymerases I, II, and III subunit RPABC5 [KO:K03007]
117723443  DNA-directed RNA polymerases I, II, and III subunit RPABC4-like [KO:K03009]
117718861  Polr2k; DNA-directed RNA polymerases I, II, and III subunit RPABC4 isoform X1 [KO:K03009]
117697763  Polr2j; DNA-directed RNA polymerase II subunit RPB11-a [KO:K03008]
117699734  Polr2m; protein GRINL1A [KO:K21987]
117724022  Cdk7; cyclin-dependent kinase 7 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
117697492  Mnat1; CDK-activating kinase assembly factor MAT1 [KO:K10842]
117700412  Ccnh; cyclin-H [KO:K06634]
117719809  Ercc3; general transcription and DNA repair factor IIH helicase subunit XPB [KO:K10843] [EC:5.6.2.4]
117705050  Ercc2; general transcription and DNA repair factor IIH helicase subunit XPD isoform X1 [KO:K10844] [EC:5.6.2.3]
117700151  Gtf2h5; general transcription factor IIH subunit 5 isoform X1 [KO:K10845]
117714747  Gtf2h1; general transcription factor IIH subunit 1 [KO:K03141]
117723989  Gtf2h2c; general transcription factor IIH subunit 2-like protein [KO:K03142]
117697946  Gtf2h3; general transcription factor IIH subunit 3 [KO:K03143]
117724961  Gtf2h4; general transcription factor IIH subunit 4 [KO:K03144]
117705400  Ercc5; DNA repair protein complementing XP-G cells isoform X1 [KO:K10846]
117708494  Xpa; DNA repair protein complementing XP-A cells [KO:K10847]
117711019  Rpa1; replication protein A 70 kDa DNA-binding subunit [KO:K07466]
117708220  Rpa2; replication protein A 32 kDa subunit [KO:K10739]
117720682  Rpa3; replication protein A 14 kDa subunit [KO:K10740]
117711069  Ercc4; DNA repair endonuclease XPF [KO:K10848] [EC:3.1.-.-]
117693836  Ercc1; DNA excision repair protein ERCC-1 [KO:K10849]
117696394  Pold1; DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
117712473  Pold2; DNA polymerase delta subunit 2 isoform X1 [KO:K02328]
117697052  Pold3; DNA polymerase delta subunit 3 isoform X1 [KO:K03504]
117702189  DNA polymerase delta subunit 3-like [KO:K03504]
117714813  Pold4; DNA polymerase delta subunit 4 isoform X1 [KO:K03505]
117697974  Pole; DNA polymerase epsilon catalytic subunit A isoform X1 [KO:K02324] [EC:2.7.7.7]
117716946  Pole2; DNA polymerase epsilon subunit 2 isoform X1 [KO:K02325] [EC:2.7.7.7]
117709165  Pole3; DNA polymerase epsilon subunit 3 [KO:K02326] [EC:2.7.7.7]
117715521  Pole4; DNA polymerase epsilon subunit 4 isoform X1 [KO:K03506] [EC:2.7.7.7]
117704518  Pcna; proliferating cell nuclear antigen [KO:K04802]
117712592  Rfc1; replication factor C subunit 1 isoform X1 [KO:K10754]
117697676  Rfc2; replication factor C subunit 2 [KO:K10755]
117717587  Rfc4; replication factor C subunit 4 [KO:K10755]
117697637  Rfc3; replication factor C subunit 3 [KO:K10756]
117698348  Rfc5; replication factor C subunit 5 [KO:K10756]
117700455  Lig1; DNA ligase 1 isoform X1 [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
Reference
PMID:11436314
  Authors
Sugasawa K.
  Title
[Molecular mechanism of mammalian nucleotide excision repair]
  Journal
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Reference
PMID:11436316
  Authors
Nakatsu Y.
  Title
[Transcription-coupled repair and Cockayne syndrome]
  Journal
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Reference
PMID:11436323
  Authors
Nakagawa N, Masui R, Kuramitsu S.
  Title
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8]
  Journal
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Reference
PMID:17276014
  Authors
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
  Title
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
  Journal
Neuroscience 145:1388-96 (2007)
DOI:10.1016/j.neuroscience.2006.12.020
Reference
PMID:17884153
  Authors
Saldivar JS, Wu X, Follen M, Gershenson D.
  Title
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
  Journal
Gynecol Oncol 107:S56-71 (2007)
DOI:10.1016/j.ygyno.2007.07.043
Reference
PMID:16922398
  Authors
Sugasawa K.
  Title
[DNA repair pathways involving Cul4A ubiquitin ligases]
  Journal
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Reference
PMID:18018633
  Authors
Ito S, Ando D, Tanaka K.
  Title
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders]
  Journal
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
Related
pathway
anu03020  RNA polymerase
anu04120  Ubiquitin mediated proteolysis
KO pathway
ko03420   
LinkDB

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