KEGG   PATHWAY: asn03013
Entry
asn03013                    Pathway                                
Name
Nucleocytoplasmic transport - Alligator sinensis (Chinese alligator)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
asn03013  Nucleocytoplasmic transport
asn03013

Other DBs
GO: 0050658
Organism
Alligator sinensis (Chinese alligator) [GN:asn]
Gene
102370809  AAAS; aladin isoform X1 [KO:K14320]
102369788  NUPL2; nucleoporin-like protein 2 [KO:K14321]
102378218  nucleoporin GLE1 isoform X9 [KO:K18723]
102372492  LOW QUALITY PROTEIN: ATP-dependent RNA helicase DDX19B [KO:K18655] [EC:5.6.2.7]
102382389  RAE1; mRNA export factor isoform X1 [KO:K14298]
102376484  NUP98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
102375132  LOW QUALITY PROTEIN: nuclear pore complex protein Nup214 [KO:K14317]
102374912  NUP88; LOW QUALITY PROTEIN: nuclear pore complex protein Nup88 [KO:K14318]
106721793  E3 SUMO-protein ligase RanBP2 isoform X1 [KO:K12172] [EC:2.3.2.-]
102371399  RANGAP1; ran GTPase-activating protein 1 isoform X1 [KO:K14319]
102384245  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
102375514  SUMO2; small ubiquitin-related modifier 2 [KO:K12160]
102382249  small ubiquitin-related modifier 3 [KO:K12160]
102370284  SUMO1; small ubiquitin-related modifier 1 isoform X7 [KO:K12160]
102381189  NUP160; nuclear pore complex protein Nup160 [KO:K14303]
102375430  NUP85; nuclear pore complex protein Nup85 isoform X1 [KO:K14304]
102378054  SEC13; protein SEC13 homolog [KO:K14004]
102382399  NUP107; nuclear pore complex protein Nup107 isoform X2 [KO:K14301]
102370935  NUP133; nuclear pore complex protein Nup133 [KO:K14300]
102369821  SEH1L; nucleoporin SEH1 [KO:K14299]
102382749  NUP43; nucleoporin Nup43 [KO:K14305]
102373550  NUP37; nucleoporin Nup37 isoform X1 [KO:K14302]
102378864  AHCTF1; protein ELYS [KO:K25129]
102382199  NUP62CL; nucleoporin-62 C-terminal-like protein [KO:K14306]
102387318  NUP58; nucleoporin p58/p45 [KO:K14307]
102375574  NUP54; nucleoporin p54 isoform X1 [KO:K14308]
102372468  NUP205; LOW QUALITY PROTEIN: nuclear pore complex protein Nup205 [KO:K14310]
102382564  NUP188; nucleoporin NUP188 homolog isoform X8 [KO:K14311]
102387498  NUP155; nuclear pore complex protein Nup155 [KO:K14312]
102378973  NUP93; nuclear pore complex protein Nup93 isoform X1 [KO:K14309]
102383540  NUP35; nucleoporin NUP35 [KO:K14313]
102371908  NDC1; nucleoporin NDC1 [KO:K14315]
102375609  NUP210; nuclear pore membrane glycoprotein 210 isoform X1 [KO:K14314]
102379787  NUP210L; nuclear pore membrane glycoprotein 210-like [KO:K14314]
102376311  nuclear envelope pore membrane protein POM 121C isoform X2 [KO:K14316]
102375974  TMEM33; LOW QUALITY PROTEIN: transmembrane protein 33 [KO:K20724]
102370070  TPR; nucleoprotein TPR isoform X1 [KO:K09291]
102374426  NUP50; nuclear pore complex protein Nup50 isoform X1 [KO:K14295]
102384036  NUP153; nuclear pore complex protein Nup153 [KO:K14296]
102380630  SENP2; sentrin-specific protease 2 isoform X5 [KO:K03345] [EC:3.4.22.68]
112551423  sentrin-specific protease 2-like [KO:K03345] [EC:3.4.22.68]
102381358  KPNA1; importin subunit alpha-5 isoform X1 [KO:K23940]
102379500  KPNA2; importin subunit alpha-1 [KO:K15043]
102386511  KPNA7; importin subunit alpha-8 [KO:K15043]
102373291  KPNA3; importin subunit alpha-4 [KO:K23583]
102380904  KPNA4; importin subunit alpha-3 isoform X2 [KO:K23583]
102370890  KPNA5; importin subunit alpha-6 isoform X3 [KO:K15042]
102372955  KPNA6; importin subunit alpha-7 isoform X2 [KO:K15042]
102367998  KPNB1; importin subunit beta-1 isoform X2 [KO:K14293]
102374234  TNPO1; transportin-1 [KO:K18752]
102378131  TNPO2; transportin-2 [KO:K18727]
102380961  TNPO3; transportin-3 [KO:K15436]
102386968  IPO4; importin-4 [KO:K20221]
102377772  IPO5; importin-5 [KO:K20222]
102384090  IPO7; importin-7 [KO:K20223]
102373907  IPO8; importin-8 [KO:K18755]
102381525  IPO9; importin-9 [KO:K20224]
102385106  IPO11; importin-11 isoform X2 [KO:K25201]
102377066  IPO13; importin-13 [KO:K25202]
102377425  SNUPN; snurportin-1 [KO:K13151]
102370119  XPO1; exportin-1 isoform X1 [KO:K14290]
102382113  CSE1L; exportin-2 isoform X1 [KO:K18423]
102383655  XPOT; exportin-T isoform X1 [KO:K14288]
102384164  XPO4; exportin-4 isoform X1 [KO:K25203]
102386957  XPO5; exportin-5 [KO:K14289]
102388294  XPO6; exportin-6 isoform X1 [KO:K25204]
102380556  XPO7; exportin-7 isoform X2 [KO:K18460]
102375096  RANBP17; ran-binding protein 17 isoform X3 [KO:K24115]
102370450  RAN; GTP-binding nuclear protein Ran [KO:K07936]
102387838  EEF1A1; elongation factor 1-alpha 1 [KO:K03231]
102375530  EEF1A2; elongation factor 1-alpha 2 [KO:K03231]
102384014  elongation factor 1-alpha, oocyte form-like [KO:K03231]
102370149  elongation factor 1-alpha-like [KO:K03231]
102387088  PHAX; phosphorylated adapter RNA export protein isoform X2 [KO:K14291]
102374216  NCBP1; LOW QUALITY PROTEIN: nuclear cap-binding protein subunit 1 [KO:K12882]
102388601  nuclear cap-binding protein subunit 2 [KO:K12883]
102379359  NMD3; 60S ribosomal export protein NMD3 [KO:K07562]
102384545  RBM8A; RNA-binding protein 8A [KO:K12876]
102370798  MAGOH; protein mago nashi homolog [KO:K12877]
102379835  CASC3; protein CASC3 [KO:K14323]
102385527  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
102381515  ACIN1; LOW QUALITY PROTEIN: apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
102388823  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
102372769  RNPS1; RNA-binding protein with serine-rich domain 1 [KO:K14325]
102378096  PNN; LOW QUALITY PROTEIN: pinin [KO:K13114]
102383182  ALYREF; THO complex subunit 4 [KO:K12881]
102384608  UPF1; LOW QUALITY PROTEIN: regulator of nonsense transcripts 1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
102373885  UPF2; regulator of nonsense transcripts 2 isoform X1 [KO:K14327]
102377674  UPF3A; regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
102376629  UPF3B; regulator of nonsense transcripts 3B isoform X1 [KO:K14328]
102374093  NXF1; nuclear RNA export factor 1 [KO:K14284]
102379715  NXT2; NTF2-related export protein 2 isoform X2 [KO:K14285]
102378570  DDX39B; spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
102379339  SRRM1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
102375572  PYM1; partner of Y14 and mago [KO:K14294]
102377036  THOC1; THO complex subunit 1 [KO:K12878]
102375147  THOC2; THO complex subunit 2 isoform X3 [KO:K12879]
102388817  THOC5; THO complex subunit 5 homolog isoform X1 [KO:K13174]
102368095  THOC6; THO complex subunit 6 homolog isoform X1 [KO:K13175]
102375439  THOC7; THO complex subunit 7 homolog isoform X1 [KO:K13176]
102388155  THOC3; THO complex subunit 3 [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
asn03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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