KEGG   PATHWAY: bceo00260
Entry
bceo00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Burkholderia cenocepacia H111
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bceo00260  Glycine, serine and threonine metabolism
bceo00260

Module
bceo_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bceo00260]
bceo_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bceo00260]
bceo_M00555  Betaine biosynthesis, choline => betaine [PATH:bceo00260]
bceo_M00621  Glycine cleavage system [PATH:bceo00260]
bceo_M00919  Ectoine degradation, ectoine => aspartate [PATH:bceo00260]
bceo_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:bceo00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Burkholderia cenocepacia H111 [GN:bceo]
Gene
I35_2074  ask; Aspartokinase [KO:K00928] [EC:2.7.2.4]
I35_4908  asd; Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
I35_1846  hom; Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
I35_4812  Homoserine kinase [KO:K02204] [EC:2.7.1.39]
I35_1845  thrC; Threonine synthase [KO:K01733] [EC:4.2.3.1]
I35_6565  ltaE; Low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
I35_7812  Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
I35_7821  Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
I35_0654  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
I35_6217  glyA; Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
I35_1661  hprA; Hydroxypyruvate reductase [KO:K00018] [EC:1.1.1.29]
I35_7403  D-3-phosphoglycerate dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
I35_3033  D-3-phosphoglycerate dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
I35_1718  tkrA; 2-ketogluconate 6-phosphate reductase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
I35_0972  Glyoxylate reductase / Glyoxylate reductase / Hydroxypyruvate reductase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
I35_1920  Glycerate kinase [KO:K00865] [EC:2.7.1.165]
I35_2927  gmpA; Phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
I35_0533  Phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
I35_3205  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
I35_5585  D-3-phosphoglycerate dehydrogenase [EC:1.1.1.95] [KO:K00058] [EC:1.1.1.95 1.1.1.399]
I35_6485  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
I35_0908  serC; Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
I35_1769  Phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
I35_0653  Short chain dehydrogenase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
I35_4010  kbl; 2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
I35_4011  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
I35_0075  gcvP; Glycine dehydrogenase [decarboxylating] (glycine cleavage system P protein) [KO:K00281] [EC:1.4.4.2]
I35_0077  gcvT; Aminomethyltransferase (glycine cleavage system T protein) [KO:K00605] [EC:2.1.2.10]
I35_2136  putative dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
I35_1415  odhL; Dihydrolipoamide dehydrogenase of 2-oxoglutarate dehydrogenase [KO:K00382] [EC:1.8.1.4]
I35_1126  lpdV; Dihydrolipoamide dehydrogenase of branched-chain alpha-keto acid dehydrogenase [KO:K00382] [EC:1.8.1.4]
I35_0076  gcvH; Glycine cleavage system H protein [KO:K02437]
I35_2280  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
I35_6236  betA; Choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
I35_4324  NAD-dependent aldehyde dehydrogenases [KO:K00130] [EC:1.2.1.8]
I35_6235  betB; Betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
I35_6210  Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [KO:K00479] [EC:1.14.13.251]
I35_7808  Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [KO:K00479] [EC:1.14.13.251]
I35_7807  Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [KO:K21832] [EC:1.14.13.251]
I35_6209  Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [KO:K21832] [EC:1.14.13.251]
I35_6214  putative FMN oxidoreductase [KO:K21833] [EC:1.5.7.3]
I35_6213  Iron-sulphur-binding reductase [KO:K21834]
I35_6212  etfA; Electron transfer flavoprotein, alpha subunit [KO:K25960]
I35_6211  etfB; Electron transfer flavoprotein, beta subunit [KO:K25961]
I35_6285  soxA; Sarcosine oxidase alpha subunit [KO:K00302] [EC:1.5.3.24 1.5.3.1]
I35_6287  soxB; Sarcosine oxidase beta subunit [KO:K00303] [EC:1.5.3.24 1.5.3.1]
I35_6284  soxG; Sarcosine oxidase gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
I35_6286  soxD; Sarcosine oxidase delta subunit [KO:K00304] [EC:1.5.3.24 1.5.3.1]
I35_0073  sdaA; L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
I35_6288  sdaB; L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
I35_1942  putative amino-acid dehydratase [KO:K01754] [EC:4.3.1.19]
I35_7024  eutB; Threonine dehydratase, catabolic [KO:K01754] [EC:4.3.1.19]
I35_2800  ilvA; Threonine dehydratase biosynthetic [KO:K01754] [EC:4.3.1.19]
I35_1141  L-serine dehydratase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
I35_2805  D-serine deaminase [KO:K01753] [EC:4.3.1.18]
I35_2144  Aspartate racemase [KO:K25316] [EC:5.1.1.10]
I35_4915  trpA; Tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
I35_4913  trpB; Tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
I35_7026  Xaa-Pro aminopeptidase [KO:K15783] [EC:3.5.4.44]
I35_7027  succinate dehydrogenase subunit [KO:K15784] [EC:3.5.1.125]
I35_7030  Gamma-aminobutyrate:alpha-ketoglutarate aminotransferase [KO:K15785] [EC:2.6.1.76]
I35_7029  Succinate-semialdehyde dehydrogenase [NADP+] [KO:K15786] [EC:1.2.1.-]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bceo00010  Glycolysis / Gluconeogenesis
bceo00020  Citrate cycle (TCA cycle)
bceo00230  Purine metabolism
bceo00250  Alanine, aspartate and glutamate metabolism
bceo00270  Cysteine and methionine metabolism
bceo00290  Valine, leucine and isoleucine biosynthesis
bceo00300  Lysine biosynthesis
bceo00330  Arginine and proline metabolism
bceo00460  Cyanoamino acid metabolism
bceo00470  D-Amino acid metabolism
bceo00564  Glycerophospholipid metabolism
bceo00600  Sphingolipid metabolism
bceo00620  Pyruvate metabolism
bceo00630  Glyoxylate and dicarboxylate metabolism
bceo00640  Propanoate metabolism
bceo00680  Methane metabolism
bceo00860  Porphyrin metabolism
bceo00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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