KEGG   PATHWAY: bfo00590
Entry
bfo00590                    Pathway                                
Name
Arachidonic acid metabolism - Branchiostoma floridae (Florida lancelet)
Class
Metabolism; Lipid metabolism
Pathway map
bfo00590  Arachidonic acid metabolism
bfo00590

Other DBs
GO: 0019369
Organism
Branchiostoma floridae (Florida lancelet) [GN:bfo]
Gene
118411976  basic phospholipase A2 6-like isoform X1 [KO:K01047] [EC:3.1.1.4]
118411979  basic phospholipase A2 nigexine-like isoform X1 [KO:K01047] [EC:3.1.1.4]
118412599  group XIIA secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
118413000  acidic phospholipase A2 2-like [KO:K01047] [EC:3.1.1.4]
118407929  acidic phospholipase A2 2-like [KO:K01047] [EC:3.1.1.4]
118408049  phospholipase A2 A2-actitoxin-Ucs2a-like [KO:K01047] [EC:3.1.1.4]
118424511  basic phospholipase A2 PA-11-like [KO:K01047] [EC:3.1.1.4]
118424625  basic phospholipase A2 Cc2-PLA2-like [KO:K01047] [EC:3.1.1.4]
118424757  acidic phospholipase A2 E-like [KO:K01047] [EC:3.1.1.4]
118424759  neutral phospholipase A2 3-like [KO:K01047] [EC:3.1.1.4]
118424760  acidic phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
118424762  acidic phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
118426362  uncharacterized protein LOC118426362 [KO:K01047] [EC:3.1.1.4]
118426731  group 3 secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
118418855  uncharacterized protein LOC118418855 isoform X1 [KO:K01047] [EC:3.1.1.4]
118428251  basic phospholipase A2 PA-11-like [KO:K01047] [EC:3.1.1.4]
118428914  acidic phospholipase A2 PA4-like [KO:K01047] [EC:3.1.1.4]
118421715  cytosolic phospholipase A2-like [KO:K16342] [EC:3.1.1.4]
118429598  85/88 kDa calcium-independent phospholipase A2-like [KO:K16343] [EC:3.1.1.4]
118404819  phospholipase B1, membrane-associated-like [KO:K14621] [EC:3.1.1.4 3.1.1.5]
118422874  phospholipase B1, membrane-associated-like [KO:K14621] [EC:3.1.1.4 3.1.1.5]
118431592  phospholipase A and acyltransferase 2-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
118431594  lecithin retinol acyltransferase-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
118431965  phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
118427666  LOW QUALITY PROTEIN: prostaglandin G/H synthase 2-like [KO:K11987] [EC:1.14.99.1]
118421716  prostaglandin G/H synthase 2-like [KO:K11987] [EC:1.14.99.1]
118418361  prostaglandin E synthase-like [KO:K15729] [EC:5.3.99.3]
118420744  prostaglandin E synthase 2-like [KO:K05309] [EC:5.3.99.3]
118424575  prostaglandin E synthase 3-like isoform X1 [KO:K15730] [EC:5.3.99.3]
118415952  carbonyl reductase [NADPH] 1-like isoform X1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
118406581  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
118432795  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
118423977  LOW QUALITY PROTEIN: carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
118423978  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
118423979  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
118423980  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
118423984  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
118429862  prostamide/prostaglandin F synthase-like [KO:K15717] [EC:1.11.1.20]
118417101  15-hydroxyprostaglandin dehydrogenase [NAD(+)]-like [KO:K00069] [EC:1.1.1.141]
118417986  15-hydroxyprostaglandin dehydrogenase [NAD(+)]-like [KO:K00069] [EC:1.1.1.141]
118418567  15-hydroxyprostaglandin dehydrogenase [NAD(+)]-like [KO:K00069] [EC:1.1.1.141]
118413722  glutathione S-transferase 1-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
118414944  hematopoietic prostaglandin D synthase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
118411828  uncharacterized protein LOC118411828 [KO:K04097] [EC:5.3.99.2 2.5.1.18]
118411829  glutathione S-transferase 1-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
118412049  hematopoietic prostaglandin D synthase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
118412050  hematopoietic prostaglandin D synthase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
118412051  glutathione S-transferase 1-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
118412113  hematopoietic prostaglandin D synthase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
118412175  hematopoietic prostaglandin D synthase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
118412337  hematopoietic prostaglandin D synthase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
118412395  hematopoietic prostaglandin D synthase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
118412524  hematopoietic prostaglandin D synthase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
118412719  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
118413210  hematopoietic prostaglandin D synthase-like isoform X1 [KO:K04097] [EC:5.3.99.2 2.5.1.18]
118405781  glutathione S-transferase 1-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
118405782  hematopoietic prostaglandin D synthase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
118405835  hematopoietic prostaglandin D synthase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
118410782  hematopoietic prostaglandin D synthase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
118411000  hematopoietic prostaglandin D synthase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
118407044  allene oxide synthase-lipoxygenase protein-like [KO:K00461] [EC:1.13.11.34]
118407190  polyunsaturated fatty acid 5-lipoxygenase-like [KO:K00461] [EC:1.13.11.34]
118410745  allene oxide synthase-lipoxygenase protein-like [KO:K00461] [EC:1.13.11.34]
118423903  polyunsaturated fatty acid 5-lipoxygenase-like [KO:K00461] [EC:1.13.11.34]
118424144  polyunsaturated fatty acid 5-lipoxygenase-like [KO:K00461] [EC:1.13.11.34]
118416628  polyunsaturated fatty acid 5-lipoxygenase-like [KO:K00461] [EC:1.13.11.34]
118419219  allene oxide synthase-lipoxygenase protein-like [KO:K00461] [EC:1.13.11.34]
118419222  allene oxide synthase-lipoxygenase protein-like [KO:K00461] [EC:1.13.11.34]
118416024  leukotriene A-4 hydrolase-like [KO:K01254] [EC:3.3.2.6]
118413996  prostaglandin reductase 3-like [KO:K07119] [EC:1.3.1.48]
118413997  prostaglandin reductase-3-like [KO:K07119] [EC:1.3.1.48]
118429235  prostaglandin reductase 2-like isoform X1 [KO:K13949] [EC:1.3.1.48]
118414069  prostaglandin reductase 1-like [KO:K13948] [EC:1.3.1.74 1.3.1.48]
118414068  prostaglandin reductase 1-like isoform X1 [KO:K13948] [EC:1.3.1.74 1.3.1.48]
118413605  prostaglandin reductase 1-like [KO:K13948] [EC:1.3.1.74 1.3.1.48]
118406608  prostaglandin reductase 1-like isoform X1 [KO:K13948] [EC:1.3.1.74 1.3.1.48]
118407035  prostaglandin reductase 1-like [KO:K13948] [EC:1.3.1.74 1.3.1.48]
118407043  prostaglandin reductase 1-like [KO:K13948] [EC:1.3.1.74 1.3.1.48]
118407053  prostaglandin reductase 1-like [KO:K13948] [EC:1.3.1.74 1.3.1.48]
118416772  prostaglandin reductase 1-like [KO:K13948] [EC:1.3.1.74 1.3.1.48]
118404633  glutathione hydrolase 1 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
118425266  glutathione hydrolase 1 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
118425267  glutathione hydrolase 1 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
118425268  glutathione hydrolase 1 proenzyme-like isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
118425271  glutathione hydrolase 1 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
118425359  glutathione hydrolase 1 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
118425360  glutathione hydrolase 1 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
118425971  glutathione hydrolase 1 proenzyme-like isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
118427701  glutathione hydrolase 1 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
118421311  glutathione peroxidase-like isoform X1 [KO:K05361] [EC:1.11.1.12]
118405297  cytochrome P450 2U1-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
118407101  cytochrome P450 2J6-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
118419304  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
118428418  cytochrome P450 2C15-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
118429635  cytochrome P450 2J6-like isoform X1 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
118432366  cytochrome P450 2J6-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
118418294  cytochrome P450 2U1-like [KO:K07422] [EC:1.14.14.80]
118422566  cytochrome P450 2J1-like [KO:K07422] [EC:1.14.14.80]
118406569  cytochrome P450 2B4-like [KO:K07422] [EC:1.14.14.80]
118413155  cytochrome P450 2U1-like [KO:K07422] [EC:1.14.14.80]
118413160  cytochrome P450 2U1-like [KO:K07422] [EC:1.14.14.80]
118415263  cytochrome P450 2U1-like [KO:K07422] [EC:1.14.14.80]
118408308  cytochrome P450 2U1-like [KO:K07422] [EC:1.14.14.80]
118414775  allene oxide synthase-lipoxygenase protein-like [KO:K08022] [EC:1.13.11.33 1.13.11.-]
118414896  polyunsaturated fatty acid lipoxygenase ALOX15B-like [KO:K08022] [EC:1.13.11.33 1.13.11.-]
118426947  polyunsaturated fatty acid lipoxygenase ALOX15B-like [KO:K08022] [EC:1.13.11.33 1.13.11.-]
118429456  polyunsaturated fatty acid lipoxygenase ALOX15B-like [KO:K08022] [EC:1.13.11.33 1.13.11.-]
118426513  allene oxide synthase-lipoxygenase protein-like isoform X1 [KO:K26082] [EC:1.13.11.40 4.2.1.-]
118427757  allene oxide synthase-lipoxygenase protein-like [KO:K26082] [EC:1.13.11.40 4.2.1.-]
118427444  allene oxide synthase-lipoxygenase protein-like [KO:K26082] [EC:1.13.11.40 4.2.1.-]
118416246  cytochrome P450 2C16-like [KO:K07413] [EC:1.14.14.1]
118420112  bifunctional epoxide hydrolase 2-like [KO:K08726] [EC:3.3.2.10 3.1.3.76]
Compound
C00157  Phosphatidylcholine
C00219  Arachidonate
C00427  Prostaglandin H2
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00696  Prostaglandin D2
C00909  Leukotriene A4
C01312  Prostaglandin I2
C02165  Leukotriene B4
C02166  Leukotriene C4
C02198  Thromboxane A2
C03577  20-Hydroxyleukotriene E4
C04577  15-OxoETE
C04671  (5Z)-11alpha-Hydroxy-9,15-dioxoprostanoate
C04707  (5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-5,13-dienoate
C04742  (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
C04758  (5Z,13E)-9alpha-Hydroxy-11,15-dioxoprosta-5,13-dienoate
C04805  5(S)-HETE
C04822  8(R)-HPETE
C04835  (5Z,13E)-6,9alpha-Epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate
C04853  20-OH-Leukotriene B4
C05356  5(S)-HPETE
C05949  12-Keto-leukotriene B4
C05950  20-COOH-Leukotriene B4
C05951  Leukotriene D4
C05952  Leukotriene E4
C05953  Prostaglandin A2
C05954  Prostaglandin B2
C05955  Prostaglandin C2
C05956  Prostaglandin G2
C05957  Prostaglandin J2
C05958  Delta-12-Prostaglandin J2
C05959  11-epi-Prostaglandin F2alpha
C05960  15-Keto-prostaglandin F2alpha
C05961  6-Keto-prostaglandin F1alpha
C05962  6-Keto-prostaglandin E1
C05963  Thromboxane B2
C05964  11-Dehydro-thromboxane B2
C05965  12(S)-HPETE
C05966  15(S)-HPETE
C06314  Lipoxin A4
C06315  Lipoxin B4
C06462  Leukotriene F4
C13809  9,11,15-Trihydroxy-prosta-5,13-dien-1-oic acid
C14717  15-Deoxy-Delta12,14-PGJ2
C14732  5-OxoETE
C14748  20-HETE
C14749  19(S)-HETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
C14772  5,6-DHET
C14773  8,9-DHET
C14774  11,12-DHET
C14775  14,15-DHET
C14776  8(S)-HETE
C14777  12(S)-HETE
C14778  16(R)-HETE
C14779  9(S)-HETE
C14780  11(R)-HETE
C14781  15H-11,12-EETA
C14782  11,12,15-THETA
C14794  2,3-Dinor-8-iso prostaglandin F2alpha
C14795  2,3-Dinor-8-iso prostaglandin F1alpha
C14807  12-OxoETE
C14808  Hepoxilin A3
C14809  Trioxilin A3
C14810  Hepoxilin B3
C14811  Trioxilin B3
C14812  12(R)-HPETE
C14813  11H-14,15-EETA
C14814  11,14,15-THETA
C14815  5,6-Epoxytetraene
C14820  11(R)-HPETE
C14821  9(S)-HPETE
C14822  12(R)-HETE
C14823  8(S)-HPETE
C14824  8(R)-HETE
Reference
PMID:14636671
  Authors
Spector AA, Fang X, Snyder GD, Weintraub NL.
  Title
Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function.
  Journal
Prog Lipid Res 43:55-90 (2004)
DOI:10.1016/S0163-7827(03)00049-3
Reference
PMID:15292194
  Authors
Harman CA, Rieke CJ, Garavito RM, Smith WL.
  Title
Crystal structure of arachidonic acid bound to a mutant of prostaglandin endoperoxide H synthase-1 that forms predominantly 11-hydroperoxyeicosatetraenoic acid.
  Journal
J Biol Chem 279:42929-35 (2004)
DOI:10.1074/jbc.M403013200
Reference
PMID:15205388
  Authors
Poloyac SM, Tortorici MA, Przychodzin DI, Reynolds RB, Xie W, Frye RF, Zemaitis MA.
  Title
The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney.
  Journal
Drug Metab Dispos 32:727-33 (2004)
DOI:10.1124/dmd.32.7.727
Reference
PMID:14660610
  Authors
Chuang SS, Helvig C, Taimi M, Ramshaw HA, Collop AH, Amad M, White JA, Petkovich M, Jones G, Korczak B.
  Title
CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids.
  Journal
J Biol Chem 279:6305-14 (2004)
DOI:10.1074/jbc.M311830200
Reference
PMID:14626496
  Authors
Sacerdoti D, Gatta A, McGiff JC.
  Title
Role of cytochrome P450-dependent arachidonic acid metabolites in liver physiology and pathophysiology.
  Journal
Prostaglandins Other Lipid Mediat 72:51-71 (2003)
DOI:10.1016/S1098-8823(03)00077-7
Reference
PMID:14622984
  Authors
Pfister SL, Spitzbarth N, Zeldin DC, Lafite P, Mansuy D, Campbell WB.
  Title
Rabbit aorta converts 15-HPETE to trihydroxyeicosatrienoic acids: potential role of cytochrome P450.
  Journal
Arch Biochem Biophys 420:142-52 (2003)
DOI:10.1016/j.abb.2003.09.026
Reference
PMID:11679404
  Authors
Fleming I.
  Title
Cytochrome p450 and vascular homeostasis.
  Journal
Circ Res 89:753-62 (2001)
DOI:10.1161/hh2101.099268
Reference
PMID:11328810
  Authors
Qu W, Bradbury JA, Tsao CC, Maronpot R, Harry GJ, Parker CE, Davis LS, Breyer MD, Waalkes MP, Falck JR, Chen J, Rosenberg RL, Zeldin DC.
  Title
Cytochrome P450 CYP2J9, a new mouse arachidonic acid omega-1 hydroxylase predominantly expressed in brain.
  Journal
J Biol Chem 276:25467-79 (2001)
DOI:10.1074/jbc.M100545200
Reference
PMID:10908295
  Authors
Tsao CC, Foley J, Coulter SJ, Maronpot R, Zeldin DC, Goldstein JA.
  Title
CYP2C40, a unique arachidonic acid 16-hydroxylase, is the major CYP2C in murine intestinal tract.
  Journal
Mol Pharmacol 58:279-87 (2000)
DOI:10.1124/mol.58.2.279
Reference
PMID:9812980
  Authors
Pfister SL, Spitzbarth N, Nithipatikom K, Edgemond WS, Falck JR, Campbell WB.
  Title
Identification of the 11,14,15- and 11,12, 15-trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta.
  Journal
J Biol Chem 273:30879-87 (1998)
DOI:10.1074/jbc.273.47.30879
Related
pathway
bfo00591  Linoleic acid metabolism
KO pathway
ko00590   
LinkDB

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