KEGG   PATHWAY: bly00260
Entry
bly00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Brevibacterium linens BS258
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bly00260  Glycine, serine and threonine metabolism
bly00260

Module
bly_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bly00260]
bly_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bly00260]
bly_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:bly00260]
bly_M00555  Betaine biosynthesis, choline => betaine [PATH:bly00260]
bly_M00621  Glycine cleavage system [PATH:bly00260]
bly_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:bly00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Brevibacterium linens BS258 [GN:bly]
Gene
A2T55_04915  aspartate kinase [KO:K00928] [EC:2.7.2.4]
A2T55_04920  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
A2T55_08145  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
A2T55_08155  homoserine kinase [KO:K00872] [EC:2.7.1.39]
A2T55_08150  threonine synthase [KO:K01733] [EC:4.2.3.1]
A2T55_12705  threonine aldolase [KO:K01620] [EC:4.1.2.48]
A2T55_01315  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
A2T55_06110  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
A2T55_04505  glycerate kinase [KO:K00865] [EC:2.7.1.165]
A2T55_14975  phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
A2T55_12220  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
A2T55_14640  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
A2T55_09520  phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
A2T55_03850  histamine oxidase [KO:K00276] [EC:1.4.3.21]
A2T55_02720  glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
A2T55_02725  glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
A2T55_09000  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
A2T55_02730  glycine cleavage system protein H [KO:K02437]
A2T55_10755  glycine cleavage system protein H [KO:K02437]
A2T55_01300  creatininase [KO:K08688] [EC:3.5.3.3]
A2T55_10975  choline oxidase [KO:K17755] [EC:1.1.3.17]
A2T55_10970  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
A2T55_13075  homocysteine methyltransferase [KO:K00544] [EC:2.1.1.5]
A2T55_01510  (Fe-S)-binding protein [KO:K00479] [EC:1.14.13.251]
A2T55_00270  hybrid-cluster NAD(P)-dependent oxidoreductase [KO:K21832] [EC:1.14.13.251]
A2T55_01515  oxidoreductase [KO:K21832] [EC:1.14.13.251]
A2T55_01520  sarcosine dehydrogenase [KO:K00309] [EC:1.5.3.10]
A2T55_13700  sarcosine oxidase [KO:K00301] [EC:1.5.3.1]
A2T55_01330  ferredoxin [KO:K00302] [EC:1.5.3.24 1.5.3.1]
A2T55_01320  sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
A2T55_01335  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
A2T55_01325  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
A2T55_01340  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
A2T55_02735  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
A2T55_01385  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
A2T55_15775  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
A2T55_00310  D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
A2T55_09790  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
A2T55_09795  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
A2T55_02745  diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
A2T55_02740  diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
A2T55_02750  ectC; L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
A2T55_13495  pyridoxal-dependent decarboxylase [KO:K13745] [EC:4.1.1.86]
A2T55_10320  creatinase [KO:K15783] [EC:3.5.4.44]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bly00010  Glycolysis / Gluconeogenesis
bly00020  Citrate cycle (TCA cycle)
bly00230  Purine metabolism
bly00250  Alanine, aspartate and glutamate metabolism
bly00270  Cysteine and methionine metabolism
bly00290  Valine, leucine and isoleucine biosynthesis
bly00300  Lysine biosynthesis
bly00330  Arginine and proline metabolism
bly00460  Cyanoamino acid metabolism
bly00470  D-Amino acid metabolism
bly00564  Glycerophospholipid metabolism
bly00620  Pyruvate metabolism
bly00630  Glyoxylate and dicarboxylate metabolism
bly00640  Propanoate metabolism
bly00680  Methane metabolism
bly00860  Porphyrin metabolism
bly00920  Sulfur metabolism
KO pathway
ko00260   
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