Entry
Name
Spliceosome - Buceros rhinoceros silvestris (rhinoceros hornbill)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
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Pathway map
Ortholog table
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Organism
Buceros rhinoceros silvestris (rhinoceros hornbill) [GN:
brhi ]
Gene
104501324 small nuclear ribonucleoprotein-associated protein B' [KO:K11086 ]
104495446 LOW QUALITY PROTEIN: transcription elongation regulator 1-like [KO:K12824 ]
104494586 PUF60; poly(U)-binding-splicing factor PUF60 isoform X1 [KO:K12838 ]
104500122 survival of motor neuron-related-splicing factor 30-like [KO:K12839 ]
104488106 CHERP; calcium homeostasis endoplasmic reticulum protein [KO:K12841 ]
104495398 U2SURP; U2 snRNP-associated SURP motif-containing protein [KO:K12842 ]
104490710 PRPF4; LOW QUALITY PROTEIN: U4/U6 small nuclear ribonucleoprotein Prp4 [KO:K12662 ]
104489416 EFTUD2; 116 kDa U5 small nuclear ribonucleoprotein component [KO:K12852 ]
104493993 PRPF6; LOW QUALITY PROTEIN: pre-mRNA-processing factor 6 [KO:K12855 ]
104494107 SNRNP40; U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857 ]
104502395 RBM22; LOW QUALITY PROTEIN: pre-mRNA-splicing factor RBM22 [KO:K12872 ]
104496679 HNRNPK; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886 ]
104498357 HNRNPM; heterogeneous nuclear ribonucleoprotein M isoform X1 [KO:K12887 ]
104494565 serine/arginine-rich splicing factor 5-like isoform X1 [KO:K12893 ]
104488534 LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 6-like [KO:K12893 ]
Reference
Authors
Wahl MC, Will CL, Luhrmann R
Title
The spliceosome: design principles of a dynamic RNP machine.
Journal
Reference
Authors
Morris DP, Greenleaf AL
Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
Journal
Reference
Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
Journal
Reference
Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
Title
Spliceosome structure: piece by piece.
Journal
KO pathway
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