KEGG   PATHWAY: btab04141
Entry
btab04141                   Pathway                                
Name
Protein processing in endoplasmic reticulum - Bemisia tabaci (sweet potato whitefly)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
btab04141  Protein processing in endoplasmic reticulum
btab04141

Other DBs
GO: 0030433 0034976
Organism
Bemisia tabaci (sweet potato whitefly) [GN:btab]
Gene
109032299  protein transport protein Sec61 subunit alpha [KO:K10956]
109029702  protein transport protein Sec61 subunit beta [KO:K09481]
109043470  protein transport protein Sec61 subunit gamma [KO:K07342]
109036760  protein transport protein Sec61 subunit gamma [KO:K07342]
109040031  translocation protein SEC62 [KO:K12275]
109037340  translocation protein SEC63 homolog isoform X1 [KO:K09540]
109036096  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 [KO:K12666]
109038986  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [KO:K12667]
109043213  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
109034478  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit-like [KO:K12670]
109036627  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit-like [KO:K12670]
109042314  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B isoform X1 [KO:K07151] [EC:2.4.99.18]
109032682  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
109030877  tumor suppressor candidate 3-like [KO:K19478]
109034733  tumor suppressor candidate 3-like [KO:K19478]
109040964  oligosaccharyltransferase complex subunit ostc isoform X1 [KO:K26501]
109041890  transmembrane protein 258 [KO:K26502]
109030234  mannosyl-oligosaccharide glucosidase GCS1 isoform X1 [KO:K01228] [EC:3.2.1.106]
109038336  ribosome-binding protein 1-like [KO:K14000]
109039854  nucleotide exchange factor SIL1 [KO:K14001]
109030974  hypoxia up-regulated protein 1 [KO:K09486]
109032808  heat shock 70 kDa protein cognate 3 [KO:K09490] [EC:3.6.4.10]
109042484  dnaJ homolog subfamily B member 11 [KO:K09517]
109034113  dnaJ homolog subfamily C member 1 [KO:K09521]
109044274  dnaJ homolog subfamily C member 3 [KO:K09523]
109034030  dnaJ homolog subfamily C member 10-like [KO:K09530] [EC:1.8.4.-]
109031534  endoplasmin [KO:K09487]
109041180  neutral alpha-glucosidase AB [KO:K05546] [EC:3.2.1.207]
109040793  glucosidase 2 subunit beta [KO:K08288]
109031482  calnexin-like [KO:K08054]
109036774  LOW QUALITY PROTEIN: protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
109031123  calreticulin [KO:K08057]
109036238  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA [KO:K01230] [EC:3.2.1.113]
109029927  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase [KO:K23741] [EC:3.2.1.209]
109036721  VIP36-like protein [KO:K10082]
109042444  protein ERGIC-53 isoform X1 [KO:K10080]
109044589  prolactin regulatory element-binding protein [KO:K14003]
109034808  GTP-binding protein SAR1b [KO:K07953] [EC:3.6.5.-]
109038090  protein SEC13 homolog [KO:K14004]
109029928  protein transport protein Sec31A [KO:K14005]
109032612  protein transport protein Sec23A-like [KO:K14006]
109039616  protein transport protein Sec23A-like [KO:K14006]
109032677  protein transport protein Sec24A isoform X1 [KO:K14007]
109044522  protein transport protein Sec24C [KO:K14007]
109040289  UDP-glucose:glycoprotein glucosyltransferase [KO:K11718] [EC:2.4.1.-]
109041375  ER degradation-enhancing alpha-mannosidase-like protein 1 [KO:K10084]
109038260  ER degradation-enhancing alpha-mannosidase-like protein 2 [KO:K10085]
109043580  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1 [KO:K10086]
109040761  protein disulfide-isomerase [KO:K09580] [EC:5.3.4.1]
109042439  protein disulfide-isomerase A6 [KO:K09584] [EC:5.3.4.1]
109041259  endoplasmic reticulum resident protein 29 [KO:K09586]
109031560  thioredoxin domain-containing protein 5-like [KO:K13984] [EC:5.3.4.1]
109039975  ero1-like protein isoform X1 [KO:K10950] [EC:1.8.4.-]
109037464  endoplasmic reticulum lectin 1 isoform X1 [KO:K14008]
109032498  translocon-associated protein subunit alpha [KO:K13249]
109039575  translocon-associated protein subunit beta [KO:K13250]
109033129  translocon-associated protein subunit gamma [KO:K13251]
109043014  translocon-associated protein subunit delta [KO:K04571]
109039095  B-cell receptor-associated protein 31 [KO:K14009]
109031574  translocating chain-associated membrane protein 1 [KO:K14010]
109043635  derlin-1 [KO:K11519]
109031403  derlin-2 [KO:K13989]
109032739  UBX domain-containing protein 1-B-like [KO:K24348]
109037456  UBX domain-containing protein 6 [KO:K14011]
109037952  NSFL1 cofactor p47-like [KO:K14012]
109037900  small VCP/p97-interacting protein [KO:K14014]
109033887  transitional endoplasmic reticulum ATPase TER94 [KO:K13525]
109043627  nuclear protein localization protein 4 homolog [KO:K14015]
109030989  ubiquitin fusion degradation protein 1 homolog [KO:K14016]
109039787  heat shock protein 68-like [KO:K03283]
109043908  heat shock protein 68-like [KO:K03283]
109039834  heat shock protein 70 B2-like [KO:K03283]
109039835  heat shock protein 70 B2-like [KO:K03283]
109039836  heat shock protein 70 B2-like [KO:K03283]
109035112  heat shock protein 68-like [KO:K03283]
109042138  major heat shock 70 kDa protein Ab-like [KO:K03283]
109038376  heat shock 70 kDa protein cognate 4 [KO:K03283]
109038391  heat shock protein 70 B2-like [KO:K03283]
109040186  heat shock protein 68-like [KO:K03283]
109040256  heat shock protein 68-like [KO:K03283]
109039224  heat shock protein 68-like isoform X1 [KO:K03283]
109033203  dnaJ homolog subfamily A member 1 [KO:K09502]
109039690  dnaJ homolog subfamily A member 2-like [KO:K09503]
109030740  dnaJ homolog subfamily B member 12 [KO:K09518]
109038053  dnaJ homolog subfamily C member 5 isoform X1 [KO:K09525]
109031295  heat shock protein 83-like [KO:K04079]
109031045  heat shock protein 83 [KO:K04079]
109031937  heat shock 70 kDa protein 4 [KO:K09485]
109034598  BAG family molecular chaperone regulator 2 [KO:K09556]
109041335  hsp70-binding protein 1 [KO:K09562]
109044373  protein lethal(2)essential for life-like [KO:K09542]
109037043  protein lethal(2)essential for life-like [KO:K09542]
109042427  protein lethal(2)essential for life-like [KO:K09542]
109043483  protein lethal(2)essential for life-like [KO:K09542]
109031274  protein lethal(2)essential for life-like [KO:K09542]
109030403  ubiquitin thioesterase OTU1 [KO:K13719] [EC:3.1.2.-]
109039242  phospholipase A-2-activating protein [KO:K14018]
109044505  UV excision repair protein RAD23 homolog B [KO:K10839]
109036399  ubiquilin-1 [KO:K04523]
109033724  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase isoform X1 [KO:K01456] [EC:3.5.1.52]
109041517  ataxin-3-like [KO:K11863] [EC:3.4.22.-]
109041127  ubiquitin conjugation factor E4 B [KO:K10597] [EC:2.3.2.27]
109035970  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
109033366  activating transcription factor of chaperone isoform X1 [KO:K04374]
109036364  cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
109037666  wolframin isoform X1 [KO:K14020]
109040752  membrane-bound transcription factor site-1 protease [KO:K08653] [EC:3.4.21.112]
109040122  membrane-bound transcription factor site-2 protease [KO:K07765] [EC:3.4.24.85]
109043660  serine/threonine-protein kinase/endoribonuclease IRE1-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
109034576  dual specificity mitogen-activated protein kinase kinase 7-like [KO:K04431] [EC:2.7.12.2]
109038553  stress-activated protein kinase JNK isoform X1 [KO:K04440] [EC:2.7.11.24]
109041859  E3 ubiquitin-protein ligase MARCH6 isoform X1 [KO:K10661] [EC:2.3.2.27]
109039346  ubiquitin-conjugating enzyme E2 J1-like [KO:K10578] [EC:2.3.2.23]
109039290  ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
109030270  ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
109031134  ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
109037724  E3 ubiquitin-protein ligase synoviolin A [KO:K10601] [EC:2.3.2.27]
109040868  selenoprotein S-like [KO:K14025]
109033944  protein sel-1 homolog 1-like [KO:K14026]
109038877  protein sel-1 homolog 1-like [KO:K14026]
109034781  E3 ubiquitin-protein ligase AMFR-like [KO:K10636] [EC:2.3.2.36]
109032485  E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
109030891  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
109038844  E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
109044484  RING-box protein 1A [KO:K03868] [EC:2.3.2.32]
109034997  cullin-1 [KO:K03347]
109042339  S-phase kinase-associated protein 1-like [KO:K03094]
109032106  F-box only protein 6-like [KO:K10100]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
btab00510  N-Glycan biosynthesis
btab03050  Proteasome
btab03060  Protein export
KO pathway
ko04141   
LinkDB

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