KEGG   PATHWAY: cang00983
Entry
cang00983                   Pathway                                
Name
Drug metabolism - other enzymes - Colobus angolensis palliatus (Angola colobus)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
cang00983  Drug metabolism - other enzymes
cang00983

Organism
Colobus angolensis palliatus (Angola colobus) [GN:cang]
Gene
105516497  HPRT1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
105509719  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
105509994  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
105511972  inosine-5'-monophosphate dehydrogenase 1-like isoform X1 [KO:K00088] [EC:1.1.1.205]
105524006  GMPS; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
105526679  TPMT; thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
105525039  XDH; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
105512745  ITPA; inosine triphosphate pyrophosphatase isoform X1 [KO:K01519] [EC:3.6.1.66]
105502140  liver carboxylesterase 1-like [KO:K01044] [EC:3.1.1.1]
105504634  LOW QUALITY PROTEIN: cocaine esterase-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
105504588  LOW QUALITY PROTEIN: cocaine esterase-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
105501230  UDP-glucuronosyltransferase 2B9 isoform X1 [KO:K00699] [EC:2.4.1.17]
105501231  UDP-glucuronosyltransferase 2B19-like isoform X1 [KO:K00699] [EC:2.4.1.17]
105501232  UDP-glucuronosyltransferase 2B19-like isoform X1 [KO:K00699] [EC:2.4.1.17]
105501234  UDP-glucuronosyltransferase 2B33 isoform X1 [KO:K00699] [EC:2.4.1.17]
105501235  UDP-glucuronosyltransferase 2B23 isoform X1 [KO:K00699] [EC:2.4.1.17]
105501239  UGT2A1; UDP-glucuronosyltransferase 2A1 isoform X1 [KO:K00699] [EC:2.4.1.17]
105501344  UDP-glucuronosyltransferase 2B9-like [KO:K00699] [EC:2.4.1.17]
105502936  UDP-glucuronosyltransferase 1-5 isoform X1 [KO:K00699] [EC:2.4.1.17]
105505112  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 1-9-like [KO:K00699] [EC:2.4.1.17]
105518889  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 1-8-like [KO:K00699] [EC:2.4.1.17]
105527722  UDP-glucuronosyltransferase 2B18 isoform X1 [KO:K00699] [EC:2.4.1.17]
105500445  UGT2A3; UDP-glucuronosyltransferase 2A3 [KO:K00699] [EC:2.4.1.17]
105500776  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 1-7-like [KO:K00699] [EC:2.4.1.17]
105500778  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 1-8-like [KO:K00699] [EC:2.4.1.17]
105518950  beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
105513064  cytochrome P450 3A8 isoform X1 [KO:K17689] [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
105505995  CDA; cytidine deaminase isoform X1 [KO:K01489] [EC:3.5.4.5]
105512006  TYMP; thymidine phosphorylase [KO:K00758] [EC:2.4.2.4]
105524218  DPYD; dihydropyrimidine dehydrogenase [NADP(+)] isoform X1 [KO:K00207] [EC:1.3.1.2]
105503929  DPYS; dihydropyrimidinase [KO:K01464] [EC:3.5.2.2]
105500438  UPB1; beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
105515704  UPP1; uridine phosphorylase 1 isoform X1 [KO:K00757] [EC:2.4.2.3]
105516844  UPP2; LOW QUALITY PROTEIN: uridine phosphorylase 2 [KO:K00757] [EC:2.4.2.3]
105504144  UCK1; uridine-cytidine kinase 1 [KO:K00876] [EC:2.7.1.48]
105505575  UCK2; uridine-cytidine kinase 2 [KO:K00876] [EC:2.7.1.48]
105506340  UCKL1; uridine-cytidine kinase-like 1 [KO:K00876] [EC:2.7.1.48]
105504602  TK2; thymidine kinase 2, mitochondrial isoform X1 [KO:K00857] [EC:2.7.1.21]
105520715  TK1; thymidine kinase, cytosolic isoform X1 [KO:K00857] [EC:2.7.1.21]
105517982  UMPS; uridine 5'-monophosphate synthase isoform X1 [KO:K13421] [EC:2.4.2.10 4.1.1.23]
105500728  CMPK1; UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
105522325  RRM1; LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
105504121  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
105525327  RRM2; ribonucleoside-diphosphate reductase subunit M2 isoform X1 [KO:K10808] [EC:1.17.4.1]
105522886  NME3; nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
105509742  NME6; nucleoside diphosphate kinase 6 isoform X1 [KO:K00940] [EC:2.7.4.6]
105524636  nucleoside diphosphate kinase B isoform X1 [KO:K00940] [EC:2.7.4.6]
105524710  NME4; nucleoside diphosphate kinase, mitochondrial isoform X1 [KO:K00940] [EC:2.7.4.6]
105505560  NME7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
105527449  nucleoside diphosphate kinase A-like [KO:K00940] [EC:2.7.4.6]
105507198  nucleoside diphosphate kinase A isoform X1 [KO:K00940] [EC:2.7.4.6]
105502182  DUT; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 [KO:K01520] [EC:3.6.1.23]
105520104  MPO; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
105506650  NAT1; arylamine N-acetyltransferase 1 [KO:K00622] [EC:2.3.1.5]
105506651  NAT2; arylamine N-acetyltransferase 2 [KO:K00622] [EC:2.3.1.5]
105511789  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
105516056  GSTM3; glutathione S-transferase Mu 3 isoform X1 [KO:K00799] [EC:2.5.1.18]
105516058  glutathione S-transferase Mu 5 isoform X1 [KO:K00799] [EC:2.5.1.18]
105516060  glutathione S-transferase Mu 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
105516061  GSTM4; glutathione S-transferase Mu 4 isoform X1 [KO:K00799] [EC:2.5.1.18]
105522749  GSTO1; glutathione S-transferase omega-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
105524315  glutathione S-transferase Mu 5 [KO:K00799] [EC:2.5.1.18]
105524818  GSTA4; glutathione S-transferase A4 isoform X1 [KO:K00799] [EC:2.5.1.18]
105524819  glutathione S-transferase A1-like [KO:K00799] [EC:2.5.1.18]
105524820  glutathione S-transferase A1 isoform X1 [KO:K00799] [EC:2.5.1.18]
105524822  GSTA3; glutathione S-transferase A3 [KO:K00799] [EC:2.5.1.18]
105525270  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
105525271  glutathione S-transferase theta-4-like [KO:K00799] [EC:2.5.1.18]
105525272  GSTT2B; glutathione S-transferase theta-2B isoform X1 [KO:K00799] [EC:2.5.1.18]
105525274  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
105525815  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
105505517  MGST3; microsomal glutathione S-transferase 3 isoform X1 [KO:K00799] [EC:2.5.1.18]
105519994  glutathione S-transferase Mu 3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
105513719  microsomal glutathione S-transferase 2-like [KO:K00799] [EC:2.5.1.18]
105520671  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
105521576  MGST2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
105512082  GSTP1; glutathione S-transferase P isoform X1 [KO:K23790] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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