KEGG   PATHWAY: cfr04814
Entry
cfr04814                    Pathway                                
Name
Motor proteins - Camelus ferus (Wild Bactrian camel)
Class
Cellular Processes; Cell motility
Pathway map
cfr04814  Motor proteins
cfr04814

Organism
Camelus ferus (Wild Bactrian camel) [GN:cfr]
Gene
102519680  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
102515854  DYNC2H1; LOW QUALITY PROTEIN: cytoplasmic dynein 2 heavy chain 1 [KO:K10414]
102518003  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
102520357  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X6 [KO:K10415]
102512192  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
102518349  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
102504780  DYNC2LI1; cytoplasmic dynein 2 light intermediate chain 1 isoform X2 [KO:K10417]
102516593  DYNLL1; dynein light chain 1, cytoplasmic [KO:K10418]
102508853  DYNLL2; dynein light chain 2, cytoplasmic [KO:K10418]
102511881  DYNLRB2; dynein light chain roadblock-type 2 isoform X1 [KO:K10419]
102524047  DYNLRB1; dynein light chain roadblock-type 1 isoform X1 [KO:K10419]
102511206  DYNLT1; dynein light chain Tctex-type 1 [KO:K10420]
102518333  DYNLT3; dynein light chain Tctex-type 3 [KO:K10420]
116665355  dynein light chain Tctex-type 1-like [KO:K10420]
102512442  TCTE3; tctex1 domain-containing protein 3 [KO:K25419]
102506277  TCTEX1D4; tctex1 domain-containing protein 4 [KO:K25420]
102522689  TCTEX1D1; tctex1 domain-containing protein 1 [KO:K25421]
102518700  DNAH7; dynein heavy chain 7, axonemal [KO:K10408]
102509803  DNAH5; LOW QUALITY PROTEIN: dynein heavy chain 5, axonemal [KO:K10408]
102507171  DNAH6; dynein heavy chain 6, axonemal [KO:K10408]
102513082  DNAH9; LOW QUALITY PROTEIN: dynein heavy chain 9, axonemal [KO:K10408]
102516457  DNAH12; dynein heavy chain 12, axonemal [KO:K10408]
102518470  DNAH8; LOW QUALITY PROTEIN: dynein heavy chain 8, axonemal [KO:K10408]
102520086  DNAH10; dynein heavy chain 10, axonemal [KO:K10408]
102513136  DNAH17; LOW QUALITY PROTEIN: dynein heavy chain 17, axonemal [KO:K10408]
102511164  DNAH14; dynein heavy chain 14, axonemal [KO:K10408]
102508411  DNAH2; dynein heavy chain 2, axonemal [KO:K10408]
102506868  DNAH3; LOW QUALITY PROTEIN: dynein heavy chain 3, axonemal [KO:K10408]
102514536  DNAH1; dynein heavy chain 1, axonemal isoform X1 [KO:K10408]
102518110  DNAH11; LOW QUALITY PROTEIN: dynein heavy chain 11, axonemal [KO:K10408]
102521975  DNAI1; LOW QUALITY PROTEIN: dynein intermediate chain 1, axonemal [KO:K10409]
102514425  DNAI2; dynein intermediate chain 2, axonemal isoform X1 [KO:K11143]
102523699  WDR63; WD repeat-containing protein 63 [KO:K24722]
102507999  WDR78; WD repeat-containing protein 78 isoform X1 [KO:K24723]
102518938  DNALI1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
102504852  DNAL1; dynein light chain 1, axonemal [KO:K10411]
102509708  DNAL4; dynein light chain 4, axonemal isoform X1 [KO:K10412]
102505844  DCTN1; dynactin subunit 1 isoform X1 [KO:K04648]
102518272  DCTN2; dynactin subunit 2 isoform X1 [KO:K10424]
102522650  DCTN3; dynactin subunit 3 [KO:K10425]
102510178  DCTN4; dynactin subunit 4 [KO:K10426]
102512500  DCTN5; dynactin subunit 5 [KO:K10427]
102519298  DCTN6; dynactin subunit 6 [KO:K10428]
102523981  ACTR1B; beta-centractin isoform X1 [KO:K16575]
102517533  ACTR1A; alpha-centractin [KO:K16575]
102509264  ACTR10; actin-related protein 10 isoform X1 [KO:K16576]
102518518  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
102511599  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
102507351  CAPZB; F-actin-capping protein subunit beta isoform X4 [KO:K10365]
102513315  BICDL2; BICD family-like cargo adapter 2 isoform X1 [KO:K16756]
102509715  BICDL1; BICD family-like cargo adapter 1 isoform X1 [KO:K16756]
102511237  HOOK3; protein Hook homolog 3 isoform X1 [KO:K16536]
102522963  tubulin alpha-1B chain [KO:K07374]
102523472  TUBA1A; tubulin alpha-1A chain [KO:K07374]
102515991  tubulin alpha-1C chain [KO:K07374]
102521054  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
102522237  TUBA4A; tubulin alpha-4A chain [KO:K07374]
102512533  LOW QUALITY PROTEIN: tubulin alpha-1D chain [KO:K07374]
102508381  tubulin alpha chain [KO:K07374]
102505604  LOW QUALITY PROTEIN: tubulin alpha-1A chain [KO:K07374]
102518229  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
102505031  tubulin alpha-3 chain [KO:K07374]
102511248  TUBB3; tubulin beta-3 chain [KO:K07375]
102514505  TUBB2A; LOW QUALITY PROTEIN: tubulin beta-2A chain [KO:K07375]
102514940  LOW QUALITY PROTEIN: tubulin beta-2B chain [KO:K07375]
102514277  TUBB1; tubulin beta-1 chain [KO:K07375]
102522960  TUBB4A; tubulin beta-4A chain [KO:K07375]
102511603  TUBB4B; LOW QUALITY PROTEIN: tubulin beta-4B chain [KO:K07375]
102523678  TUBB6; tubulin beta-6 chain [KO:K07375]
102506772  TUBB; tubulin beta chain isoform X2 [KO:K07375]
102523283  TUBG1; tubulin gamma-1 chain [KO:K10389]
102517906  tubulin gamma-2 chain [KO:K10389]
102512144  TUBD1; tubulin delta chain isoform X1 [KO:K10390]
102505985  TUBE1; tubulin epsilon chain isoform X1 [KO:K10391]
102518661  KIF5A; kinesin heavy chain isoform X3 [KO:K10396]
102517013  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396]
102519328  KIF5C; kinesin heavy chain [KO:K10396]
102510359  KLC2; kinesin light chain 2 isoform X1 [KO:K10407]
102511669  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
102523618  KLC3; kinesin light chain 3 isoform X3 [KO:K10407]
102509206  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
102515753  KIF3A; kinesin-like protein KIF3A isoform X1 [KO:K10394]
102508598  KIF3B; kinesin-like protein KIF3B [KO:K20196]
102523436  KIFAP3; kinesin-associated protein 3 isoform X1 [KO:K25388]
102516126  KIF3C; kinesin-like protein KIF3C isoform X1 [KO:K20197]
102521822  KIF17; kinesin-like protein KIF17 [KO:K20198]
102506444  KIF1A; LOW QUALITY PROTEIN: kinesin-like protein KIF1A [KO:K10392]
102512655  KIF1C; kinesin-like protein KIF1C [KO:K10392]
102508605  KIF1B; kinesin-like protein KIF1B isoform X1 [KO:K10392]
102509407  KIF13B; kinesin-like protein KIF13B isoform X1 [KO:K17914]
102513564  KIF13A; LOW QUALITY PROTEIN: kinesin-like protein KIF13A [KO:K17914]
102506389  KIF14; kinesin-like protein KIF14 [KO:K17915]
102520362  KIF16B; kinesin-like protein KIF16B isoform X1 [KO:K17916]
102507674  STARD9; stAR-related lipid transfer protein 9 isoform X1 [KO:K16491]
102513790  KIF4A; chromosome-associated kinesin KIF4A [KO:K10395]
102521126  KIF7; kinesin-like protein KIF7 isoform X1 [KO:K18806]
102511102  KIF21B; kinesin-like protein KIF21B isoform X1 [KO:K24185]
102511386  KIF21A; LOW QUALITY PROTEIN: kinesin-like protein KIF21A [KO:K24185]
102509418  LOW QUALITY PROTEIN: kinesin-like protein KIF27 [KO:K24186]
102504765  KIF11; kinesin-like protein KIF11 [KO:K10398]
102516012  KIF20A; kinesin-like protein KIF20A [KO:K10402]
102508370  KIF20B; kinesin-like protein KIF20B isoform X3 [KO:K10402]
102505498  KIF23; kinesin-like protein KIF23 isoform X1 [KO:K17387]
102514341  CENPE; centromere-associated protein E isoform X1 [KO:K11498]
102511461  KIF18A; kinesin-like protein KIF18A [KO:K10401]
102506324  KIF18B; kinesin-like protein KIF18B [KO:K26156]
102514183  KIF19; LOW QUALITY PROTEIN: kinesin-like protein KIF19 [KO:K26157]
102507469  kinesin-like protein KIF19 [KO:K26157]
102511985  KIF9; kinesin-like protein KIF9 isoform X2 [KO:K10397]
102503867  KIF6; kinesin-like protein KIF6 isoform X3 [KO:K10397]
102521651  KIF22; kinesin-like protein KIF22 [KO:K10403]
102508538  KIF26B; kinesin-like protein KIF26B isoform X1 [KO:K10404]
106730037  KIF26A; LOW QUALITY PROTEIN: kinesin-like protein KIF26A [KO:K10404]
102504011  KIF12; kinesin-like protein KIF12 isoform X1 [KO:K10399]
102508720  KIF15; LOW QUALITY PROTEIN: kinesin-like protein KIF15 [KO:K10400]
102512978  KIF2C; kinesin-like protein KIF2C [KO:K10393]
102520758  KIF24; LOW QUALITY PROTEIN: kinesin-like protein KIF24 [KO:K10393]
102506754  KIF2A; kinesin-like protein KIF2A isoform X1 [KO:K10393]
102516312  KIF2B; kinesin-like protein KIF2B [KO:K10393]
102515246  KIFC1; kinesin-like protein KIFC1 isoform X1 [KO:K10405]
102517608  KIFC3; kinesin-like protein KIFC3 isoform X1 [KO:K10406]
102506832  KIFC2; kinesin-like protein KIFC2 isoform X1 [KO:K10406]
102514545  KIF25; kinesin-like protein KIF25 isoform X1 [KO:K18627]
102515128  MYO1H; unconventional myosin-Ih [KO:K10356]
102504286  MYO1G; unconventional myosin-Ig isoform X1 [KO:K10356]
102523578  MYO1E; unconventional myosin-Ie [KO:K10356]
102509267  MYO1B; unconventional myosin-Ib isoform X1 [KO:K10356]
102509782  MYO1A; LOW QUALITY PROTEIN: unconventional myosin-Ia [KO:K10356]
102515533  MYO1D; unconventional myosin-Id isoform X1 [KO:K10356]
102523931  MYO1F; unconventional myosin-If isoform X1 [KO:K10356]
102513502  MYO1C; unconventional myosin-Ic isoform X2 [KO:K10356]
102522763  MYO3B; myosin-IIIb [KO:K08834] [EC:2.7.11.1]
102508952  MYO3A; LOW QUALITY PROTEIN: myosin-IIIa [KO:K08834] [EC:2.7.11.1]
102510976  MYO5B; LOW QUALITY PROTEIN: unconventional myosin-Vb [KO:K10357]
102510434  MYO5C; unconventional myosin-Vc isoform X1 [KO:K10357]
102509893  MYO5A; unconventional myosin-Va isoform X1 [KO:K10357]
102510446  MYO6; unconventional myosin-VI isoform X1 [KO:K10358]
102514010  MYO7A; LOW QUALITY PROTEIN: unconventional myosin-VIIa [KO:K10359]
102512569  MYO7B; unconventional myosin-VIIb isoform X1 [KO:K21868]
102512046  MYO9A; LOW QUALITY PROTEIN: unconventional myosin-IXa [KO:K10360]
102521353  MYO9B; unconventional myosin-IXb isoform X1 [KO:K10360]
102517429  MYO10; LOW QUALITY PROTEIN: unconventional myosin-X [KO:K12559]
102509619  MYO15A; unconventional myosin-XV [KO:K10361]
102505079  MYO15B; LOW QUALITY PROTEIN: myosin XVB [KO:K10361]
102512677  MYO16; unconventional myosin-XVI [KO:K17481]
102504935  MYO18B; unconventional myosin-XVIIIb isoform X1 [KO:K10362]
102505537  MYO18A; unconventional myosin-XVIIIa isoform X1 [KO:K10362]
102508303  MYO19; unconventional myosin-XIX isoform X8 [KO:K25838]
102508086  MYH1; myosin-1 [KO:K24220]
102507574  MYH8; LOW QUALITY PROTEIN: myosin-8 [KO:K24220]
102510524  MYH2; myosin-2 [KO:K24220]
102510919  LOW QUALITY PROTEIN: myosin-3 [KO:K24220]
102505990  MYH7B; myosin-7B [KO:K24220]
102510247  MYH15; myosin-15 [KO:K24220]
102507826  LOW QUALITY PROTEIN: myosin-4 [KO:K24220]
102507296  myosin-13 [KO:K24220]
102504269  MYH6; myosin-6 isoform X1 [KO:K17751]
102514829  LOW QUALITY PROTEIN: myosin-7 [KO:K17751]
102524206  MYH14; myosin-14 isoform X1 [KO:K10352]
102520731  MYH10; LOW QUALITY PROTEIN: myosin-10 [KO:K10352]
102520349  MYH9; LOW QUALITY PROTEIN: myosin-9 [KO:K10352]
102508342  MYH11; myosin-11 isoform X2 [KO:K10352]
102515373  MYL1; myosin light chain 1/3, skeletal muscle isoform isoform X1 [KO:K05738]
102513520  MYL3; myosin light chain 3 [KO:K12749]
102511774  MYL4; myosin light chain 4 isoform X2 [KO:K12750]
102508255  MYL6B; myosin light chain 6B isoform X1 [KO:K12751]
102507851  MYL6; myosin light polypeptide 6 isoform X2 [KO:K12751]
102509636  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
102509719  MYL5; myosin light chain 5 [KO:K12753]
102524212  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
102517225  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
102506727  MYL10; myosin regulatory light chain 10 [KO:K12756]
102511070  myosin regulatory light polypeptide 9 isoform X1 [KO:K12757]
102510666  myosin regulatory light chain 12B [KO:K12757]
102520437  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
102507445  ACTA1; actin, alpha skeletal muscle [KO:K10354]
102516380  ACTA2; actin, aortic smooth muscle isoform X1 [KO:K12313]
102524504  ACTC1; actin, alpha cardiac muscle 1 [KO:K12314]
102523114  ACTG2; actin, gamma-enteric smooth muscle [KO:K12315]
102514032  ACTB; actin, cytoplasmic 1 [KO:K05692]
102509393  actin, cytoplasmic 1 [KO:K05692]
102516333  LOW QUALITY PROTEIN: actin, clone 302 [KO:K05692]
116660822  actin, cytoplasmic 1-like isoform X1 [KO:K05692]
102519581  ACTG1; actin, cytoplasmic 2 [KO:K05692]
102515914  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
102517809  TNNI1; troponin I, slow skeletal muscle [KO:K10371]
102512153  TNNT1; troponin T, slow skeletal muscle isoform X1 [KO:K10372]
102518537  TNNC2; troponin C, skeletal muscle [KO:K12042]
116666558  TNNI2; troponin I, fast skeletal muscle [KO:K12043]
102512551  TNNI3; troponin I, cardiac muscle isoform X1 [KO:K12044]
102518192  TPM1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
102505904  TPM2; tropomyosin beta chain isoform X1 [KO:K10374]
102518235  TPM3; tropomyosin alpha-3 chain isoform X4 [KO:K09290]
102517416  TPM4; tropomyosin alpha-4 chain isoform X1 [KO:K10375]
Reference
PMID:21092854
  Authors
Hirokawa N, Niwa S, Tanaka Y
  Title
Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease.
  Journal
Neuron 68:610-38 (2010)
DOI:10.1016/j.neuron.2010.09.039
Reference
PMID:25470043 (PDB:4RH7)
  Authors
Schmidt H, Zalyte R, Urnavicius L, Carter AP
  Title
Structure of human cytoplasmic dynein-2 primed for its power stroke.
  Journal
Nature 518:435-438 (2015)
DOI:10.1038/nature14023
Reference
PMID:22398446 (PDB:3VKG 3VKH)
  Authors
Kon T, Oyama T, Shimo-Kon R, Imamula K, Shima T, Sutoh K, Kurisu G
  Title
The 2.8 A crystal structure of the dynein motor domain.
  Journal
Nature 484:345-50 (2012)
DOI:10.1038/nature10955
Reference
PMID:22997337 (PDB:3J1T 3J1U)
  Authors
Redwine WB, Hernandez-Lopez R, Zou S, Huang J, Reck-Peterson SL, Leschziner AE
  Title
Structural basis for microtubule binding and release by dynein.
  Journal
Science 337:1532-1536 (2012)
DOI:10.1126/science.1224151
Reference
PMID:26410600
  Authors
Gibbs KL, Greensmith L, Schiavo G
  Title
Regulation of Axonal Transport by Protein Kinases.
  Journal
Trends Biochem Sci 40:597-610 (2015)
DOI:10.1016/j.tibs.2015.08.003
Reference
PMID:28602352 (PDB:5NUG 5NVS 5NVU 5NW4)
  Authors
Zhang K, Foster HE, Rondelet A, Lacey SE, Bahi-Buisson N, Bird AW, Carter AP
  Title
Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated.
  Journal
Cell 169:1303-1314.e18 (2017)
DOI:10.1016/j.cell.2017.05.025
Reference
PMID:25814576 (PDB:5ADX 5AFR 5AFU)
  Authors
Urnavicius L, Zhang K, Diamant AG, Motz C, Schlager MA, Yu M, Patel NA, Robinson CV, Carter AP
  Title
The structure of the dynactin complex and its interaction with dynein.
  Journal
Science 347:1441-1446 (2015)
DOI:10.1126/science.aaa4080
Reference
PMID:29420470 (PDB:5OWO 6F1T 6F1U 6F1V 6F1Y 6F1Z 6F38 6F3A)
  Authors
Urnavicius L, Lau CK, Elshenawy MM, Morales-Rios E, Motz C, Yildiz A, Carter AP
  Title
Cryo-EM shows how dynactin recruits two dyneins for faster movement.
  Journal
Nature 554:202-206 (2018)
DOI:10.1038/nature25462
Reference
PMID:29662141
  Authors
Reck-Peterson SL, Redwine WB, Vale RD, Carter AP
  Title
The cytoplasmic dynein transport machinery and its many cargoes.
  Journal
Nat Rev Mol Cell Biol 19:382-398 (2018)
DOI:10.1038/s41580-018-0004-3
Reference
PMID:23434508 (PDB:3J2U)
  Authors
Asenjo AB, Chatterjee C, Tan D, DePaoli V, Rice WJ, Diaz-Avalos R, Silvestry M, Sosa H
  Title
Structural model for tubulin recognition and deformation by kinesin-13 microtubule depolymerases.
  Journal
Cell Rep 3:759-68 (2013)
DOI:10.1016/j.celrep.2013.01.030
Reference
PMID:10338210 (PDB:1B7T)
  Authors
Houdusse A, Kalabokis VN, Himmel D, Szent-Gyorgyi AG, Cohen C
  Title
Atomic structure of scallop myosin subfragment S1 complexed with MgADP: a novel conformation of the myosin head.
  Journal
Cell 97:459-70 (1999)
DOI:10.1016/s0092-8674(00)80756-4
Reference
PMID:9428521 (PDB:3KIN)
  Authors
Kozielski F, Sack S, Marx A, Thormahlen M, Schonbrunn E, Biou V, Thompson A, Mandelkow EM, Mandelkow E
  Title
The crystal structure of dimeric kinesin and implications for microtubule-dependent motility.
  Journal
Cell 91:985-94 (1997)
DOI:10.1016/s0092-8674(00)80489-4
Reference
PMID:8316857 (PDB:2MYS)
  Authors
Rayment I, Rypniewski WR, Schmidt-Base K, Smith R, Tomchick DR, Benning MM, Winkelmann DA, Wesenberg G, Holden HM
  Title
Three-dimensional structure of myosin subfragment-1: a molecular motor.
  Journal
Science 261:50-8 (1993)
DOI:10.1126/science.8316857
Reference
PMID:20428469
  Authors
Parker D, Bryant Z, Delp SL
  Title
Coarse-Grained Structural Modeling of Molecular Motors Using Multibody Dynamics.
  Journal
Cell Mol Bioeng 2:366-374 (2009)
DOI:10.1007/s12195-009-0084-4
Reference
PMID:21314430
  Authors
Dominguez R, Holmes KC
  Title
Actin structure and function.
  Journal
Annu Rev Biophys 40:169-86 (2011)
DOI:10.1146/annurev-biophys-042910-155359
Reference
PMID:31919429 (PDB:6KN7 6KN8)
  Authors
Yamada Y, Namba K, Fujii T
  Title
Cardiac muscle thin filament structures reveal calcium regulatory mechanism.
  Journal
Nat Commun 11:153 (2020)
DOI:10.1038/s41467-019-14008-1
Reference
PMID:33912943
  Authors
Kruppa AJ, Buss F
  Title
Motor proteins at the mitochondria-cytoskeleton interface.
  Journal
J Cell Sci 134:239092 (2021)
DOI:10.1242/jcs.226084
KO pathway
ko04814   
LinkDB

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