KEGG   PATHWAY: chx00983
Entry
chx00983                    Pathway                                
Name
Drug metabolism - other enzymes - Capra hircus (goat)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
chx00983  Drug metabolism - other enzymes
chx00983

Organism
Capra hircus (goat) [GN:chx]
Gene
102183404  HPRT1; hypoxanthine-guanine phosphoribosyltransferase isoform X1 [KO:K00760] [EC:2.4.2.8]
102184671  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X2 [KO:K00088] [EC:1.1.1.205]
102170200  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 [KO:K00088] [EC:1.1.1.205]
102178400  GMPS; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
100860988  TPMT; thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
100861280  XDH; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
102182146  ITPA; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
102188887  liver carboxylesterase isoform X1 [KO:K01044] [EC:3.1.1.1]
102188073  liver carboxylesterase isoform X1 [KO:K01044] [EC:3.1.1.1]
102175705  CES2; cocaine esterase [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
108635036  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
108635048  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
106501841  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2B17 [KO:K00699] [EC:2.4.1.17]
108635495  UDP-glucuronosyltransferase 2B4-like [KO:K00699] [EC:2.4.1.17]
108635540  UDP-glucuronosyltransferase 2B4-like [KO:K00699] [EC:2.4.1.17]
102186850  UDP-glucuronosyltransferase 2B31 isoform X1 [KO:K00699] [EC:2.4.1.17]
102175204  UDP-glucuronosyltransferase 2B4 [KO:K00699] [EC:2.4.1.17]
108633246  UDP-glucuronosyltransferase 2B4-like [KO:K00699] [EC:2.4.1.17]
102171967  UDP-glucuronosyltransferase 2B4-like isoform X1 [KO:K00699] [EC:2.4.1.17]
102172432  UDP-glucuronosyltransferase 2B4 [KO:K00699] [EC:2.4.1.17]
102173083  UDP-glucuronosyltransferase 2B4-like [KO:K00699] [EC:2.4.1.17]
102173552  UDP-glucuronosyltransferase 2B4 [KO:K00699] [EC:2.4.1.17]
106503958  UDP-glucuronosyltransferase 2C1 [KO:K00699] [EC:2.4.1.17]
102168532  UDP-glucuronosyltransferase 2C1 isoform X1 [KO:K00699] [EC:2.4.1.17]
102175670  UDP-glucuronosyltransferase 2C1 [KO:K00699] [EC:2.4.1.17]
102183140  UDP-glucuronosyltransferase 2C1 isoform X1 [KO:K00699] [EC:2.4.1.17]
108633190  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
102168522  UDP-glucuronosyltransferase 2A2 isoform X1 [KO:K00699] [EC:2.4.1.17]
102190288  UDP-glucuronosyltransferase 1-1 isoform X2 [KO:K00699] [EC:2.4.1.17]
102173709  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 1-3 [KO:K00699] [EC:2.4.1.17]
102185703  GUSB; beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
102174355  LOW QUALITY PROTEIN: beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
102191092  CDA; cytidine deaminase [KO:K01489] [EC:3.5.4.5]
102181553  DPYD; dihydropyrimidine dehydrogenase [NADP(+)] [KO:K00207] [EC:1.3.1.2]
102187332  DPYS; dihydropyrimidinase [KO:K01464] [EC:3.5.2.2]
102183534  UPB1; beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
100861371  UPP2; uridine phosphorylase 2 [KO:K00757] [EC:2.4.2.3]
102174717  UPP1; uridine phosphorylase 1 [KO:K00757] [EC:2.4.2.3]
102191568  UCK2; uridine-cytidine kinase 2 isoform X1 [KO:K00876] [EC:2.7.1.48]
102168465  UCKL1; uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
102175413  UCK1; uridine-cytidine kinase 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
102188253  TK1; thymidine kinase, cytosolic [KO:K00857] [EC:2.7.1.21]
102174503  TK2; thymidine kinase 2, mitochondrial isoform X1 [KO:K00857] [EC:2.7.1.21]
102168204  UMPS; uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
102191483  CMPK1; UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
102189416  RRM1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
102173102  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
102185371  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
102191543  NME7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
102168496  NME6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
102175795  nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
102176263  NME1; nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
102190038  NME3; nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
102171208  NME4; nucleoside diphosphate kinase, mitochondrial isoform X1 [KO:K00940] [EC:2.7.4.6]
102180676  DUT; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X3 [KO:K01520] [EC:3.6.1.23]
102185772  MPO; myeloperoxidase precursor [KO:K10789] [EC:1.11.2.2]
102169935  arylamine N-acetyltransferase 1 [KO:K00622] [EC:2.3.1.5]
102182294  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
100860758  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
102174170  glutathione S-transferase A1 [KO:K00799] [EC:2.5.1.18]
102188913  GSTM3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
100861222  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
102189813  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
102190481  glutathione S-transferase Mu 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
102185621  glutathione S-transferase Mu 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
108637838  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
102178383  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
102185021  MGST2; microsomal glutathione S-transferase 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
102190488  GSTO2; glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
102174444  glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
102173702  glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
102175171  glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
102174708  glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
102190016  glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
102189370  glutathione S-transferase omega-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
106503993  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
108633298  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
108636034  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
102179973  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
100861197  glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
102184041  glutathione S-transferase P isoform X1 [KO:K23790] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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