KEGG   PATHWAY: csem04310
Entry
csem04310                   Pathway                                
Name
Wnt signaling pathway - Cynoglossus semilaevis (tongue sole)
Description
Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class
Environmental Information Processing; Signal transduction
Pathway map
csem04310  Wnt signaling pathway
csem04310

Other DBs
GO: 0016055
Organism
Cynoglossus semilaevis (tongue sole) [GN:csem]
Gene
103385376  porcn; protein-serine O-palmitoleoyltransferase porcupine [KO:K00181] [EC:2.3.1.250]
103384848  protein-serine O-palmitoleoyltransferase porcupine-like [KO:K00181] [EC:2.3.1.250]
103385099  wnt1; proto-oncogene Wnt-1 [KO:K03209]
103379582  wnt2; protein Wnt-2 isoform X2 [KO:K00182]
103384543  protein Wnt-2b-A-like [KO:K00182]
103386704  wnt2b; protein Wnt-2b [KO:K00182]
103381861  proto-oncogene Wnt-3 isoform X1 [KO:K00312]
103396377  wnt3a; protein Wnt-3a [KO:K00312]
103388020  protein Wnt-4-like [KO:K00408]
103386287  wnt4; protein Wnt-4 [KO:K00408]
103382784  wnt5b; protein Wnt-5b isoform X1 [KO:K00444]
103384668  protein Wnt-5a-like [KO:K00444]
103392496  protein Wnt-6-like [KO:K00445]
103380318  protein Wnt-7b isoform X1 [KO:K00572]
103382897  wnt7b; protein Wnt-7b [KO:K00572]
103385523  protein Wnt-7a [KO:K00572]
103391415  protein Wnt-8c-like [KO:K00714]
103387233  wnt8b; protein Wnt-8b [KO:K00714]
103391414  protein Wnt-8a-like [KO:K00714]
103392609  protein Wnt-9b [KO:K01064]
103396378  wnt9a; protein Wnt-9a [KO:K01064]
103385100  wnt10b; protein Wnt-10b [KO:K01357]
103392497  wnt10a; protein Wnt-10a [KO:K01357]
103394821  wnt11; protein Wnt-11 [KO:K01384]
103382461  wnt16; protein Wnt-16 [KO:K01558]
103384177  DAN domain family member 5-like [KO:K01645]
103384064  carboxylesterase notum2-like isoform X1 [KO:K19882] [EC:3.1.1.98]
103392826  notum; palmitoleoyl-protein carboxylesterase NOTUM [KO:K19882] [EC:3.1.1.98]
103381851  sost; sclerostin [KO:K16834]
103389499  dickkopf-related protein 2-like [KO:K02165]
103387688  dickkopf-related protein 1-like [KO:K02165]
103383519  dkk2; dickkopf-related protein 2 isoform X1 [KO:K02165]
103395641  pigment epithelium-derived factor [KO:K19614]
103397412  LOW QUALITY PROTEIN: secreted frizzled-related protein 1 [KO:K02166]
103378548  secreted frizzled-related protein 2-like [KO:K02176]
103383606  sfrp2; secreted frizzled-related protein 2 [KO:K02176]
103391550  frzb; secreted frizzled-related protein 3 [KO:K25481]
103387307  sfrp5; secreted frizzled-related protein 5 [KO:K02222]
103387910  rspo1; R-spondin-1 precursor [KO:K19471]
103386515  R-spondin-2-like [KO:K23097]
103388664  rspo2; R-spondin-2 precursor [KO:K23097]
103380800  R-spondin-3-like [KO:K23098]
103388599  R-spondin-3-like [KO:K23098]
103378699  lgr4; leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1 [KO:K04309]
103383136  LOW QUALITY PROTEIN: leucine-rich repeat-containing G-protein coupled receptor 5 [KO:K04308]
103384416  leucine-rich repeat-containing G-protein coupled receptor 6-like [KO:K08399]
103395172  rnf43; E3 ubiquitin-protein ligase RNF43 isoform X1 [KO:K15694] [EC:2.3.2.27]
103397863  E3 ubiquitin-protein ligase ZNRF3-like isoform X1 [KO:K16273] [EC:2.3.2.27]
103396896  E3 ubiquitin-protein ligase ZNRF3-like [KO:K16273] [EC:2.3.2.27]
103392299  frizzled-7-A-like [KO:K02432]
103388930  frizzled-1-like [KO:K02432]
103393162  fzd2; frizzled-2 [KO:K02235]
103398519  fzd3; frizzled-3 [KO:K02329]
103378539  fzd4; frizzled-4 [KO:K02354]
103377040  fzd8; frizzled-8 [KO:K02375]
103396637  frizzled-8-like [KO:K02375]
103391603  fzd5; frizzled-5 [KO:K02375]
103388915  fzd6; frizzled-6 [KO:K02376]
103378576  fzd9; frizzled-9 [KO:K02842]
103398796  fzd10; frizzled-10 [KO:K02842]
103379514  lrp5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
103382475  lrp6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
103377099  BMP and activin membrane-bound inhibitor homolog [KO:K10162]
103377111  BMP and activin membrane-bound inhibitor homolog [KO:K10162]
103396519  apcdd1; protein APCDD1 [KO:K25812]
103386741  protein APCDD1-like [KO:K25812]
103393353  csnk1e; casein kinase I [KO:K08960] [EC:2.7.11.1]
103382085  casein kinase I-like [KO:K08960] [EC:2.7.11.1]
103383489  LOW QUALITY PROTEIN: protein Daple [KO:K25811]
103382638  dvl3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
103385359  dvl1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
103386914  dvl2; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
103395894  segment polarity protein dishevelled homolog DVL-3-like isoform X1 [KO:K02353]
103388054  GSK-3-binding protein FRAT2-like [KO:K03096]
103378870  casein kinase II subunit alpha'-like [KO:K03097] [EC:2.7.11.1]
103379463  csnk2a2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
103388495  casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
103394065  casein kinase II subunit beta [KO:K03115]
103388489  casein kinase II subunit beta [KO:K03115]
103398554  nkd1; protein naked cuticle homolog 1 [KO:K03213]
103388373  nkd2; protein naked cuticle homolog 2 isoform X1 [KO:K03213]
103394421  protein naked cuticle homolog 2-like isoform X2 [KO:K03213]
103383529  cxxc4; CXXC-type zinc finger protein 4 [KO:K03344]
107989037  CXXC-type zinc finger protein 4-like [KO:K03344]
103378445  sentrin-specific protease 2 [KO:K03345] [EC:3.4.22.68]
103392124  gsk3b; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
103388302  catenin beta-1 [KO:K02105]
103394609  catenin beta-1-like [KO:K02105]
103383461  LOW QUALITY PROTEIN: axin-1-like [KO:K02157]
103392632  axin1; axin-1 isoform X1 [KO:K02157]
103384244  axin-2-like isoform X1 [KO:K04385]
103393014  axin-2-like isoform X1 [KO:K04385]
103398463  apc2; adenomatous polyposis coli protein 2 [KO:K02085]
103390350  apc; adenomatous polyposis coli protein isoform X1 [KO:K02085]
103391433  csnk1a1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
103394864  tcf7; transcription factor 7 isoform X1 [KO:K02620]
103397348  transcription factor 7-like 1-A isoform X1 [KO:K04490]
103389353  transcription factor 7-like 1-B isoform X1 [KO:K04490]
103397252  transcription factor 7-like 1-A isoform X2 [KO:K04490]
103381486  tcf7l2; transcription factor 7-like 2 isoform X1 [KO:K04491]
103385014  transcription factor 7-like 2 isoform X1 [KO:K04491]
103383851  lef1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
103384774  lymphoid enhancer-binding factor 1-like isoform X1 [KO:K04492]
107988365  transcription factor 7-like 1-B [KO:K04492]
103381559  lzts2; leucine zipper putative tumor suppressor 2 [KO:K26471]
103387202  leucine zipper putative tumor suppressor 2 homolog [KO:K26471]
103385040  ctnnbip1; beta-catenin-interacting protein 1 [KO:K04493]
103382078  cby1; protein chibby homolog 1 isoform X1 [KO:K23402]
103396586  chd8; chromodomain-helicase-DNA-binding protein 8 [KO:K04494] [EC:5.6.2.-]
103391355  sirt1; LOW QUALITY PROTEIN: NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
103381637  uncharacterized protein LOC103381637 isoform X1 [KO:K04496] [EC:1.1.1.428]
103390633  C-terminal-binding protein 1 [KO:K04496] [EC:1.1.1.428]
103391014  C-terminal-binding protein 1-like isoform X1 [KO:K04496] [EC:1.1.1.428]
103387658  C-terminal-binding protein 2-like isoform X1 [KO:K04496] [EC:1.1.1.428]
103380252  protein groucho-2 isoform X1 [KO:K04497]
103397886  LOW QUALITY PROTEIN: transducin-like enhancer protein 1 [KO:K04497]
103397916  transducin-like enhancer protein 4 isoform X4 [KO:K04497]
103398303  LOW QUALITY PROTEIN: transducin-like enhancer protein 1 [KO:K04497]
103379113  protein groucho-2 isoform X1 [KO:K04497]
103398165  transducin-like enhancer protein 4 isoform X1 [KO:K04497]
103376912  catenin delta-2-like isoform X2 [KO:K23491]
103396670  catenin delta-2-like [KO:K23491]
103384092  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
103382144  histone acetyltransferase p300-like isoform X1 [KO:K04498] [EC:2.3.1.48]
103393050  crebbp; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
103393331  ep300; LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
103385931  ruvbl1; ruvB-like 1 [KO:K04499] [EC:5.6.2.4]
103397887  mothers against decapentaplegic homolog 4-like [KO:K04501]
103390155  mothers against decapentaplegic homolog 4-like [KO:K04501]
103394304  LOW QUALITY PROTEIN: mothers against decapentaplegic homolog 4-like [KO:K04501]
103380246  smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
103379082  mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
103380691  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
103377708  nlk; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
103393459  serine/threonine-protein kinase NLK2-like [KO:K04468] [EC:2.7.11.24]
103377415  LOW QUALITY PROTEIN: transcriptional regulator Myc [KO:K04377]
103386756  transcriptional regulator Myc-A-like [KO:K04377]
103398819  transcription factor AP-1-like isoform X2 [KO:K04448]
103376719  jun; transcription factor AP-1 [KO:K04448]
103379080  G1/S-specific cyclin-D1 [KO:K04503]
103379853  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
103379657  G1/S-specific cyclin-D2-like isoform X1 [KO:K10151]
103382708  ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
103392544  G1/S-specific cyclin-D1-like [KO:K10151]
103385889  ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
103394605  wisp1; WNT1-inducible-signaling pathway protein 1 [KO:K22471]
103384615  ppard; peroxisome proliferator-activated receptor delta [KO:K04504]
103381643  presenilin-1-like [KO:K04505] [EC:3.4.23.-]
103392719  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
103396312  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
103392208  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
103387239  tp53; cellular tumor antigen p53 [KO:K04451]
103379652  siah1; E3 ubiquitin-protein ligase SIAH1 isoform X2 [KO:K04506] [EC:2.3.2.27]
103396051  cacybp; calcyclin-binding protein [KO:K04507]
103394863  skp1; S-phase kinase-associated protein 1 [KO:K03094]
103376811  F-box-like/WD repeat-containing protein TBL1XR1 [KO:K04508]
103396158  F-box-like/WD repeat-containing protein TBL1XR1 [KO:K04508]
103392009  tbl1x; F-box-like/WD repeat-containing protein TBL1X [KO:K04508]
103390898  fbxw11; F-box/WD repeat-containing protein 11 [KO:K03362]
103377187  cul1; cullin-1 [KO:K03347]
103393328  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
103391285  glypican-4-like [KO:K08110]
103395515  ror1; inactive tyrosine-protein kinase transmembrane receptor ROR1 [KO:K05122] [EC:2.7.10.1]
103389852  ror2; tyrosine-protein kinase transmembrane receptor ROR2 [KO:K05123] [EC:2.7.10.1]
103399981  ryk; tyrosine-protein kinase RYK [KO:K05128] [EC:2.7.10.1]
103389773  vangl1; vang-like protein 1 [KO:K04510]
103392073  vang-like protein 1 [KO:K04510]
103385960  vang-like protein 2 [KO:K04510]
103396734  vangl2; vang-like protein 2 [KO:K04510]
103380120  prickle-like protein 1 [KO:K04511]
103382842  prickle1; prickle-like protein 1 isoform X1 [KO:K04511]
103385507  prickle-like protein 2 [KO:K04511]
103386199  prickle2; prickle-like protein 2 isoform X1 [KO:K04511]
103385391  prickle3; prickle-like protein 3 isoform X1 [KO:K04511]
103388142  invs; inversin [KO:K19626]
103380817  daam1; disheveled-associated activator of morphogenesis 1 isoform X1 [KO:K04512]
103377950  daam2; disheveled-associated activator of morphogenesis 2 [KO:K04512]
103385009  rho-related GTP-binding protein RhoA-B [KO:K04513]
103384870  rho-related GTP-binding protein RhoA-C [KO:K04513]
103385834  transforming protein RhoA [KO:K04513]
103386563  rho-related GTP-binding protein RhoA-D [KO:K04513]
103380939  rho-associated protein kinase 2-like [KO:K17388] [EC:2.7.11.1]
103383692  rho-associated protein kinase 2-like [KO:K17388] [EC:2.7.11.1]
103382358  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
103397120  rho-related BTB domain-containing protein 1-like [KO:K04392]
103393020  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
103383441  rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
103381664  ras-related C3 botulinum toxin substrate 3 [KO:K07861]
103382123  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
103391026  mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
103390257  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
103387363  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
103381058  plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
103381059  plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
103385127  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
103387749  LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
103389807  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
103381519  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
103383722  calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
103386999  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X8 [KO:K04515] [EC:2.7.11.17]
103388894  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
103397867  LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II delta chain [KO:K04515] [EC:2.7.11.17]
103395616  camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
103389653  camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
103391288  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like [KO:K04348] [EC:3.1.3.16]
103395725  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like [KO:K04348] [EC:3.1.3.16]
103390394  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like [KO:K04348] [EC:3.1.3.16]
103390268  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
103386871  ppp3r1; calcineurin subunit B type 1 [KO:K06268]
103383975  prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
103383625  LOW QUALITY PROTEIN: protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
103393234  prkcb; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
103387841  protein kinase C gamma type-like isoform X1 [KO:K19663] [EC:2.7.11.13]
103393969  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X2 [KO:K04446]
103388659  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
103385231  nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
103386737  nuclear factor of activated T-cells, cytoplasmic 2-like [KO:K17332]
103379683  LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
103379360  nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
103396729  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
Compound
C00076  Calcium cation
Reference
PMID:14635791
  Authors
Hatsell S, Rowlands T, Hiremath M, Cowin P.
  Title
Beta-catenin and Tcfs in mammary development and cancer.
  Journal
J Mammary Gland Biol Neoplasia 8:145-58 (2003)
DOI:10.1023/A:1025944723047
Reference
PMID:14745971
  Authors
Yang Y.
  Title
Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
  Journal
Birth Defects Res Part C Embryo Today 69:305-17 (2003)
DOI:10.1002/bdrc.10026
Reference
PMID:12446114
  Authors
Kalderon D.
  Title
Similarities between the Hedgehog and Wnt signaling pathways.
  Journal
Trends Cell Biol 12:523-31 (2002)
DOI:10.1016/S0962-8924(02)02388-7
Reference
PMID:14530294
  Authors
Nusse R.
  Title
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
  Journal
Development 130:5297-305 (2003)
DOI:10.1242/dev.00821
Reference
PMID:15102436
  Authors
Jope RS, Johnson GV.
  Title
The glamour and gloom of glycogen synthase kinase-3.
  Journal
Trends Biochem Sci 29:95-102 (2004)
DOI:10.1016/j.tibs.2003.12.004
Reference
PMID:12967557
  Authors
Veeman MT, Axelrod JD, Moon RT.
  Title
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
  Journal
Dev Cell 5:367-77 (2003)
DOI:10.1016/S1534-5807(03)00266-1
Reference
PMID:11433294
  Authors
Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
  Title
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
  Journal
Nat Cell Biol 3:628-36 (2001)
DOI:10.1038/35083016
Reference
PMID:23256519
  Authors
Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
  Title
The way Wnt works: Components and mechanism.
  Journal
Growth Factors 31:1-31 (2013)
DOI:10.3109/08977194.2012.752737
Reference
PMID:19482104
  Authors
Carethers JM
  Title
Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
  Journal
Gastroenterology 137:33-6 (2009)
DOI:10.1053/j.gastro.2009.05.011
Reference
PMID:18838381
  Authors
Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
  Title
The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
  Journal
J Biol Chem 283:33053-8 (2008)
DOI:10.1074/jbc.M804039200
Reference
PMID:23151663
  Authors
Niehrs C
  Title
The complex world of WNT receptor signalling.
  Journal
Nat Rev Mol Cell Biol 13:767-79 (2012)
DOI:10.1038/nrm3470
Reference
PMID:28522145
  Authors
Abou Ziki MD, Mani A
  Title
Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
  Journal
Atherosclerosis 262:171-178 (2017)
DOI:10.1016/j.atherosclerosis.2017.05.001
Reference
PMID:25808920
  Authors
He Y, Ki H, Kim H, Kim K
  Title
delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
  Journal
Cell Biol Int 39:954-61 (2015)
DOI:10.1002/cbin.10465
Reference
PMID:32888647
  Authors
Esaki N, Enomoto A, Takagishi M, Mizutani Y, Iida T, Ushida K, Shiraki Y, Mii S, Takahashi M
  Title
The Daple-CK1epsilon complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
  Journal
Biochem Biophys Res Commun 532:406-413 (2020)
DOI:10.1016/j.bbrc.2020.08.066
Reference
PMID:28242765
  Authors
Yiew NKH, Chatterjee TK, Tang YL, Pellenberg R, Stansfield BK, Bagi Z, Fulton DJ, Stepp DW, Chen W, Patel V, Kamath VM, Litwin SE, Hui DY, Rudich SM, Kim HW, Weintraub NL
  Title
A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.
  Journal
J Biol Chem 292:6312-6324 (2017)
DOI:10.1074/jbc.M116.758078
Related
pathway
csem04010  MAPK signaling pathway
csem04110  Cell cycle
csem04115  p53 signaling pathway
csem04120  Ubiquitin mediated proteolysis
csem04350  TGF-beta signaling pathway
csem04510  Focal adhesion
csem04520  Adherens junction
KO pathway
ko04310   
LinkDB

DBGET integrated database retrieval system