KEGG   PATHWAY: csyr04814
Entry
csyr04814                   Pathway                                
Name
Motor proteins - Carlito syrichta (Philippine tarsier)
Class
Cellular Processes; Cell motility
Pathway map
csyr04814  Motor proteins
csyr04814

Organism
Carlito syrichta (Philippine tarsier) [GN:csyr]
Gene
103266450  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
103260634  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 [KO:K10414]
103255813  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 [KO:K10415]
103276440  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X2 [KO:K10415]
103260794  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
103252054  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
103260468  DYNC2LI1; cytoplasmic dynein 2 light intermediate chain 1 isoform X1 [KO:K10417]
103260407  DYNLL2; dynein light chain 2, cytoplasmic [KO:K10418]
103254064  dynein light chain 1, cytoplasmic-like [KO:K10418]
110595862  dynein light chain 1, cytoplasmic-like [KO:K10418]
110595927  dynein light chain 1, cytoplasmic-like [KO:K10418]
103276153  DYNLL1; dynein light chain 1, cytoplasmic [KO:K10418]
103270083  DYNLRB1; dynein light chain roadblock-type 1 isoform X2 [KO:K10419]
103267366  DYNLRB2; dynein light chain roadblock-type 2 isoform X2 [KO:K10419]
103250391  DYNLT1; dynein light chain Tctex-type 1 isoform X1 [KO:K10420]
103271874  DYNLT3; dynein light chain Tctex-type 3 [KO:K10420]
103269937  TCTE3; tctex1 domain-containing protein 3 [KO:K25419]
103270116  TCTEX1D4; tctex1 domain-containing protein 4 [KO:K25420]
103274773  TCTEX1D1; tctex1 domain-containing protein 1 [KO:K25421]
103261454  DNAH5; dynein heavy chain 5, axonemal [KO:K10408]
103259689  DNAH10; dynein heavy chain 10, axonemal [KO:K10408]
110595630  DNAH3; dynein heavy chain 3, axonemal [KO:K10408]
103272927  DNAH17; dynein heavy chain 17, axonemal [KO:K10408]
103264641  DNAH2; dynein heavy chain 2, axonemal [KO:K10408]
103268211  LOW QUALITY PROTEIN: dynein heavy chain 11, axonemal-like [KO:K10408]
103274289  DNAH12; dynein heavy chain 12, axonemal [KO:K10408]
103265790  DNAH6; dynein heavy chain 6, axonemal [KO:K10408]
103265883  DNAH7; dynein heavy chain 7, axonemal [KO:K10408]
103257252  DNAH1; dynein heavy chain 1, axonemal [KO:K10408]
103273431  DNAI1; dynein intermediate chain 1, axonemal [KO:K10409]
103255303  DNAI2; dynein intermediate chain 2, axonemal [KO:K11143]
103267202  WDR63; WD repeat-containing protein 63 [KO:K24722]
103274770  WDR78; WD repeat-containing protein 78 isoform X2 [KO:K24723]
103263993  DNALI1; LOW QUALITY PROTEIN: axonemal dynein light intermediate polypeptide 1 [KO:K10410]
103262619  DNAL1; dynein light chain 1, axonemal isoform X2 [KO:K10411]
103271264  DNAL4; dynein light chain 4, axonemal isoform X1 [KO:K10412]
103266735  DCTN1; dynactin subunit 1 isoform X2 [KO:K04648]
103263162  DCTN2; dynactin subunit 2 isoform X1 [KO:K10424]
103273388  DCTN3; dynactin subunit 3 isoform X1 [KO:K10425]
103266105  DCTN4; dynactin subunit 4 isoform X1 [KO:K10426]
103257864  DCTN5; dynactin subunit 5 isoform X1 [KO:K10427]
103259145  DCTN6; dynactin subunit 6 [KO:K10428]
103251689  ACTR1B; beta-centractin [KO:K16575]
103252560  ACTR1A; alpha-centractin isoform X1 [KO:K16575]
103259026  ACTR10; actin-related protein 10 isoform X1 [KO:K16576]
103260934  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
103264116  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
110596285  LOW QUALITY PROTEIN: F-actin-capping protein subunit alpha-1-like [KO:K10364]
103257115  CAPZA1; F-actin-capping protein subunit alpha-1 isoform X1 [KO:K10364]
103267847  F-actin-capping protein subunit alpha-1 [KO:K10364]
103276186  CAPZB; F-actin-capping protein subunit beta [KO:K10365]
103271810  BICDL1; BICD family-like cargo adapter 1 [KO:K16756]
103266319  BICDL2; BICD family-like cargo adapter 2 [KO:K16756]
103262250  HOOK3; protein Hook homolog 3 [KO:K16536]
103261248  TUBA4A; tubulin alpha-4A chain isoform X1 [KO:K07374]
103261588  tubulin alpha-1 chain-like [KO:K07374]
103262680  TUBA8; tubulin alpha-8 chain [KO:K07374]
103271714  tubulin alpha-3 chain [KO:K07374]
103253635  tubulin alpha-1 chain-like [KO:K07374]
103261884  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
103273447  TUBA1B; tubulin alpha-1B chain isoform X1 [KO:K07374]
103271353  tubulin alpha-3 chain [KO:K07374]
103269656  tubulin beta-4A chain isoform X1 [KO:K07375]
103270010  TUBB1; tubulin beta-1 chain isoform X2 [KO:K07375]
103250978  tubulin beta-4B chain-like isoform X1 [KO:K07375]
103261319  TUBB; tubulin beta chain isoform X1 [KO:K07375]
103253258  tubulin beta-6 chain [KO:K07375]
103253520  tubulin beta chain-like isoform X1 [KO:K07375]
103272009  tubulin beta-2A chain isoform X3 [KO:K07375]
103272010  tubulin beta-2B chain isoform X2 [KO:K07375]
103250228  tubulin gamma-1 chain isoform X1 [KO:K10389]
103270692  tubulin gamma-2 chain isoform X2 [KO:K10389]
103273415  TUBD1; tubulin delta chain isoform X1 [KO:K10390]
103261357  TUBE1; tubulin epsilon chain [KO:K10391]
103263163  KIF5A; kinesin heavy chain isoform X1 [KO:K10396]
103256923  KIF5C; kinesin heavy chain isoform X1 [KO:K10396]
103266619  KIF5B; kinesin-1 heavy chain [KO:K10396]
103249209  KLC3; kinesin light chain 3 [KO:K10407]
103249378  KLC2; kinesin light chain 2 isoform X1 [KO:K10407]
103268540  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
103259259  KIF3A; kinesin-like protein KIF3A isoform X3 [KO:K10394]
103250857  KIF3B; kinesin-like protein KIF3B isoform X1 [KO:K20196]
103253494  KIFAP3; kinesin-associated protein 3 isoform X1 [KO:K25388]
103271883  kinesin-like protein KIF3C [KO:K20197]
103254799  KIF17; LOW QUALITY PROTEIN: kinesin-like protein KIF17 [KO:K20198]
103256357  KIF1A; kinesin-like protein KIF1A isoform X3 [KO:K10392]
103267350  KIF1B; kinesin-like protein KIF1B isoform X4 [KO:K10392]
103268369  KIF1C; kinesin-like protein KIF1C [KO:K10392]
103250669  KIF13B; kinesin-like protein KIF13B [KO:K17914]
103261035  KIF13A; kinesin-like protein KIF13A [KO:K17914]
103269538  KIF14; kinesin-like protein KIF14 isoform X1 [KO:K17915]
103258230  KIF16B; kinesin-like protein KIF16B isoform X2 [KO:K17916]
103261891  STARD9; stAR-related lipid transfer protein 9 [KO:K16491]
103273874  chromosome-associated kinesin KIF4A [KO:K10395]
103273203  KIF7; kinesin-like protein KIF7 [KO:K18806]
103258449  KIF21A; kinesin-like protein KIF21A isoform X1 [KO:K24185]
103269559  KIF21B; kinesin-like protein KIF21B isoform X1 [KO:K24185]
103275126  KIF27; kinesin-like protein KIF27 isoform X1 [KO:K24186]
103266022  KIF11; kinesin-like protein KIF11 [KO:K10398]
103261703  KIF20A; kinesin-like protein KIF20A [KO:K10402]
103257275  KIF20B; kinesin-like protein KIF20B [KO:K10402]
103273817  KIF23; kinesin-like protein KIF23 [KO:K17387]
103261991  CENPE; LOW QUALITY PROTEIN: centromere-associated protein E [KO:K11498]
103257048  KIF18A; kinesin-like protein KIF18A [KO:K10401]
103258862  KIF18B; kinesin-like protein KIF18B [KO:K26156]
103255304  KIF19; kinesin-like protein KIF19 [KO:K26157]
103273789  kinesin-like protein KIF9 isoform X1 [KO:K10397]
103270096  KIF22; kinesin-like protein KIF22 [KO:K10403]
103268184  KIF26B; kinesin-like protein KIF26B [KO:K10404]
103259834  KIF26A; kinesin-like protein KIF26A [KO:K10404]
103251573  KIF12; kinesin-like protein KIF12 [KO:K10399]
103273905  KIF15; kinesin-like protein KIF15 isoform X1 [KO:K10400]
103270119  KIF2C; LOW QUALITY PROTEIN: kinesin-like protein KIF2C [KO:K10393]
103273571  KIF24; kinesin-like protein KIF24 [KO:K10393]
103274787  KIF2B; kinesin-like protein KIF2B [KO:K10393]
103257405  KIF2A; kinesin-like protein KIF2A isoform X1 [KO:K10393]
103262534  KIFC1; kinesin-like protein KIFC1 [KO:K10405]
103270498  KIFC3; kinesin-like protein KIFC3 [KO:K10406]
103272491  KIFC2; kinesin-like protein KIFC2 [KO:K10406]
103261022  kinesin-like protein KIFC1 [KO:K18627]
103251581  kinesin-like protein KIF25 [KO:K18627]
103251068  unconventional myosin-Id [KO:K10356]
103263818  MYO1E; unconventional myosin-Ie [KO:K10356]
103269290  MYO1G; unconventional myosin-Ig [KO:K10356]
103256877  unconventional myosin-If [KO:K10356]
103275952  MYO1C; unconventional myosin-Ic [KO:K10356]
103267654  MYO1A; unconventional myosin-Ia isoform X1 [KO:K10356]
103276906  MYO1B; unconventional myosin-Ib [KO:K10356]
103273510  MYO3B; myosin-IIIb [KO:K08834] [EC:2.7.11.1]
103259501  MYO3A; myosin-IIIa [KO:K08834] [EC:2.7.11.1]
103261836  unconventional myosin-Va [KO:K10357]
103266900  MYO5B; unconventional myosin-Vb [KO:K10357]
103275174  MYO5C; unconventional myosin-Vc [KO:K10357]
103254773  MYO6; unconventional myosin-VI [KO:K10358]
103266821  MYO7A; unconventional myosin-VIIa [KO:K10359]
103262241  MYO7B; LOW QUALITY PROTEIN: unconventional myosin-VIIb [KO:K21868]
103262436  MYO9B; unconventional myosin-IXb [KO:K10360]
103263782  MYO9A; unconventional myosin-IXa [KO:K10360]
103269307  MYO10; LOW QUALITY PROTEIN: unconventional myosin-X [KO:K12559]
103249576  MYO15A; unconventional myosin-XV [KO:K10361]
103252760  MYO15B; myosin XVB [KO:K10361]
103265734  MYO16; unconventional myosin-XVI [KO:K17481]
103266553  MYO18A; unconventional myosin-XVIIIa isoform X1 [KO:K10362]
103265956  MYO18B; unconventional myosin-XVIIIb [KO:K10362]
103249980  MYH15; myosin-15 [KO:K24220]
103252143  MYH13; myosin-13 [KO:K24220]
103252144  myosin-8 [KO:K24220]
103252145  MYH4; myosin-4 [KO:K24220]
103252146  myosin-1 isoform X1 [KO:K24220]
103252147  myosin-2 [KO:K24220]
103252148  myosin-3 [KO:K24220]
103272803  MYH7B; myosin-7B [KO:K24220]
103270244  myosin-7 [KO:K17751]
103270245  myosin-6 [KO:K17751]
103252352  myosin-14 [KO:K10352]
103255041  myosin-11 [KO:K10352]
103263458  MYH10; myosin-10 isoform X2 [KO:K10352]
103258614  MYH9; myosin-9 isoform X1 [KO:K10352]
103265848  MYL1; myosin light chain 1/3, skeletal muscle isoform isoform X1 [KO:K05738]
103273785  MYL3; myosin light chain 3 [KO:K12749]
103252912  MYL4; myosin light chain 4 [KO:K12750]
103249535  LOW QUALITY PROTEIN: myosin light polypeptide 6 [KO:K12751]
103249536  MYL6B; myosin light chain 6B [KO:K12751]
103249841  myosin light polypeptide 6-like [KO:K12751]
103258791  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
103266402  MYL5; myosin light chain 5 [KO:K12753]
103259590  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
103249472  myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
103274606  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
103256881  MYL10; myosin regulatory light chain 10 [KO:K12756]
103255576  myosin regulatory light chain 12B-like isoform X1 [KO:K12757]
103267542  LOW QUALITY PROTEIN: myosin regulatory light chain, striated muscle, 25 kDa isoform-like [KO:K12757]
103277366  myosin regulatory light polypeptide 9 isoform X2 [KO:K12757]
103277367  myosin regulatory light chain 12B [KO:K12757]
103275165  myosin regulatory light chain RLC-A-like [KO:K12757]
103270153  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
103260552  ACTA2; actin, aortic smooth muscle [KO:K12313]
103268331  ACTC1; actin, alpha cardiac muscle 1 isoform X1 [KO:K12314]
103264435  ACTBL2; LOW QUALITY PROTEIN: beta-actin-like protein 2 [KO:K12315]
103266744  ACTG2; actin, gamma-enteric smooth muscle isoform X1 [KO:K12315]
103250241  ACTG1; actin, cytoplasmic 2 [KO:K05692]
103258260  actin-like isoform X1 [KO:K05692]
103252825  actin, cytoplasmic 2 [KO:K05692]
103263822  actin, cytoplasmic 1-like isoform X1 [KO:K05692]
103257238  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
103269547  TNNI1; troponin I, slow skeletal muscle isoform X2 [KO:K10371]
103267508  TNNT1; troponin T, slow skeletal muscle [KO:K10372]
103260280  TNNC2; troponin C, skeletal muscle [KO:K12042]
103260671  TNNT3; troponin T, fast skeletal muscle [KO:K12046]
103267496  TNNI3; troponin I, cardiac muscle [KO:K12044]
103269546  TNNT2; troponin T, cardiac muscle isoform X1 [KO:K12045]
103253538  tropomyosin alpha-1 chain [KO:K10373]
103262462  tropomyosin alpha-4 chain isoform X3 [KO:K10373]
103265468  TPM2; tropomyosin beta chain isoform X1 [KO:K10374]
103260087  tropomyosin alpha-3 chain isoform X1 [KO:K09290]
103250795  tropomyosin alpha-3 chain-like isoform X1 [KO:K09290]
103262877  TPM3; tropomyosin alpha-3 chain isoform X2 [KO:K09290]
103267800  tropomyosin alpha-3 chain-like isoform X1 [KO:K09290]
103276591  TPM4; tropomyosin alpha-4 chain isoform X1 [KO:K10375]
Reference
PMID:21092854
  Authors
Hirokawa N, Niwa S, Tanaka Y
  Title
Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease.
  Journal
Neuron 68:610-38 (2010)
DOI:10.1016/j.neuron.2010.09.039
Reference
PMID:25470043 (PDB:4RH7)
  Authors
Schmidt H, Zalyte R, Urnavicius L, Carter AP
  Title
Structure of human cytoplasmic dynein-2 primed for its power stroke.
  Journal
Nature 518:435-438 (2015)
DOI:10.1038/nature14023
Reference
PMID:22398446 (PDB:3VKG 3VKH)
  Authors
Kon T, Oyama T, Shimo-Kon R, Imamula K, Shima T, Sutoh K, Kurisu G
  Title
The 2.8 A crystal structure of the dynein motor domain.
  Journal
Nature 484:345-50 (2012)
DOI:10.1038/nature10955
Reference
PMID:22997337 (PDB:3J1T 3J1U)
  Authors
Redwine WB, Hernandez-Lopez R, Zou S, Huang J, Reck-Peterson SL, Leschziner AE
  Title
Structural basis for microtubule binding and release by dynein.
  Journal
Science 337:1532-1536 (2012)
DOI:10.1126/science.1224151
Reference
PMID:26410600
  Authors
Gibbs KL, Greensmith L, Schiavo G
  Title
Regulation of Axonal Transport by Protein Kinases.
  Journal
Trends Biochem Sci 40:597-610 (2015)
DOI:10.1016/j.tibs.2015.08.003
Reference
PMID:28602352 (PDB:5NUG 5NVS 5NVU 5NW4)
  Authors
Zhang K, Foster HE, Rondelet A, Lacey SE, Bahi-Buisson N, Bird AW, Carter AP
  Title
Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated.
  Journal
Cell 169:1303-1314.e18 (2017)
DOI:10.1016/j.cell.2017.05.025
Reference
PMID:25814576 (PDB:5ADX 5AFR 5AFU)
  Authors
Urnavicius L, Zhang K, Diamant AG, Motz C, Schlager MA, Yu M, Patel NA, Robinson CV, Carter AP
  Title
The structure of the dynactin complex and its interaction with dynein.
  Journal
Science 347:1441-1446 (2015)
DOI:10.1126/science.aaa4080
Reference
PMID:29420470 (PDB:5OWO 6F1T 6F1U 6F1V 6F1Y 6F1Z 6F38 6F3A)
  Authors
Urnavicius L, Lau CK, Elshenawy MM, Morales-Rios E, Motz C, Yildiz A, Carter AP
  Title
Cryo-EM shows how dynactin recruits two dyneins for faster movement.
  Journal
Nature 554:202-206 (2018)
DOI:10.1038/nature25462
Reference
PMID:29662141
  Authors
Reck-Peterson SL, Redwine WB, Vale RD, Carter AP
  Title
The cytoplasmic dynein transport machinery and its many cargoes.
  Journal
Nat Rev Mol Cell Biol 19:382-398 (2018)
DOI:10.1038/s41580-018-0004-3
Reference
PMID:23434508 (PDB:3J2U)
  Authors
Asenjo AB, Chatterjee C, Tan D, DePaoli V, Rice WJ, Diaz-Avalos R, Silvestry M, Sosa H
  Title
Structural model for tubulin recognition and deformation by kinesin-13 microtubule depolymerases.
  Journal
Cell Rep 3:759-68 (2013)
DOI:10.1016/j.celrep.2013.01.030
Reference
PMID:10338210 (PDB:1B7T)
  Authors
Houdusse A, Kalabokis VN, Himmel D, Szent-Gyorgyi AG, Cohen C
  Title
Atomic structure of scallop myosin subfragment S1 complexed with MgADP: a novel conformation of the myosin head.
  Journal
Cell 97:459-70 (1999)
DOI:10.1016/s0092-8674(00)80756-4
Reference
PMID:9428521 (PDB:3KIN)
  Authors
Kozielski F, Sack S, Marx A, Thormahlen M, Schonbrunn E, Biou V, Thompson A, Mandelkow EM, Mandelkow E
  Title
The crystal structure of dimeric kinesin and implications for microtubule-dependent motility.
  Journal
Cell 91:985-94 (1997)
DOI:10.1016/s0092-8674(00)80489-4
Reference
PMID:8316857 (PDB:2MYS)
  Authors
Rayment I, Rypniewski WR, Schmidt-Base K, Smith R, Tomchick DR, Benning MM, Winkelmann DA, Wesenberg G, Holden HM
  Title
Three-dimensional structure of myosin subfragment-1: a molecular motor.
  Journal
Science 261:50-8 (1993)
DOI:10.1126/science.8316857
Reference
PMID:20428469
  Authors
Parker D, Bryant Z, Delp SL
  Title
Coarse-Grained Structural Modeling of Molecular Motors Using Multibody Dynamics.
  Journal
Cell Mol Bioeng 2:366-374 (2009)
DOI:10.1007/s12195-009-0084-4
Reference
PMID:21314430
  Authors
Dominguez R, Holmes KC
  Title
Actin structure and function.
  Journal
Annu Rev Biophys 40:169-86 (2011)
DOI:10.1146/annurev-biophys-042910-155359
Reference
PMID:31919429 (PDB:6KN7 6KN8)
  Authors
Yamada Y, Namba K, Fujii T
  Title
Cardiac muscle thin filament structures reveal calcium regulatory mechanism.
  Journal
Nat Commun 11:153 (2020)
DOI:10.1038/s41467-019-14008-1
Reference
PMID:33912943
  Authors
Kruppa AJ, Buss F
  Title
Motor proteins at the mitochondria-cytoskeleton interface.
  Journal
J Cell Sci 134:239092 (2021)
DOI:10.1242/jcs.226084
KO pathway
ko04814   
LinkDB

DBGET integrated database retrieval system