KEGG   PATHWAY: dme04310
dme04310                    Pathway                                
Wnt signaling pathway - Drosophila melanogaster (fruit fly)
Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Environmental Information Processing; Signal transduction
Pathway map
dme04310  Wnt signaling pathway

Other DBs
GO: 0016055
Drosophila melanogaster (fruit fly) [GN:dme]
Dmel_CG6205  por; porcupine, isoform B [KO:K00181] [EC:]
Dmel_CG4889  wg; wingless [KO:K03209]
Dmel_CG6407  Wnt5; Wnt oncogene analog 5, isoform B [KO:K00444]
Dmel_CG4969  Wnt6; Wnt oncogene analog 6, isoform C [KO:K00445]
Dmel_CG8458  wntD; wnt inhibitor of dorsal [KO:K00714]
Dmel_CG4971  Wnt10; Wnt oncogene analog 10 [KO:K01357]
Dmel_CG13076  Notum; notum [KO:K19882] [EC:]
Dmel_CG3135  shf; shifted, isoform A [KO:K01691]
Dmel_CG4974  dally; division abnormally delayed, isoform B [KO:K02306]
Dmel_CG8930  rk; rickets [KO:K08399]
Dmel_CG17697  fz; frizzled, isoform A [KO:K02432]
Dmel_CG4626  fz4; frizzled 4, isoform A [KO:K02354]
Dmel_CG9739  fz2; frizzled 2, isoform C [KO:K02375]
Dmel_CG16785  fz3; frizzled 3, isoform C [KO:K04690]
Dmel_CG5912  arr; arrow [KO:K03068]
Dmel_CG2048  dco; discs overgrown, isoform D [KO:K08960] [EC:]
Dmel_CG18361  dsh; dishevelled [KO:K02353]
Dmel_CG17520  CkIIalpha; casein kinase IIalpha, isoform D [KO:K03097] [EC:]
Dmel_CG13591  Ssl; suppressor of Stellate-like [KO:K03115]
Dmel_CG8914  CkIIbeta2; casein kinase II beta2 subunit [KO:K03115]
Dmel_CG15224  CkIIbeta; casein kinase II beta subunit, isoform E [KO:K03115]
Dmel_CG33242  Ste:CG33242 [KO:K03115]
Dmel_CG33239  Ste:CG33239 [KO:K03115]
Dmel_CG33241  Ste:CG33241 [KO:K03115]
Dmel_CG33236  Ste:CG33236 [KO:K03115]
Dmel_CG33237  Ste:CG33237 [KO:K03115]
Dmel_CG33240  Ste:CG33240 [KO:K03115]
Dmel_CG33244  Ste:CG33244 [KO:K03115]
Dmel_CG33245  Ste:CG33245 [KO:K03115]
Dmel_CG33247  Ste:CG33247 [KO:K03115]
Dmel_CG32616  Ste12DOR; stellate 12D orphon [KO:K03115]
Dmel_CG33243  Ste:CG33243 [KO:K03115]
Dmel_CG33238  Ste:CG33238 [KO:K03115]
Dmel_CG33246  Ste:CG33246 [KO:K03115]
Dmel_CG42398  SteXh:CG42398 [KO:K03115]
Dmel_CG40635  CG40635; uncharacterized protein [KO:K03115]
Dmel_CG11614  nkd; naked cuticle, isoform A [KO:K03213]
Dmel_CG2621  sgg; shaggy, isoform B [KO:K03083] [EC:]
Dmel_CG31003  gskt; gasket [KO:K03083] [EC:]
Dmel_CG11579  arm; armadillo, isoform F [KO:K02105]
Dmel_CG7926  Axn; axin, isoform A [KO:K02157]
Dmel_CG6193  Apc2; adenomatous polyposis coli 2, isoform B [KO:K02085]
Dmel_CG1451  Apc; APC-like, isoform B [KO:K02085]
Dmel_CG2028  CkIalpha; casein kinase ialpha, isoform D [KO:K08957] [EC:]
Dmel_CG12147  CG12147; uncharacterized protein [KO:K08957] [EC:]
Dmel_CG2577  CG2577; uncharacterized protein [KO:K08957] [EC:]
Dmel_CG7094  CG7094; uncharacterized protein [KO:K08957] [EC:]
Dmel_CG34403  pan; pangolin, isoform R [KO:K04491]
Dmel_CG15365  CG15365; uncharacterized protein, isoform B [KO:K26471]
Dmel_CG13415  Cby; chibby, isoform C [KO:K23402]
Dmel_CG34404  CG34404; uncharacterized protein, isoform E [KO:K26734]
Dmel_CG5216  Sirt1; sirtuin 1 [KO:K11411] [EC:]
Dmel_CG7583  CtBP; C-terminal binding protein, isoform E [KO:K04496] [EC:]
Dmel_CG8384  gro; groucho, isoform E [KO:K04497]
Dmel_CG17484  p120ctn; p120 catenin [KO:K23491]
Dmel_CG15319  nej; nejire, isoform C [KO:K04498] [EC:]
Dmel_CG4003  pont; pontin [KO:K04499] [EC:]
Dmel_CG1775  Med; medea, isoform A [KO:K04501]
Dmel_CG2262  Smox; smad on X, isoform B [KO:K23605]
Dmel_CG18492  Tak1; TGF-beta activated kinase 1, isoform A [KO:K04427] [EC:]
Dmel_CG4803  Takl2; Tak1-like 2 [KO:K04427] [EC:]
Dmel_CG31421  Takl1; Tak1-like 1 [KO:K04427] [EC:]
Dmel_CG7892  nmo; nemo, isoform H [KO:K04468] [EC:]
Dmel_CG10798  Myc; Myc, isoform B [KO:K04377]
Dmel_CG2275  Jra; Jun-related antigen, isoform A [KO:K04448]
Dmel_CG9096  CycD; cyclin D, isoform D [KO:K10151]
Dmel_CG18803  Psn; presenilin, isoform E [KO:K04505] [EC:3.4.23.-]
Dmel_CG4379  Pka-C1; protein kinase, cAMP-dependent, catalytic subunit 1, isoform D [KO:K04345] [EC:]
Dmel_CG12066  Pka-C2; protein kinase, cAMP-dependent, catalytic subunit 2, isoform B [KO:K04345] [EC:]
Dmel_CG9949  sina; seven in absentia, isoform C [KO:K04506] [EC:]
Dmel_CG13030  sinah; sina homologue [KO:K04506] [EC:]
Dmel_CG3226  CG3226; uncharacterized protein [KO:K04507]
Dmel_CG16983  SkpA; SKP1-related A, isoform H [KO:K03094]
Dmel_CG12227  SkpF; SKP1-related F [KO:K03094]
Dmel_CG8881  SkpB; SKP1-related B [KO:K03094]
Dmel_CG11942  SkpE; SKP1-related E [KO:K03094]
Dmel_CG11941  SkpC; SKP1-related C [KO:K03094]
Dmel_CG12700  SkpD; SKP1-related D [KO:K03094]
Dmel_CG15800  CG15800; uncharacterized protein [KO:K03094]
Dmel_CG43089  CG43089; uncharacterized protein, isoform B [KO:K03094]
Dmel_CG4063  ebi; ebi [KO:K04508]
Dmel_CG3412  slmb; supernumerary limbs, isoform C [KO:K03362]
Dmel_CG1877  Cul1; cullin 1, isoform D [KO:K03347]
Dmel_CG11261  Cul6; cullin 6 [KO:K03347]
Dmel_CG16982  Roc1a; regulator of cullins 1a, isoform D [KO:K03868] [EC:]
Dmel_CG16988  Roc1b; regulator of cullins 1b [KO:K03868] [EC:]
Dmel_CG32146  dlp; dally-like, isoform A [KO:K08110]
Dmel_CG4926  Ror; Ror [KO:K05122] [EC:]
Dmel_CG17348  drl; derailed, isoform A [KO:K05128] [EC:]
Dmel_CG17559  dnt; doughnut on 2, isoform B [KO:K05128] [EC:]
Dmel_CG8075  Vang; Van gogh, isoform B [KO:K04510]
Dmel_CG11084  pk; prickle, isoform C [KO:K04511]
Dmel_CG43722  esn; espinas, isoform B [KO:K04511]
Dmel_CG14622  DAAM; dishevelled associated activator of morphogenesis, isoform D [KO:K04512]
Dmel_CG8416  Rho1; Rho1, isoform A [KO:K04513]
Dmel_CG2248  Rac1; Rac1, isoform B [KO:K04392]
Dmel_CG9366  RhoL; Rho-like, isoform A [KO:K04392]
Dmel_CG5588  Mtl; Mig-2-like, isoform B [KO:K04392]
Dmel_CG8556  Rac2; Rac2, isoform B [KO:K04392]
Dmel_CG5680  bsk; basket, isoform F [KO:K04440] [EC:]
Dmel_CG4574  Plc21C; phospholipase C at 21C, isoform D [KO:K05858] [EC:]
Dmel_CG3620  norpA; no receptor potential A, isoform D [KO:K05858] [EC:]
Dmel_CG18069  CaMKII; Calcium/calmodulin-dependent protein kinase II, isoform I [KO:K04515] [EC:]
Dmel_CG1455  CanA1; calcineurin A1, isoform D [KO:K04348] [EC:]
Dmel_CG9842  Pp2B-14D; protein phosphatase 2B at 14D, isoform C [KO:K04348] [EC:]
Dmel_CG9819  CanA-14F; calcineurin A at 14F, isoform C [KO:K04348] [EC:]
Dmel_CG11217  CanB2; calcineurin B2, isoform B [KO:K06268]
Dmel_CG4209  CanB; calcineurin B, isoform B [KO:K06268]
Dmel_CG6518  inaC; inactivation no afterpotential C [KO:K02677] [EC:]
Dmel_CG6622  Pkc53E; protein C kinase 53E, isoform B [KO:K02677] [EC:]
C00076  Calcium cation
Hatsell S, Rowlands T, Hiremath M, Cowin P.
Beta-catenin and Tcfs in mammary development and cancer.
J Mammary Gland Biol Neoplasia 8:145-58 (2003)
Yang Y.
Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
Birth Defects Res Part C Embryo Today 69:305-17 (2003)
Kalderon D.
Similarities between the Hedgehog and Wnt signaling pathways.
Trends Cell Biol 12:523-31 (2002)
Nusse R.
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
Development 130:5297-305 (2003)
Jope RS, Johnson GV.
The glamour and gloom of glycogen synthase kinase-3.
Trends Biochem Sci 29:95-102 (2004)
Veeman MT, Axelrod JD, Moon RT.
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
Dev Cell 5:367-77 (2003)
Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
Nat Cell Biol 3:628-36 (2001)
Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
The way Wnt works: Components and mechanism.
Growth Factors 31:1-31 (2013)
Carethers JM
Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
Gastroenterology 137:33-6 (2009)
Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
J Biol Chem 283:33053-8 (2008)
Niehrs C
The complex world of WNT receptor signalling.
Nat Rev Mol Cell Biol 13:767-79 (2012)
Abou Ziki MD, Mani A
Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
Atherosclerosis 262:171-178 (2017)
He Y, Ki H, Kim H, Kim K
delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
Cell Biol Int 39:954-61 (2015)
Esaki N, Enomoto A, Takagishi M, Mizutani Y, Iida T, Ushida K, Shiraki Y, Mii S, Takahashi M
The Daple-CK1epsilon complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
Biochem Biophys Res Commun 532:406-413 (2020)
Yiew NKH, Chatterjee TK, Tang YL, Pellenberg R, Stansfield BK, Bagi Z, Fulton DJ, Stepp DW, Chen W, Patel V, Kamath VM, Litwin SE, Hui DY, Rudich SM, Kim HW, Weintraub NL
A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.
J Biol Chem 292:6312-6324 (2017)
dme04120  Ubiquitin mediated proteolysis
dme04350  TGF-beta signaling pathway
KO pathway

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