KEGG   PATHWAY: dpol04146
Entry
dpol04146                   Pathway                                
Name
Peroxisome - Dreissena polymorpha (zebra mussel)
Description
Peroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies.
Class
Cellular Processes; Transport and catabolism
Pathway map
dpol04146  Peroxisome
dpol04146

Other DBs
GO: 0005777
Organism
Dreissena polymorpha (zebra mussel) [GN:dpol]
Gene
127880318  peroxisomal membrane protein PEX16-like [KO:K13335]
127861993  peroxisomal biogenesis factor 3-like isoform X1 [KO:K13336]
127859303  peroxisomal biogenesis factor 19-like [KO:K13337]
127874203  ATP-binding cassette sub-family D member 3-like isoform X1 [KO:K05677] [EC:7.6.2.4]
127872749  peroxisome assembly factor 2-like isoform X1 [KO:K13339]
127852274  peroxisome assembly protein 26-like [KO:K13340]
127842561  peroxisome assembly protein 26-like [KO:K13340]
127854262  peroxisomal targeting signal 2 receptor-like isoform X1 [KO:K13341]
127865291  peroxisomal targeting signal 1 receptor-like [KO:K13342]
127871621  peroxisomal targeting signal 1 receptor-like isoform X1 [KO:K13342]
127882363  peroxisomal membrane protein PEX14-like [KO:K13343]
127861877  probable peroxisomal membrane protein PEX13 [KO:K13344]
127834602  peroxisome assembly protein 12-like [KO:K13345]
127834606  peroxisome assembly protein 12-like [KO:K13345]
127837964  peroxisome biogenesis factor 10-like [KO:K13346]
127837966  peroxisome biogenesis factor 10-like [KO:K13346]
127839369  peroxisome biogenesis factor 10-like isoform X1 [KO:K13346]
127839370  peroxisome biogenesis factor 10-like [KO:K13346]
127831655  peroxisome biogenesis factor 2-like [KO:K06664]
127856450  peroxisomal membrane protein 2-like [KO:K13347]
127846538  mpv17-like protein 2 [KO:K13348]
127858409  uncharacterized protein LOC127858409 [KO:K13348]
127862339  mpv17-like protein 2 [KO:K13348]
127846699  peroxisomal membrane protein 4-like [KO:K13350]
127880337  peroxisomal membrane protein 11B-like [KO:K13352]
127831798  peroxisomal membrane protein 11C-like [KO:K13353]
127866070  peroxisomal membrane protein PMP34-like isoform X1 [KO:K13354]
127855304  2-hydroxyacyl-CoA lyase 1-like [KO:K12261] [EC:4.1.2.63]
127877989  alpha-methylacyl-CoA racemase-like [KO:K01796] [EC:5.1.99.4]
127882046  peroxisomal acyl-coenzyme A oxidase 1-like [KO:K00232] [EC:1.3.3.6]
127848339  peroxisomal acyl-coenzyme A oxidase 1-like [KO:K00232] [EC:1.3.3.6]
127855383  peroxisomal acyl-coenzyme A oxidase 3-like [KO:K00232] [EC:1.3.3.6]
127875952  peroxisomal multifunctional enzyme type 2-like [KO:K12405] [EC:1.1.1.- 4.2.1.107 4.2.1.119]
127877757  sterol carrier protein 2-like [KO:K08764] [EC:2.3.1.176]
127861931  sterol carrier protein 2-like [KO:K08764] [EC:2.3.1.176]
127870784  acyl-coenzyme A amino acid N-acyltransferase 1-like isoform X1 [KO:K00659] [EC:2.3.1.65 3.1.2.2]
127853306  bile acid-CoA:amino acid N-acyltransferase-like isoform X1 [KO:K00659] [EC:2.3.1.65 3.1.2.2]
127853745  bile acid-CoA:amino acid N-acyltransferase-like [KO:K00659] [EC:2.3.1.65 3.1.2.2]
127873764  peroxisomal succinyl-coenzyme A thioesterase-like isoform X1 [KO:K00659] [EC:2.3.1.65 3.1.2.2]
127839426  peroxisomal bifunctional enzyme-like [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
127855352  3-ketoacyl-CoA thiolase B, peroxisomal-like isoform X1 [KO:K07513] [EC:2.3.1.16]
127856119  3-ketoacyl-CoA thiolase B, peroxisomal-like [KO:K07513] [EC:2.3.1.16]
127865755  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]-like [KO:K13237] [EC:1.3.1.124]
127873388  delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial-like isoform X1 [KO:K12663] [EC:5.3.3.21]
127865085  ATP-binding cassette sub-family D member 1-like [KO:K05676] [EC:7.6.2.4]
127873327  lysosomal cobalamin transporter ABCD4-like isoform X1 [KO:K05678] [EC:7.6.2.8]
127879317  long-chain fatty acid transport protein 2-like isoform X1 [KO:K08746] [EC:6.2.1.- 6.2.1.3]
127868004  long-chain-fatty-acid--CoA ligase 1-like isoform X1 [KO:K01897] [EC:6.2.1.3]
127851026  long-chain-fatty-acid--CoA ligase 5-like isoform X1 [KO:K01897] [EC:6.2.1.3]
127833395  fatty acid CoA ligase Acsl3-like [KO:K01897] [EC:6.2.1.3]
127860748  peroxisomal trans-2-enoyl-CoA reductase-like [KO:K07753] [EC:1.3.1.38]
127860750  peroxisomal trans-2-enoyl-CoA reductase-like [KO:K07753] [EC:1.3.1.38]
127844507  enoyl-CoA delta isomerase 2-like isoform X1 [KO:K13239] [EC:5.3.3.8]
127845679  enoyl-CoA delta isomerase 2-like isoform X1 [KO:K13239] [EC:5.3.3.8]
127872622  enoyl-CoA delta isomerase 2-like [KO:K13239] [EC:5.3.3.8]
127846584  uncharacterized Nudix hydrolase NudL-like isoform X1 [KO:K17879] [EC:3.6.1.77]
127879086  NAD-capped RNA hydrolase NUDT12-like isoform X1 [KO:K03426] [EC:3.6.1.22]
127844279  acyl-coenzyme A diphosphatase NUDT19-like [KO:K13355] [EC:3.6.1.77]
127882083  acyl-coenzyme A thioesterase 8-like [KO:K11992] [EC:3.1.2.27]
127882376  acyl-coenzyme A thioesterase 8-like isoform X1 [KO:K11992] [EC:3.1.2.27]
127837843  carnitine O-acetyltransferase-like isoform X1 [KO:K00624] [EC:2.3.1.7]
127837844  carnitine O-acetyltransferase-like isoform X1 [KO:K00624] [EC:2.3.1.7]
127855167  peroxisomal carnitine O-octanoyltransferase-like isoform X1 [KO:K05940] [EC:2.3.1.137]
127855772  peroxisomal carnitine O-octanoyltransferase-like isoform X1 [KO:K05940] [EC:2.3.1.137]
127850113  malonyl-CoA decarboxylase, mitochondrial-like [KO:K01578] [EC:4.1.1.9]
127851105  malonyl-CoA decarboxylase, mitochondrial-like [KO:K01578] [EC:4.1.1.9]
127872763  dihydroxyacetone phosphate acyltransferase-like isoform X1 [KO:K00649] [EC:2.3.1.42]
127860099  alkyldihydroxyacetonephosphate synthase, peroxisomal-like [KO:K00803] [EC:2.5.1.26]
127835630  fatty acyl-CoA reductase 1-like isoform X1 [KO:K13356] [EC:1.2.1.84]
127842616  fatty acyl-CoA reductase 1-like isoform X1 [KO:K13356] [EC:1.2.1.84]
127844023  mevalonate kinase-like isoform X1 [KO:K00869] [EC:2.7.1.36]
127876269  delta-like protein 4 [KO:K13273] [EC:2.7.4.2]
127832441  alanine--glyoxylate aminotransferase-like isoform X1 [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
127844478  D-aspartate oxidase-like isoform X1 [KO:K00272] [EC:1.4.3.1]
127845141  D-aspartate oxidase-like [KO:K00272] [EC:1.4.3.1]
127874462  D-aspartate oxidase-like isoform X1 [KO:K00272] [EC:1.4.3.1]
127864480  isocitrate dehydrogenase [NADP], mitochondrial-like [KO:K00031] [EC:1.1.1.42]
127871413  isocitrate dehydrogenase [NADP] cytoplasmic-like [KO:K00031] [EC:1.1.1.42]
127866284  spermine oxidase-like isoform X1 [KO:K00308] [EC:1.5.3.13]
127866285  spermine oxidase-like [KO:K00308] [EC:1.5.3.13]
127863154  LOW QUALITY PROTEIN: peroxisomal sarcosine oxidase-like [KO:K00306] [EC:1.5.3.1 1.5.3.7]
127861796  peroxisomal sarcosine oxidase-like isoform X1 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
127857017  hydroxymethylglutaryl-CoA lyase, mitochondrial-like isoform X1 [KO:K01640] [EC:4.1.3.4]
127849679  catalase-like [KO:K03781] [EC:1.11.1.6]
127849695  catalase-like [KO:K03781] [EC:1.11.1.6]
127851525  catalase-like [KO:K03781] [EC:1.11.1.6]
127851622  catalase-like isoform X1 [KO:K03781] [EC:1.11.1.6]
127854756  catalase-like [KO:K03781] [EC:1.11.1.6]
127873273  peroxiredoxin-5, mitochondrial-like [KO:K11187] [EC:1.11.1.24]
127862984  superoxide dismutase [Cu-Zn]-like [KO:K04565] [EC:1.15.1.1]
127851269  superoxide dismutase [Cu-Zn]-like [KO:K04565] [EC:1.15.1.1]
127851409  superoxide dismutase [Cu-Zn]-like isoform X1 [KO:K04565] [EC:1.15.1.1]
127851411  uncharacterized protein LOC127851411 [KO:K04565] [EC:1.15.1.1]
127854258  uncharacterized protein LOC127854258 isoform X1 [KO:K04565] [EC:1.15.1.1]
127848834  superoxide dismutase [Mn], mitochondrial-like [KO:K04564] [EC:1.15.1.1]
127861945  peroxiredoxin-1-like isoform X1 [KO:K13279] [EC:1.11.1.24]
127881506  glutathione S-transferase kappa 1-like [KO:K13299] [EC:2.5.1.18]
127832115  glutathione S-transferase kappa 1-like isoform X1 [KO:K13299] [EC:2.5.1.18]
127842373  glutathione S-transferase kappa 1-like [KO:K13299] [EC:2.5.1.18]
127865162  uncharacterized protein LOC127865162 isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
127852722  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
127852926  uncharacterized protein LOC127852926 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
127871794  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
127877386  xanthine dehydrogenase/oxidase-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
127845835  dehydrogenase/reductase SDR family member 4-like isoform X1 [KO:K11147] [EC:1.1.-.-]
127846509  dehydrogenase/reductase SDR family member 4-like [KO:K11147] [EC:1.1.-.-]
127846786  dehydrogenase/reductase SDR family member 4-like isoform X1 [KO:K11147] [EC:1.1.-.-]
Reference
PMID:17055078
  Authors
Wanders RJ, Waterham HR
  Title
Peroxisomal disorders: the single peroxisomal enzyme deficiencies.
  Journal
Biochim Biophys Acta 1763:1707-20 (2006)
DOI:10.1016/j.bbamcr.2006.08.010
Reference
PMID:17055079
  Authors
Steinberg SJ, Dodt G, Raymond GV, Braverman NE, Moser AB, Moser HW
  Title
Peroxisome biogenesis disorders.
  Journal
Biochim Biophys Acta 1763:1733-48 (2006)
DOI:10.1016/j.bbamcr.2006.09.010
Reference
PMID:17010456
  Authors
Rottensteiner H, Theodoulou FL
  Title
The ins and outs of peroxisomes: co-ordination of membrane transport and peroxisomal metabolism.
  Journal
Biochim Biophys Acta 1763:1527-40 (2006)
DOI:10.1016/j.bbamcr.2006.08.012
Reference
PMID:16631601
  Authors
Iida R, Yasuda T, Tsubota E, Takatsuka H, Matsuki T, Kishi K
  Title
Human Mpv17-like protein is localized in peroxisomes and regulates expression of antioxidant enzymes.
  Journal
Biochem Biophys Res Commun 344:948-54 (2006)
DOI:10.1016/j.bbrc.2006.04.008
Related
pathway
dpol00071  Fatty acid degradation
dpol00230  Purine metabolism
dpol00564  Glycerophospholipid metabolism
dpol00565  Ether lipid metabolism
dpol00830  Retinol metabolism
dpol00900  Terpenoid backbone biosynthesis
KO pathway
ko04146   
LinkDB

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