KEGG   PATHWAY: dsp00983
Entry
dsp00983                    Pathway                                
Name
Drug metabolism - other enzymes - Dipodomys spectabilis (banner-tailed kangaroo rat)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
dsp00983  Drug metabolism - other enzymes
dsp00983

Organism
Dipodomys spectabilis (banner-tailed kangaroo rat) [GN:dsp]
Gene
122102110  Hprt1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
122095741  Impdh2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
122121857  Impdh1; inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
122112674  Gmps; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
122107017  Tpmt; thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
122122529  Xdh; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
122120270  Itpa; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
122116314  carboxylesterase 1D-like isoform X1 [KO:K01044] [EC:3.1.1.1]
122116316  carboxylesterase 1D-like [KO:K01044] [EC:3.1.1.1]
122116317  carboxylesterase 1E-like [KO:K01044] [EC:3.1.1.1]
122126094  pyrethroid hydrolase Ces2e-like isoform X1 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
122126097  pyrethroid hydrolase Ces2e-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
122126103  pyrethroid hydrolase Ces2e-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
122126105  LOW QUALITY PROTEIN: acylcarnitine hydrolase-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
122126069  pyrethroid hydrolase Ces2e-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
122126095  cocaine esterase-like isoform X1 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
122126068  pyrethroid hydrolase Ces2e-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
122106621  UDP-glucuronosyltransferase 2B15-like isoform X1 [KO:K00699] [EC:2.4.1.17]
122106622  UDP-glucuronosyltransferase 2B15-like isoform X1 [KO:K00699] [EC:2.4.1.17]
122106623  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
122106624  UDP-glucuronosyltransferase 2B15-like isoform X1 [KO:K00699] [EC:2.4.1.17]
122106641  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
122106682  UDP-glucuronosyltransferase 2A2 isoform X1 [KO:K00699] [EC:2.4.1.17]
122106689  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
122106690  UDP-glucuronosyltransferase 2B31-like isoform X1 [KO:K00699] [EC:2.4.1.17]
122106726  UDP-glucuronosyltransferase 2A3-like [KO:K00699] [EC:2.4.1.17]
122106780  UDP-glucuronosyltransferase 2B31-like isoform X1 [KO:K00699] [EC:2.4.1.17]
122106781  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
122106782  UDP-glucuronosyltransferase 2B31-like isoform X1 [KO:K00699] [EC:2.4.1.17]
122106783  UDP-glucuronosyltransferase 2B17-like isoform X1 [KO:K00699] [EC:2.4.1.17]
122106784  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
122106894  UDP-glucuronosyltransferase 2B15-like isoform X1 [KO:K00699] [EC:2.4.1.17]
122107325  UDP-glucuronosyltransferase 1-2-like [KO:K00699] [EC:2.4.1.17]
122107326  UDP-glucuronosyltransferase 1A5-like isoform X1 [KO:K00699] [EC:2.4.1.17]
122107524  UDP-glucuronosyltransferase 1A9-like [KO:K00699] [EC:2.4.1.17]
122107525  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 1A7-like [KO:K00699] [EC:2.4.1.17]
122114877  Gusb; beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
122115220  Cda; cytidine deaminase [KO:K01489] [EC:3.5.4.5]
122123562  thymidine phosphorylase [KO:K00758] [EC:2.4.2.4]
122106473  Dpyd; dihydropyrimidine dehydrogenase [NADP(+)] [KO:K00207] [EC:1.3.1.2]
122102462  Dpys; dihydropyrimidinase [KO:K01464] [EC:3.5.2.2]
122095934  Upb1; beta-ureidopropionase isoform X1 [KO:K01431] [EC:3.5.1.6]
122110810  Upp2; uridine phosphorylase 2 [KO:K00757] [EC:2.4.2.3]
122120758  uridine phosphorylase 1-like [KO:K00757] [EC:2.4.2.3]
122120777  Upp1; uridine phosphorylase 1 [KO:K00757] [EC:2.4.2.3]
122120849  uridine phosphorylase 1 isoform X1 [KO:K00757] [EC:2.4.2.3]
122120893  uridine phosphorylase 1-like [KO:K00757] [EC:2.4.2.3]
122106078  Uck2; uridine-cytidine kinase 2 [KO:K00876] [EC:2.7.1.48]
122108900  Uck1; uridine-cytidine kinase 1 [KO:K00876] [EC:2.7.1.48]
122101829  Uckl1; uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
122096587  Tk1; thymidine kinase, cytosolic [KO:K00857] [EC:2.7.1.21]
122126250  Tk2; thymidine kinase 2, mitochondrial [KO:K00857] [EC:2.7.1.21]
122098671  Umps; uridine 5'-monophosphate synthase isoform X1 [KO:K13421] [EC:2.4.2.10 4.1.1.23]
122105223  Cmpk1; UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
122115134  Rrm1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
122108782  Rrm2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
122102316  Rrm2b; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
122103691  Nme7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
122095679  Nme6; nucleoside diphosphate kinase 6 isoform X1 [KO:K00940] [EC:2.7.4.6]
122123774  Nme3; nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
122103199  nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
122103200  Nme1; nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
122127246  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like [KO:K01520] [EC:3.6.1.23]
122096441  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like [KO:K01520] [EC:3.6.1.23]
122114700  Dut; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial [KO:K01520] [EC:3.6.1.23]
122117268  LOW QUALITY PROTEIN: deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like [KO:K01520] [EC:3.6.1.23]
122119242  Mpo; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
122126233  arylamine N-acetyltransferase 2 [KO:K00622] [EC:2.3.1.5]
122126857  arylamine N-acetyltransferase 2-like [KO:K00622] [EC:2.3.1.5]
122126940  arylamine N-acetyltransferase 2-like [KO:K00622] [EC:2.3.1.5]
122095015  cytochrome P450 2E1-like [KO:K07415] [EC:1.14.14.-]
122095017  cytochrome P450 2E1-like [KO:K07415] [EC:1.14.14.-]
122127841  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
122127203  Mgst2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
122095885  glutathione S-transferase theta-4-like [KO:K00799] [EC:2.5.1.18]
122095930  glutathione S-transferase theta-3 [KO:K00799] [EC:2.5.1.18]
122095972  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
122106063  Mgst3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
122108196  Gstm3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
122108206  glutathione S-transferase Mu 4 [KO:K00799] [EC:2.5.1.18]
122108215  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
122108223  glutathione S-transferase Mu 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
122108253  glutathione S-transferase Mu 2 [KO:K00799] [EC:2.5.1.18]
122108258  LOW QUALITY PROTEIN: glutathione S-transferase Mu 4-like [KO:K00799] [EC:2.5.1.18]
122108271  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
122108287  glutathione S-transferase Mu 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
122115922  Gsto2; glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
122115966  Gsto1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
122101582  glutathione S-transferase A2-like isoform X1 [KO:K00799] [EC:2.5.1.18]
122101584  glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
122101585  glutathione S-transferase A3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
122101586  glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
122102713  Mgst1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
122105104  glutathione S-transferase P isoform X1 [KO:K23790] [EC:2.5.1.18]
122105105  glutathione S-transferase P-like isoform X1 [KO:K23790] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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