KEGG   PATHWAY: ecb03083
Entry
ecb03083                    Pathway                                
Name
Polycomb repressive complex - Equus caballus (horse)
Class
Genetic Information Processing; Chromosome
Pathway map
ecb03083  Polycomb repressive complex
ecb03083

Organism
Equus caballus (horse) [GN:ecb]
Gene
100052411  EZH1; histone-lysine N-methyltransferase EZH1 [KO:K17451] [EC:2.1.1.356]
100051290  EZH2; histone-lysine N-methyltransferase EZH2 isoform X1 [KO:K11430] [EC:2.1.1.356]
100061139  EED; polycomb protein EED isoform X1 [KO:K11462]
100071831  SUZ12; polycomb protein SUZ12 isoform X1 [KO:K11463]
100070175  RBBP4; histone-binding protein RBBP4 isoform X1 [KO:K10752]
100056761  RBBP7; histone-binding protein RBBP7 isoform X1 [KO:K11659]
100061619  PHF1; PHD finger protein 1 isoform X1 [KO:K11467]
100051293  MTF2; metal-response element-binding transcription factor 2 isoform X1 [KO:K11485]
100071777  PHF19; PHD finger protein 19 [KO:K11486]
100068588  EPOP; elongin BC and Polycomb repressive complex 2-associated protein [KO:K26259]
100070763  LCOR; ligand-dependent corepressor isoform X2 [KO:K26260]
100067927  AEBP2; zinc finger protein AEBP2 isoform X1 [KO:K17452]
100051819  JARID2; protein Jumonji isoform X2 [KO:K11478]
100051934  BAP1; ubiquitin carboxyl-terminal hydrolase BAP1 isoform X1 [KO:K08588] [EC:3.4.19.12]
100066642  ASXL3; LOW QUALITY PROTEIN: putative Polycomb group protein ASXL3 [KO:K11471]
100071411  ASXL2; putative Polycomb group protein ASXL2 isoform X1 [KO:K11471]
100053850  ASXL1; putative Polycomb group protein ASXL1 isoform X1 [KO:K11471]
100056148  OGT; UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1 [KO:K09667] [EC:2.4.1.255]
100058080  HCFC1; host cell factor 1 isoform X1 [KO:K14966]
100630389  YY1; transcriptional repressor protein YY1 [KO:K09201]
100049894  MBD5; methyl-CpG-binding domain protein 5 isoform X1 [KO:K23219]
100146477  MBD6; methyl-CpG-binding domain protein 6 isoform X4 [KO:K26585]
100056711  FOXK2; forkhead box protein K2 [KO:K09404]
100060644  FOXK1; LOW QUALITY PROTEIN: forkhead box protein K1 [KO:K09404]
100056141  RNF2; E3 ubiquitin-protein ligase RING2 [KO:K10695] [EC:2.3.2.27]
100061452  RING1; E3 ubiquitin-protein ligase RING1 [KO:K10695] [EC:2.3.2.27]
100055282  PCGF2; polycomb group RING finger protein 2 isoform X1 [KO:K11460]
102148742  polycomb complex protein BMI-1 [KO:K11459]
100056959  CBX2; chromobox protein homolog 2 [KO:K11451]
100146225  CBX4; E3 SUMO-protein ligase CBX4 [KO:K11452] [EC:2.3.2.-]
100055293  CBX6; chromobox protein homolog 6 [KO:K11453]
100070273  CBX7; chromobox protein homolog 7 isoform X1 [KO:K11454]
100050416  CBX8; chromobox protein homolog 8 [KO:K11455]
100053465  PHC1; polyhomeotic-like protein 1 isoform X1 [KO:K11456]
100070002  PHC2; polyhomeotic-like protein 2 isoform X2 [KO:K11457]
100057566  PHC3; polyhomeotic-like protein 3 isoform X1 [KO:K11458]
102148124  SCML1; sex comb on midleg-like protein 1 isoform X1 [KO:K11464]
100057593  SCML2; sex comb on midleg-like protein 2 [KO:K11465]
100067888  SCMH1; polycomb protein SCMH1 isoform X5 [KO:K11461]
100057049  SFMBT2; scm-like with four MBT domains protein 2 isoform X1 [KO:K26269]
100051403  SFMBT1; scm-like with four MBT domains protein 1 isoform X2 [KO:K26269]
100073050  AURKB; aurora kinase B isoform X1 [KO:K11479] [EC:2.7.11.1]
100062598  UBE2D1; ubiquitin-conjugating enzyme E2 D1 [KO:K06689] [EC:2.3.2.23]
100064918  UBE2D4; ubiquitin-conjugating enzyme E2 D4 isoform X1 [KO:K06689] [EC:2.3.2.23]
100630045  UBE2D2; ubiquitin-conjugating enzyme E2 D2 isoform X2 [KO:K06689] [EC:2.3.2.23]
100630481  UBE2D3; ubiquitin-conjugating enzyme E2 D3 isoform X3 [KO:K06689] [EC:2.3.2.23]
111771588  ubiquitin-conjugating enzyme E2 D2-like [KO:K06689] [EC:2.3.2.23]
100071616  USP45; ubiquitin carboxyl-terminal hydrolase 45 isoform X1 [KO:K11844] [EC:3.4.19.12]
100053798  USP16; ubiquitin carboxyl-terminal hydrolase 16 [KO:K11844] [EC:3.4.19.12]
100062395  RYBP; RING1 and YY1-binding protein [KO:K11469]
100054055  YAF2; YY1-associated factor 2 isoform X1 [KO:K11468]
100053783  PCGF1; polycomb group RING finger protein 1 isoform X2 [KO:K11487]
100059690  KDM2B; lysine-specific demethylase 2B isoform X1 [KO:K10276] [EC:1.14.11.27]
100052955  KDM2A; lysine-specific demethylase 2A isoform X2 [KO:K10276] [EC:1.14.11.27]
100050335  BCOR; BCL-6 corepressor isoform X1 [KO:K23215]
100054632  BCORL1; BCL-6 corepressor-like protein 1 isoform X1 [KO:K26199]
100062946  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
100057484  USP7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
100051730  PCGF3; polycomb group RING finger protein 3 [KO:K11488]
100062658  polycomb group RING finger protein 5 isoform X1 [KO:K11489]
100062041  PCGF5; polycomb group RING finger protein 5 isoform X1 [KO:K11489]
100058658  CSNK2B; casein kinase II subunit beta isoform X2 [KO:K03115]
100062562  AUTS2; autism susceptibility gene 2 protein isoform X1 [KO:K23214]
111767507  FBRS; probable fibrosin-1 [KO:K26253]
100061800  FBRSL1; LOW QUALITY PROTEIN: fibrosin-1-like protein [KO:K26254]
100054273  DCAF7; DDB1- and CUL4-associated factor 7 [KO:K11805]
100063401  TEX10; testis-expressed protein 10 isoform X1 [KO:K14827]
100055626  EP300; histone acetyltransferase p300 isoform X2 [KO:K04498] [EC:2.3.1.48]
100069613  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
100069783  PCGF6; polycomb group RING finger protein 6 isoform X2 [KO:K11470]
100072285  E2F6; transcription factor E2F6 isoform X1 [KO:K09390]
100069163  TFDP1; transcription factor Dp-1 [KO:K04683]
100062536  MAX; protein max isoform X2 [KO:K04453]
100056831  MGA; MAX gene-associated protein isoform X1 [KO:K23399]
100067448  L3MBTL3; lethal(3)malignant brain tumor-like protein 3 isoform X1 [KO:K24387]
100070590  L3MBTL2; lethal(3)malignant brain tumor-like protein 2 [KO:K24387]
100059405  L3MBTL4; LOW QUALITY PROTEIN: lethal(3)malignant brain tumor-like protein 4 [KO:K24387]
100054158  CBX3; chromobox protein homolog 3 isoform X1 [KO:K11586]
100070656  WDR5B; WD repeat-containing protein 5B [KO:K14963]
100069126  WDR5; WD repeat-containing protein 5 [KO:K14963]
100072578  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
100070281  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
Reference
PMID:21881606
  Authors
Richly H, Aloia L, Di Croce L
  Title
Roles of the Polycomb group proteins in stem cells and cancer.
  Journal
Cell Death Dis 2:e204 (2011)
DOI:10.1038/cddis.2011.84
Reference
PMID:28202673
  Authors
Chittock EC, Latwiel S, Miller TC, Muller CW
  Title
Molecular architecture of polycomb repressive complexes.
  Journal
Biochem Soc Trans 45:193-205 (2017)
DOI:10.1042/BST20160173
Reference
PMID:33202645
  Authors
Geng Z, Gao Z
  Title
Mammalian PRC1 Complexes: Compositional Complexity and Diverse Molecular Mechanisms.
  Journal
Int J Mol Sci 21:ijms21228594 (2020)
DOI:10.3390/ijms21228594
Reference
PMID:35681061
  Authors
Kim JJ, Kingston RE
  Title
Context-specific Polycomb mechanisms in development.
  Journal
Nat Rev Genet 23:680-695 (2022)
DOI:10.1038/s41576-022-00499-0
Reference
PMID:36076977
  Authors
Dong GJ, Xu JL, Qi YR, Yuan ZQ, Zhao W
  Title
Critical Roles of Polycomb Repressive Complexes in Transcription and Cancer.
  Journal
Int J Mol Sci 23:ijms23179574 (2022)
DOI:10.3390/ijms23179574
Reference
PMID:37086328
  Authors
Ryan CW, Peirent ER, Regan SL, Guxholli A, Bielas SL
  Title
H2A monoubiquitination: insights from human genetics and animal models.
  Journal
Hum Genet 10.1007/s00439-023-02557-x (2023)
DOI:10.1007/s00439-023-02557-x
KO pathway
ko03083   
LinkDB

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