KEGG   PATHWAY: elh00230
Entry
elh00230                    Pathway                                
Name
Purine metabolism - Escherichia coli O78:H11:K80 H10407 (ETEC)
Class
Metabolism; Nucleotide metabolism
Pathway map
elh00230  Purine metabolism
elh00230

Module
elh_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:elh00230]
elh_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:elh00230]
elh_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:elh00230]
elh_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:elh00230]
elh_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:elh00230]
elh_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:elh00230]
elh_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:elh00230]
Other DBs
GO: 0006163 0042278
Organism
Escherichia coli O78:H11:K80 H10407 (ETEC) [GN:elh]
Gene
ETEC_3306  ADP-ribose pyrophosphatase [KO:K01515] [EC:3.6.1.13 3.6.1.-]
ETEC_3647  ADP compounds hydrolase [KO:K08312] [EC:3.6.1.-]
ETEC_3630  metalloenzyme superfamily protein [KO:K01839] [EC:5.4.2.7]
ETEC_4739  phosphopentomutase [KO:K01839] [EC:5.4.2.7]
ETEC_0705  phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
ETEC_1311  ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
ETEC_2448  amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
ETEC_4264  phosphoribosylglycineamide synthetase [KO:K01945] [EC:6.3.4.13]
ETEC_2605  phosphoribosylglycinamide formyltransferase 1 [KO:K11175] [EC:2.1.2.2]
ETEC_1882  phosphoribosylglycinamide formyltransferase 2 [KO:K08289] [EC:6.3.1.21]
ETEC_2714  Phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
ETEC_2604  phosphoribosylaminoimidazole synthetase [KO:K01933] [EC:6.3.3.1]
ETEC_0574  phosphoribosylaminoimidazole carboxylase ATPase subunit [KO:K01589] [EC:6.3.4.18]
ETEC_0575  phosphoribosylaminoimidazole carboxylase catalytic subunit [KO:K01588] [EC:5.4.99.18]
ETEC_2581  phosphoribosylaminoimidazole-succinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
ETEC_1255  adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
ETEC_4265  bifunctional purine biosynthesis protein [includes phosphoribosylaminoimidazolecarboxamide formyltransferase; IMP cyclohydrolase] [KO:K00602] [EC:2.1.2.3 3.5.4.10]
ETEC_0521  adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
ETEC_0532  protein UshA precursor [includes: UDP-sugar hydrolase; 5'-nucleotidase] [KO:K11751] [EC:3.1.3.5 3.6.1.45]
ETEC_2935  multifunctional stationary-phase survival protein [includes: 5'/3'-nucleotidase; exopolyphosphatase] [KO:K03787] [EC:3.1.3.5 3.1.3.6]
ETEC_0692  putative N-acetylglucosamine metabolism protein [KO:K02566] [EC:3.1.3.5]
ETEC_3649  putative hydrolase [KO:K20881] [EC:3.1.3.-]
ETEC_0529  inosine-guanosine kinase [KO:K00892] [EC:2.7.1.73]
ETEC_2519  purine nucleoside phosphorylase II [KO:K03783] [EC:2.4.2.1]
ETEC_4740  purine nucleoside phosphorylase [KO:K03784] [EC:2.4.2.1]
ETEC_0444  conserved hypothetical protein [KO:K09913] [EC:2.4.2.1 2.4.2.2]
ETEC_2802  conserved hypothetical protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
ETEC_0121  hypoxanthine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
ETEC_2665  inosine-5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
ETEC_2675  ndk; putative nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
ETEC_4749  conserved hypothetical protein [KO:K01529] [EC:3.6.1.73]
ETEC_3144  conserved hypothetical protein [KO:K01519] [EC:3.6.1.66]
ETEC_0261  xanthine phosphoribosyltransferase [KO:K00769] [EC:2.4.2.22]
ETEC_3060  xanthine dehydrogenase molybdenum-binding subunit [KO:K00087] [EC:1.17.1.4]
ETEC_3061  xanthine dehydrogenase FAD-binding subunit [KO:K13479] [EC:1.17.1.4]
ETEC_3062  xanthine dehydrogenase iron-sulfur-binding subunit [KO:K13480]
ETEC_0341  putative xanthine dehydrogenase, molybdenum-binding subunit [KO:K11177] [EC:1.17.1.4]
ETEC_0342  putative xanthine dehydrogenase, FAD-binding subunit [KO:K11178] [EC:1.17.1.4]
ETEC_0343  putative xanthine dehydrogenase, iron-sulfur binding subunit [KO:K13483]
ETEC_2664  GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
ETEC_0101  GMP reductase [KO:K00364] [EC:1.7.1.7]
ETEC_3077  guanine deaminase [KO:K01487] [EC:3.5.4.3]
ETEC_3889  guanylate kinase [KO:K00942] [EC:2.7.4.8]
ETEC_2367  ribonucleoside-diphosphate reductase 1 alpha chain [KO:K00525] [EC:1.17.4.1]
ETEC_2872  ribonucleoside-diphosphate reductase 2 alpha chain [KO:K00525] [EC:1.17.4.1]
ETEC_2368  ribonucleoside-diphosphate reductase 1 beta chain [KO:K00526] [EC:1.17.4.1]
ETEC_2873  ribonucleoside-diphosphate reductase 2 beta chain [KO:K00526] [EC:1.17.4.1]
ETEC_4586  anaerobic ribonucleoside-triphosphate reductase [KO:K21636] [EC:1.1.98.6]
ETEC_0156  deoxyguanosinetriphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
ETEC_2426  5'-nucleotidase [KO:K08722] [EC:3.1.3.89]
ETEC_4312  conserved hypothetical protein [KO:K06952] [EC:3.1.3.89]
ETEC_0271  conserved hypothetical protein [KO:K06952] [EC:3.1.3.89]
ETEC_4679  conserved hypothetical protein [KO:K06952] [EC:3.1.3.89]
ETEC_3891  guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase [KO:K01139] [EC:2.7.6.5 3.1.7.2]
ETEC_4061  guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
ETEC_2607  exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
ETEC_2974  GTP pyrophosphokinase [KO:K00951] [EC:2.7.6.5]
ETEC_4085  adenylate cyclase [KO:K05851] [EC:4.6.1.1]
ETEC_4523  adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
ETEC_1657  adenosine deaminase [KO:K01488] [EC:3.5.4.4]
ETEC_2095  AMP nucleosidase [KO:K01241] [EC:3.2.2.4]
ETEC_2985  putative decarboxylase [KO:K06966] [EC:3.2.2.10 3.2.2.-]
ETEC_3959  adenine deaminase [KO:K01486] [EC:3.5.4.2]
ETEC_4566  2',3'-cyclic-nucleotide 2'-phosphodiesterase [KO:K01119] [EC:3.1.4.16 3.1.3.6]
ETEC_0526  adenylate kinase [KO:K00939] [EC:2.7.4.3]
ETEC_2973  nucleoside triphosphate pyrophosphohydrolase [KO:K04765] [EC:3.6.1.9]
ETEC_3304  putative phosphoesterase [KO:K03651] [EC:3.1.4.53]
ETEC_0049  bis(5'-nucleosyl)-tetraphosphatase [KO:K01525] [EC:3.6.1.41]
ETEC_2941  adenosine 5-phosphosulfate kinase [KO:K00860] [EC:2.7.1.25]
ETEC_2942  Sulfate adenylyltransferase subunit 1 [KO:K00956] [EC:2.7.7.4]
ETEC_2943  Sulfate adenylyltransferase subunit 2 [KO:K00957] [EC:2.7.7.4]
ETEC_2070  transthyretin-like protein [KO:K07127] [EC:3.5.2.17]
ETEC_0564  allantoinase [KO:K01466] [EC:3.5.2.5]
ETEC_0568  allantoate amidohydrolase [KO:K02083] [EC:3.5.3.9]
ETEC_0567  conserved hypothetical protein [KO:K14977] [EC:3.5.3.26]
ETEC_0558  ureidoglycolate hydrolase [KO:K01483] [EC:4.3.2.3]
ETEC_0569  ureidoglycolate dehydrogenase [KO:K00073] [EC:1.1.1.350]
ETEC_0380  carbamate kinase-like protein [KO:K00926] [EC:2.7.2.2]
ETEC_3068  carbamate kinase [KO:K00926] [EC:2.7.2.2]
ETEC_0573  carbamate kinase [KO:K00926] [EC:2.7.2.2]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
elh00030  Pentose phosphate pathway
elh00220  Arginine biosynthesis
elh00250  Alanine, aspartate and glutamate metabolism
elh00260  Glycine, serine and threonine metabolism
elh00340  Histidine metabolism
elh00630  Glyoxylate and dicarboxylate metabolism
elh00730  Thiamine metabolism
elh00740  Riboflavin metabolism
elh00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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