KEGG   PATHWAY: emc04514
Entry
emc04514                    Pathway                                
Name
Cell adhesion molecules - Eublepharis macularius (Leopard gecko)
Description
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
emc04514  Cell adhesion molecules
emc04514

Other DBs
GO: 0050839
Organism
Eublepharis macularius (Leopard gecko) [GN:emc]
Gene
129345552  CD58; lymphocyte function-associated antigen 3 isoform X1 [KO:K06492]
129326165  CD2; T-cell surface antigen CD2 [KO:K06449]
129331962  VSIR; V-type immunoglobulin domain-containing suppressor of T-cell activation [KO:K23268]
129334328  immunoglobulin superfamily member 11-like [KO:K06791]
129326154  IGSF11; LOW QUALITY PROTEIN: immunoglobulin superfamily member 11 [KO:K06791]
129326267  CD80; T-lymphocyte activation antigen CD80 [KO:K05412]
129324912  CD28; T-cell-specific surface glycoprotein CD28 [KO:K06470]
129324996  CTLA4; cytotoxic T-lymphocyte protein 4 [KO:K06538]
129325980  ICOSLG; ICOS ligand [KO:K06710]
129324885  uncharacterized protein LOC129324885 [KO:K06713]
129327984  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
129328039  mamu class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
129328040  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
129328041  rano class II histocompatibility antigen, A beta chain-like [KO:K06752]
129328043  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
129328044  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
129328045  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
129328487  H-2 class II histocompatibility antigen, E-S beta chain-like isoform X1 [KO:K06752]
129328493  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
129328494  H-2 class II histocompatibility antigen, E-S beta chain-like isoform X1 [KO:K06752]
129328495  H-2 class II histocompatibility antigen, E-S beta chain-like isoform X1 [KO:K06752]
129328497  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
129328498  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
129328499  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
129328500  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
129328502  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
129328503  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
129328504  HLA class II histocompatibility antigen, DR alpha chain-like isoform X1 [KO:K06752]
129328506  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
129328507  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
129328508  HLA class II histocompatibility antigen, DR alpha chain-like isoform X1 [KO:K06752]
129328509  SLA class II histocompatibility antigen, DQ haplotype C beta chain-like [KO:K06752]
129328511  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
129327021  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
129327024  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
129327434  HLA class II histocompatibility antigen, DR alpha chain-like isoform X1 [KO:K06752]
129339799  uncharacterized protein LOC129339799 [KO:K10784]
129328479  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
129327209  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
129327210  major histocompatibility complex class I-related gene protein-like [KO:K06751]
129327212  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
129334578  CD274; programmed cell death 1 ligand 1 isoform X1 [KO:K06708]
129345793  CD276; CD276 antigen [KO:K06746]
129332399  PDCD1; programmed cell death protein 1 [KO:K06744]
129329679  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
129341522  CD40LG; CD40 ligand [KO:K03161]
129326098  ALCAM; CD166 antigen isoform X1 [KO:K06547]
129324852  CD6; T-cell differentiation antigen CD6 isoform X1 [KO:K06456]
129333818  CD226; CD226 antigen [KO:K06567]
129343342  NECTIN2; nectin-2 isoform X1 [KO:K06531]
129338513  ITGAL; integrin alpha-L [KO:K05718]
129328095  ITGB2; integrin beta-2 [KO:K06464]
129331227  PTPRC; receptor-type tyrosine-protein phosphatase C isoform X1 [KO:K06478] [EC:3.1.3.48]
129336854  SIGLEC1; LOW QUALITY PROTEIN: sialoadhesin [KO:K06548]
129325696  NECTIN3; nectin-3 isoform X1 [KO:K06592]
129340129  claudin-9-like [KO:K06087]
129340130  claudin-4-like [KO:K06087]
129334761  CLDN23; claudin-23 [KO:K06087]
129340421  CLDN7; claudin-7 [KO:K06087]
129323334  CLDN20; claudin-20 [KO:K06087]
129340906  CLDN2; claudin-2 [KO:K06087]
129341629  CLDN5; claudin-5 [KO:K06087]
129342559  CLDN25; putative claudin-25 [KO:K06087]
129337156  claudin-22-like [KO:K06087]
129325936  CLDN10; claudin-10 isoform X1 [KO:K06087]
129326096  claudin-8-like [KO:K06087]
129332141  CLDN1; claudin-1 [KO:K06087]
129326540  CLDN14; claudin-14 [KO:K06087]
129326696  claudin-8-like [KO:K06087]
129332470  CLDN11; claudin-11 [KO:K06087]
129338426  CLDN15; claudin-15 isoform X1 [KO:K06087]
129332840  CLDN18; claudin-18 [KO:K06087]
129332874  CLDN16; claudin-16 [KO:K06087]
129332929  claudin-19-like [KO:K06087]
129344619  CLDN4; claudin-4 [KO:K06087]
129344766  CLDN19; claudin-19 [KO:K06087]
129344775  CLDN3; claudin-3 [KO:K06087]
129344784  claudin-3-like [KO:K06087]
129338043  CLDN12; claudin-12 [KO:K06087]
129334508  OCLN; occludin [KO:K06088]
129336051  occludin-like [KO:K06088]
129331124  occludin-like [KO:K06088]
129341315  F11R; junctional adhesion molecule A isoform X1 [KO:K06089]
129326504  JAM2; junctional adhesion molecule B isoform X1 [KO:K06735]
129342308  JAM3; junctional adhesion molecule C [KO:K06785]
129342550  ESAM; LOW QUALITY PROTEIN: endothelial cell-selective adhesion molecule [KO:K06787]
129344317  CDH5; cadherin-5 [KO:K06533]
129346196  PECAM1; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
129341685  CD99L2; CD99 antigen-like protein 2 isoform X1 [KO:K06520]
129325970  CD99 antigen-like isoform X1 [KO:K06520]
129326500  CD99 antigen-like [KO:K06520]
129331446  SELP; P-selectin isoform X1 [KO:K06496]
129325087  ITGA4; integrin alpha-4 [KO:K06483]
129337291  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
129338012  ITGA9; integrin alpha-9 [KO:K06585]
129330810  VCAM1; vascular cell adhesion protein 1 [KO:K06527]
129346169  ITGB7; integrin beta-7 [KO:K06590]
129331182  MADCAM1; mucosal addressin cell adhesion molecule 1 isoform X1 [KO:K06779]
129331176  CD34; hematopoietic progenitor cell antigen CD34 isoform X1 [KO:K06474]
129343825  GLG1; Golgi apparatus protein 1 isoform X1 [KO:K06816]
129330758  SELE; E-selectin [KO:K06494]
129342021  NECTIN1; nectin-1 [KO:K06081]
129333337  CDH2; cadherin-2 [KO:K06736]
129342018  NCAM1; neural cell adhesion molecule 1 isoform X1 [KO:K06491]
129325838  NCAM2; neural cell adhesion molecule 2 [KO:K06491]
129346150  L1CAM; neural cell adhesion molecule L1 [KO:K06550]
129342040  CADM1; cell adhesion molecule 1 isoform X1 [KO:K06781]
129330148  NEGR1; neuronal growth regulator 1 isoform X1 [KO:K06775]
129331313  NTNG1; netrin-G1 isoform X1 [KO:K07522]
129324960  LRRC4C; leucine-rich repeat-containing protein 4C [KO:K07523]
129342369  NTNG2; netrin-G2 isoform X1 [KO:K16359]
129335570  LRRC4; leucine-rich repeat-containing protein 4 [KO:K16351]
129329844  PTPRF; receptor-type tyrosine-protein phosphatase F isoform X1 [KO:K05695] [EC:3.1.3.48]
129340344  LRRC4B; leucine-rich repeat-containing protein 4B [KO:K16360]
129336113  SDC1; syndecan-1 [KO:K06257]
129333749  SDC2; syndecan-2 isoform X1 [KO:K16336]
129343311  SDC3; syndecan-3 [KO:K16337]
129330700  SDC4; syndecan-4 [KO:K16338]
129323943  ITGAV; integrin alpha-V [KO:K06487]
129337946  ITGB8; integrin beta-8 [KO:K06591]
129337844  ITGA8; integrin alpha-8 [KO:K06584]
129334083  NRXN1; neurexin-1 [KO:K07377]
129324622  NRXN3; neurexin 3 isoform X1 [KO:K07377]
129337170  NRXN2; neurexin-2-beta isoform X1 [KO:K07377]
129340361  NLGN2; neuroligin-2 isoform X1 [KO:K07378]
129341219  NLGN3; neuroligin-3 isoform X1 [KO:K07378]
129325795  NLGN4X; neuroligin-4, X-linked isoform X1 [KO:K07378]
129332158  NLGN1; neuroligin-1 isoform X1 [KO:K07378]
129330050  PTPRS; receptor-type tyrosine-protein phosphatase S [KO:K06778] [EC:3.1.3.48]
129326481  SLITRK1; SLIT and NTRK-like protein 1 [KO:K25832]
129341471  SLITRK2; SLIT and NTRK-like protein 2 [KO:K25833]
129341546  SLITRK4; SLIT and NTRK-like protein 4 [KO:K25835]
129326167  SLITRK5; SLIT and NTRK-like protein 5 [KO:K25836]
129326003  SLITRK6; SLIT and NTRK-like protein 6 [KO:K25837]
129334316  PTPRD; receptor-type tyrosine-protein phosphatase delta [KO:K06777] [EC:3.1.3.48]
129332514  SLITRK3; SLIT and NTRK-like protein 3 [KO:K25834]
129339025  CADM3; cell adhesion molecule 3 isoform X1 [KO:K06780]
129335451  NRCAM; neuronal cell adhesion molecule isoform X1 [KO:K06756]
129335341  CNTN1; contactin-1 [KO:K06759]
129333448  PTPRM; receptor-type tyrosine-protein phosphatase mu isoform X1 [KO:K05693] [EC:3.1.3.48]
129330213  CNTN2; contactin-2 [KO:K06760]
129331333  NFASC; neurofascin isoform X1 [KO:K06757]
129339081  CNTNAP1; contactin-associated protein 1 [KO:K07379]
129337304  CNTNAP2; contactin-associated protein-like 2 [KO:K07380]
129329514  MPZ; myelin protein P0 [KO:K06770]
129343464  MAG; myelin-associated glycoprotein isoform X1 [KO:K06771]
129344298  B-cadherin-like [KO:K05689]
129334778  VCAN; versican core protein [KO:K06793]
129323836  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
129344031  B-cadherin-like [KO:K06796]
129330432  CDH4; cadherin-4 [KO:K06797]
129343796  CDH15; cadherin-15 [KO:K06809]
129345204  NEO1; neogenin isoform X1 [KO:K06766]
Reference
PMID:14690046
  Authors
Barclay AN.
  Title
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
  Journal
Semin Immunol 15:215-23 (2003)
DOI:10.1016/S1044-5323(03)00047-2
Reference
PMID:11910893
  Authors
Sharpe AH, Freeman GJ.
  Title
The B7-CD28 superfamily.
  Journal
Nat Rev Immunol 2:116-26 (2002)
DOI:10.1038/nri727
Reference
PMID:9597126
  Authors
Grewal IS, Flavell RA.
  Title
CD40 and CD154 in cell-mediated immunity.
  Journal
Annu Rev Immunol 16:111-35 (1998)
DOI:10.1146/annurev.immunol.16.1.111
Reference
PMID:16034094
  Authors
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
  Title
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
  Journal
J Immunol 175:1558-65 (2005)
DOI:10.4049/jimmunol.175.3.1558
Reference
PMID:12234363
  Authors
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
  Title
Cell adhesion and polarity during immune interactions.
  Journal
Immunol Rev 186:68-82 (2002)
DOI:10.1034/j.1600-065X.2002.18607.x
Reference
PMID:15071551
  Authors
Dejana E.
  Title
Endothelial cell-cell junctions: happy together.
  Journal
Nat Rev Mol Cell Biol 5:261-70 (2004)
DOI:10.1038/nrm1357
Reference
PMID:14519386
  Authors
Bazzoni G.
  Title
The JAM family of junctional adhesion molecules.
  Journal
Curr Opin Cell Biol 15:525-30 (2003)
DOI:10.1016/S0955-0674(03)00104-2
Reference
PMID:10798271
  Authors
Becker BF, Heindl B, Kupatt C, Zahler S.
  Title
Endothelial function and hemostasis.
  Journal
Z Kardiol 89:160-7 (2000)
DOI:10.1007/PL00007320
Reference
PMID:9150551
  Authors
Elangbam CS, Qualls CW Jr, Dahlgren RR.
  Title
Cell adhesion molecules--update.
  Journal
Vet Pathol 34:61-73 (1997)
DOI:10.1177/030098589703400113
Reference
PMID:12810109
  Authors
Muller WA.
  Title
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
  Journal
Trends Immunol 24:327-34 (2003)
DOI:10.1016/S1471-4906(03)00117-0
Reference
PMID:14519398
  Authors
Yamagata M, Sanes JR, Weiner JA.
  Title
Synaptic adhesion molecules.
  Journal
Curr Opin Cell Biol 15:621-32 (2003)
DOI:10.1016/S0955-0674(03)00107-8
Reference
PMID:15882774
  Authors
Ethell IM, Pasquale EB.
  Title
Molecular mechanisms of dendritic spine development and remodeling.
  Journal
Prog Neurobiol 75:161-205 (2005)
DOI:10.1016/j.pneurobio.2005.02.003
Reference
PMID:11050419
  Authors
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
  Title
Making memories stick: cell-adhesion molecules in synaptic plasticity.
  Journal
Trends Cell Biol 10:473-82 (2000)
DOI:10.1016/S0962-8924(00)01838-9
Reference
PMID:11860281
  Authors
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
  Title
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
  Journal
Mol Cell Neurosci 19:292-306 (2002)
DOI:10.1006/mcne.2001.1071
Reference
PMID:10964748
  Authors
Dunican DJ, Doherty P.
  Title
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
  Journal
Mol Cell Biol Res Commun 3:255-63 (2000)
DOI:10.1006/mcbr.2000.0225
Reference
PMID:12367625
  Authors
Girault JA, Peles E.
  Title
Development of nodes of Ranvier.
  Journal
Curr Opin Neurobiol 12:476-85 (2002)
DOI:10.1016/S0959-4388(02)00370-7
Reference
PMID:10664064
  Authors
Arroyo EJ, Scherer SS.
  Title
On the molecular architecture of myelinated fibers.
  Journal
Histochem Cell Biol 113:1-18 (2000)
DOI:10.1007/s004180050001
Reference
PMID:14556710
  Authors
Salzer JL.
  Title
Polarized domains of myelinated axons.
  Journal
Neuron 40:297-318 (2003)
DOI:10.1016/S0896-6273(03)00628-7
Reference
PMID:15561584
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Reference
PMID:15551862
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
PMID:15115723
  Authors
Siu MK, Cheng CY.
  Title
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
  Journal
Biol Reprod 71:375-91 (2004)
DOI:10.1095/biolreprod.104.028225
Reference
PMID:15056568
  Authors
Lee NP, Cheng CY.
  Title
Adaptors, junction dynamics, and spermatogenesis.
  Journal
Biol Reprod 71:392-404 (2004)
DOI:10.1095/biolreprod.104.027268
Reference
PMID:15728677
  Authors
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
  Title
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
  Journal
Development 132:1525-37 (2005)
DOI:10.1242/dev.01697
Reference
PMID:12500939
  Authors
Marthiens V, Gavard J, Lambert M, Mege RM.
  Title
Cadherin-based cell adhesion in neuromuscular development.
  Journal
Biol Cell 94:315-26 (2002)
DOI:10.1016/S0248-4900(02)00005-9
Reference
PMID:15923648
  Authors
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
  Title
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
  Journal
J Cell Sci 118:2355-62 (2005)
DOI:10.1242/jcs.02397
Related
pathway
emc04520  Adherens junction
emc04530  Tight junction
KO pathway
ko04514   
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