KEGG   PATHWAY: fox00270
Entry
fox00270                    Pathway                                
Name
Cysteine and methionine metabolism - Fusarium oxysporum
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
fox00270  Cysteine and methionine metabolism
fox00270

Module
fox_M00017  Methionine biosynthesis, aspartate => homoserine => methionine [PATH:fox00270]
fox_M00035  Methionine degradation [PATH:fox00270]
fox_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:fox00270]
Other DBs
GO: 0006534 0006555
Organism
Fusarium oxysporum [GN:fox]
Gene
FOXG_00881  cysteine synthase A [KO:K01738] [EC:2.5.1.47]
FOXG_02128  cysteine synthase [KO:K01738] [EC:2.5.1.47]
FOXG_11296  O-acetylhomoserine (thiol)-lyase [KO:K17069] [EC:2.5.1.49 2.5.1.47]
FOXG_15240  O-acetylhomoserine (thiol)-lyase [KO:K17069] [EC:2.5.1.49 2.5.1.47]
FOXG_00214  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
FOXG_04200  cystathionine beta-lyase [KO:K01760] [EC:4.4.1.13]
FOXG_02418  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
FOXG_06028  homocysteine S-methyltransferase [KO:K00547] [EC:2.1.1.10]
FOXG_12759  5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase [KO:K00549] [EC:2.1.1.14]
FOXG_00630  S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]
FOXG_08982  adenosylmethionine decarboxylase [KO:K01611] [EC:4.1.1.50]
FOXG_18989  spermidine synthase [KO:K00797] [EC:2.5.1.16]
FOXG_03256  5'-methylthioadenosine phosphorylase [KO:K00772] [EC:2.4.2.28]
FOXG_08645  methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]
FOXG_00563  methylthioribulose-1-phosphate dehydratase [KO:K08964] [EC:4.2.1.109]
FOXG_10513  hypothetical protein [KO:K08967] [EC:1.13.11.53 1.13.11.54]
FOXG_00100  aromatic amino acid aminotransferase I [KO:K00838] [EC:2.6.1.57 2.6.1.39 2.6.1.27 2.6.1.5]
FOXG_05640  aromatic amino acid aminotransferase I [KO:K00838] [EC:2.6.1.57 2.6.1.39 2.6.1.27 2.6.1.5]
FOXG_09911  hypothetical protein [KO:K00838] [EC:2.6.1.57 2.6.1.39 2.6.1.27 2.6.1.5]
FOXG_05423  GAF protein [KO:K08968] [EC:1.8.4.14]
FOXG_03151  DNA (cytosine-5-)-methyltransferase [KO:K00558] [EC:2.1.1.37]
FOXG_12693  DNA (cytosine-5-)-methyltransferase [KO:K00558] [EC:2.1.1.37]
FOXG_09273  adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]
FOXG_10376  hypothetical protein [KO:K01505] [EC:3.5.99.7]
FOXG_08649  1-aminocyclopropane-1-carboxylate deaminase [KO:K01505] [EC:3.5.99.7]
FOXG_15247  hypothetical protein [KO:K00928] [EC:2.7.2.4]
FOXG_01470  aspartate kinase [KO:K00928] [EC:2.7.2.4]
FOXG_03301  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
FOXG_05956  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
FOXG_09225  homoserine O-acetyltransferase [KO:K00641] [EC:2.3.1.31 2.3.1.46]
FOXG_15243  homoserine O-acetyltransferase [KO:K00641] [EC:2.3.1.31 2.3.1.46]
FOXG_03640  hypothetical protein [KO:K01739] [EC:2.5.1.48]
FOXG_08167  cystathionine gamma-synthase [KO:K01739] [EC:2.5.1.48]
FOXG_00553  hypothetical protein [KO:K01739] [EC:2.5.1.48]
FOXG_13660  branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
FOXG_15207  hypothetical protein [KO:K00826] [EC:2.6.1.42]
FOXG_11975  branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
FOXG_06208  branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
FOXG_08699  branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
FOXG_05341  glutamate-cysteine ligase [KO:K11204] [EC:6.3.2.2]
FOXG_05369  hypothetical protein [KO:K11205]
FOXG_02149  glutathione synthetase [KO:K21456] [EC:6.3.2.3]
FOXG_08236  cysteine dioxygenase [KO:K00456] [EC:1.13.11.20]
FOXG_13311  cysteine dioxygenase [KO:K00456] [EC:1.13.11.20]
FOXG_18864  hypothetical protein [KO:K14454] [EC:2.6.1.1]
FOXG_08326  aspartate aminotransferase [KO:K14454] [EC:2.6.1.1]
FOXG_15613  hypothetical protein [KO:K14454] [EC:2.6.1.1]
FOXG_13157  aspartate aminotransferase [KO:K14454] [EC:2.6.1.1]
FOXG_02529  hypothetical protein [KO:K14454] [EC:2.6.1.1]
FOXG_10787  aspartate aminotransferase [KO:K14454] [EC:2.6.1.1]
FOXG_16069  hypothetical protein [KO:K14454] [EC:2.6.1.1]
FOXG_12671  aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
FOXG_11226  hypothetical protein [KO:K01011] [EC:2.8.1.1 2.8.1.2]
FOXG_16181  L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]
FOXG_16199  L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]
FOXG_06502  L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]
FOXG_06558  L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]
FOXG_16348  L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]
FOXG_22336  L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]
FOXG_22343  L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]
FOXG_22379  L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]
FOXG_22383  L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]
FOXG_22806  L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]
FOXG_07173  L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]
FOXG_19436  L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]
FOXG_19431  L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]
FOXG_06760  L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]
FOXG_06830  L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]
FOXG_07268  L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]
FOXG_06704  L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]
FOXG_06958  L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]
FOXG_07322  L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]
FOXG_14637  L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]
FOXG_10533  malate dehydrogenase, NAD-dependent [KO:K00026] [EC:1.1.1.37]
FOXG_10419  malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
FOXG_07483  malate dehydrogenase, NAD-dependent [KO:K00026] [EC:1.1.1.37]
FOXG_01638  hypothetical protein [KO:K17989] [EC:4.3.1.17 4.3.1.19]
FOXG_01425  D-3-phosphoglycerate dehydrogenase 2 [KO:K00058] [EC:1.1.1.95 1.1.1.399]
FOXG_06175  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
FOXG_07963  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
PMID:15102328
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
PMID:14551435
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
PMID:12022921
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
PMID:12670965
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
PMID:17169919
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
PMID:17030798
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
PMID:18625006
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
PMID:18391471
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
PMID:10613873
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
PMID:12644499
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
PMID:18520135
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19270684
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
fox00010  Glycolysis / Gluconeogenesis
fox00250  Alanine, aspartate and glutamate metabolism
fox00260  Glycine, serine and threonine metabolism
fox00290  Valine, leucine and isoleucine biosynthesis
fox00430  Taurine and hypotaurine metabolism
fox00480  Glutathione metabolism
fox00620  Pyruvate metabolism
fox00640  Propanoate metabolism
fox00770  Pantothenate and CoA biosynthesis
fox00900  Terpenoid backbone biosynthesis
fox00920  Sulfur metabolism
KO pathway
ko00270   
LinkDB

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