KEGG   PATHWAY: gacu04146
Entry
gacu04146                   Pathway                                
Name
Peroxisome - Gymnodraco acuticeps
Description
Peroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies.
Class
Cellular Processes; Transport and catabolism
Pathway map
gacu04146  Peroxisome
gacu04146

Other DBs
GO: 0005777
Organism
Gymnodraco acuticeps [GN:gacu]
Gene
117537431  pex3; peroxisomal biogenesis factor 3 [KO:K13336]
117540827  pex19; peroxisomal biogenesis factor 19 [KO:K13337]
117542832  abcd3a; ATP-binding cassette sub-family D member 3a isoform X1 [KO:K05677] [EC:7.6.2.4]
117562913  pex1; peroxisome biogenesis factor 1 [KO:K13338]
117535941  pex6; LOW QUALITY PROTEIN: peroxisome assembly factor 2 [KO:K13339]
117559156  pex26; peroxisome assembly protein 26 [KO:K13340]
117555086  pex5la; LOW QUALITY PROTEIN: PEX5-related protein [KO:K13342]
117549606  pex5; peroxisomal biogenesis factor 5 isoform X1 [KO:K13342]
117542067  pex14; peroxisomal membrane protein PEX14 [KO:K13343]
117551572  pex13; peroxisome biogenesis factor 13 [KO:K13344]
117533510  pex12; peroxisome assembly protein 12 isoform X1 [KO:K13345]
117547684  pex10; peroxisome biogenesis factor 10 isoform X1 [KO:K13346]
117551869  pex2; peroxisome biogenesis factor 2 [KO:K06664]
117561063  peroxisomal membrane protein 2-like [KO:K13347]
117536680  mpv17l2; mpv17-like protein 2 isoform X1 [KO:K13348]
117535931  mpv17; protein Mpv17 [KO:K13348]
117537289  mpv17-like protein [KO:K13349]
117533461  si:ch211-120k19.1; mpv17-like protein [KO:K13349]
117539848  mpv17-like protein [KO:K13349]
117539567  pxmp4; peroxisomal membrane protein 4 [KO:K13350]
117557644  pex11a; peroxisomal membrane protein 11A [KO:K13351]
117561840  pex11b; peroxisomal membrane protein 11B [KO:K13352]
117544247  pex11g; peroxisomal membrane protein 11C [KO:K13353]
117551992  slc25a17; peroxisomal membrane protein PMP34 [KO:K13354]
117548625  peroxisomal membrane protein PMP34 [KO:K13354]
117554061  hacl1; 2-hydroxyacyl-CoA lyase 1 [KO:K12261] [EC:4.1.2.63]
117555025  amacr; alpha-methylacyl-CoA racemase [KO:K01796] [EC:5.1.99.4]
117547168  phyh; phytanoyl-CoA dioxygenase, peroxisomal [KO:K00477] [EC:1.14.11.18]
117537963  acox1; peroxisomal acyl-coenzyme A oxidase 1 isoform X1 [KO:K00232] [EC:1.3.3.6]
117556564  acox3; LOW QUALITY PROTEIN: peroxisomal acyl-coenzyme A oxidase 3 [KO:K00232] [EC:1.3.3.6]
117560874  LOW QUALITY PROTEIN: peroxisomal multifunctional enzyme type 2-like [KO:K12405] [EC:1.1.1.- 4.2.1.107 4.2.1.119]
117545647  scp2a; non-specific lipid-transfer protein [KO:K08764] [EC:2.3.1.176]
117534190  bile acid-CoA:amino acid N-acyltransferase-like isoform X1 [KO:K00659] [EC:2.3.1.65 3.1.2.2]
117556838  ehhadh; peroxisomal bifunctional enzyme isoform X1 [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
117533558  acaa1; 3-ketoacyl-CoA thiolase, peroxisomal [KO:K07513] [EC:2.3.1.16]
117545098  decr2; peroxisomal 2,4-dienoyl-CoA reductase isoform X1 [KO:K13237] [EC:1.3.1.124]
117561902  ech1; LOW QUALITY PROTEIN: delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial [KO:K12663] [EC:5.3.3.21]
117558272  ATP-binding cassette sub-family D member 2-like [KO:K05676] [EC:7.6.2.4]
117533786  abcd4; ATP-binding cassette sub-family D member 4 [KO:K05678] [EC:7.6.2.8]
117538926  very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
117538966  very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
117549289  very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
117549290  very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
117550372  long-chain-fatty-acid--CoA ligase 1-like isoform X1 [KO:K01897] [EC:6.2.1.3]
117550706  acsl4a; long-chain-fatty-acid--CoA ligase 4 [KO:K01897] [EC:6.2.1.3]
117532677  acsl3b; long-chain-fatty-acid--CoA ligase 3b [KO:K01897] [EC:6.2.1.3]
117537751  acsl1a; long-chain-fatty-acid--CoA ligase 1a isoform X1 [KO:K01897] [EC:6.2.1.3]
117540112  acsl6; long-chain-fatty-acid--CoA ligase 6 isoform X1 [KO:K01897] [EC:6.2.1.3]
117547377  acsl5; long-chain-fatty-acid--CoA ligase 5 [KO:K01897] [EC:6.2.1.3]
117534513  long-chain-fatty-acid--CoA ligase 3-like [KO:K01897] [EC:6.2.1.3]
117561109  acsl2; long-chain-fatty-acid--CoA ligase 1 [KO:K01897] [EC:6.2.1.3]
117556639  pecr; peroxisomal trans-2-enoyl-CoA reductase isoform X1 [KO:K07753] [EC:1.3.1.38]
117560631  eci2; enoyl-CoA delta isomerase 2, mitochondrial [KO:K13239] [EC:5.3.3.8]
117545732  nudt7; LOW QUALITY PROTEIN: peroxisomal coenzyme A diphosphatase NUDT7 [KO:K17879] [EC:3.6.1.77]
117555373  nudt12; peroxisomal NADH pyrophosphatase NUDT12 [KO:K03426] [EC:3.6.1.22]
117556682  nudt19; LOW QUALITY PROTEIN: nucleoside diphosphate-linked moiety X motif 19 [KO:K13355] [EC:3.6.1.77]
117560402  acot8; acyl-coenzyme A thioesterase 8 [KO:K11992] [EC:3.1.2.27]
117543934  zgc:154046; carnitine O-acetyltransferase [KO:K00624] [EC:2.3.1.7]
117542573  cratb; carnitine O-acetyltransferase b isoform X1 [KO:K00624] [EC:2.3.1.7]
117558194  carnitine O-acetyltransferase-like [KO:K00624] [EC:2.3.1.7]
117561311  carnitine O-acetyltransferase-like [KO:K00624] [EC:2.3.1.7]
117554056  peroxisomal carnitine O-octanoyltransferase-like isoform X1 [KO:K05940] [EC:2.3.1.137]
117561848  mlycd; malonyl-CoA decarboxylase, mitochondrial [KO:K01578] [EC:4.1.1.9]
117538559  si:ch73-21k16.5; dihydroxyacetone phosphate acyltransferase isoform X1 [KO:K00649] [EC:2.3.1.42]
117535639  gnpat; dihydroxyacetone phosphate acyltransferase [KO:K00649] [EC:2.3.1.42]
117544393  agps; alkyldihydroxyacetonephosphate synthase, peroxisomal [KO:K00803] [EC:2.5.1.26]
117553228  far1; fatty acyl-CoA reductase 1 isoform X1 [KO:K13356] [EC:1.2.1.84]
117559163  si:dkey-97m3.1; fatty acyl-CoA reductase 1 [KO:K13356] [EC:1.2.1.84]
117535768  mvk; mevalonate kinase isoform X1 [KO:K00869] [EC:2.7.1.36]
117557012  pmvk; LOW QUALITY PROTEIN: phosphomevalonate kinase [KO:K13273] [EC:2.7.4.2]
117558463  agxtb; alanine--glyoxylate and serine--pyruvate aminotransferase b isoform X1 [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
117559052  agxta; alanine--glyoxylate and serine--pyruvate aminotransferase a [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
117561018  D-amino-acid oxidase-like [KO:K00273] [EC:1.4.3.3]
117553820  LOW QUALITY PROTEIN: D-aspartate oxidase-like [KO:K00272] [EC:1.4.3.1]
117557677  idh2; isocitrate dehydrogenase [NADP], mitochondrial [KO:K00031] [EC:1.1.1.42]
117533017  isocitrate dehydrogenase [NADP], mitochondrial-like [KO:K00031] [EC:1.1.1.42]
117549688  idh1; isocitrate dehydrogenase [NADP] cytoplasmic [KO:K00031] [EC:1.1.1.42]
117536785  peroxisomal N(1)-acetyl-spermine/spermidine oxidase-like [KO:K00308] [EC:1.5.3.13]
117539640  pipox; peroxisomal sarcosine oxidase isoform X1 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
117536858  hmgcll1; 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic isoform X1 [KO:K01640] [EC:4.1.3.4]
117550102  hmgcl; hydroxymethylglutaryl-CoA lyase, mitochondrial isoform X1 [KO:K01640] [EC:4.1.3.4]
117536551  hao2; hydroxyacid oxidase 2 isoform X1 [KO:K11517] [EC:1.1.3.15]
117560061  hao1; hydroxyacid oxidase 1 [KO:K11517] [EC:1.1.3.15]
117559381  cat; catalase [KO:K03781] [EC:1.11.1.6]
117553015  prdx5; peroxiredoxin-5, mitochondrial [KO:K11187] [EC:1.11.1.24]
117536942  sod1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
117556343  sod2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
117537301  prdx2; peroxiredoxin-2 [KO:K13279] [EC:1.11.1.24]
117545645  prdx1; peroxiredoxin-1 [KO:K13279] [EC:1.11.1.24]
117543225  glutathione S-transferase kappa 1-like [KO:K13299] [EC:2.5.1.18]
117543226  glutathione S-transferase kappa 1-like [KO:K13299] [EC:2.5.1.18]
117543227  glutathione S-transferase kappa 1-like [KO:K13299] [EC:2.5.1.18]
117543230  glutathione S-transferase kappa 1-like [KO:K13299] [EC:2.5.1.18]
117539241  dhrs4; dehydrogenase/reductase SDR family member 4 [KO:K11147] [EC:1.1.-.-]
Reference
PMID:17055078
  Authors
Wanders RJ, Waterham HR
  Title
Peroxisomal disorders: the single peroxisomal enzyme deficiencies.
  Journal
Biochim Biophys Acta 1763:1707-20 (2006)
DOI:10.1016/j.bbamcr.2006.08.010
Reference
PMID:17055079
  Authors
Steinberg SJ, Dodt G, Raymond GV, Braverman NE, Moser AB, Moser HW
  Title
Peroxisome biogenesis disorders.
  Journal
Biochim Biophys Acta 1763:1733-48 (2006)
DOI:10.1016/j.bbamcr.2006.09.010
Reference
PMID:17010456
  Authors
Rottensteiner H, Theodoulou FL
  Title
The ins and outs of peroxisomes: co-ordination of membrane transport and peroxisomal metabolism.
  Journal
Biochim Biophys Acta 1763:1527-40 (2006)
DOI:10.1016/j.bbamcr.2006.08.012
Reference
PMID:16631601
  Authors
Iida R, Yasuda T, Tsubota E, Takatsuka H, Matsuki T, Kishi K
  Title
Human Mpv17-like protein is localized in peroxisomes and regulates expression of antioxidant enzymes.
  Journal
Biochem Biophys Res Commun 344:948-54 (2006)
DOI:10.1016/j.bbrc.2006.04.008
Related
pathway
gacu00071  Fatty acid degradation
gacu00120  Primary bile acid biosynthesis
gacu00230  Purine metabolism
gacu00564  Glycerophospholipid metabolism
gacu00565  Ether lipid metabolism
gacu00830  Retinol metabolism
gacu00900  Terpenoid backbone biosynthesis
gacu03320  PPAR signaling pathway
KO pathway
ko04146   
LinkDB

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