KEGG   PATHWAY: ghi00260
Entry
ghi00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Gossypium hirsutum (upland cotton)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
ghi00260  Glycine, serine and threonine metabolism
ghi00260

Module
ghi_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:ghi00260]
ghi_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:ghi00260]
ghi_M00555  Betaine biosynthesis, choline => betaine [PATH:ghi00260]
ghi_M00621  Glycine cleavage system [PATH:ghi00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Gossypium hirsutum (upland cotton) [GN:ghi]
Gene
107924660  aspartokinase 2, chloroplastic [KO:K00928] [EC:2.7.2.4]
107934909  aspartokinase 2, chloroplastic isoform X1 [KO:K00928] [EC:2.7.2.4]
107912377  aspartokinase 2, chloroplastic isoform X1 [KO:K00928] [EC:2.7.2.4]
107935849  aspartokinase 2, chloroplastic isoform X1 [KO:K00928] [EC:2.7.2.4]
107928365  bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic [KO:K12524] [EC:2.7.2.4 1.1.1.3]
107909137  bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic [KO:K12524] [EC:2.7.2.4 1.1.1.3]
107920710  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
107913502  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
107938728  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
107940824  homoserine kinase-like [KO:K00872] [EC:2.7.1.39]
107908983  homoserine kinase-like [KO:K00872] [EC:2.7.1.39]
107958770  threonine synthase 1, chloroplastic [KO:K01733] [EC:4.2.3.1]
107901092  threonine synthase 1, chloroplastic-like [KO:K01733] [EC:4.2.3.1]
107897428  threonine synthase, chloroplastic [KO:K01733] [EC:4.2.3.1]
107916403  threonine synthase, chloroplastic-like [KO:K01733] [EC:4.2.3.1]
107907118  threonine synthase 1, chloroplastic [KO:K01733] [EC:4.2.3.1]
107889605  probable low-specificity L-threonine aldolase 1 isoform X1 [KO:K01620] [EC:4.1.2.48]
107893194  probable low-specificity L-threonine aldolase 1 [KO:K01620] [EC:4.1.2.48]
107936772  probable low-specificity L-threonine aldolase 1 [KO:K01620] [EC:4.1.2.48]
107926773  probable low-specificity L-threonine aldolase 1 isoform X3 [KO:K01620] [EC:4.1.2.48]
107962949  probable low-specificity L-threonine aldolase 1 isoform X2 [KO:K01620] [EC:4.1.2.48]
121223477  probable low-specificity L-threonine aldolase 1 [KO:K01620] [EC:4.1.2.48]
107942782  serine hydroxymethyltransferase 7 [KO:K00600] [EC:2.1.2.1]
107905031  serine hydroxymethyltransferase 7 [KO:K00600] [EC:2.1.2.1]
107910342  serine hydroxymethyltransferase 2, mitochondrial [KO:K00600] [EC:2.1.2.1]
107951434  serine hydroxymethyltransferase 7 isoform X1 [KO:K00600] [EC:2.1.2.1]
107924076  LOW QUALITY PROTEIN: serine hydroxymethyltransferase 7 [KO:K00600] [EC:2.1.2.1]
107908767  serine hydroxymethyltransferase 6 [KO:K00600] [EC:2.1.2.1]
107962865  serine hydroxymethyltransferase 3, chloroplastic isoform X1 [KO:K00600] [EC:2.1.2.1]
107927934  serine hydroxymethyltransferase 6-like [KO:K00600] [EC:2.1.2.1]
107890500  serine hydroxymethyltransferase 4 [KO:K00600] [EC:2.1.2.1]
107914785  serine hydroxymethyltransferase 4 [KO:K00600] [EC:2.1.2.1]
107906992  serine hydroxymethyltransferase 3, chloroplastic [KO:K00600] [EC:2.1.2.1]
107891834  serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
107901493  serine hydroxymethyltransferase 3, chloroplastic [KO:K00600] [EC:2.1.2.1]
107901893  serine hydroxymethyltransferase 1, mitochondrial [KO:K00600] [EC:2.1.2.1]
107910588  serine hydroxymethyltransferase 7 [KO:K00600] [EC:2.1.2.1]
107943813  serine hydroxymethyltransferase 4-like [KO:K00600] [EC:2.1.2.1]
107952202  serine hydroxymethyltransferase 2, mitochondrial [KO:K00600] [EC:2.1.2.1]
121222201  serine hydroxymethyltransferase 4 [KO:K00600] [EC:2.1.2.1]
107891094  serine hydroxymethyltransferase 6-like [KO:K00600] [EC:2.1.2.1]
107939451  serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
107945155  serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
107959294  serine--glyoxylate aminotransferase-like [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
107906707  serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
107921219  glycerate dehydrogenase [KO:K15893] [EC:1.1.1.29]
107947132  glycerate dehydrogenase [KO:K15893] [EC:1.1.1.29]
107929297  glyoxylate/hydroxypyruvate reductase HPR3 [KO:K15919] [EC:1.1.1.79 1.1.1.81]
107929296  glyoxylate/hydroxypyruvate reductase HPR3 [KO:K15919] [EC:1.1.1.79 1.1.1.81]
107954583  glyoxylate/hydroxypyruvate reductase HPR3-like isoform X2 [KO:K15919] [EC:1.1.1.79 1.1.1.81]
107963690  glyoxylate/hydroxypyruvate reductase HPR3-like [KO:K15919] [EC:1.1.1.79 1.1.1.81]
107963691  glyoxylate/hydroxypyruvate reductase HPR3 [KO:K15919] [EC:1.1.1.79 1.1.1.81]
107941083  glyoxylate/hydroxypyruvate/pyruvate reductase 2KGR [KO:K15919] [EC:1.1.1.79 1.1.1.81]
107906523  glyoxylate/hydroxypyruvate/pyruvate reductase 2KGR [KO:K15919] [EC:1.1.1.79 1.1.1.81]
107936430  glyoxylate/hydroxypyruvate reductase HPR3-like isoform X1 [KO:K15919] [EC:1.1.1.79 1.1.1.81]
107949200  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 1-like [KO:K01834] [EC:5.4.2.11]
107962433  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 1-like [KO:K01834] [EC:5.4.2.11]
107905043  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 1-like [KO:K01834] [EC:5.4.2.11]
107957731  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
107945412  phosphoglycerate mutase-like protein 4 [KO:K15634] [EC:5.4.2.11]
107913202  phosphoglycerate mutase-like protein 4 isoform X1 [KO:K15634] [EC:5.4.2.11]
107897819  phosphoglycerate mutase-like protein 4 isoform X1 [KO:K15634] [EC:5.4.2.11]
107927473  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
107910752  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
107902893  2,3-bisphosphoglycerate-independent phosphoglycerate mutase isoform X1 [KO:K15633] [EC:5.4.2.12]
107915995  2,3-bisphosphoglycerate-independent phosphoglycerate mutase-like [KO:K15633] [EC:5.4.2.12]
107951353  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
107906497  D-glycerate 3-kinase, chloroplastic [KO:K15918] [EC:2.7.1.31]
107940949  D-glycerate 3-kinase, chloroplastic [KO:K15918] [EC:2.7.1.31]
107949570  D-glycerate 3-kinase, chloroplastic [KO:K15918] [EC:2.7.1.31]
107951854  D-glycerate 3-kinase, chloroplastic-like [KO:K15918] [EC:2.7.1.31]
107894299  D-3-phosphoglycerate dehydrogenase 1, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
107945142  D-3-phosphoglycerate dehydrogenase 1, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
107930587  D-3-phosphoglycerate dehydrogenase 3, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
107938153  D-3-phosphoglycerate dehydrogenase 1, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
107943858  D-3-phosphoglycerate dehydrogenase 1, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
121218179  D-3-phosphoglycerate dehydrogenase 3, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
121228261  D-3-phosphoglycerate dehydrogenase 1, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
107953378  D-3-phosphoglycerate dehydrogenase 1, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
107955090  phosphoserine aminotransferase 2, chloroplastic [KO:K00831] [EC:2.6.1.52]
107955620  phosphoserine aminotransferase 2, chloroplastic [KO:K00831] [EC:2.6.1.52]
107941439  phosphoserine phosphatase, chloroplastic isoform X1 [KO:K01079] [EC:3.1.3.3]
107948997  phosphoserine phosphatase, chloroplastic [KO:K01079] [EC:3.1.3.3]
107962834  phosphoserine phosphatase-like isoform X1 [KO:K01079] [EC:3.1.3.3]
107899356  phosphoserine phosphatase, chloroplastic-like isoform X1 [KO:K01079] [EC:3.1.3.3]
107953478  phosphoserine phosphatase, chloroplastic isoform X1 [KO:K01079] [EC:3.1.3.3]
107949638  copper methylamine oxidase [KO:K00276] [EC:1.4.3.21]
107886210  copper methylamine oxidase [KO:K00276] [EC:1.4.3.21]
107922409  copper methylamine oxidase [KO:K00276] [EC:1.4.3.21]
107946240  copper methylamine oxidase [KO:K00276] [EC:1.4.3.21]
107928693  copper methylamine oxidase [KO:K00276] [EC:1.4.3.21]
107931297  primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
107895118  primary amine oxidase [KO:K00276] [EC:1.4.3.21]
107928452  primary amine oxidase 1 [KO:K00276] [EC:1.4.3.21]
107963669  LOW QUALITY PROTEIN: primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
107927763  primary amine oxidase [KO:K00276] [EC:1.4.3.21]
121214757  primary amine oxidase-like isoform X1 [KO:K00276] [EC:1.4.3.21]
107962876  glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
107958881  glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
107907004  glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
121218502  glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
107958283  aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
107962001  aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
107900587  aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
107905916  aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
107892112  dihydrolipoyl dehydrogenase 2, chloroplastic isoform X1 [KO:K00382] [EC:1.8.1.4]
107888950  dihydrolipoyl dehydrogenase 2, chloroplastic isoform X1 [KO:K00382] [EC:1.8.1.4]
107943359  dihydrolipoyl dehydrogenase 2, chloroplastic [KO:K00382] [EC:1.8.1.4]
107951589  dihydrolipoyl dehydrogenase 1, mitochondrial [KO:K00382] [EC:1.8.1.4]
107926533  dihydrolipoyl dehydrogenase 2, chloroplastic [KO:K00382] [EC:1.8.1.4]
107910553  dihydrolipoyl dehydrogenase 1, mitochondrial [KO:K00382] [EC:1.8.1.4]
107924637  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
107933689  glycine cleavage system H protein, mitochondrial [KO:K02437]
107928653  glycine cleavage system H protein 2, mitochondrial [KO:K02437]
107945219  glycine cleavage system H protein 2, mitochondrial [KO:K02437]
107912193  glycine cleavage system H protein, mitochondrial [KO:K02437]
121223358  glycine cleavage system H protein, mitochondrial [KO:K02437]
107928548  alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
107914378  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
107935989  alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
107914562  alanine--glyoxylate aminotransferase 2 homolog 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
107903538  alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
107896807  alanine--glyoxylate aminotransferase 2 homolog 2, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
121206319  alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
121208248  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
107909695  glutamate--glyoxylate aminotransferase 2 [KO:K14272] [EC:2.6.1.4 2.6.1.2 2.6.1.44]
121219607  glutamate--glyoxylate aminotransferase 2 [KO:K14272] [EC:2.6.1.4 2.6.1.2 2.6.1.44]
107892700  uncharacterized protein LOC107892700 [KO:K00499] [EC:1.14.15.7]
107904302  choline monooxygenase, chloroplastic isoform X1 [KO:K00499] [EC:1.14.15.7]
107931614  choline monooxygenase, chloroplastic isoform X2 [KO:K00499] [EC:1.14.15.7]
107912041  betaine aldehyde dehydrogenase 1, chloroplastic [KO:K00130] [EC:1.2.1.8]
107924276  betaine aldehyde dehydrogenase 1, chloroplastic isoform X1 [KO:K00130] [EC:1.2.1.8]
107926694  betaine aldehyde dehydrogenase 1, chloroplastic [KO:K00130] [EC:1.2.1.8]
107953542  betaine aldehyde dehydrogenase 1, chloroplastic [KO:K00130] [EC:1.2.1.8]
107900603  aldehyde dehydrogenase family 7 member B4 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
107962338  probable sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
107901637  probable sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
107890152  threonine dehydratase biosynthetic, chloroplastic [KO:K01754] [EC:4.3.1.19]
107907693  threonine dehydratase biosynthetic, chloroplastic-like [KO:K01754] [EC:4.3.1.19]
107899512  threonine dehydratase biosynthetic, chloroplastic [KO:K01754] [EC:4.3.1.19]
107947019  serine racemase [KO:K12235] [EC:5.1.1.18]
107894099  serine racemase-like [KO:K12235] [EC:5.1.1.18]
107936474  tryptophan synthase alpha chain isoform X1 [KO:K01695] [EC:4.2.1.20]
107940215  tryptophan synthase alpha chain isoform X1 [KO:K01695] [EC:4.2.1.20]
107961973  tryptophan synthase beta chain 1-like isoform X1 [KO:K01696] [EC:4.2.1.20]
107919875  tryptophan synthase beta chain 1 [KO:K01696] [EC:4.2.1.20]
121202926  tryptophan synthase beta chain 1 [KO:K01696] [EC:4.2.1.20]
121203179  tryptophan synthase beta chain 1-like [KO:K01696] [EC:4.2.1.20]
107895427  tryptophan synthase beta chain 2 isoform X1 [KO:K06001] [EC:4.2.1.20]
107912895  tryptophan synthase beta chain 2 isoform X1 [KO:K06001] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
ghi00010  Glycolysis / Gluconeogenesis
ghi00020  Citrate cycle (TCA cycle)
ghi00230  Purine metabolism
ghi00250  Alanine, aspartate and glutamate metabolism
ghi00270  Cysteine and methionine metabolism
ghi00290  Valine, leucine and isoleucine biosynthesis
ghi00300  Lysine biosynthesis
ghi00330  Arginine and proline metabolism
ghi00460  Cyanoamino acid metabolism
ghi00470  D-Amino acid metabolism
ghi00564  Glycerophospholipid metabolism
ghi00600  Sphingolipid metabolism
ghi00620  Pyruvate metabolism
ghi00630  Glyoxylate and dicarboxylate metabolism
ghi00640  Propanoate metabolism
ghi00860  Porphyrin metabolism
ghi00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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