KEGG   PATHWAY: gor00260
Entry
gor00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Gordonia sp. KTR9
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
gor00260  Glycine, serine and threonine metabolism
gor00260

Module
gor_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:gor00260]
gor_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:gor00260]
gor_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:gor00260]
gor_M00555  Betaine biosynthesis, choline => betaine [PATH:gor00260]
gor_M00621  Glycine cleavage system [PATH:gor00260]
gor_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:gor00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Gordonia sp. KTR9 [GN:gor]
Gene
KTR9_0387  Aspartokinase [KO:K00928] [EC:2.7.2.4]
KTR9_0388  Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
KTR9_1848  Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
KTR9_1850  Homoserine kinase [KO:K00872] [EC:2.7.1.39]
KTR9_1849  Threonine synthase [KO:K01733] [EC:4.2.3.1]
KTR9_1624  Glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
KTR9_1858  Glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
KTR9_4292  Glycerate kinase [KO:K00865] [EC:2.7.1.165]
KTR9_3058  Glycerate kinase [KO:K00865] [EC:2.7.1.165]
KTR9_0895  Phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
KTR9_3262  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
KTR9_1162  Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
KTR9_3321  Phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
KTR9_2560  Threonine dehydrogenase [KO:K00060] [EC:1.1.1.103]
KTR9_2645  Glycine cleavage system, glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
KTR9_3063  Glycine cleavage system T protein (aminomethyltransferase) [KO:K00605] [EC:2.1.2.10]
KTR9_0639  putative 2-oxoisovalerate dehydrogenase, dihydrolipoamide dehydrogenase component [KO:K00382] [EC:1.8.1.4]
KTR9_2650  Glycine cleavage system H protein (lipoate-binding) [KO:K02437]
KTR9_0578  Phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
KTR9_0772  putative octanol dehydrogenase [KO:K17755] [EC:1.1.3.17]
KTR9_0773  NAD-dependent aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
KTR9_1197  Rieske (2Fe-2S) iron-sulfur domain protein [KO:K00479] [EC:1.14.13.251]
KTR9_1196  Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [KO:K21832] [EC:1.14.13.251]
KTR9_1190  FAD dependent oxidoreductase [KO:K00309] [EC:1.5.3.10]
KTR9_0614  D-amino acid oxidase [KO:K00301] [EC:1.5.3.1]
KTR9_1193  sarcosine oxidase, alpha subunit [KO:K00302] [EC:1.5.3.24 1.5.3.1]
KTR9_1195  sarcosine oxidase, beta subunit [KO:K00303] [EC:1.5.3.24 1.5.3.1]
KTR9_1192  Sarcosine oxidase, gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
KTR9_1194  Sarcosine oxidase, delta subunit [KO:K00304] [EC:1.5.3.24 1.5.3.1]
KTR9_1593  putative cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
KTR9_1198  L-serine deaminase [KO:K01752] [EC:4.3.1.17]
KTR9_1598  Threonine dehydratase [KO:K01754] [EC:4.3.1.19]
KTR9_1688  Threonine dehydratase [KO:K01754] [EC:4.3.1.19]
KTR9_2985  Threonine dehydratase [KO:K01754] [EC:4.3.1.19]
KTR9_2941  indoleglycerol phosphate aldolase [KO:K01695] [EC:4.2.1.20]
KTR9_2942  Tryptophan synthase [KO:K01696] [EC:4.2.1.20]
KTR9_4634  pyridoxal-phosphate dependent TrpB-like enzyme [KO:K06001] [EC:4.2.1.20]
KTR9_1995  L-2,4-diaminobutyric aminotransferase [KO:K00836] [EC:2.6.1.76]
KTR9_1996  L-2,4-diaminobutyric acid acetyltransferase [KO:K06718] [EC:2.3.1.178]
KTR9_1994  L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
KTR9_4109  hydroxylase [KO:K10674] [EC:1.14.11.55]
KTR9_0499  pyridoxal-dependent decarboxylase [KO:K13745] [EC:4.1.1.86]
KTR9_4008  Xaa-Pro aminopeptidase [KO:K15783] [EC:3.5.4.44]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
gor00010  Glycolysis / Gluconeogenesis
gor00020  Citrate cycle (TCA cycle)
gor00230  Purine metabolism
gor00250  Alanine, aspartate and glutamate metabolism
gor00270  Cysteine and methionine metabolism
gor00290  Valine, leucine and isoleucine biosynthesis
gor00300  Lysine biosynthesis
gor00330  Arginine and proline metabolism
gor00460  Cyanoamino acid metabolism
gor00470  D-Amino acid metabolism
gor00564  Glycerophospholipid metabolism
gor00600  Sphingolipid metabolism
gor00620  Pyruvate metabolism
gor00630  Glyoxylate and dicarboxylate metabolism
gor00640  Propanoate metabolism
gor00680  Methane metabolism
gor00860  Porphyrin metabolism
gor00920  Sulfur metabolism
KO pathway
ko00260   
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