KEGG   PATHWAY: hhv03083
Entry
hhv03083                    Pathway                                
Name
Polycomb repressive complex - Hyaena hyaena (striped hyena)
Class
Genetic Information Processing; Chromosome
Pathway map
hhv03083  Polycomb repressive complex
hhv03083

Organism
Hyaena hyaena (striped hyena) [GN:hhv]
Gene
120248460  EZH1; histone-lysine N-methyltransferase EZH1 isoform X1 [KO:K17451] [EC:2.1.1.356]
120246406  EZH2; histone-lysine N-methyltransferase EZH2 isoform X1 [KO:K11430] [EC:2.1.1.356]
120220056  EED; polycomb protein EED isoform X1 [KO:K11462]
120246131  SUZ12; polycomb protein SUZ12 isoform X1 [KO:K11463]
120231926  RBBP4; histone-binding protein RBBP4 isoform X1 [KO:K10752]
120232888  RBBP7; histone-binding protein RBBP7 isoform X1 [KO:K11659]
120238212  PHF1; PHD finger protein 1 isoform X1 [KO:K11467]
120234547  MTF2; metal-response element-binding transcription factor 2 isoform X1 [KO:K11485]
120233420  PHF19; PHD finger protein 19 [KO:K11486]
120228981  elongin BC and Polycomb repressive complex 2-associated protein [KO:K26259]
120230605  LCOR; ligand-dependent corepressor isoform X1 [KO:K26260]
120243017  AEBP2; zinc finger protein AEBP2 [KO:K17452]
120244755  JARID2; protein Jumonji isoform X1 [KO:K11478]
120239424  BAP1; ubiquitin carboxyl-terminal hydrolase BAP1 isoform X1 [KO:K08588] [EC:3.4.19.12]
120235410  ASXL1; polycomb group protein ASXL1 isoform X1 [KO:K11471]
120235794  ASXL2; putative Polycomb group protein ASXL2 [KO:K11471]
120248916  ASXL3; putative Polycomb group protein ASXL3 [KO:K11471]
120246039  OGT; UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1 [KO:K09667] [EC:2.4.1.255]
120221696  HCFC1; host cell factor 1 isoform X1 [KO:K14966]
120224319  YY2; transcription factor YY2 [KO:K09201]
120245749  YY1; transcriptional repressor protein YY1 [KO:K09201]
120240005  MBD5; methyl-CpG-binding domain protein 5 [KO:K23219]
120248007  MBD6; methyl-CpG-binding domain protein 6 isoform X1 [KO:K26585]
120227959  FOXK1; forkhead box protein K1 [KO:K09404]
120228201  FOXK2; forkhead box protein K2 [KO:K09404]
120238213  RING1; E3 ubiquitin-protein ligase RING1 [KO:K10695] [EC:2.3.2.27]
120248315  RNF2; E3 ubiquitin-protein ligase RING2 isoform X1 [KO:K10695] [EC:2.3.2.27]
120229087  PCGF2; polycomb group RING finger protein 2 isoform X1 [KO:K11460]
120244593  polycomb group RING finger protein 2-like [KO:K11460]
120232365  BMI1; polycomb complex protein BMI-1 isoform X1 [KO:K11459]
120228290  CBX2; chromobox protein homolog 2 [KO:K11451]
120228273  CBX4; E3 SUMO-protein ligase CBX4 [KO:K11452] [EC:2.3.2.-]
120241151  CBX6; chromobox protein homolog 6 [KO:K11453]
120235223  CBX7; chromobox protein homolog 7 isoform X1 [KO:K11454]
120228305  CBX8; chromobox protein homolog 8 [KO:K11455]
120222713  PHC1; polyhomeotic-like protein 1 isoform X1 [KO:K11456]
120231512  PHC2; polyhomeotic-like protein 2 isoform X1 [KO:K11457]
120234595  PHC3; polyhomeotic-like protein 3 isoform X1 [KO:K11458]
120232906  SCML1; sex comb on midleg-like protein 1 isoform X1 [KO:K11464]
120241970  SCML2; sex comb on midleg-like protein 2 [KO:K11465]
120247873  SCMH1; polycomb protein SCMH1 isoform X1 [KO:K11461]
120219785  SFMBT2; scm-like with four MBT domains protein 2 isoform X1 [KO:K26269]
120239431  SFMBT1; scm-like with four MBT domains protein 1 isoform X1 [KO:K26269]
120231474  AURKB; aurora kinase B isoform X1 [KO:K11479] [EC:2.7.11.1]
120227147  UBE2D1; ubiquitin-conjugating enzyme E2 D1 isoform X1 [KO:K06689] [EC:2.3.2.23]
120222814  UBE2D3; ubiquitin-conjugating enzyme E2 D3 [KO:K06689] [EC:2.3.2.23]
120245629  UBE2D2; ubiquitin-conjugating enzyme E2 D2 isoform X1 [KO:K06689] [EC:2.3.2.23]
120235127  USP16; ubiquitin carboxyl-terminal hydrolase 16 isoform X1 [KO:K11844] [EC:3.4.19.12]
120245199  USP45; ubiquitin carboxyl-terminal hydrolase 45 isoform X1 [KO:K11844] [EC:3.4.19.12]
120230818  RING1 and YY1-binding protein [KO:K11469]
120243251  YAF2; YY1-associated factor 2 isoform X1 [KO:K11468]
120237037  PCGF1; polycomb group RING finger protein 1 [KO:K11487]
120233876  KDM2A; lysine-specific demethylase 2A isoform X1 [KO:K10276] [EC:1.14.11.27]
120231486  KDM2B; lysine-specific demethylase 2B isoform X1 [KO:K10276] [EC:1.14.11.27]
120247971  BCOR; BCL-6 corepressor isoform X1 [KO:K23215]
120244345  BCORL1; BCL-6 corepressor-like protein 1 isoform X1 [KO:K26199]
120237069  S-phase kinase-associated protein 1-like [KO:K03094]
120238518  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
120249038  LOW QUALITY PROTEIN: S-phase kinase-associated protein 1-like [KO:K03094]
120239827  USP7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
120222522  PCGF3; polycomb group RING finger protein 3 isoform X1 [KO:K11488]
120219860  PCGF5; polycomb group RING finger protein 5 isoform X1 [KO:K11489]
120221884  CSNK2B; casein kinase II subunit beta isoform X1 [KO:K03115]
120235654  AUTS2; autism susceptibility gene 2 protein [KO:K23214]
120242230  FBRS; probable fibrosin-1 [KO:K26253]
120223263  FBRSL1; fibrosin-1-like protein isoform X1 [KO:K26254]
120234201  DCAF7; DDB1- and CUL4-associated factor 7 isoform X1 [KO:K11805]
120248282  TEX10; testis-expressed protein 10 isoform X1 [KO:K14827]
120235007  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
120236454  CREB-binding protein [KO:K04498] [EC:2.3.1.48]
120239615  PCGF6; polycomb group RING finger protein 6 isoform X1 [KO:K11470]
120231151  E2F6; transcription factor E2F6 isoform X1 [KO:K09390]
120223459  TFDP1; transcription factor Dp-1 isoform X1 [KO:K04683]
120238410  MAX; protein max isoform X1 [KO:K04453]
120232294  MGA; MAX gene-associated protein isoform X1 [KO:K23399]
120237239  L3MBTL3; lethal(3)malignant brain tumor-like protein 3 isoform X1 [KO:K24387]
120233895  L3MBTL2; lethal(3)malignant brain tumor-like protein 2 isoform X1 [KO:K24387]
120221774  L3MBTL4; lethal(3)malignant brain tumor-like protein 4 [KO:K24387]
120242609  L3MBTL1; lethal(3)malignant brain tumor-like protein 1 isoform X1 [KO:K24387]
120220359  chromobox protein homolog 3-like [KO:K11586]
120230304  CBX3; chromobox protein homolog 3 [KO:K11586]
120235218  LOW QUALITY PROTEIN: chromobox protein homolog 3-like [KO:K11586]
120237355  WDR5B; WD repeat-containing protein 5B [KO:K14963]
120247316  WDR5; WD repeat-containing protein 5 isoform X1 [KO:K14963]
120243735  HDAC2; LOW QUALITY PROTEIN: histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
120231446  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
Reference
PMID:21881606
  Authors
Richly H, Aloia L, Di Croce L
  Title
Roles of the Polycomb group proteins in stem cells and cancer.
  Journal
Cell Death Dis 2:e204 (2011)
DOI:10.1038/cddis.2011.84
Reference
PMID:28202673
  Authors
Chittock EC, Latwiel S, Miller TC, Muller CW
  Title
Molecular architecture of polycomb repressive complexes.
  Journal
Biochem Soc Trans 45:193-205 (2017)
DOI:10.1042/BST20160173
Reference
PMID:33202645
  Authors
Geng Z, Gao Z
  Title
Mammalian PRC1 Complexes: Compositional Complexity and Diverse Molecular Mechanisms.
  Journal
Int J Mol Sci 21:ijms21228594 (2020)
DOI:10.3390/ijms21228594
Reference
PMID:35681061
  Authors
Kim JJ, Kingston RE
  Title
Context-specific Polycomb mechanisms in development.
  Journal
Nat Rev Genet 23:680-695 (2022)
DOI:10.1038/s41576-022-00499-0
Reference
PMID:36076977
  Authors
Dong GJ, Xu JL, Qi YR, Yuan ZQ, Zhao W
  Title
Critical Roles of Polycomb Repressive Complexes in Transcription and Cancer.
  Journal
Int J Mol Sci 23:ijms23179574 (2022)
DOI:10.3390/ijms23179574
Reference
PMID:37086328
  Authors
Ryan CW, Peirent ER, Regan SL, Guxholli A, Bielas SL
  Title
H2A monoubiquitination: insights from human genetics and animal models.
  Journal
Hum Genet 10.1007/s00439-023-02557-x (2023)
DOI:10.1007/s00439-023-02557-x
KO pathway
ko03083   
LinkDB

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