KEGG   PATHWAY: hle03040
Entry
hle03040                    Pathway                                
Name
Spliceosome - Haliaeetus leucocephalus (bald eagle)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
hle03040  Spliceosome
hle03040

Other DBs
GO: 0005681
Organism
Haliaeetus leucocephalus (bald eagle) [GN:hle]
Gene
104839074  DDX46; probable ATP-dependent RNA helicase DDX46 [KO:K12811] [EC:5.6.2.7]
104834068  DHX16; putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [KO:K12813] [EC:5.6.2.6]
104839312  DHX38; pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 [KO:K12815] [EC:5.6.2.6]
104828159  CDC40; pre-mRNA-processing factor 17 [KO:K12816]
104840191  PRPF18; pre-mRNA-splicing factor 18 isoform X1 [KO:K12817]
104842964  DHX8; ATP-dependent RNA helicase DHX8 isoform X1 [KO:K12818] [EC:5.6.2.6]
104839018  SLU7; pre-mRNA-splicing factor SLU7 isoform X1 [KO:K12819]
104837614  DHX15; putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 isoform X1 [KO:K12820] [EC:5.6.2.6]
104832930  SNRPB; small nuclear ribonucleoprotein-associated proteins B and B' [KO:K11086]
104828398  SNRPD1; small nuclear ribonucleoprotein Sm D1 [KO:K11087]
104831526  SNRPD2; small nuclear ribonucleoprotein Sm D2 [KO:K11096]
104836546  SNRPD3; small nuclear ribonucleoprotein Sm D3 [KO:K11088]
104839622  SNRPE; small nuclear ribonucleoprotein E [KO:K11097]
104828294  SNRPF; small nuclear ribonucleoprotein F [KO:K11098]
104828863  SNRPG; small nuclear ribonucleoprotein G [KO:K11099]
104831507  SNRPA; U1 small nuclear ribonucleoprotein A [KO:K11091]
104842368  SNRPC; U1 small nuclear ribonucleoprotein C [KO:K11095]
104829043  PRPF40A; pre-mRNA-processing factor 40 homolog A isoform X1 [KO:K12821]
104831125  RBM25; RNA-binding protein 25 isoform X1 [KO:K12822]
104838729  DDX5; probable ATP-dependent RNA helicase DDX5 isoform X1 [KO:K12823] [EC:5.6.2.7]
104838818  TCERG1; transcription elongation regulator 1 isoform X1 [KO:K12824]
104835810  FUS; RNA-binding protein FUS [KO:K13098]
104834742  SNRPA1; U2 small nuclear ribonucleoprotein A' [KO:K11092]
104836289  SNRPB2; U2 small nuclear ribonucleoprotein B'' [KO:K11094]
104829220  SF3A1; splicing factor 3A subunit 1 [KO:K12825]
104831203  SF3A2; splicing factor 3A subunit 2 [KO:K12826]
104837077  SF3A3; splicing factor 3A subunit 3 [KO:K12827]
104829762  SF3B1; splicing factor 3B subunit 1 isoform X1 [KO:K12828]
104834890  SF3B2; splicing factor 3B subunit 2 [KO:K12829]
104842013  SF3B3; splicing factor 3B subunit 3 [KO:K12830]
104830584  SF3B4; splicing factor 3B subunit 4 [KO:K12831]
104842269  SF3B5; splicing factor 3B subunit 5 [KO:K12832]
104842141  SF3B6; splicing factor 3B subunit 6 [KO:K12833]
104842959  PHF5A; PHD finger-like domain-containing protein 5A isoform X1 [KO:K12834]
104827986  DDX42; ATP-dependent RNA helicase DDX42 isoform X1 [KO:K12835] [EC:5.6.2.7]
104839775  U2AF1; splicing factor U2AF 35 kDa subunit isoform X1 [KO:K12836]
104831299  PUF60; poly(U)-binding-splicing factor PUF60 isoform X1 [KO:K12838]
104830077  SMNDC1; survival of motor neuron-related-splicing factor 30 [KO:K12839]
104840219  RBM17; splicing factor 45 isoform X1 [KO:K12840]
104828505  CHERP; calcium homeostasis endoplasmic reticulum protein isoform X1 [KO:K12841]
104832257  U2SURP; U2 snRNP-associated SURP motif-containing protein isoform X1 [KO:K12842]
104832033  RP9; retinitis pigmentosa 9 protein [KO:K19604]
104834372  LSM3; U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
104828483  LSM4; U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
104831802  LOW QUALITY PROTEIN: U6 snRNA-associated Sm-like protein LSm5 [KO:K12624]
104832038  LSM5; U6 snRNA-associated Sm-like protein LSm5 isoform X1 [KO:K12624]
104837121  LSM6; U6 snRNA-associated Sm-like protein LSm6 isoform X1 [KO:K12625]
104840089  LSM7; U6 snRNA-associated Sm-like protein LSm7 isoform X1 [KO:K12626]
104835812  LSM8; LSM8 homolog, U6 small nuclear RNA associated [KO:K12627]
104830554  PRPF3; U4/U6 small nuclear ribonucleoprotein Prp3 isoform X1 [KO:K12843]
104833994  PRPF4; U4/U6 small nuclear ribonucleoprotein Prp4 [KO:K12662]
104837809  PPIH; peptidyl-prolyl cis-trans isomerase H [KO:K09567] [EC:5.2.1.8]
104828921  USP39; U4/U6.U5 tri-snRNP-associated protein 2 [KO:K12847]
104834889  SART1; U4/U6.U5 tri-snRNP-associated protein 1 [KO:K11984]
104830803  ZMAT2; zinc finger matrin-type protein 2 isoform X1 [KO:K12848]
104841017  PRPF38A; pre-mRNA-splicing factor 38A [KO:K12849]
104829281  PRPF38B; pre-mRNA-splicing factor 38B [KO:K12850]
104827946  EFTUD2; 116 kDa U5 small nuclear ribonucleoprotein component isoform X1 [KO:K12852]
104828867  SNRNP200; U5 small nuclear ribonucleoprotein 200 kDa helicase [KO:K12854] [EC:5.6.2.6]
104833011  PRPF6; pre-mRNA-processing factor 6 [KO:K12855]
104835569  PRPF8; pre-mRNA-processing-splicing factor 8 [KO:K12856]
104837333  SNRNP40; U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857]
104831152  DDX23; probable ATP-dependent RNA helicase DDX23 isoform X1 [KO:K12858] [EC:5.6.2.7]
104837687  TXNL4A; thioredoxin-like protein 4A [KO:K12859]
104829795  PRPF19; pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
104841426  CDC5L; cell division cycle 5-like protein isoform X1 [KO:K12860]
104843272  PLRG1; pleiotropic regulator 1 [KO:K12862]
104838466  CWC15; spliceosome-associated protein CWC15 homolog [KO:K12863]
104832946  CTNNBL1; beta-catenin-like protein 1 isoform X1 [KO:K12864]
104840469  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
104832827  WBP11; WW domain-binding protein 11 [KO:K12866]
104841837  SNW1; SNW domain-containing protein 1 isoform X1 [KO:K06063]
104836575  XAB2; pre-mRNA-splicing factor SYF1 [KO:K12867]
104837170  SYF2; pre-mRNA-splicing factor SYF2 [KO:K12868]
104836357  CRNKL1; crooked neck-like protein 1 [KO:K12869]
104842224  ISY1; pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
104842318  PPIL1; peptidyl-prolyl cis-trans isomerase-like 1 [KO:K12733] [EC:5.2.1.8]
104837143  PPIE; peptidyl-prolyl cis-trans isomerase E isoform X1 [KO:K09564] [EC:5.2.1.8]
104828275  CCDC12; coiled-coil domain-containing protein 12 isoform X1 [KO:K12871]
104838907  RBM22; pre-mRNA-splicing factor RBM22 [KO:K12872]
104833588  BUD31; protein BUD31 homolog [KO:K12873]
104835949  AQR; intron-binding protein aquarius isoform X1 [KO:K12874]
104828644  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
104830580  RBM8A; RNA-binding protein 8A [KO:K12876]
104841008  MAGOH; protein mago nashi homolog isoform X1 [KO:K12877]
104836006  THOC1; THO complex subunit 1 isoform X1 [KO:K12878]
104832678  THOC2; THO complex subunit 2 isoform X1 [KO:K12879]
104838953  THOC3; LOW QUALITY PROTEIN: THO complex subunit 3 [KO:K12880]
104838426  NCBP1; nuclear cap-binding protein subunit 1 [KO:K12882]
104832307  nuclear cap-binding protein subunit 2-like [KO:K12883]
104830418  nuclear cap-binding protein subunit 2 [KO:K12883]
104830319  HNRNPA1; heterogeneous nuclear ribonucleoprotein A1 [KO:K12741]
104830935  HNRNPA3; heterogeneous nuclear ribonucleoprotein A3 isoform X1 [KO:K12741]
104834826  RBMX; RNA-binding motif protein, X chromosome isoform X1 [KO:K12885]
104832453  HNRNPK; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886]
104828530  HNRNPM; heterogeneous nuclear ribonucleoprotein M isoform X1 [KO:K12887]
104828932  HNRNPU; heterogeneous nuclear ribonucleoprotein U [KO:K12888]
104835793  SRSF1; LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 1 [KO:K12890]
104842339  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
104837223  SRSF4; serine/arginine-rich splicing factor 4 isoform X1 [KO:K12893]
104829968  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
104835908  SRSF5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893]
104835917  serine/arginine-rich splicing factor 5-like [KO:K12893]
104828671  SRSF7; serine/arginine-rich splicing factor 7 [KO:K12896]
104838067  TRA2A; transformer-2 protein homolog alpha isoform X1 [KO:K12897]
104827878  TRA2B; transformer-2 protein homolog beta isoform X1 [KO:K12897]
104837163  SRSF10; serine/arginine-rich splicing factor 10 isoform X1 [KO:K12900]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

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