KEGG   PATHWAY: hmh00330
Entry
hmh00330                    Pathway                                
Name
Arginine and proline metabolism - Hylobates moloch (silvery gibbon)
Class
Metabolism; Amino acid metabolism
Pathway map
hmh00330  Arginine and proline metabolism
hmh00330

Module
hmh_M00015  Proline biosynthesis, glutamate => proline [PATH:hmh00330]
hmh_M00047  Creatine pathway [PATH:hmh00330]
hmh_M00134  Polyamine biosynthesis, arginine => ornithine => putrescine [PATH:hmh00330]
hmh_M00135  GABA biosynthesis, eukaryotes, putrescine => GABA [PATH:hmh00330]
hmh_M00970  Proline degradation, proline => glutamate [PATH:hmh00330]
hmh_M00972  Proline metabolism [PATH:hmh00330]
Other DBs
GO: 0006525 0006560
Organism
Hylobates moloch (silvery gibbon) [GN:hmh]
Gene
116482566  GATM; glycine amidinotransferase, mitochondrial isoform X1 [KO:K00613] [EC:2.1.4.1]
116484169  GAMT; guanidinoacetate N-methyltransferase isoform X1 [KO:K00542] [EC:2.1.1.2]
116471047  CKMT2; creatine kinase S-type, mitochondrial [KO:K00933] [EC:2.7.3.2]
116482179  CKMT1B; creatine kinase U-type, mitochondrial isoform X1 [KO:K00933] [EC:2.7.3.2]
116456101  CKB; creatine kinase B-type isoform X1 [KO:K00933] [EC:2.7.3.2]
116483454  CKM; creatine kinase M-type [KO:K27382] [EC:2.7.3.2]
116472901  AZIN2; antizyme inhibitor 2 isoform X1 [KO:K01583] [EC:4.1.1.19]
116480225  ODC1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
116810535  LOW QUALITY PROTEIN: spermidine synthase-like [KO:K00797] [EC:2.5.1.16]
116813770  SRM; spermidine synthase [KO:K00797] [EC:2.5.1.16]
116469176  LOW QUALITY PROTEIN: spermine synthase-like [KO:K00802] [EC:2.5.1.22]
116811569  SMS; spermine synthase isoform X1 [KO:K00802] [EC:2.5.1.22]
116470942  AMD1; S-adenosylmethionine decarboxylase proenzyme isoform X2 [KO:K01611] [EC:4.1.1.50]
116470978  S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
116814531  AOC1; amiloride-sensitive amine oxidase [copper-containing] [KO:K11182] [EC:1.4.3.22]
116461430  SMOX; spermine oxidase isoform X1 [KO:K12259] [EC:1.5.3.16 1.5.3.-]
116477912  ALDH2; aldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
116483121  ALDH3A2; aldehyde dehydrogenase family 3 member A2 isoform X1 [KO:K00128] [EC:1.2.1.3]
116475108  ALDH1B1; aldehyde dehydrogenase X, mitochondrial [KO:K00128] [EC:1.2.1.3]
116470879  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
116473299  ALDH9A1; 4-trimethylaminobutyraldehyde dehydrogenase [KO:K00149] [EC:1.2.1.47 1.2.1.3]
116468465  CNDP1; beta-Ala-His dipeptidase isoform X1 [KO:K05604] [EC:3.4.13.20]
116468466  CNDP2; cytosolic non-specific dipeptidase isoform X1 [KO:K08660] [EC:3.4.13.18]
116469075  CARNS1; carnosine synthase 1 isoform X1 [KO:K14755] [EC:6.3.2.11]
116459049  SAT2; thialysine N-epsilon-acetyltransferase isoform X3 [KO:K00657] [EC:2.3.1.57]
116811578  SAT1; diamine acetyltransferase 1 isoform X1 [KO:K00657] [EC:2.3.1.57]
116811618  MAOA; amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
116811619  MAOB; amine oxidase [flavin-containing] B isoform X1 [KO:K00274] [EC:1.4.3.4]
116812960  AGMAT; guanidino acid hydrolase, mitochondrial [KO:K27001] [EC:3.5.3.- 3.5.3.7 3.5.3.17]
116477857  NOS1; nitric oxide synthase 1 isoform X2 [KO:K13240] [EC:1.14.13.39]
116474634  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
116814534  NOS3; nitric oxide synthase 3 isoform X1 [KO:K13242] [EC:1.14.13.39]
116472286  ARG1; arginase-1 isoform X2 [KO:K01476] [EC:3.5.3.1]
116456112  ARG2; arginase-2, mitochondrial isoform X1 [KO:K01476] [EC:3.5.3.1]
116482361  OAT; ornithine aminotransferase, mitochondrial [KO:K00819] [EC:2.6.1.13]
116813666  PYCR3; pyrroline-5-carboxylate reductase 3 isoform X1 [KO:K00286] [EC:1.5.1.2]
116483754  PYCR1; pyrroline-5-carboxylate reductase 1, mitochondrial isoform X4 [KO:K00286] [EC:1.5.1.2]
116457410  PYCR2; pyrroline-5-carboxylate reductase 2 isoform X1 [KO:K00286] [EC:1.5.1.2]
116459187  proline dehydrogenase 1, mitochondrial-like [KO:K00318] [EC:1.5.5.2]
116459292  proline dehydrogenase 1, mitochondrial isoform X1 [KO:K00318] [EC:1.5.5.2]
116813001  ALDH4A1; delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial [KO:K00294] [EC:1.2.1.88]
116456943  ALDH18A1; delta-1-pyrroline-5-carboxylate synthase isoform X1 [KO:K12657] [EC:2.7.2.11 1.2.1.41]
116456718  LAP3; cytosol aminopeptidase [KO:K11142] [EC:3.4.11.1 3.4.11.5]
116476676  P4HA3; prolyl 4-hydroxylase subunit alpha-3 isoform X2 [KO:K00472] [EC:1.14.11.2]
116470845  P4HA2; prolyl 4-hydroxylase subunit alpha-2 isoform X1 [KO:K00472] [EC:1.14.11.2]
116463680  prolyl 4-hydroxylase subunit alpha-1 isoform X1 [KO:K00472] [EC:1.14.11.2]
116463692  prolyl 4-hydroxylase subunit alpha-1 isoform X1 [KO:K00472] [EC:1.14.11.2]
116479635  PRODH2; hydroxyproline dehydrogenase isoform X1 [KO:K11394] [EC:1.5.5.3]
116461927  GOT1L1; putative aspartate aminotransferase, cytoplasmic 2 isoform X1 [KO:K14454] [EC:2.6.1.1]
116456108  GOT1; aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
116471334  GOT2; aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
116456320  HOGA1; 4-hydroxy-2-oxoglutarate aldolase, mitochondrial isoform X1 [KO:K18123] [EC:4.1.3.16]
116477976  DAO; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
116456355  L3HYPDH; trans-3-hydroxy-L-proline dehydratase isoform X1 [KO:K18384] [EC:4.2.1.77]
Compound
C00012  Peptide
C00019  S-Adenosyl-L-methionine
C00022  Pyruvate
C00025  L-Glutamate
C00048  Glyoxylate
C00062  L-Arginine
C00077  L-Ornithine
C00086  Urea
C00134  Putrescine
C00148  L-Proline
C00179  Agmatine
C00213  Sarcosine
C00223  p-Coumaroyl-CoA
C00300  Creatine
C00315  Spermidine
C00334  4-Aminobutanoate
C00406  Feruloyl-CoA
C00431  5-Aminopentanoate
C00436  N-Carbamoylputrescine
C00441  L-Aspartate 4-semialdehyde
C00533  Nitric oxide
C00555  4-Aminobutyraldehyde
C00581  Guanidinoacetate
C00750  Spermine
C00763  D-Proline
C00791  Creatinine
C00884  Homocarnosine
C00986  1,3-Diaminopropane
C01035  4-Guanidinobutanoate
C01043  N-Carbamoylsarcosine
C01110  5-Amino-2-oxopentanoic acid
C01137  S-Adenosylmethioninamine
C01157  Hydroxyproline
C01165  L-Glutamate 5-semialdehyde
C01250  N-Acetyl-L-glutamate 5-semialdehyde
C01682  Nopaline
C02305  Phosphocreatine
C02565  N-Methylhydantoin
C02647  4-Guanidinobutanal
C02714  N-Acetylputrescine
C02946  4-Acetamidobutanoate
C03078  4-Guanidinobutanamide
C03166  Phosphoguanidinoacetate
C03287  L-Glutamyl 5-phosphate
C03296  N2-Succinyl-L-arginine
C03375  Norspermidine
C03415  N2-Succinyl-L-ornithine
C03564  1-Pyrroline-2-carboxylate
C03771  5-Guanidino-2-oxopentanoate
C03912  (S)-1-Pyrroline-5-carboxylate
C04137  Octopine
C04281  L-1-Pyrroline-3-hydroxy-5-carboxylate
C05147  trans-3-Hydroxy-L-proline
C05931  N-Succinyl-L-glutamate
C05932  N-Succinyl-L-glutamate 5-semialdehyde
C05933  N(omega)-Hydroxyarginine
C05936  N4-Acetylaminobutanal
C05938  L-4-Hydroxyglutamate semialdehyde
C05945  L-Arginine phosphate
C05946  (4R)-4-Hydroxy-2-oxoglutarate
C05947  L-erythro-4-Hydroxyglutamate
C10497  Feruloylputrescine
C15699  gamma-L-Glutamylputrescine
C15700  gamma-Glutamyl-gamma-aminobutyraldehyde
C15767  4-(L-gamma-Glutamylamino)butanoate
C18172  Carboxyspermidine
C18174  Carboxynorspermidine
C18326  p-Coumaroylputrescine
C19706  cis-3-Hydroxy-L-proline
C20560  N1-(3-Aminopropyl)agmatine
C22886  N1-[(S)-3-amino-3-carboxypropyl]agmatine
Reference
PMID:5288244
  Authors
Haake P, Allen GW.
  Title
Studies on phosphorylation by phosphoroguanidinates. The mechanism of action of creatine: ATP transphosphorylase (creatine kinase).
  Journal
Proc Natl Acad Sci U S A 68:2691-3 (1971)
DOI:10.1073/pnas.68.11.2691
Reference
PMID:16499623
  Authors
Kurihara S, Oda S, Kumagai H, Suzuki H.
  Title
Gamma-glutamyl-gamma-aminobutyrate hydrolase in the putrescine utilization pathway of Escherichia coli K-12.
  Journal
FEMS Microbiol Lett 256:318-23 (2006)
DOI:10.1111/j.1574-6968.2006.00137.x
Reference
PMID:15590624
  Authors
Kurihara S, Oda S, Kato K, Kim HG, Koyanagi T, Kumagai H, Suzuki H.
  Title
A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12.
  Journal
J Biol Chem 280:4602-8 (2005)
DOI:10.1074/jbc.M411114200
Related
pathway
hmh00020  Citrate cycle (TCA cycle)
hmh00220  Arginine biosynthesis
hmh00250  Alanine, aspartate and glutamate metabolism
hmh00260  Glycine, serine and threonine metabolism
hmh00270  Cysteine and methionine metabolism
hmh00310  Lysine degradation
hmh00410  beta-Alanine metabolism
hmh00470  D-Amino acid metabolism
hmh00480  Glutathione metabolism
hmh00630  Glyoxylate and dicarboxylate metabolism
hmh00650  Butanoate metabolism
hmh00770  Pantothenate and CoA biosynthesis
KO pathway
ko00330   
LinkDB

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