KEGG   PATHWAY: hrf04150
Entry
hrf04150                    Pathway                                
Name
mTOR signaling pathway - Haliotis rufescens (red abalone)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
hrf04150  mTOR signaling pathway
hrf04150

Organism
Haliotis rufescens (red abalone) [GN:hrf]
Gene
124142567  cystine/glutamate transporter-like [KO:K13780]
124135276  Y+L amino acid transporter 2-like isoform X1 [KO:K13780]
124122195  large neutral amino acids transporter small subunit 2-like [KO:K13780]
124113229  large neutral amino acids transporter small subunit 1-like isoform X1 [KO:K13780]
124147286  cystine/glutamate transporter-like [KO:K13780]
124147983  large neutral amino acids transporter small subunit 2-like [KO:K13780]
124140880  Y+L amino acid transporter 2-like [KO:K13780]
124134624  sodium-coupled neutral amino acid transporter 9-like [KO:K14995]
124132894  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
124136622  V-type proton ATPase subunit B [KO:K02147]
124116847  V-type proton ATPase subunit C-like [KO:K02148]
124145207  V-type proton ATPase subunit D-like [KO:K02149]
124126316  V-type proton ATPase subunit E-like [KO:K02150]
124114900  V-type proton ATPase subunit F-like [KO:K02151]
124139765  V-type proton ATPase subunit H-like isoform X1 [KO:K02144]
124128224  ragulator complex protein LAMTOR1-like [KO:K20397]
124153100  ragulator complex protein LAMTOR2-like isoform X1 [KO:K20398]
125377966  ragulator complex protein LAMTOR3-B-like [KO:K04370]
124111552  ragulator complex protein LAMTOR5-like [KO:K16344]
124151761  folliculin-like [KO:K09594]
124131108  folliculin-interacting protein 1-like isoform X1 [KO:K20401]
124111157  ras-related GTP-binding protein A [KO:K16185]
124131683  ras-related GTP-binding protein C-like isoform X1 [KO:K16186]
124117117  GATOR complex protein MIOS-like [KO:K20407]
124148291  nucleoporin SEH1-like [KO:K14299]
124114695  GATOR complex protein WDR24-like isoform X1 [KO:K20408]
124120847  GATOR complex protein WDR59-like isoform X1 [KO:K20409]
124134440  protein SEC13 homolog [KO:K14004]
124137815  GATOR complex protein Iml1-like isoform X1 [KO:K20404]
124133093  GATOR complex protein NPRL2-like [KO:K20405]
124137381  GATOR complex protein NPRL3-like [KO:K20406]
124118386  S-phase kinase-associated protein 2-like [KO:K03875]
124137273  regulatory-associated protein of mTOR-like isoform X1 [KO:K07204]
124141052  uncharacterized protein LOC124141052 [KO:K16184]
124110769  serine/threonine-protein kinase mTOR-like isoform X1 [KO:K07203] [EC:2.7.11.1]
124133211  DEP domain-containing mTOR-interacting protein-like [KO:K20402]
124139291  target of rapamycin complex subunit lst8-like [KO:K08266]
124113712  telomere length regulation protein TEL2 homolog isoform X1 [KO:K11137]
124126622  TELO2-interacting protein 1 homolog isoform X1 [KO:K20403]
124126894  CAP-Gly domain-containing linker protein 1-like isoform X1 [KO:K10421]
124131681  phosphatidate phosphatase LPIN3-like [KO:K15728] [EC:3.1.3.4]
124142104  serine/threonine-protein kinase unc-51-like isoform X1 [KO:K08269] [EC:2.7.11.1]
124142310  eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205]
124118186  eukaryotic translation initiation factor 4E-like [KO:K03259]
124110671  eukaryotic translation initiation factor 4E type 2-like isoform X1 [KO:K03259]
124141669  ribosomal protein S6 kinase beta-1-like isoform X1 [KO:K04688] [EC:2.7.11.1]
124135802  eukaryotic translation initiation factor 4B-like isoform X2 [KO:K03258]
124131383  40S ribosomal protein S6-like [KO:K02991]
124143038  STE20-related kinase adapter protein alpha-like isoform X1 [KO:K08271]
124142189  serine/threonine-protein kinase STK11-like [KO:K07298] [EC:2.7.11.1]
124119711  calcium-binding protein 39-like [KO:K08272]
124113732  5'-AMP-activated protein kinase catalytic subunit alpha-2-like [KO:K07198] [EC:2.7.11.31]
124144643  hamartin-like [KO:K07206]
124123002  tuberin-like isoform X1 [KO:K07207]
124121709  TBC1 domain family member 7-like [KO:K20396]
124135840  GTP-binding protein Rheb-like [KO:K07208]
124119865  protein Wnt-1-like isoform X1 [KO:K03209]
124136038  protein Wnt-2b-like isoform X1 [KO:K00182]
124110776  protein Wnt-4-like [KO:K00408]
124115571  protein Wnt-4-like [KO:K00408]
124118959  protein Wnt-5a-like [KO:K00444]
124119862  protein Wnt-6-like isoform X1 [KO:K00445]
124118950  protein Wnt-7b-like isoform X1 [KO:K00572]
124119866  protein Wnt-9a-like [KO:K01064]
124149544  protein Wnt-10a-like isoform X1 [KO:K01357]
124144276  protein Wnt-16-like [KO:K01558]
124134689  frizzled-2-like [KO:K02432]
124147657  frizzled-4-like [KO:K02354]
124140510  frizzled-5-like [KO:K02375]
124111243  frizzled-9-like [KO:K02842]
124111435  low-density lipoprotein receptor-related protein 6-like isoform X1 [KO:K03068]
124125989  low-density lipoprotein receptor-related protein 4-like [KO:K03068]
124138972  uncharacterized protein LOC124138972 isoform X1 [KO:K03068]
124121145  segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
124121146  segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
124121140  segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
124148324  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
124122761  uncharacterized protein LOC124122761 isoform X1 [KO:K03156]
124112246  uncharacterized protein LOC124112246 isoform X1 [KO:K03156]
124112272  uncharacterized protein LOC124112272 isoform X1 [KO:K03156]
124125180  uncharacterized protein LOC124125180 [KO:K03156]
124125924  tumor necrosis factor-like [KO:K03156]
124125927  tumor necrosis factor-like [KO:K03156]
124126653  uncharacterized protein LOC124126653 [KO:K03156]
124126657  uncharacterized protein LOC124126657 isoform X1 [KO:K03156]
124148507  uncharacterized protein LOC124148507 isoform X2 [KO:K03156]
124133455  molluscan insulin-related peptide 3-like [KO:K04526]
124125324  con-Ins Im2-like [KO:K04526]
124149140  con-Ins Im2-like [KO:K05459]
124150084  putative molluscan insulin-related peptide(s) receptor [KO:K04527] [EC:2.7.10.1]
124134295  growth factor receptor-bound protein 2-like [KO:K04364]
124134296  growth factor receptor-bound protein 2-like [KO:K04364]
124134298  growth factor receptor-bound protein 2-like [KO:K04364]
124144642  son of sevenless homolog 1-like [KO:K03099]
124111437  GTPase HRas [KO:K07827]
124145871  serine/threonine-protein kinase A-Raf-like isoform X1 [KO:K04365] [EC:2.7.11.1]
124145034  dual specificity mitogen-activated protein kinase kinase 1-like isoform X1 [KO:K04368] [EC:2.7.12.2]
124135171  mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
124133565  ribosomal protein S6 kinase alpha-1-like [KO:K04373] [EC:2.7.11.1]
124139711  insulin receptor substrate 1-B-like isoform X1 [KO:K16172]
124146266  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
124146269  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
124119737  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
124116467  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
124116468  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
124131244  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
124110633  3-phosphoinositide-dependent protein kinase 1-like isoform X1 [KO:K06276] [EC:2.7.11.1]
124134879  RAC-gamma serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
124132163  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
124145542  target of rapamycin complex 2 subunit MAPKAP1-like isoform X1 [KO:K20410]
124114467  rapamycin-insensitive companion of mTOR-like isoform X1 [KO:K08267]
124150644  proline-rich protein 5-like isoform X1 [KO:K20411]
124134563  ras-like GTP-binding protein RHO [KO:K04513]
124134572  ras-like GTP-binding protein Rho1 [KO:K04513]
124134625  transforming protein RhoA-like [KO:K04513]
124134632  transforming protein RhoA-like [KO:K04513]
124134639  transforming protein RhoA-like [KO:K04513]
124124705  ras-like GTP-binding protein rhoA [KO:K04513]
124136692  rho-related GTP-binding protein RhoC-like [KO:K04513]
124124706  ras-like GTP-binding protein rhoA [KO:K04513]
124124711  ras-like GTP-binding protein rhoA [KO:K04513]
125380997  ras-like GTP-binding protein RHO isoform X1 [KO:K04513]
124132567  calcium-dependent protein kinase C-like isoform X1 [KO:K02677] [EC:2.7.11.13]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
hrf00561  Glycerolipid metabolism
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KO pathway
ko04150   
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