KEGG   PATHWAY: hrj04146
Entry
hrj04146                    Pathway                                
Name
Peroxisome - Haliotis rubra (blacklip abalone)
Description
Peroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies.
Class
Cellular Processes; Transport and catabolism
Pathway map
hrj04146  Peroxisome
hrj04146

Other DBs
GO: 0005777
Organism
Haliotis rubra (blacklip abalone) [GN:hrj]
Gene
124267951  LOW QUALITY PROTEIN: peroxisomal biogenesis factor 3-like [KO:K13336]
124261734  LOW QUALITY PROTEIN: peroxisomal biogenesis factor 19-like [KO:K13337]
124285907  ATP-binding cassette sub-family D member 3-like [KO:K05677] [EC:7.6.2.4]
124262458  LOW QUALITY PROTEIN: peroxisome biogenesis factor 1-like [KO:K13338]
124275519  peroxisome assembly factor 2-like [KO:K13339]
124290394  peroxisome assembly protein 26-like [KO:K13340]
124290627  peroxisomal targeting signal 2 receptor-like [KO:K13341]
124257119  peroxisomal targeting signal 1 receptor-like [KO:K13342]
124287444  LOW QUALITY PROTEIN: peroxisomal membrane protein PEX14-like [KO:K13343]
124257597  peroxisomal membrane protein PEX13-like [KO:K13344]
124260209  peroxisome assembly protein 12-like [KO:K13345]
124270532  LOW QUALITY PROTEIN: peroxisome biogenesis factor 10-like [KO:K13346]
124271408  LOW QUALITY PROTEIN: peroxisome biogenesis factor 2-like [KO:K06664]
124259249  peroxisomal membrane protein 2-like [KO:K13347]
124288974  protein Mpv17-like [KO:K13348]
124267009  mpv17-like protein 2 isoform X1 [KO:K13348]
124267933  LOW QUALITY PROTEIN: mpv17-like protein 2 [KO:K13348]
124261846  mpv17-like protein [KO:K13349]
124267595  peroxisomal membrane protein 4-like [KO:K13350]
124281395  peroxisomal membrane protein 11A-like [KO:K13352]
124282476  peroxisomal membrane protein 11B-like [KO:K13352]
124265069  peroxisomal membrane protein 11C-like isoform X1 [KO:K13353]
124262539  peroxisomal membrane protein PMP34-like [KO:K13354]
124281687  2-hydroxyacyl-CoA lyase 1-like [KO:K12261] [EC:4.1.2.63]
124288965  alpha-methylacyl-CoA racemase-like isoform X1 [KO:K01796] [EC:5.1.99.4]
124291902  phytanoyl-CoA dioxygenase, peroxisomal-like isoform X1 [KO:K00477] [EC:1.14.11.18]
124291911  phytanoyl-CoA dioxygenase, peroxisomal-like isoform X1 [KO:K00477] [EC:1.14.11.18]
124282920  phytanoyl-CoA dioxygenase, peroxisomal-like [KO:K00477] [EC:1.14.11.18]
124263279  LOW QUALITY PROTEIN: peroxisomal acyl-coenzyme A oxidase 3-like [KO:K00232] [EC:1.3.3.6]
124256479  LOW QUALITY PROTEIN: peroxisomal acyl-coenzyme A oxidase 1-like [KO:K00232] [EC:1.3.3.6]
124254675  peroxisomal acyl-coenzyme A oxidase 1-like [KO:K00232] [EC:1.3.3.6]
124264477  peroxisomal multifunctional enzyme type 2-like [KO:K12405] [EC:1.1.1.- 4.2.1.107 4.2.1.119]
124279878  LOW QUALITY PROTEIN: sterol carrier protein 2-like [KO:K08764] [EC:2.3.1.176]
124292508  sterol carrier protein 2-like [KO:K08764] [EC:2.3.1.176]
124276134  bile acid-CoA:amino acid N-acyltransferase-like isoform X1 [KO:K00659] [EC:2.3.1.65 3.1.2.2]
124277115  bile acid-CoA:amino acid N-acyltransferase-like [KO:K00659] [EC:2.3.1.65 3.1.2.2]
124277116  acyl-coenzyme A thioesterase 1-like [KO:K00659] [EC:2.3.1.65 3.1.2.2]
124268350  acyl-coenzyme A thioesterase 1-like [KO:K00659] [EC:2.3.1.65 3.1.2.2]
124270995  bile acid-CoA:amino acid N-acyltransferase-like [KO:K00659] [EC:2.3.1.65 3.1.2.2]
124270996  acyl-coenzyme A amino acid N-acyltransferase 2-like [KO:K00659] [EC:2.3.1.65 3.1.2.2]
124270998  bile acid-CoA:amino acid N-acyltransferase-like [KO:K00659] [EC:2.3.1.65 3.1.2.2]
124258930  peroxisomal bifunctional enzyme-like [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
124264492  LOW QUALITY PROTEIN: 3-ketoacyl-CoA thiolase B, peroxisomal-like [KO:K07513] [EC:2.3.1.16]
124279566  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]-like [KO:K13237] [EC:1.3.1.124]
124255393  LOW QUALITY PROTEIN: delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial-like [KO:K12663] [EC:5.3.3.21]
124255394  delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial-like isoform X1 [KO:K12663] [EC:5.3.3.21]
124270158  LOW QUALITY PROTEIN: ATP-binding cassette sub-family D member 2-like [KO:K05676] [EC:7.6.2.4]
124285399  lysosomal cobalamin transporter ABCD4-like [KO:K05678] [EC:7.6.2.8]
124285406  lysosomal cobalamin transporter ABCD4-like [KO:K05678] [EC:7.6.2.8]
124289804  very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
124289995  very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
124282453  LOW QUALITY PROTEIN: very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
124282457  very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
124282512  very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
124269329  long-chain-fatty-acid--CoA ligase 1-like [KO:K01897] [EC:6.2.1.3]
124269330  LOW QUALITY PROTEIN: long-chain-fatty-acid--CoA ligase 5-like [KO:K01897] [EC:6.2.1.3]
124269620  long-chain-fatty-acid--CoA ligase 4-like isoform X1 [KO:K01897] [EC:6.2.1.3]
124284138  LOW QUALITY PROTEIN: long-chain-fatty-acid--CoA ligase 1-like [KO:K01897] [EC:6.2.1.3]
124287672  peroxisomal trans-2-enoyl-CoA reductase-like [KO:K07753] [EC:1.3.1.38]
124257761  LOW QUALITY PROTEIN: enoyl-CoA delta isomerase 2-like [KO:K13239] [EC:5.3.3.8]
124262016  uncharacterized Nudix hydrolase NudL-like [KO:K17879] [EC:3.6.1.77]
124262635  nudix hydrolase 11-like [KO:K17879] [EC:3.6.1.77]
124285925  LOW QUALITY PROTEIN: NAD-capped RNA hydrolase NUDT12-like [KO:K03426] [EC:3.6.1.22]
124252768  acyl-coenzyme A diphosphatase NUDT19-like [KO:K13355] [EC:3.6.1.77]
124277693  acyl-coenzyme A diphosphatase NUDT19-like [KO:K13355] [EC:3.6.1.77]
124287001  LOW QUALITY PROTEIN: acyl-coenzyme A thioesterase 8-like [KO:K11992] [EC:3.1.2.27]
124287035  acyl-coenzyme A thioesterase 8-like [KO:K11992] [EC:3.1.2.27]
124257554  carnitine O-acetyltransferase-like isoform X1 [KO:K00624] [EC:2.3.1.7]
124260565  peroxisomal carnitine O-octanoyltransferase-like [KO:K05940] [EC:2.3.1.137]
124280749  LOW QUALITY PROTEIN: malonyl-CoA decarboxylase, mitochondrial-like [KO:K01578] [EC:4.1.1.9]
124287319  LOW QUALITY PROTEIN: dihydroxyacetone phosphate acyltransferase-like [KO:K00649] [EC:2.3.1.42]
124259569  alkyldihydroxyacetonephosphate synthase, peroxisomal-like [KO:K00803] [EC:2.5.1.26]
124281828  LOW QUALITY PROTEIN: fatty acyl-CoA reductase 1-like [KO:K13356] [EC:1.2.1.84]
124283981  LOW QUALITY PROTEIN: fatty acyl-CoA reductase 1-like [KO:K13356] [EC:1.2.1.84]
124258703  mevalonate kinase-like [KO:K00869] [EC:2.7.1.36]
124267802  LOW QUALITY PROTEIN: serine--pyruvate aminotransferase, mitochondrial-like [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
124270537  D-amino-acid oxidase-like isoform X1 [KO:K00273] [EC:1.4.3.3]
124270563  D-amino-acid oxidase-like [KO:K00273] [EC:1.4.3.3]
124270572  D-amino-acid oxidase-like isoform X1 [KO:K00273] [EC:1.4.3.3]
124253281  D-aspartate oxidase-like [KO:K00272] [EC:1.4.3.1]
124259154  D-aspartate oxidase-like [KO:K00272] [EC:1.4.3.1]
124262218  D-aspartate oxidase-like [KO:K00272] [EC:1.4.3.1]
124286011  D-aspartate oxidase-like [KO:K00272] [EC:1.4.3.1]
124255941  isocitrate dehydrogenase [NADP], mitochondrial-like [KO:K00031] [EC:1.1.1.42]
124280723  LOW QUALITY PROTEIN: isocitrate dehydrogenase [NADP] cytoplasmic-like [KO:K00031] [EC:1.1.1.42]
124276736  spermine oxidase-like [KO:K00308] [EC:1.5.3.13]
124256892  peroxisomal sarcosine oxidase-like [KO:K00306] [EC:1.5.3.1 1.5.3.7]
124256905  peroxisomal sarcosine oxidase-like [KO:K00306] [EC:1.5.3.1 1.5.3.7]
124272993  peroxisomal sarcosine oxidase-like [KO:K00306] [EC:1.5.3.1 1.5.3.7]
124272994  LOW QUALITY PROTEIN: peroxisomal sarcosine oxidase-like [KO:K00306] [EC:1.5.3.1 1.5.3.7]
124259028  hydroxymethylglutaryl-CoA lyase, mitochondrial-like isoform X1 [KO:K01640] [EC:4.1.3.4]
124283655  hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
124283657  hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
124283667  hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
124283669  hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
124254553  catalase-like [KO:K03781] [EC:1.11.1.6]
124261188  LOW QUALITY PROTEIN: catalase-like [KO:K03781] [EC:1.11.1.6]
124289809  LOW QUALITY PROTEIN: peroxiredoxin-5, mitochondrial-like [KO:K11187] [EC:1.11.1.24]
124285377  peroxiredoxin-5, mitochondrial-like isoform X1 [KO:K11187] [EC:1.11.1.24]
124256070  superoxide dismutase [Cu-Zn]-like [KO:K04565] [EC:1.15.1.1]
124256084  superoxide dismutase [Cu-Zn]-like [KO:K04565] [EC:1.15.1.1]
124256087  superoxide dismutase [Cu-Zn]-like [KO:K04565] [EC:1.15.1.1]
124281079  superoxide dismutase [Cu-Zn]-like isoform X1 [KO:K04565] [EC:1.15.1.1]
124269703  superoxide dismutase [Cu-Zn]-like [KO:K04565] [EC:1.15.1.1]
124259954  superoxide dismutase [Cu-Zn]-like isoform X1 [KO:K04565] [EC:1.15.1.1]
124272092  superoxide dismutase [Cu-Zn], chloroplastic-like [KO:K04565] [EC:1.15.1.1]
124258023  superoxide dismutase [Mn], mitochondrial-like [KO:K04564] [EC:1.15.1.1]
124284331  superoxide dismutase [Mn]-like isoform X1 [KO:K04564] [EC:1.15.1.1]
124290557  peroxiredoxin-2-like isoform X1 [KO:K13279] [EC:1.11.1.24]
124260908  glutathione S-transferase kappa 1-like [KO:K13299] [EC:2.5.1.18]
124290733  indole-3-acetaldehyde oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
124290734  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
124280457  LOW QUALITY PROTEIN: xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
124280458  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
124268728  xanthine dehydrogenase-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
124268729  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
124268730  xanthine dehydrogenase-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
124268731  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
124268793  LOW QUALITY PROTEIN: indole-3-acetaldehyde oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
124268795  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
124268796  indole-3-acetaldehyde oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
124268798  LOW QUALITY PROTEIN: xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
124283166  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
124283210  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
124283229  LOW QUALITY PROTEIN: xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
124284107  probable aldehyde oxidase 2 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
124254246  dehydrogenase/reductase SDR family member 4-like isoform X1 [KO:K11147] [EC:1.1.-.-]
Reference
PMID:17055078
  Authors
Wanders RJ, Waterham HR
  Title
Peroxisomal disorders: the single peroxisomal enzyme deficiencies.
  Journal
Biochim Biophys Acta 1763:1707-20 (2006)
DOI:10.1016/j.bbamcr.2006.08.010
Reference
PMID:17055079
  Authors
Steinberg SJ, Dodt G, Raymond GV, Braverman NE, Moser AB, Moser HW
  Title
Peroxisome biogenesis disorders.
  Journal
Biochim Biophys Acta 1763:1733-48 (2006)
DOI:10.1016/j.bbamcr.2006.09.010
Reference
PMID:17010456
  Authors
Rottensteiner H, Theodoulou FL
  Title
The ins and outs of peroxisomes: co-ordination of membrane transport and peroxisomal metabolism.
  Journal
Biochim Biophys Acta 1763:1527-40 (2006)
DOI:10.1016/j.bbamcr.2006.08.012
Reference
PMID:16631601
  Authors
Iida R, Yasuda T, Tsubota E, Takatsuka H, Matsuki T, Kishi K
  Title
Human Mpv17-like protein is localized in peroxisomes and regulates expression of antioxidant enzymes.
  Journal
Biochem Biophys Res Commun 344:948-54 (2006)
DOI:10.1016/j.bbrc.2006.04.008
Related
pathway
hrj00071  Fatty acid degradation
hrj00230  Purine metabolism
hrj00564  Glycerophospholipid metabolism
hrj00565  Ether lipid metabolism
hrj00830  Retinol metabolism
hrj00900  Terpenoid backbone biosynthesis
KO pathway
ko04146   
LinkDB

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