KEGG   PATHWAY: itr00053
Entry
itr00053                    Pathway                                
Name
Ascorbate and aldarate metabolism - Ipomoea triloba (trilobed morning glory)
Class
Metabolism; Carbohydrate metabolism
Pathway map
itr00053  Ascorbate and aldarate metabolism
itr00053

Module
itr_M00114  Ascorbate biosynthesis, plants, fructose-6P => ascorbate [PATH:itr00053]
Other DBs
GO: 0019852 0019577 0019572
Organism
Ipomoea triloba (trilobed morning glory) [GN:itr]
Gene
116018777  UDP-glucose 6-dehydrogenase 1 [KO:K00012] [EC:1.1.1.22]
115995616  UDP-glucose 6-dehydrogenase 1-like [KO:K00012] [EC:1.1.1.22]
116013290  UDP-glucose 6-dehydrogenase 3-like [KO:K00012] [EC:1.1.1.22]
115999040  UDP-glucose 6-dehydrogenase 2 [KO:K00012] [EC:1.1.1.22]
116014919  UDP-sugar pyrophosphorylase [KO:K12447] [EC:2.7.7.64]
116000382  glucuronokinase 1 [KO:K16190] [EC:2.7.1.43]
115998366  inositol oxygenase 4-like isoform X1 [KO:K00469] [EC:1.13.99.1]
116014196  inositol oxygenase 2-like [KO:K00469] [EC:1.13.99.1]
115999881  probable inositol oxygenase [KO:K00469] [EC:1.13.99.1]
116009286  inositol oxygenase 1-like [KO:K00469] [EC:1.13.99.1]
116006400  aldose reductase [KO:K00002] [EC:1.1.1.2]
116007538  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
116001767  probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
116001970  probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
116001971  probable L-gulonolactone oxidase 4 [KO:K00103] [EC:1.1.3.8]
116006391  L-gulonolactone oxidase 3 [KO:K00103] [EC:1.1.3.8]
116012272  probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
116030730  GDP-mannose 3,5-epimerase 2-like [KO:K10046] [EC:5.1.3.18 5.1.3.-]
115999714  GDP-mannose 3,5-epimerase 2 [KO:K10046] [EC:5.1.3.18 5.1.3.-]
115999799  GDP-L-galactose phosphorylase 1-like [KO:K14190] [EC:2.7.7.69]
116029063  GDP-L-galactose phosphorylase 1-like [KO:K14190] [EC:2.7.7.69]
116032181  inositol monophosphatase 3 isoform X1 [KO:K10047] [EC:3.1.3.25 3.1.3.93]
116015736  bifunctional phosphatase IMPL2, chloroplastic isoform X1 [KO:K18649] [EC:3.1.3.25 3.1.3.93 3.1.3.15]
116031480  L-galactose dehydrogenase [KO:K17744] [EC:1.1.1.316]
116006922  L-galactono-1,4-lactone dehydrogenase, mitochondrial [KO:K00225] [EC:1.3.2.3]
116016719  UDP-glucuronate 4-epimerase 6-like [KO:K08679] [EC:5.1.3.6]
116031225  UDP-glucuronate 4-epimerase 6-like [KO:K08679] [EC:5.1.3.6]
115997206  UDP-glucuronate 4-epimerase 3 [KO:K08679] [EC:5.1.3.6]
116013365  UDP-glucuronate 4-epimerase 1 [KO:K08679] [EC:5.1.3.6]
116027557  UDP-glucuronate 4-epimerase 3 [KO:K08679] [EC:5.1.3.6]
116014935  UDP-glucuronate 4-epimerase 3 [KO:K08679] [EC:5.1.3.6]
116029931  UDP-glucuronate 4-epimerase 3-like [KO:K08679] [EC:5.1.3.6]
116003821  D-galacturonate reductase-like [KO:K19642] [EC:1.1.1.365]
116032709  monodehydroascorbate reductase, chloroplastic/mitochondrial [KO:K08232] [EC:1.6.5.4]
116020037  monodehydroascorbate reductase 4, peroxisomal-like [KO:K08232] [EC:1.6.5.4]
116006714  monodehydroascorbate reductase [KO:K08232] [EC:1.6.5.4]
116006715  monodehydroascorbate reductase-like [KO:K08232] [EC:1.6.5.4]
115998870  monodehydroascorbate reductase-like [KO:K08232] [EC:1.6.5.4]
115999725  monodehydroascorbate reductase 4, peroxisomal-like [KO:K08232] [EC:1.6.5.4]
116002721  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial isoform X1 [KO:K00434] [EC:1.11.1.11]
116017364  L-ascorbate peroxidase, cytosolic-like [KO:K00434] [EC:1.11.1.11]
116032398  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
116006215  putative L-ascorbate peroxidase 6 [KO:K00434] [EC:1.11.1.11]
116024878  L-ascorbate peroxidase, cytosolic-like [KO:K00434] [EC:1.11.1.11]
116024879  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
116000189  probable L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
116012783  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
116000003  glutathione S-transferase DHAR3, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
116002889  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
116002911  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
116017225  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
116017404  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
116004932  L-ascorbate oxidase-like [KO:K00423] [EC:1.10.3.3]
116026100  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
116015631  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
116022580  aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
116010362  aldehyde dehydrogenase family 2 member B7, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
116011026  aldehyde dehydrogenase family 2 member B7, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
116025391  aldehyde dehydrogenase family 2 member B7, mitochondrial [KO:K00128] [EC:1.2.1.3]
115998339  monothiol glutaredoxin-S6-like [KO:K00128] [EC:1.2.1.3]
116000350  aldehyde dehydrogenase family 3 member F1 [KO:K00128] [EC:1.2.1.3]
116015126  aldehyde dehydrogenase family 3 member F1-like [KO:K00128] [EC:1.2.1.3]
116010431  aldehyde dehydrogenase family 7 member B4-like isoform X1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
115996535  aldehyde dehydrogenase family 7 member B4-like [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
Compound
C00022  Pyruvate
C00026  2-Oxoglutarate
C00029  UDP-glucose
C00072  Ascorbate
C00096  GDP-mannose
C00137  myo-Inositol
C00167  UDP-glucuronate
C00191  D-Glucuronate
C00216  D-Arabinose
C00231  D-Xylulose 5-phosphate
C00259  L-Arabinose
C00333  D-Galacturonate
C00433  2,5-Dioxopentanoate
C00545  L-Arabinonate
C00558  D-Tagaturonate
C00617  UDP-D-galacturonate
C00618  3-Dehydro-L-gulonate
C00652  D-Arabinono-1,4-lactone
C00679  5-Dehydro-4-deoxy-D-glucarate
C00684  2-Dehydro-3-deoxy-L-arabinonate
C00800  L-Gulonate
C00818  D-Glucarate
C00878  D-Arabinonate
C00879  D-Galactarate
C01040  L-Gulono-1,4-lactone
C01041  Monodehydroascorbate
C01101  L-Ribulose 5-phosphate
C01114  L-Arabinono-1,4-lactone
C01115  L-Galactono-1,4-lactone
C01146  2-Hydroxy-3-oxopropanoate
C01620  Threonate
C01825  L-Galactose
C02280  GDP-L-galactose
C02670  D-Glucuronolactone
C03033  beta-D-Glucuronoside
C03064  3-Dehydro-L-threonate
C03289  L-xylo-Hexulonolactone
C03291  L-Xylulose 5-phosphate
C03826  2-Dehydro-3-deoxy-D-xylonate
C03921  2-Dehydro-3-deoxy-D-glucarate
C04037  1-Phospho-alpha-D-galacturonate
C04575  (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
C05385  D-Glucuronate 1-phosphate
C05411  L-Xylonate
C05412  L-Lyxonate
C05422  Dehydroascorbate
C06316  Dehydro-D-arabinono-1,4-lactone
C14899  3-Dehydro-L-gulonate 6-phosphate
C15923  L-Gulose
C15924  L-Gulose 1-phosphate
C15925  GDP-L-gulose
C15926  beta-L-Galactose 1-phosphate
C15930  L-Galactonate
C16186  L-Ascorbate 6-phosphate
C20889  D-Galactaro-1,5-lactone
C20896  D-Galactaro-1,4-lactone
C21955  L-Galactono-1,5-lactone
Reference
PMID:17222174
  Authors
Linster CL, Van Schaftingen E
  Title
Vitamin C. Biosynthesis, recycling and degradation in mammals.
  Journal
FEBS J 274:1-22 (2007)
DOI:10.1111/j.1742-4658.2006.05607.x
Reference
PMID:15564123
  Authors
Valpuesta V, Botella MA.
  Title
Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.
  Journal
Trends Plant Sci 9:573-7 (2004)
DOI:10.1016/j.tplants.2004.10.002
Reference
PMID:10517845
  Authors
Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.
  Title
Ascorbate biosynthesis in Arabidopsis cell suspension culture.
  Journal
Plant Physiol 121:535-43 (1999)
DOI:10.1104/pp.121.2.535
Reference
PMID:16595667
  Authors
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  Title
Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  Journal
J Biol Chem 281:15662-70 (2006)
DOI:10.1074/jbc.M601409200
Reference
PMID:17462988
  Authors
Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  Title
Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  Journal
J Biol Chem 282:18879-85 (2007)
DOI:10.1074/jbc.M702094200
Reference
PMID:14996803
  Authors
Campos E, Baldoma L, Aguilar J, Badia J.
  Title
Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.
  Journal
J Bacteriol 186:1720-8 (2004)
DOI:10.1128/JB.186.6.1720-1728.2004
Reference
PMID:12644495
  Authors
Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.
  Title
The ascorbate transporter of Escherichia coli.
  Journal
J Bacteriol 185:2243-50 (2003)
DOI:10.1128/JB.185.7.2243-2250.2003
Related
pathway
itr00020  Citrate cycle (TCA cycle)
itr00040  Pentose and glucuronate interconversions
itr00051  Fructose and mannose metabolism
itr00520  Amino sugar and nucleotide sugar metabolism
itr00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00053   
LinkDB

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