KEGG   PATHWAY: lch03070
Entry
lch03070                    Pathway                                
Name
Bacterial secretion system - Leptothrix cholodnii
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
lch03070  Bacterial secretion system
lch03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Organism
Leptothrix cholodnii [GN:lch]
Gene
Lcho_2439  type I secretion outer membrane protein, TolC family [KO:K12340]
Lcho_2998  type I secretion system ATPase [KO:K11004]
Lcho_3884  type II and III secretion system protein [KO:K02453]
Lcho_2619  type II and III secretion system protein [KO:K02453]
Lcho_3427  general secretion pathway protein D [KO:K02453]
Lcho_3789  type II and III secretion system protein [KO:K02453]
Lcho_3418  general secretion pathway protein C [KO:K02452]
Lcho_3879  type II secretion system protein [KO:K02455]
Lcho_2613  type II secretion system protein [KO:K02455]
Lcho_3429  general secretion pathway protein F [KO:K02455]
Lcho_3885  conserved hypothetical protein [KO:K02456]
Lcho_3886  type II secretion system protein G [KO:K02456]
Lcho_3419  general secretion pathway protein G [KO:K02456]
Lcho_2612  general secretion pathway protein G [KO:K02456]
Lcho_2620  putative general secretion pathway GspG related transmembrane protein [KO:K02456]
Lcho_2621  type II secretion system protein G [KO:K02456]
Lcho_3420  general secretion pathway protein H [KO:K02457]
Lcho_3421  general secretion pathway protein I [KO:K02458]
Lcho_3422  general secretion pathway protein J [KO:K02459]
Lcho_3423  General secretion pathway protein K [KO:K02460]
Lcho_3424  General secretion pathway L [KO:K02461]
Lcho_3425  General secretion pathway M protein [KO:K02462]
Lcho_2310  type II secretion system protein E [KO:K02454] [EC:7.4.2.8]
Lcho_3880  type II secretion system protein E [KO:K02454] [EC:7.4.2.8]
Lcho_3428  general secretory pathway protein E [KO:K02454] [EC:7.4.2.8]
Lcho_2614  type II secretion system protein E [KO:K02454] [EC:7.4.2.8]
Lcho_0344  protein-export membrane protein SecD [KO:K03072]
Lcho_0345  protein-export membrane protein SecF [KO:K03074]
Lcho_3873  preprotein translocase, SecE subunit [KO:K03073]
Lcho_1500  preprotein translocase, SecG subunit [KO:K03075]
Lcho_3929  preprotein translocase, SecY subunit [KO:K03076]
Lcho_0343  preprotein translocase, YajC subunit [KO:K03210]
Lcho_4385  60 kDa inner membrane insertion protein [KO:K03217]
Lcho_0745  preprotein translocase, SecA subunit [KO:K03070] [EC:7.4.2.8]
Lcho_3504  signal recognition particle-docking protein FtsY [KO:K03110]
Lcho_3813  protein-export protein SecB [KO:K03071]
Lcho_0376  signal recognition particle protein [KO:K03106] [EC:3.6.5.4]
Lcho_1608  twin-arginine translocation protein, TatA/E family subunit [KO:K03116]
Lcho_1607  twin-arginine translocation protein, TatB subunit [KO:K03117]
Lcho_1606  Sec-independent protein translocase, TatC subunit [KO:K03118]
Lcho_0873  Lytic transglycosylase catalytic [KO:K03194]
Lcho_0872  Conjugal transfer protein TrbC [KO:K03197]
Lcho_0871  type IV secretory pathway VirB3 family protein [KO:K03198]
Lcho_0867  type IV secretion system family protein [KO:K03200]
Lcho_0865  Conjugal transfer protein TrbG/VirB9/CagX [KO:K03204]
Lcho_0868  TrbL/VirB6 plasmid conjugal transfer protein [KO:K03201]
Lcho_0866  VirB8 family protein [KO:K03203]
Lcho_0864  conjugation TrbI family protein [KO:K03195]
Lcho_0870  type IV secretion/conjugal transfer ATPase, VirB4 family [KO:K03199] [EC:7.4.2.8]
Lcho_0863  P-type DNA transfer ATPase VirB11 [KO:K03196] [EC:7.4.2.8]
Lcho_0862  TRAG family protein [KO:K03205] [EC:7.4.2.8]
Lcho_4080  type VI secretion system Vgr family protein [KO:K11904]
Lcho_4088  type VI secretion system effector, Hcp1 family [KO:K11903]
Lcho_4089  protein of unknown function DUF796 [KO:K11903]
Lcho_4054  conserved hypothetical protein [KO:K11906]
Lcho_4057  type VI secretion protein IcmF [KO:K11891]
Lcho_4056  type IV / VI secretion system protein, DotU family [KO:K11892]
Lcho_4084  type VI secretion ATPase, ClpV1 family [KO:K11907]
Compound
C00002  ATP
Reference
PMID:11173102
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
PMID:11309112
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
PMID:11413015
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
PMID:10047550
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
PMID:10920394
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
PMID:11309113
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
PMID:10481178
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
PMID:11309111
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
PMID:11349009
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
PMID:15546664
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
PMID:18406342
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
PMID:16448494
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
PMID:15546665
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
PMID:19396170
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
PMID:15590783
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
PMID:12360191
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
PMID:17215876
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
PMID:17943123
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
PMID:16092524
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
PMID:15546668
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
PMID:15590781
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
PMID:18524912
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
PMID:19251641
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
PMID:17603507
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
PMID:18078384
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
PMID:14641032
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03070   
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