KEGG   PATHWAY: lcq04141
Entry
lcq04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Lucilia cuprina (Australian sheep blowfly)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
lcq04141  Protein processing in endoplasmic reticulum
lcq04141

Other DBs
GO: 0030433 0034976
Organism
Lucilia cuprina (Australian sheep blowfly) [GN:lcq]
Gene
111674554  protein transport protein Sec61 subunit alpha [KO:K10956]
111686109  protein transport protein Sec61 subunit beta [KO:K09481]
111681439  protein transport protein Sec61 subunit beta-like [KO:K09481]
111687621  protein transport protein Sec61 gamma-2 subunit [KO:K07342]
111684231  translocation protein SEC62 [KO:K12275]
111677683  translocation protein SEC63 homolog [KO:K09540]
111674921  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 [KO:K12666]
111683737  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [KO:K12667]
111691021  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
111691128  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
111683863  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
111684335  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
111686621  tumor suppressor candidate 3 [KO:K19478]
111678551  putative oligosaccharyltransferase complex subunit CG9662 [KO:K26501]
111681419  transmembrane protein 258 [KO:K26502]
111674816  mannosyl-oligosaccharide glucosidase [KO:K01228] [EC:3.2.1.106]
111680268  nucleotide exchange factor Sil1 isoform X2 [KO:K14001]
111675136  hypoxia up-regulated protein 1 [KO:K09486]
111689731  endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
124419527  endoplasmic reticulum chaperone BiP-like [KO:K09490] [EC:3.6.4.10]
111675757  dnaJ homolog shv [KO:K09517]
111688573  uncharacterized protein F54F2.9 [KO:K09521]
111682975  dnaJ homolog subfamily C member 3 [KO:K09523]
111674611  endoplasmin homolog [KO:K09487]
111675737  neutral alpha-glucosidase AB [KO:K05546] [EC:3.2.1.207]
111680777  glucosidase 2 subunit beta [KO:K08288]
111685578  calnexin isoform X1 [KO:K08054]
111680269  uncharacterized protein LOC111680269 [KO:K08056] [EC:5.3.4.1]
111678577  protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
111689757  calreticulin [KO:K08057]
111684411  mannosyl-oligosaccharide alpha-1,2-mannosidase IA isoform X1 [KO:K01230] [EC:3.2.1.113]
111690671  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase [KO:K23741] [EC:3.2.1.209]
111678265  vesicular integral-membrane protein VIP36 [KO:K10082]
111685308  protein ERGIC-53 [KO:K10080]
111683847  prolactin regulatory element-binding protein [KO:K14003]
111687861  GTP-binding protein SAR1b [KO:K07953] [EC:3.6.5.-]
111680087  protein SEC13 homolog [KO:K14004]
111689979  protein transport protein Sec31A [KO:K14005]
111681610  protein transport protein Sec23A isoform X1 [KO:K14006]
111688755  protein transport protein Sec24C [KO:K14007]
111675420  protein transport protein Sec24A [KO:K14007]
111676616  UDP-glucose:glycoprotein glucosyltransferase [KO:K11718] [EC:2.4.1.-]
111677444  uncharacterized protein LOC111677444 [KO:K10085]
111685590  protein disulfide-isomerase [KO:K09580] [EC:5.3.4.1]
111683706  protein disulfide-isomerase A6 homolog [KO:K09584] [EC:5.3.4.1]
111677578  protein windbeutel [KO:K09586]
111677237  thioredoxin domain-containing protein 5 homolog [KO:K13984] [EC:5.3.4.1]
111678675  ero1-like protein [KO:K10950] [EC:1.8.4.-]
111679041  endoplasmic reticulum lectin 1 [KO:K14008]
111690363  translocon-associated protein subunit alpha [KO:K13249]
111683461  translocon-associated protein subunit beta [KO:K13250]
111676621  translocon-associated protein subunit gamma [KO:K13251]
111678149  translocon-associated protein subunit delta [KO:K04571]
111678522  B-cell receptor-associated protein 31 isoform X1 [KO:K14009]
111687254  translocating chain-associated membrane protein 1 [KO:K14010]
111676994  derlin-1 [KO:K11519]
111676179  derlin-2 [KO:K13989]
111683300  UBX domain-containing protein 1 [KO:K24348]
111685700  UBX domain-containing protein 4 [KO:K24348]
111685583  UBX domain-containing protein 6 [KO:K14011]
111675878  NSFL1 cofactor p47 isoform X1 [KO:K14012]
111689545  small VCP/p97-interacting protein [KO:K14014]
111684586  transitional endoplasmic reticulum ATPase TER94 isoform X3 [KO:K13525]
111678233  nuclear protein localization protein 4 homolog isoform X1 [KO:K14015]
111685164  ubiquitin fusion degradation protein 1 homolog [KO:K14016]
111681612  heat shock protein 70 [KO:K03283]
111681632  heat shock protein 70 [KO:K03283]
111681634  heat shock protein 68-like [KO:K03283]
111687157  heat shock protein 68 [KO:K03283]
111679075  heat shock 70 kDa protein cognate 2 [KO:K03283]
111680172  heat shock 70 kDa protein cognate 4 [KO:K03283]
111677121  heat shock 70 kDa protein cognate 4 [KO:K03283]
124419641  heat shock protein 68-like [KO:K03283]
124419642  heat shock protein 68 [KO:K03283]
124419643  heat shock protein 70 [KO:K03283]
124419644  heat shock protein 70 [KO:K03283]
124419829  heat shock protein 70 [KO:K03283]
124419830  heat shock protein 70-like [KO:K03283]
111675658  dnaJ homolog subfamily A member 1 [KO:K09502]
111679532  dnaJ homolog subfamily A member 2 [KO:K09503]
111682295  dnaJ homolog subfamily B member 12 [KO:K09518]
111677094  dnaJ homolog subfamily C member 5 homolog [KO:K09525]
111679400  heat shock protein 83 [KO:K04079]
111690807  heat shock 70 kDa protein 4 isoform X1 [KO:K09485]
111674920  BAG family molecular chaperone regulator 2 isoform X1 [KO:K09556]
111685360  ubiquitin thioesterase OTU1 [KO:K13719] [EC:3.1.2.-]
111687661  phospholipase A-2-activating protein isoform X2 [KO:K14018]
111675323  UV excision repair protein RAD23 homolog B-like [KO:K10839]
111675325  UV excision repair protein RAD23 homolog A-like [KO:K10839]
111680245  ubiquilin-1 [KO:K04523]
111678177  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase [KO:K01456] [EC:3.5.1.52]
111683723  ubiquitin conjugation factor E4 B [KO:K10597] [EC:2.3.2.27]
111684872  eukaryotic translation initiation factor 2-alpha kinase [KO:K08860] [EC:2.7.11.1]
111681148  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
111680754  uncharacterized protein LOC111680754 [KO:K04374]
111678583  uncharacterized protein LOC111678583 [KO:K09054]
111678253  wolframin [KO:K14020]
111688160  membrane-bound transcription factor site-2 protease [KO:K07765] [EC:3.4.24.85]
111680384  LOW QUALITY PROTEIN: ras guanine nucleotide exchange factor R [KO:K09027]
111676783  serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
111682647  mitogen-activated protein kinase kinase kinase 15 isoform X1 [KO:K04426] [EC:2.7.11.25]
111679763  dual specificity mitogen-activated protein kinase kinase hemipterous [KO:K04431] [EC:2.7.12.2]
111677462  stress-activated protein kinase JNK-like [KO:K04440] [EC:2.7.11.24]
111677464  stress-activated protein kinase JNK-like [KO:K04440] [EC:2.7.11.24]
111687549  stress-activated protein kinase JNK isoform X1 [KO:K04440] [EC:2.7.11.24]
111677281  E3 ubiquitin-protein ligase MARCHF6 [KO:K10661] [EC:2.3.2.27]
111675033  ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
111683002  ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
111679254  ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
111676515  E3 ubiquitin-protein ligase HRD1 [KO:K10601] [EC:2.3.2.27]
111681641  E3 ubiquitin-protein ligase RNF185 [KO:K10666] [EC:2.3.2.27]
111690967  protein sel-1 homolog 1 [KO:K14026]
111683672  E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
111687512  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
111685242  E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
111684342  RING-box protein 1A [KO:K03868] [EC:2.3.2.32]
111688763  RING-box protein 1A-like [KO:K03868] [EC:2.3.2.32]
111682503  cullin homolog 1 [KO:K03347]
111679592  S-phase kinase-associated protein 1 [KO:K03094]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
lcq00510  N-Glycan biosynthesis
lcq03050  Proteasome
lcq03060  Protein export
KO pathway
ko04141   
LinkDB

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