KEGG PATHWAY: lel00270

PATHWAY: lel00270

Entry

lel00270                    Pathway

Name

Cysteine and methionine metabolism - Lodderomyces elongisporus

Description

Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].

Class

Metabolism; Amino acid metabolism

Pathway map

lel00270

Cysteine and methionine metabolism

Module

lel_M00034

Methionine salvage pathway [PATH:lel00270]

lel_M00338

Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:lel00270]

Other DBs

GO:	0006534 0006555

Organism

Lodderomyces elongisporus [GN:lel]

Gene

PVL30_005102

uncharacterized protein [KO:K01738] [EC:2.5.1.47]

PVL30_005522

MCY1; Putative mitochondrial cysteine synthase [KO:K01738] [EC:2.5.1.47]

PVL30_004029

MET15; Homocysteine/cysteine synthase [KO:K17069] [EC:2.5.1.49 2.5.1.47]

PVL30_002551

CYS3; cystathionine gamma-lyase cys3 [KO:K01758] [EC:4.4.1.1]

PVL30_001172

MET2_2; homoserine O-acetyltransferase [KO:K01760] [EC:4.4.1.13]

PVL30_001564

CYS4; cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]

PVL30_000630

SAM4; AdoMet-homocysteine methyltransferase [KO:K00547] [EC:2.1.1.10]

PVL30_000195

MET6; methionine-synthesizing 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase [KO:K00549] [EC:2.1.1.14]

PVL30_000864

SAM1; methionine adenosyltransferase sam1 [KO:K00789] [EC:2.5.1.6]

PVL30_004555

SPE2; spermidine resistance protein [KO:K01611] [EC:4.1.1.50]

PVL30_003264

SPE3; putrescine aminopropyltransferase [KO:K00797] [EC:2.5.1.16]

PVL30_002895

SPE4; Spermine synthase [KO:K00802] [EC:2.5.1.22]

PVL30_002265

MEU1; S-methyl-5-thioadenosine phosphorylase [KO:K00772] [EC:2.4.2.28]

PVL30_001128

MRI1; S-methyl-5-thioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]

PVL30_004946

MDE1; Methylthioribulose-1-phosphate dehydratase [KO:K08964] [EC:4.2.1.109]

PVL30_000908

UTR4; enolase-phosphatase E1 [KO:K09880] [EC:3.1.3.77]

PVL30_000753

ADI1; 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase [KO:K08967] [EC:1.13.11.53 1.13.11.54]

PVL30_001167

ARO8; Aromatic/aminoadipate aminotransferase 1 [KO:K00838] [EC:2.6.1.57 2.6.1.39 2.6.1.27 2.6.1.5]

PVL30_004868

SAH1; S-adenosyl-L-homocysteine hydrolase [KO:K01251] [EC:3.13.2.1]

PVL30_004400

HOM3; Aspartokinase [KO:K00928] [EC:2.7.2.4]

PVL30_000722

HOM2; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]

PVL30_001573

HOM6; Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]

PVL30_001306

STR2; Cystathionine gamma-synthase [KO:K01739] [EC:2.5.1.48]

PVL30_000998

BAT2; branched-chain-amino-acid transaminase bat2 [KO:K00826] [EC:2.6.1.42]

PVL30_002268

BAT1; Mitochondrial branched-chain amino acid (BCAA) aminotransferase [KO:K00826] [EC:2.6.1.42]

PVL30_000827

GCS1_1; Zn finger-containing GTPase-Activating Protein for ARF [KO:K11204] [EC:6.3.2.2]

PVL30_002548

GSH2; Glutathione synthetase [KO:K21456] [EC:6.3.2.3]

PVL30_002456

CDG1; cysteine dioxygenase [KO:K00456] [EC:1.13.11.20]

PVL30_002561

AAT2; Aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]

PVL30_000605

AAT1; aspartate transaminase aat1 [KO:K14455] [EC:2.6.1.1]

PVL30_003601

tum1; sulfurtransferase [KO:K01011] [EC:2.8.1.1 2.8.1.2]

PVL30_000455

MDH1_1; Malate dehydrogenase, cytoplasmic [KO:K00026] [EC:1.1.1.37]

PVL30_003468

MDH2; malate DEHYDROGENASE, NAD-dependent [KO:K00026] [EC:1.1.1.37]

PVL30_003921

MDH1_3; Malate dehydrogenase, cytoplasmic [KO:K00026] [EC:1.1.1.37]

PVL30_001117

CHA1_1; catabolic L-serine/threonine dehydratase [KO:K17989] [EC:4.3.1.17 4.3.1.19]

PVL30_003556

CHA1_2; catabolic L-serine/threonine dehydratase [KO:K17989] [EC:4.3.1.17 4.3.1.19]

PVL30_000433

SER3; Phosphoglycerate dehydrogenase ser3 [KO:K00058] [EC:1.1.1.95 1.1.1.399]

PVL30_001846

SER1; Phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]

Compound

C00019

S-Adenosyl-L-methionine

C00021

S-Adenosyl-L-homocysteine

C00022

Pyruvate

C00041

L-Alanine

C00049

L-Aspartate

C00051

Glutathione

C00059

Sulfate

C00065

L-Serine

C00073

L-Methionine

C00094

Sulfite

C00097

L-Cysteine

C00109

2-Oxobutanoate

C00155

L-Homocysteine

C00170

5'-Methylthioadenosine

C00197

3-Phospho-D-glycerate

C00263

L-Homoserine

C00283

Hydrogen sulfide

C00409

Methanethiol

C00441

L-Aspartate 4-semialdehyde

C00491

L-Cystine

C00506

L-Cysteate

C00606

3-Sulfino-L-alanine

C00793

D-Cysteine

C00957

Mercaptopyruvate

C00979

O-Acetyl-L-serine

C01005

O-Phospho-L-serine

C01077

O-Acetyl-L-homoserine

C01118

O-Succinyl-L-homoserine

C01137

S-Adenosylmethioninamine

C01180

4-Methylthio-2-oxobutanoic acid

C01234

1-Aminocyclopropane-1-carboxylate

C01817

L-Homocystine

C01962

Thiocysteine

C02218

Dehydroalanine

C02291

L-Cystathionine

C02356

(S)-2-Aminobutanoate

C02989

L-Methionine S-oxide

C03082

4-Phospho-L-aspartate

C03089

5-Methylthio-D-ribose

C03145

N-Formylmethionine

C03232

3-Phosphonooxypyruvate

C03431

S-Inosyl-L-homocysteine

C03539

S-Ribosyl-L-homocysteine

C04188

S-Methyl-5-thio-D-ribose 1-phosphate

C04582

S-Methyl-5-thio-D-ribulose 1-phosphate

C05324

Nicotianamine

C05524

Aminoacyl-L-methionine

C05526

S-Glutathionyl-L-cysteine

C05527

3-Sulfinylpyruvate

C05528

3-Sulfopyruvate

C05823

3-Mercaptolactate

C05824

S-Sulfo-L-cysteine

C06547

Ethylene

C08276

3-(Methylthio)propanoate

C09306

Sulfur dioxide

C11437

1-Deoxy-D-xylulose 5-phosphate

C11481

HSO3-

C11499

(S)-3-Sulfolactate

C11537

(2R)-3-Sulfolactate

C15606

1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one

C15650

2,3-Diketo-5-methylthiopentyl-1-phosphate

C15651

2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate

C18049

N-Acyl-L-homoserine lactone

C19787

5'-S-Methyl-5'-thioinosine

C21015

gamma-L-Glutamyl-L-2-aminobutyrate

C21016

Ophthalmate

C22359

S-Methyl-1-thio-D-xylulose 5-phosphate

Reference

PMID:15102328

Authors

Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A

Title

Bacterial variations on the methionine salvage pathway.

Journal

BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9

Reference

PMID:14551435

Authors

Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.

Title

A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.

Journal

Science 302:286-90 (2003)
DOI:10.1126/science.1086997

Reference

PMID:12022921

Authors

Sekowska A, Danchin A.

Title

The methionine salvage pathway in Bacillus subtilis.

Journal

BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8

Reference

PMID:12670965

Authors

Berger BJ, English S, Chan G, Knodel MH.

Title

Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.

Journal

J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003

Reference

PMID:17169919

Authors

Goyer A, Collakova E, Shachar-Hill Y, Hanson AD

Title

Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.

Journal

Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055

Reference

PMID:17030798

Authors

Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S

Title

Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.

Journal

Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103

Reference

PMID:18625006

Authors

Pirkov I, Norbeck J, Gustafsson L, Albers E

Title

A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.

Journal

FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x

Reference

PMID:18391471

Authors

Ashida H, Saito Y, Kojima C, Yokota A

Title

Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.

Journal

Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651

Reference

PMID:10613873

Authors

Kitabatake M, So MW, Tumbula DL, Soll D

Title

Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?

Journal

J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000

Reference

PMID:12644499

Authors

Mino K, Ishikawa K

Title

Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.

Journal

J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003

Reference

PMID:18520135

Authors

Tanabe S

Title

Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.

Journal

Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:19270684

Authors