Entry Name Glucagon signaling pathway - Lynx rufus (bobcat)
Description Glucagon is conventionally regarded as a counterregulatory hormone for insulin and plays a critical anti-hypoglycemic role by maintaining glucose homeostasis in both animals and humans. To increase blood glucose, glucagon promotes hepatic glucose output by increasing glycogenolysis and gluconeogenesis and by decreasing glycogenesis and glycolysis in a concerted fashion via multiple mechanisms. Glucagon also stimulates hepatic mitochondrial beta-oxidation to supply energy for glucose production. Glucagon performs its main effect via activation of adenylate cyclase. The adenylate-cyclase-derived cAMP activates protein kinase A (PKA), which then phosphorylates downstream targets, such as cAMP response element binding protein (CREB) and the bifunctional enzyme 6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase (one of the isoforms being PFK/FBPase 1, encoded by PFKFB1).
Class Organismal Systems; Endocrine systemBRITE hierarchy
Pathway map Organism Lynx rufus (bobcat) [GN:
lruf ]
Gene Compound C00354 D-Fructose 1,6-bisphosphate
C00665 beta-D-Fructose 2,6-bisphosphate
C00668 alpha-D-Glucose 6-phosphate
C01172 beta-D-Glucose 6-phosphate
C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference Authors Jiang G, Zhang BB
Title Glucagon and regulation of glucose metabolism.
Journal Reference Authors Rui L
Title Energy metabolism in the liver.
Journal Reference Authors Jitrapakdee S
Title Transcription factors and coactivators controlling nutrient and hormonal regulation of hepatic gluconeogenesis.
Journal Reference Authors Desvergne B, Michalik L, Wahli W.
Title Transcriptional regulation of metabolism.
Journal Reference Authors Hardie DG
Title Organismal carbohydrate and lipid homeostasis.
Journal Reference Authors Hasenour CM, Berglund ED, Wasserman DH
Title Emerging role of AMP-activated protein kinase in endocrine control of metabolism in the liver.
Journal Reference Authors Quesada I, Tuduri E, Ripoll C, Nadal A
Title Physiology of the pancreatic alpha-cell and glucagon secretion: role in glucose homeostasis and diabetes.
Journal Reference Authors Oh KJ, Han HS, Kim MJ, Koo SH
Title CREB and FoxO1: two transcription factors for the regulation of hepatic gluconeogenesis.
Journal Reference Authors Cheng A, Saltiel AR
Title More TORC for the gluconeogenic engine.
Journal Reference Authors Altarejos JY, Montminy M
Title CREB and the CRTC co-activators: sensors for hormonal and metabolic signals.
Journal Reference Authors Pernicova I, Korbonits M
Title Metformin--mode of action and clinical implications for diabetes and cancer.
Journal Reference Authors Hirota K, Fukamizu A
Title Transcriptional regulation of energy metabolism in the liver.
Journal Reference Authors Chalkiadaki A, Guarente L
Title Metabolic signals regulate SIRT1 expression.
Journal Reference Authors Chalkiadaki A, Guarente L
Title Sirtuins mediate mammalian metabolic responses to nutrient availability.
Journal Reference Authors Tang BL, Chua CE
Title Is systemic activation of Sirt1 beneficial for ageing-associated metabolic disorders?
Journal Reference Authors Ozcan L, Wong CC, Li G, Xu T, Pajvani U, Park SK, Wronska A, Chen BX, Marks AR, Fukamizu A, Backs J, Singer HA, Yates JR 3rd, Accili D, Tabas I
Title Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity.
Journal Reference Authors Wang Y, Li G, Goode J, Paz JC, Ouyang K, Screaton R, Fischer WH, Chen J, Tabas I, Montminy M
Title Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes.
Journal Related KO pathway
