KEGG   PATHWAY: lsin04141
Entry
lsin04141                   Pathway                                
Name
Protein processing in endoplasmic reticulum - Leptidea sinapis (Wood White)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
lsin04141  Protein processing in endoplasmic reticulum
lsin04141

Other DBs
GO: 0030433 0034976
Organism
Leptidea sinapis (Wood White) [GN:lsin]
Gene
126973106  protein transport protein Sec61 subunit alpha [KO:K10956]
126972888  protein transport protein Sec61 subunit beta-like [KO:K09481]
126968660  protein transport protein Sec61 subunit beta-like [KO:K09481]
126977106  protein transport protein Sec61 subunit gamma [KO:K07342]
126972828  translocation protein SEC62 isoform X1 [KO:K12275]
126969326  translocation protein SEC63 homolog [KO:K09540]
126976399  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 [KO:K12666]
126976375  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [KO:K12667]
126978024  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
126964620  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
126972333  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B isoform X1 [KO:K07151] [EC:2.4.99.18]
126979396  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
126977022  tumor suppressor candidate 3 [KO:K19478]
126979946  oligosaccharyltransferase complex subunit ostc-A [KO:K26501]
126974392  transmembrane protein 258 [KO:K26502]
126979609  mannosyl-oligosaccharide glucosidase [KO:K01228] [EC:3.2.1.106]
126966673  hypoxia up-regulated protein 1 [KO:K09486]
126964502  endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
126969054  dnaJ homolog shv [KO:K09517]
126974941  uncharacterized protein F54F2.9 [KO:K09521]
126979426  dnaJ homolog subfamily C member 3 [KO:K09523]
126971768  dnaJ homolog subfamily C member 10-like [KO:K09530] [EC:1.8.4.-]
126972952  endoplasmin [KO:K09487]
126976160  neutral alpha-glucosidase AB [KO:K05546] [EC:3.2.1.207]
126965787  glucosidase 2 subunit beta [KO:K08288]
126975864  calnexin [KO:K08054]
126977258  protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
126977038  calreticulin [KO:K08057]
126968698  mannosyl-oligosaccharide alpha-1,2-mannosidase IA-like isoform X1 [KO:K01230] [EC:3.2.1.113]
126978723  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase isoform X1 [KO:K23741] [EC:3.2.1.209]
126979563  vesicular integral-membrane protein VIP36 [KO:K10082]
126971389  protein ERGIC-53 [KO:K10080]
126979758  prolactin regulatory element-binding protein [KO:K14003]
126968219  GTP-binding protein SAR1b [KO:K07953] [EC:3.6.5.-]
126964873  protein SEC13 homolog [KO:K14004]
126964859  protein transport protein Sec23A isoform X1 [KO:K14006]
126970129  protein transport protein Sec24C isoform X1 [KO:K14007]
126970231  protein transport protein Sec24A isoform X1 [KO:K14007]
126971255  UDP-glucose:glycoprotein glucosyltransferase isoform X1 [KO:K11718] [EC:2.4.1.-]
126970448  ER degradation-enhancing alpha-mannosidase-like protein 2 isoform X1 [KO:K10085]
126978803  ER degradation-enhancing alpha-mannosidase-like protein 3 [KO:K10086]
126972459  protein disulfide-isomerase [KO:K09580] [EC:5.3.4.1]
126976404  protein disulfide-isomerase A6 homolog [KO:K09584] [EC:5.3.4.1]
126967791  protein windbeutel [KO:K09586]
126976068  thioredoxin domain-containing protein 5 homolog [KO:K13984] [EC:5.3.4.1]
126979888  ero1-like protein isoform X1 [KO:K10950] [EC:1.8.4.-]
126967995  endoplasmic reticulum lectin 1 isoform X1 [KO:K14008]
126965442  translocon-associated protein subunit alpha [KO:K13249]
126968752  translocon-associated protein subunit beta [KO:K13250]
126975845  translocon-associated protein subunit gamma [KO:K13251]
126967415  translocon-associated protein subunit delta [KO:K04571]
126975522  B-cell receptor-associated protein 31-like [KO:K14009]
126979649  B-cell receptor-associated protein 31 [KO:K14009]
126966397  translocating chain-associated membrane protein 1 [KO:K14010]
126969946  derlin-1 [KO:K11519]
126976510  derlin-2 [KO:K13989]
126968024  UBX domain-containing protein 1 [KO:K24348]
126968310  UBX domain-containing protein 4 [KO:K24348]
126967940  UBX domain-containing protein 6 [KO:K14011]
126976374  NSFL1 cofactor p47 [KO:K14012]
126975643  uncharacterized protein LOC126975643 isoform X1 [KO:K14014]
126977924  transitional endoplasmic reticulum ATPase TER94 [KO:K13525]
126978999  nuclear protein localization protein 4 homolog [KO:K14015]
126967135  ubiquitin fusion degradation protein 1 homolog isoform X1 [KO:K14016]
126972721  major heat shock 70 kDa protein Ba-like [KO:K03283]
126975187  heat shock protein 68-like [KO:K03283]
126976127  heat shock protein 68-like [KO:K03283]
126976686  heat shock 70 kDa protein cognate 4 [KO:K03283]
126977036  heat shock protein 68-like isoform X1 [KO:K03283]
126968880  heat shock protein 68-like [KO:K03283]
126976810  dnaJ homolog subfamily A member 1 [KO:K09502]
126972678  dnaJ homolog subfamily A member 2-like [KO:K09503]
126976273  dnaJ protein homolog 1 [KO:K09507]
126973441  dnaJ homolog subfamily B member 12 [KO:K09518]
126965746  dnaJ homolog subfamily C member 5 [KO:K09525]
126979710  heat shock protein 83 [KO:K04079]
126969965  heat shock 70 kDa protein 4L isoform X1 [KO:K09485]
126972196  BAG family molecular chaperone regulator 2 [KO:K09556]
126967499  hsp70-binding protein 1-like isoform X1 [KO:K09562]
126974789  protein lethal(2)essential for life-like [KO:K09542]
126974791  protein lethal(2)essential for life-like [KO:K09542]
126976284  protein lethal(2)essential for life-like [KO:K09542]
126977854  protein lethal(2)essential for life [KO:K09542]
126968739  protein lethal(2)essential for life-like [KO:K09542]
126968757  protein lethal(2)essential for life-like [KO:K09542]
126968758  protein lethal(2)essential for life-like [KO:K09542]
126979830  protein lethal(2)essential for life-like [KO:K09542]
126980083  protein lethal(2)essential for life-like [KO:K09542]
126980088  protein lethal(2)essential for life-like [KO:K09542]
126980089  protein lethal(2)essential for life-like [KO:K09542]
126980090  protein lethal(2)essential for life-like [KO:K09542]
126976336  alpha-crystallin A chain-like [KO:K09542]
126964838  ubiquitin thioesterase OTU1 [KO:K13719] [EC:3.1.2.-]
126977055  phospholipase A-2-activating protein [KO:K14018]
126965069  UV excision repair protein RAD23 homolog A [KO:K10839]
126973134  ubiquilin-1 [KO:K04523]
126972075  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase [KO:K01456] [EC:3.5.1.52]
126973764  ubiquitin conjugation factor E4 B [KO:K10597] [EC:2.3.2.27]
126975439  eukaryotic translation initiation factor 2-alpha kinase [KO:K08860] [EC:2.7.11.1]
126971008  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
126970169  activating transcription factor of chaperone [KO:K04374]
126976753  wolframin isoform X1 [KO:K14020]
126978930  membrane-bound transcription factor site-1 protease isoform X1 [KO:K08653] [EC:3.4.21.112]
126974448  membrane-bound transcription factor site-2 protease [KO:K07765] [EC:3.4.24.85]
126966042  X-box-binding protein 1 [KO:K09027]
126969529  serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
126965508  mitogen-activated protein kinase kinase kinase 15 isoform X1 [KO:K04426] [EC:2.7.11.25]
126964644  dual specificity mitogen-activated protein kinase kinase 7-like isoform X1 [KO:K04431] [EC:2.7.12.2]
126965302  stress-activated protein kinase JNK isoform X1 [KO:K04440] [EC:2.7.11.24]
126965281  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
126968616  E3 ubiquitin-protein ligase MARCHF6 [KO:K10661] [EC:2.3.2.27]
126964878  ubiquitin-conjugating enzyme E2 J1-like [KO:K10578] [EC:2.3.2.23]
126967970  ubiquitin-conjugating enzyme E2 J2-like [KO:K04554] [EC:2.3.2.23]
126974228  ubiquitin-conjugating enzyme E2 G1 isoform X1 [KO:K10575] [EC:2.3.2.23]
126978304  ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
126972535  E3 ubiquitin-protein ligase synoviolin [KO:K10601] [EC:2.3.2.27]
126965801  E3 ubiquitin-protein ligase RNF185-like isoform X1 [KO:K10666] [EC:2.3.2.27]
126964917  protein sel-1 homolog 1 isoform X1 [KO:K14026]
126977961  E3 ubiquitin-protein ligase AMFR-like isoform X1 [KO:K10636] [EC:2.3.2.36]
126978638  E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
126965533  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
126973728  RING-box protein 1A [KO:K03868] [EC:2.3.2.32]
126971360  cullin-1 [KO:K03347]
126973724  S-phase kinase-associated protein 1 [KO:K03094]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
lsin00510  N-Glycan biosynthesis
lsin03050  Proteasome
lsin03060  Protein export
KO pathway
ko04141   
LinkDB

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