KEGG   PATHWAY: masi04310
Entry
masi04310                   Pathway                                
Name
Wnt signaling pathway - Myxocyprinus asiaticus (Chinese sucker)
Description
Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class
Environmental Information Processing; Signal transduction
Pathway map
masi04310  Wnt signaling pathway
masi04310

Other DBs
GO: 0016055
Organism
Myxocyprinus asiaticus (Chinese sucker) [GN:masi]
Gene
127424656  protein-serine O-palmitoleoyltransferase porcupine-like [KO:K00181] [EC:2.3.1.250]
127414821  protein-serine O-palmitoleoyltransferase porcupine-like [KO:K00181] [EC:2.3.1.250]
127423791  protein-serine O-palmitoleoyltransferase porcupine-like isoform X1 [KO:K00181] [EC:2.3.1.250]
127419190  protein Wnt-1 [KO:K03209]
127420606  protein Wnt-1-like [KO:K03209]
127424256  protein Wnt-2b-A-like [KO:K00182]
127449354  protein Wnt-2b-like [KO:K00182]
127455668  protein Wnt-2-like [KO:K00182]
127446083  protein Wnt-2b-A-like [KO:K00182]
127415302  wingless-type MMTV integration site family, member 2Bb isoform X1 [KO:K00182]
127416974  protein Wnt-2 [KO:K00182]
127427492  proto-oncogene Wnt-3-like [KO:K00312]
127440958  protein Wnt-3a [KO:K00312]
127423148  proto-oncogene Wnt-3 [KO:K00312]
127441961  protein Wnt-3a isoform X1 [KO:K00312]
127426101  protein Wnt-4a-like [KO:K00408]
127427903  protein Wnt-4a [KO:K00408]
127453404  protein Wnt-4a-like [KO:K00408]
127454103  wingless-type MMTV integration site family, member 4b [KO:K00408]
127436665  protein Wnt-5b isoform X1 [KO:K00444]
127424744  protein Wnt-5a [KO:K00444]
127435261  protein Wnt-5b isoform X1 [KO:K00444]
127446627  protein Wnt-6 [KO:K00445]
127447195  protein Wnt-6-like isoform X1 [KO:K00445]
127447880  protein Wnt-6 [KO:K00445]
127437122  protein Wnt-7b-like isoform X1 [KO:K00572]
127418935  protein Wnt-7a [KO:K00572]
127419800  protein Wnt-7a-like isoform X1 [KO:K00572]
127426216  protein Wnt-7a-like isoform X1 [KO:K00572]
127427600  wingless-type MMTV integration site family, member 7Aa [KO:K00572]
127434892  protein Wnt-7b [KO:K00572]
127436073  protein Wnt-7b isoform X1 [KO:K00572]
127436374  protein Wnt-7b-like isoform X1 [KO:K00572]
127412135  protein Wnt-8b-like [KO:K00714]
127413012  protein Wnt-8a-like [KO:K00714]
127413013  protein Wnt-8a [KO:K00714]
127414097  protein Wnt-8b [KO:K00714]
127417878  protein Wnt-8a-like [KO:K00714]
127417925  protein Wnt-8a-like [KO:K00714]
127450627  protein Wnt-9b-like [KO:K01064]
127451838  protein Wnt-9b-like [KO:K01064]
127441960  LOW QUALITY PROTEIN: protein Wnt-9a [KO:K01064]
127419189  protein Wnt-10b isoform X1 [KO:K01357]
127420605  protein Wnt-10b-like [KO:K01357]
127447192  protein Wnt-10a-like [KO:K01357]
127447877  protein Wnt-10a [KO:K01357]
127425222  protein Wnt-11 [KO:K01384]
127432911  protein Wnt-11 [KO:K01384]
127439663  protein Wnt-11-like [KO:K01384]
127434002  protein Wnt-11-like [KO:K01384]
127436965  protein Wnt-16-like [KO:K01558]
127435488  protein Wnt-16-like isoform X1 [KO:K01558]
127444798  DAN domain family member 5 [KO:K01645]
127450338  palmitoleoyl-protein carboxylesterase notum1a [KO:K19882] [EC:3.1.1.98]
127426494  palmitoleoyl-protein carboxylesterase notum1a-like [KO:K19882] [EC:3.1.1.98]
127451531  palmitoleoyl-protein carboxylesterase notum1a [KO:K19882] [EC:3.1.1.98]
127428118  palmitoleoyl-protein carboxylesterase notum1a-like [KO:K19882] [EC:3.1.1.98]
127448933  carboxylesterase notum2 [KO:K19882] [EC:3.1.1.98]
127436948  wnt inhibitory factor 1-like [KO:K01691]
127434976  wnt inhibitory factor 1-like [KO:K01691]
127427007  sclerostin-like [KO:K16834]
127423084  sclerostin [KO:K16834]
127412114  dickkopf-related protein 1-like [KO:K02165]
127444100  dickkopf-related protein 2-like [KO:K02165]
127444688  dickkopf-related protein 2-like [KO:K02165]
127426762  dickkopf-related protein 1b isoform X1 [KO:K02165]
127414420  dickkopf-related protein 1-like [KO:K02165]
127422892  dickkopf-related protein 1-like isoform X1 [KO:K02165]
127430753  pigment epithelium-derived factor isoform X1 [KO:K19614]
127428647  pigment epithelium-derived factor-like isoform X1 [KO:K19614]
127432717  secreted frizzled-related protein 1-like [KO:K02166]
127433656  secreted frizzled-related protein 1-like [KO:K02166]
127439925  secreted frizzled-related protein 1-like isoform X1 [KO:K02166]
127429010  secreted frizzled-related protein 1a [KO:K02166]
127445190  secreted frizzled-related protein 2 [KO:K02176]
127430071  secreted frizzled-related protein 2-like [KO:K02176]
127447381  secreted frizzled-related protein 3-like isoform X1 [KO:K25481]
127447922  secreted frizzled-related protein 3-like isoform X1 [KO:K25481]
127412432  secreted frizzled-related protein 5-like [KO:K02222]
127414076  secreted frizzled-related protein 5-like [KO:K02222]
127453334  R-spondin-1-like [KO:K19471]
127454612  R-spondin-1 [KO:K19471]
127452947  R-spondin-2-like isoform X1 [KO:K23097]
127453749  R-spondin-2-like [KO:K23097]
127453487  R-spondin-3-like [KO:K23098]
127454491  R-spondin-3 [KO:K23098]
127443697  leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1 [KO:K04309]
127454415  leucine-rich repeat-containing G-protein coupled receptor 4-like [KO:K04309]
127418886  leucine-rich repeat-containing G-protein coupled receptor 6 isoform X1 [KO:K08399]
127419718  leucine-rich repeat-containing G-protein coupled receptor 6-like [KO:K08399]
127433201  E3 ubiquitin-protein ligase RNF43-like [KO:K15694] [EC:2.3.2.27]
127423293  E3 ubiquitin-protein ligase RNF43-like isoform X1 [KO:K15694] [EC:2.3.2.27]
127425323  E3 ubiquitin-protein ligase znrf3-like isoform X1 [KO:K16273] [EC:2.3.2.27]
127439587  E3 ubiquitin-protein ligase znrf3 [KO:K16273] [EC:2.3.2.27]
127449498  frizzled-7-A-like [KO:K02432]
127446270  frizzled-7b [KO:K02432]
127453135  frizzled-1-like [KO:K02432]
127447453  frizzled-7a [KO:K02432]
127453650  frizzled-1-like [KO:K02432]
127448451  frizzled-7-A-like [KO:K02432]
127450804  frizzled-2-like [KO:K02235]
127451351  frizzled-2-like [KO:K02235]
127409834  frizzled-3-like [KO:K02329]
127415977  frizzled-3a isoform X1 [KO:K02329]
127411078  frizzled-3b isoform X1 [KO:K02329]
127454730  frizzled-3-like isoform X1 [KO:K02329]
127422598  frizzled-4-like [KO:K02354]
127429930  frizzled-4-like [KO:K02354]
127432024  frizzled-8-like [KO:K02375]
127447120  frizzled-5 [KO:K02375]
127434672  frizzled-8-like [KO:K02375]
127448114  frizzled-5-like [KO:K02375]
127442068  frizzled-8b [KO:K02375]
127454242  frizzled-6 [KO:K02376]
127430765  frizzled-9 [KO:K02842]
127455679  frizzled-9b [KO:K02842]
127414767  frizzled-10-like [KO:K02842]
127439862  frizzled-9-like [KO:K02842]
127416753  frizzled-9-like [KO:K02842]
127424136  frizzled-10-B-like [KO:K02842]
127437636  low-density lipoprotein receptor-related protein 5-like [KO:K03068]
127435229  low-density lipoprotein receptor-related protein 6-like [KO:K03068]
127435889  low-density lipoprotein receptor-related protein 5 [KO:K03068]
127436420  low-density lipoprotein receptor-related protein 6-like isoform X1 [KO:K03068]
127427467  BMP and activin membrane-bound inhibitor homolog [KO:K10162]
127441487  BMP and activin membrane-bound inhibitor homolog [KO:K10162]
127442031  BMP and activin membrane-bound inhibitor homolog [KO:K10162]
127423485  BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a [KO:K10162]
127449665  protein APCDD1-like [KO:K25812]
127431921  protein APCDD1-like [KO:K25812]
127445943  protein APCDD1-like [KO:K25812]
127434561  protein APCDD1-like isoform X1 [KO:K25812]
127441339  protein APCDD1-like [KO:K25812]
127443031  protein APCDD1-like [KO:K25812]
127427305  casein kinase I-like [KO:K08960] [EC:2.7.11.1]
127423456  casein kinase I [KO:K08960] [EC:2.7.11.1]
127411293  protein Daple-like isoform X1 [KO:K25811]
127454796  protein Daple [KO:K25811]
127455748  segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
127419508  segment polarity protein dishevelled homolog DVL-1-like [KO:K02353]
127419767  segment polarity protein dishevelled homolog DVL-1-like [KO:K02353]
127426369  segment polarity protein dishevelled homolog DVL-1-like isoform X1 [KO:K02353]
127415430  segment polarity protein dishevelled homolog DVL-2-like [KO:K02353]
127427973  segment polarity protein dishevelled homolog DVL-1b isoform X1 [KO:K02353]
127433836  segment polarity protein dishevelled homolog DVL-2-like isoform X1 [KO:K02353]
127441130  segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
127416885  segment polarity protein dishevelled homolog DVL-3-like isoform X1 [KO:K02353]
127417068  segment polarity protein dishevelled homolog DVL-2-like [KO:K02353]
127448654  segment polarity protein dishevelled homolog DVL-2-like [KO:K02353]
127442472  segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
127453496  GSK-3-binding protein-like [KO:K03096]
127453725  GSK-3-binding protein-like [KO:K03096]
127425545  casein kinase II subunit alpha-like isoform X1 [KO:K03097] [EC:2.7.11.1]
127437792  casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
127420879  casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
127452825  casein kinase II subunit alpha-like isoform X1 [KO:K03097] [EC:2.7.11.1]
127454281  casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
127435919  casein kinase II subunit alpha'-like isoform X1 [KO:K03097] [EC:2.7.11.1]
127454799  casein kinase II subunit alpha'-like isoform X1 [KO:K03097] [EC:2.7.11.1]
127436113  casein kinase II subunit alpha'-like [KO:K03097] [EC:2.7.11.1]
127425584  casein kinase II subunit beta [KO:K03115]
127420917  casein kinase II subunit beta-like [KO:K03115]
127444166  protein naked cuticle homolog 1 isoform X1 [KO:K03213]
127450121  protein naked cuticle homolog 1-like isoform X1 [KO:K03213]
127453149  protein naked cuticle homolog 2-like isoform X1 [KO:K03213]
127453659  protein naked cuticle homolog 2-like [KO:K03213]
127419197  CXXC-type zinc finger protein 4-like [KO:K03344]
127445191  CXXC-type zinc finger protein 4 [KO:K03344]
127420288  CXXC-type zinc finger protein 4-like [KO:K03344]
127449153  sentrin-specific protease 2-like isoform X1 [KO:K03345] [EC:3.4.22.68]
127445839  sentrin-specific protease 2-like [KO:K03345] [EC:3.4.22.68]
127444093  glycogen synthase kinase-3 beta-like [KO:K03083] [EC:2.7.11.26]
127445310  glycogen synthase kinase-3 beta-like [KO:K03083] [EC:2.7.11.26]
127447073  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
127448192  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
127425215  catenin beta-1-like [KO:K02105]
127421428  catenin beta-1-like [KO:K02105]
127452481  catenin beta-1-like isoform X1 [KO:K02105]
127454260  catenin beta-1 isoform X1 [KO:K02105]
127450669  axin-1 isoform X1 [KO:K02157]
127451857  axin-1-like isoform X1 [KO:K02157]
127449252  axin-2-like [KO:K04385]
127450323  axin-2-like [KO:K04385]
127452148  axin-2 [KO:K04385]
127426437  adenomatous polyposis coli protein 2-like [KO:K02085]
127433058  adenomatous polyposis coli protein-like isoform X1 [KO:K02085]
127427630  adenomatous polyposis coli protein 2-like [KO:K02085]
127433957  adenomatous polyposis coli protein isoform X1 [KO:K02085]
127418255  casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
127412980  casein kinase I-like isoform X1 [KO:K08957] [EC:2.7.11.1]
127430673  transcription factor 7 isoform X1 [KO:K02620]
127429142  transcription factor 7-like isoform X1 [KO:K02620]
127432983  transcription factor 7-like 1-A [KO:K04490]
127415459  transcription factor 7-like 1-B [KO:K04490]
127433839  transcription factor 7-like 1-A [KO:K04490]
127423965  transcription factor 7-like 1-B [KO:K04490]
127426883  transcription factor 7-like 2 isoform X1 [KO:K04491]
127422938  transcription factor 7-like 2 isoform X1 [KO:K04491]
127444095  lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
127445071  lymphoid enhancer-binding factor 1-like isoform X1 [KO:K04492]
127423515  leucine zipper putative tumor suppressor 2 homolog [KO:K26471]
127412478  leucine zipper putative tumor suppressor 2 homolog [KO:K26471]
127413688  leucine zipper putative tumor suppressor 2 homolog isoform X1 [KO:K26471]
127426654  leucine zipper putative tumor suppressor 2 homolog [KO:K26471]
127419516  beta-catenin-interacting protein 1 [KO:K04493]
127420150  beta-catenin-interacting protein 1 [KO:K04493]
127427052  protein chibby homolog 1 [KO:K23402]
127423102  protein chibby homolog 1-like isoform X1 [KO:K23402]
127440624  chromodomain-helicase-DNA-binding protein 8 isoform X1 [KO:K04494] [EC:5.6.2.-]
127442178  chromodomain-helicase-DNA-binding protein 8 isoform X1 [KO:K04494] [EC:5.6.2.-]
127423252  colorectal mutant cancer protein isoform X1 [KO:K26734]
127433207  colorectal mutant cancer protein-like [KO:K26734]
127432942  cell cycle and apoptosis regulator protein 2-like isoform X1 [KO:K25816]
127433518  cell cycle and apoptosis regulator protein 2-like isoform X1 [KO:K25816]
127411932  NAD-dependent protein deacetylase sirtuin-1-like [KO:K11411] [EC:2.3.1.286]
127414368  NAD-dependent protein deacetylase sirtuin-1-like [KO:K11411] [EC:2.3.1.286]
127427506  transcription factor Sox-17-alpha-like [KO:K04495]
127454209  transcription factor Sox-17-alpha-like [KO:K04495]
127412705  C-terminal-binding protein 1-like isoform X1 [KO:K04496] [EC:1.1.1.428]
127412886  C-terminal-binding protein 1 isoform X1 [KO:K04496] [EC:1.1.1.428]
127426651  C-terminal binding protein 2, like [KO:K04496] [EC:1.1.1.428]
127454727  uncharacterized protein LOC127454727 isoform X1 [KO:K04496] [EC:1.1.1.428]
127411515  C-terminal-binding protein 2a isoform X1 [KO:K04496] [EC:1.1.1.428]
127423509  uncharacterized protein LOC127423509 isoform X1 [KO:K04496] [EC:1.1.1.428]
127417793  C-terminal-binding protein 1-like isoform X1 [KO:K04496] [EC:1.1.1.428]
127417804  C-terminal-binding protein 1 isoform X1 [KO:K04496] [EC:1.1.1.428]
127436749  transducin-like enhancer protein 3-B isoform X1 [KO:K04497]
127456014  transducin-like enhancer protein 3-A [KO:K04497]
127438570  transducin-like enhancer protein 1 isoform X1 [KO:K04497]
127438571  transducin-like enhancer protein 4 isoform X1 [KO:K04497]
127439281  transducin-like enhancer protein 1 isoform X1 [KO:K04497]
127439284  transducin-like enhancer protein 4 isoform X1 [KO:K04497]
127416296  transducin-like enhancer protein 3-B isoform X1 [KO:K04497]
127416874  transducin-like enhancer protein 3-A [KO:K04497]
127432079  catenin delta-2 isoform X1 [KO:K23491]
127440320  catenin delta-2-like isoform X1 [KO:K23491]
127434765  catenin delta-2-like isoform X1 [KO:K23491]
127443090  catenin delta-2-like isoform X1 [KO:K23491]
127450211  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
127450308  histone acetyltransferase p300-like isoform X1 [KO:K04498] [EC:2.3.1.48]
127438522  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
127451390  histone acetyltransferase p300-like isoform X1 [KO:K04498] [EC:2.3.1.48]
127426772  histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
127438859  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
127451969  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
127422974  histone acetyltransferase p300-like isoform X1 [KO:K04498] [EC:2.3.1.48]
127449184  ruvB-like 1 [KO:K04499] [EC:5.6.2.4]
127446098  ruvB-like 1 [KO:K04499] [EC:5.6.2.4]
127424840  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
127420708  mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
127433081  mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
127440027  mothers against decapentaplegic homolog 4-like [KO:K04501]
127452762  mothers against decapentaplegic homolog 4-like [KO:K04501]
127433821  mothers against decapentaplegic homolog 4a isoform X1 [KO:K04501]
127428145  mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
127454639  mothers against decapentaplegic homolog 4-like [KO:K04501]
127449385  mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
127456001  mothers against decapentaplegic homolog 3-like [KO:K23605]
127453845  mothers against decapentaplegic homolog 3-like isoform X1 [KO:K23605]
127417240  mothers against decapentaplegic homolog 3-like isoform X1 [KO:K23605]
127456699  mitogen-activated protein kinase kinase kinase 7-like isoform X1 [KO:K04427] [EC:2.7.11.25]
127415933  mitogen-activated protein kinase kinase kinase 7-like isoform X1 [KO:K04427] [EC:2.7.11.25]
127450519  serine/threonine-protein kinase NLK2-like [KO:K04468] [EC:2.7.11.24]
127451586  serine/threonine-protein kinase NLK2-like [KO:K04468] [EC:2.7.11.24]
127421750  serine/threonine-protein kinase NLK-like [KO:K04468] [EC:2.7.11.24]
127429765  serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
127431776  transcriptional regulator Myc-like isoform X1 [KO:K04377]
127434738  transcriptional regulator Myc-2 [KO:K04377]
127441502  transcriptional regulator Myc-B-like [KO:K04377]
127442144  transcriptional regulator Myc-B [KO:K04377]
127416105  transcription factor Jun-like [KO:K04448]
127410395  transcription factor Jun-like [KO:K04448]
127423532  transcription factor Jun-like [KO:K04448]
127433363  transcription factor Jun-like [KO:K04448]
127413093  fos-related antigen 1-like [KO:K04502]
127417770  fos-related antigen 1-like isoform X1 [KO:K04502]
127412072  G1/S-specific cyclin-D1 [KO:K04503]
127440653  G1/S-specific cyclin-D1-like [KO:K04503]
127436727  G1/S-specific cyclin-D2b isoform X1 [KO:K10151]
127437822  G1/S-specific cyclin-D2-like isoform X1 [KO:K10151]
127435055  G1/S-specific cyclin-D2-like [KO:K10151]
127435552  G1/S-specific cyclin-D2a isoform X1 [KO:K10151]
127438397  G1/S-specific cyclin-D3 [KO:K10152]
127425496  cellular communication network factor 4a [KO:K22471]
127420816  CCN family member 4-like [KO:K22471]
127452830  CCN family member 4-like [KO:K22471]
127454116  CCN family member 4-like [KO:K22471]
127438388  peroxisome proliferator-activated receptor delta-like isoform X1 [KO:K04504]
127439130  peroxisome proliferator-activated receptor delta isoform X1 [KO:K04504]
127414985  peroxisome proliferator-activated receptor delta-like [KO:K04504]
127423822  peroxisome proliferator-activated receptor delta-like [KO:K04504]
127455381  presenilin-1 [KO:K04505] [EC:3.4.23.-]
127410966  presenilin-1 [KO:K04505] [EC:3.4.23.-]
127450164  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
127444718  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
127426444  protein kinase, cAMP-dependent, catalytic, beta a [KO:K04345] [EC:2.7.11.11]
127451641  cAMP-dependent protein kinase catalytic subunit alpha-like isoform X1 [KO:K04345] [EC:2.7.11.11]
127428000  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
127440915  cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
127442986  cAMP-dependent protein kinase catalytic subunit beta-like [KO:K04345] [EC:2.7.11.11]
127412460  cellular tumor antigen p53-like [KO:K04451]
127439189  cellular tumor antigen p53-like isoform X1 [KO:K04451]
127423032  cellular tumor antigen p53-like isoform X1 [KO:K04451]
127456508  E3 ubiquitin-protein ligase Siah1 isoform X1 [KO:K04506] [EC:2.3.2.27]
127417412  E3 ubiquitin-protein ligase Siah1 isoform X1 [KO:K04506] [EC:2.3.2.27]
127441389  calcyclin-binding protein-like [KO:K04507]
127442233  calcyclin-binding protein-like isoform X1 [KO:K04507]
127430695  S-phase kinase-associated protein 1 [KO:K03094]
127429165  S-phase kinase-associated protein 1 [KO:K03094]
127426010  F-box-like/WD repeat-containing protein TBL1XR1a isoform X1 [KO:K04508]
127446993  F-box-like/WD repeat-containing protein TBL1X [KO:K04508]
127428065  F-box-like/WD repeat-containing protein TBL1XR1 isoform X1 [KO:K04508]
127441071  F-box-like/WD repeat-containing protein TBL1XR1 [KO:K04508]
127448264  F-box-like/WD repeat-containing protein TBL1X [KO:K04508]
127442418  F-box-like/WD repeat-containing protein TBL1XR1 [KO:K04508]
127418086  F-box and WD repeat domain-containing 11-A isoform X1 [KO:K03362]
127413386  F-box and WD repeat domain-containing 11-A isoform X1 [KO:K03362]
127433015  F-box and WD repeat domain-containing 11-B isoform X1 [KO:K03362]
127433516  F-box and WD repeat domain-containing 11-B-like isoform X1 [KO:K03362]
127431758  cullin-1-like isoform X1 [KO:K03347]
127434184  cullin-1-like [KO:K03347]
127441087  cullin-1 isoform X1 [KO:K03347]
127443143  cullin-1-like [KO:K03347]
127450052  E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
127452336  RING-box protein 1-like [KO:K03868] [EC:2.3.2.32]
127413148  glypican-4 [KO:K08110]
127417670  glypican-6-like [KO:K08110]
127449663  inactive tyrosine-protein kinase transmembrane receptor ROR1-like [KO:K05122] [EC:2.7.10.1]
127446332  inactive tyrosine-protein kinase transmembrane receptor ROR1-like [KO:K05122] [EC:2.7.10.1]
127432333  tyrosine-protein kinase transmembrane receptor ROR2-like [KO:K05123] [EC:2.7.10.1]
127433274  tyrosine-protein kinase transmembrane receptor ROR2-like isoform X1 [KO:K05123] [EC:2.7.10.1]
127445727  tyrosine-protein kinase RYK-like isoform X1 [KO:K05128] [EC:2.7.10.1]
127448753  tyrosine-protein kinase RYK-like isoform X1 [KO:K05128] [EC:2.7.10.1]
127453003  vang-like protein 2 [KO:K04510]
127447481  vang-like protein 1 [KO:K04510]
127447962  vang-like protein 1 [KO:K04510]
127448894  vang-like protein 2 [KO:K04510]
127424678  prickle planar cell polarity protein 3-B-like isoform X1 [KO:K04511]
127436909  prickle-like protein 1 isoform X1 [KO:K04511]
127437107  LOW QUALITY PROTEIN: prickle-like protein 1 [KO:K04511]
127426002  prickle-like protein 2 isoform X1 [KO:K04511]
127415113  prickle planar cell polarity protein 3-B-like isoform X1 [KO:K04511]
127415293  prickle-like protein 2 [KO:K04511]
127427701  prickle-like protein 2 isoform X1 [KO:K04511]
127434961  prickle-like protein 1 isoform X1 [KO:K04511]
127424009  prickle-like protein 2 [KO:K04511]
127436231  prickle-like protein 1a [KO:K04511]
127452994  inversin isoform X1 [KO:K19626]
127455299  disheveled-associated activator of morphogenesis 1-A isoform X1 [KO:K04512]
127409824  disheveled-associated activator of morphogenesis 1-like isoform X1 [KO:K04512]
127415737  disheveled-associated activator of morphogenesis 1b isoform X1 [KO:K04512]
127410932  disheveled-associated activator of morphogenesis 2 isoform X1 [KO:K04512]
127411187  disheveled-associated activator of morphogenesis 1-like isoform X1 [KO:K04512]
127454898  disheveled-associated activator of morphogenesis 2-like isoform X1 [KO:K04512]
127424267  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
127424363  rho-related GTP-binding protein RhoA-B [KO:K04513]
127424476  rho-related GTP-binding protein RhoA-A [KO:K04513]
127449363  rho-related GTP-binding protein RhoA-D [KO:K04513]
127418951  rho-related GTP-binding protein RhoA-C [KO:K04513]
127438341  transforming protein RhoA-like isoform X1 [KO:K04513]
127420050  rho-related GTP-binding protein RhoA-C [KO:K04513]
127439001  rho-related GTP-binding protein RhoA-B-like isoform X1 [KO:K04513]
127446069  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
127414506  rho-related GTP-binding protein RhoA-B [KO:K04513]
127414736  rho-related GTP-binding protein RhoA-A [KO:K04513]
127415306  rho-related GTP-binding protein RhoA-D-like isoform X1 [KO:K04513]
127412511  rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
127413975  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.39]
127416177  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.39]
127410351  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.39]
127450419  ras-related C3 botulinum toxin substrate 1-like isoform X1 [KO:K04392]
127426846  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
127452180  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
127422926  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
127449783  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
127451446  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
127451761  ras-related C3 botulinum toxin substrate 3a [KO:K07861]
127427419  ras-related C3 botulinum toxin substrate 3-like [KO:K07861]
127422812  ras-related C3 botulinum toxin substrate 3b [KO:K07861]
127412122  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
127430781  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
127431115  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
127413972  mitogen-activated protein kinase 8B isoform X1 [KO:K04440] [EC:2.7.11.24]
127426968  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
127428642  mitogen-activated protein kinase 10-like isoform X1 [KO:K04440] [EC:2.7.11.24]
127428709  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
127423091  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
127455163  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2-like [KO:K05858] [EC:3.1.4.11]
127455164  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
127455167  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like [KO:K05858] [EC:3.1.4.11]
127409602  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858] [EC:3.1.4.11]
127415730  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
127415731  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858] [EC:3.1.4.11]
127441036  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like isoform X1 [KO:K05858] [EC:3.1.4.11]
127410687  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2-like [KO:K05858] [EC:3.1.4.11]
127410688  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
127416509  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like isoform X1 [KO:K05858] [EC:3.1.4.11]
127443398  calcium/calmodulin-dependent protein kinase type II delta 2 chain-like isoform X1 [KO:K04515] [EC:2.7.11.17]
127412494  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
127430666  calcium/calmodulin-dependent protein kinase type II subunit alpha-like isoform X1 [KO:K04515] [EC:2.7.11.17]
127419600  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
127445284  calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
127432576  calcium/calmodulin-dependent protein kinase type II subunit beta-like isoform X1 [KO:K04515] [EC:2.7.11.17]
127432635  calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
127414196  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
127426527  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
127426935  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
127433900  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
127422841  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
127454165  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
127429136  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
127418032  protein phosphatase 3 catalytic subunit alpha-like isoform X1 [KO:K04348] [EC:3.1.3.16]
127412439  protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
127431206  protein phosphatase 3 catalytic subunit alpha-like [KO:K04348] [EC:3.1.3.16]
127413194  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
127432238  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
127432387  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
127433645  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
127428420  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
127434567  protein phosphatase 3 catalytic subunit alpha-like isoform X1 [KO:K04348] [EC:3.1.3.16]
127429082  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
127412321  calcineurin subunit B type 1-like [KO:K06268]
127443801  calcineurin subunit B type 1 isoform X1 [KO:K06268]
127413639  calcineurin subunit B type 1-like isoform X1 [KO:K06268]
127445045  calcineurin subunit B type 1-like [KO:K06268]
127449253  protein kinase C, alpha, a [KO:K02677] [EC:2.7.11.13]
127450329  protein kinase C alpha type-like isoform X1 [KO:K02677] [EC:2.7.11.13]
127452151  protein kinase C alpha type-like isoform X1 [KO:K02677] [EC:2.7.11.13]
127443500  protein kinase C, beta a [KO:K19662] [EC:2.7.11.13]
127451031  protein kinase C beta type-like isoform X1 [KO:K19662] [EC:2.7.11.13]
127445425  protein kinase C beta type-like isoform X1 [KO:K19662] [EC:2.7.11.13]
127451229  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
127453517  protein kinase C alpha type-like [KO:K19663] [EC:2.7.11.13]
127453734  protein kinase C gamma type-like isoform X1 [KO:K19663] [EC:2.7.11.13]
127425076  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
127421404  nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
127452525  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
127453811  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
127418752  nuclear factor of activated T-cells, cytoplasmic 2-like isoform X1 [KO:K17332]
127419983  nuclear factor of activated T-cells, cytoplasmic 2-like [KO:K17332]
127446541  nuclear factor of activated T-cells, cytoplasmic 2-like [KO:K17332]
127448955  nuclear factor of activated T-cells, cytoplasmic 2-like [KO:K17332]
127437451  nuclear factor of activated T-cells, cytoplasmic 3-like isoform X1 [KO:K17333]
127444647  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
127416131  nuclear factor of activated T-cells, cytoplasmic 3-like isoform X1 [KO:K17333]
127436285  nuclear factor of activated T-cells, cytoplasmic 3-like isoform X1 [KO:K17333]
127441276  nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
127442571  nuclear factor of activated T-cells, cytoplasmic 4-like isoform X1 [KO:K17334]
Compound
C00076  Calcium cation
Reference
PMID:14635791
  Authors
Hatsell S, Rowlands T, Hiremath M, Cowin P.
  Title
Beta-catenin and Tcfs in mammary development and cancer.
  Journal
J Mammary Gland Biol Neoplasia 8:145-58 (2003)
DOI:10.1023/A:1025944723047
Reference
PMID:14745971
  Authors
Yang Y.
  Title
Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
  Journal
Birth Defects Res Part C Embryo Today 69:305-17 (2003)
DOI:10.1002/bdrc.10026
Reference
PMID:12446114
  Authors
Kalderon D.
  Title
Similarities between the Hedgehog and Wnt signaling pathways.
  Journal
Trends Cell Biol 12:523-31 (2002)
DOI:10.1016/S0962-8924(02)02388-7
Reference
PMID:14530294
  Authors
Nusse R.
  Title
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
  Journal
Development 130:5297-305 (2003)
DOI:10.1242/dev.00821
Reference
PMID:15102436
  Authors
Jope RS, Johnson GV.
  Title
The glamour and gloom of glycogen synthase kinase-3.
  Journal
Trends Biochem Sci 29:95-102 (2004)
DOI:10.1016/j.tibs.2003.12.004
Reference
PMID:12967557
  Authors
Veeman MT, Axelrod JD, Moon RT.
  Title
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
  Journal
Dev Cell 5:367-77 (2003)
DOI:10.1016/S1534-5807(03)00266-1
Reference
PMID:11433294
  Authors
Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
  Title
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
  Journal
Nat Cell Biol 3:628-36 (2001)
DOI:10.1038/35083016
Reference
PMID:23256519
  Authors
Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
  Title
The way Wnt works: Components and mechanism.
  Journal
Growth Factors 31:1-31 (2013)
DOI:10.3109/08977194.2012.752737
Reference
PMID:19482104
  Authors
Carethers JM
  Title
Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
  Journal
Gastroenterology 137:33-6 (2009)
DOI:10.1053/j.gastro.2009.05.011
Reference
PMID:18838381
  Authors
Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
  Title
The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
  Journal
J Biol Chem 283:33053-8 (2008)
DOI:10.1074/jbc.M804039200
Reference
PMID:23151663
  Authors
Niehrs C
  Title
The complex world of WNT receptor signalling.
  Journal
Nat Rev Mol Cell Biol 13:767-79 (2012)
DOI:10.1038/nrm3470
Reference
PMID:28522145
  Authors
Abou Ziki MD, Mani A
  Title
Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
  Journal
Atherosclerosis 262:171-178 (2017)
DOI:10.1016/j.atherosclerosis.2017.05.001
Reference
PMID:25808920
  Authors
He Y, Ki H, Kim H, Kim K
  Title
delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
  Journal
Cell Biol Int 39:954-61 (2015)
DOI:10.1002/cbin.10465
Reference
PMID:32888647
  Authors
Esaki N, Enomoto A, Takagishi M, Mizutani Y, Iida T, Ushida K, Shiraki Y, Mii S, Takahashi M
  Title
The Daple-CK1epsilon complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
  Journal
Biochem Biophys Res Commun 532:406-413 (2020)
DOI:10.1016/j.bbrc.2020.08.066
Reference
PMID:28242765
  Authors
Yiew NKH, Chatterjee TK, Tang YL, Pellenberg R, Stansfield BK, Bagi Z, Fulton DJ, Stepp DW, Chen W, Patel V, Kamath VM, Litwin SE, Hui DY, Rudich SM, Kim HW, Weintraub NL
  Title
A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.
  Journal
J Biol Chem 292:6312-6324 (2017)
DOI:10.1074/jbc.M116.758078
Related
pathway
masi04010  MAPK signaling pathway
masi04110  Cell cycle
masi04115  p53 signaling pathway
masi04120  Ubiquitin mediated proteolysis
masi04350  TGF-beta signaling pathway
masi04510  Focal adhesion
masi04520  Adherens junction
KO pathway
ko04310   
LinkDB

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